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Items: 16


Correction of ATM mutations in iPS cells from two ataxia-telangiectasia patients restores DNA damage and oxidative stress responses.

Ovchinnikov DA, Withey SL, Leeson HC, Lei UW, Sundarrajan A, Junday K, Pewarchuk M, Yeo AJ, Kijas AW, Lavin MF, Wolvetang EJ.

Hum Mol Genet. 2020 Feb 10. pii: ddaa023. doi: 10.1093/hmg/ddaa023. [Epub ahead of print]


Assaying for Radioresistant DNA Synthesis, the Hallmark Feature of the Intra-S-Phase Checkpoint Using a DNA Fiber Technique.

Kijas AW, Lavin MF.

Methods Mol Biol. 2017;1599:13-23. doi: 10.1007/978-1-4939-6955-5_2.


ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to Adaptor.

Lavin MF, Kozlov S, Gatei M, Kijas AW.

Biomolecules. 2015 Oct 23;5(4):2877-902. doi: 10.3390/biom5042877. Review.


ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.

Kijas AW, Lim YC, Bolderson E, Cerosaletti K, Gatei M, Jakob B, Tobias F, Taucher-Scholz G, Gueven N, Oakley G, Concannon P, Wolvetang E, Khanna KK, Wiesmüller L, Lavin MF.

Nucleic Acids Res. 2015 Sep 30;43(17):8352-67. doi: 10.1093/nar/gkv754. Epub 2015 Aug 3.


RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress.

Gatei M, Kijas AW, Biard D, Dörk T, Lavin MF.

Hum Mol Genet. 2014 Aug 15;23(16):4232-48. doi: 10.1093/hmg/ddu141. Epub 2014 Apr 2.


A role for homologous recombination and abnormal cell-cycle progression in radioresistance of glioma-initiating cells.

Lim YC, Roberts TL, Day BW, Harding A, Kozlov S, Kijas AW, Ensbey KS, Walker DG, Lavin MF.

Mol Cancer Ther. 2012 Sep;11(9):1863-72. doi: 10.1158/1535-7163.MCT-11-1044. Epub 2012 Jul 6.


ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.

Gatei M, Jakob B, Chen P, Kijas AW, Becherel OJ, Gueven N, Birrell G, Lee JH, Paull TT, Lerenthal Y, Fazry S, Taucher-Scholz G, Kalb R, Schindler D, Waltes R, Dörk T, Lavin MF.

J Biol Chem. 2011 Sep 9;286(36):31542-56. doi: 10.1074/jbc.M111.258152. Epub 2011 Jul 14.


Autophosphorylation and ATM activation: additional sites add to the complexity.

Kozlov SV, Graham ME, Jakob B, Tobias F, Kijas AW, Tanuji M, Chen P, Robinson PJ, Taucher-Scholz G, Suzuki K, So S, Chen D, Lavin MF.

J Biol Chem. 2011 Mar 18;286(11):9107-19. doi: 10.1074/jbc.M110.204065. Epub 2010 Dec 13.


CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response.

Becherel OJ, Jakob B, Cherry AL, Gueven N, Fusser M, Kijas AW, Peng C, Katyal S, McKinnon PJ, Chen J, Epe B, Smerdon SJ, Taucher-Scholz G, Lavin MF.

Nucleic Acids Res. 2010 Mar;38(5):1489-503. doi: 10.1093/nar/gkp1149. Epub 2009 Dec 14.


Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.

Waltes R, Kalb R, Gatei M, Kijas AW, Stumm M, Sobeck A, Wieland B, Varon R, Lerenthal Y, Lavin MF, Schindler D, Dörk T.

Am J Hum Genet. 2009 May;84(5):605-16. doi: 10.1016/j.ajhg.2009.04.010. Epub 2009 Apr 30.


A subgroup of spinocerebellar ataxias defective in DNA damage responses.

Gueven N, Chen P, Nakamura J, Becherel OJ, Kijas AW, Grattan-Smith P, Lavin MF.

Neuroscience. 2007 Apr 14;145(4):1418-25. Epub 2007 Jan 16.


Aprataxin, a novel protein that protects against genotoxic stress.

Gueven N, Becherel OJ, Kijas AW, Chen P, Howe O, Rudolph JH, Gatti R, Date H, Onodera O, Taucher-Scholz G, Lavin MF.

Hum Mol Genet. 2004 May 15;13(10):1081-93. Epub 2004 Mar 25.


Msh2 separation of function mutations confer defects in the initiation steps of mismatch repair.

Kijas AW, Studamire B, Alani E.

J Mol Biol. 2003 Aug 1;331(1):123-38.


Crystal structure and biochemical analysis of the MutS.ADP.beryllium fluoride complex suggests a conserved mechanism for ATP interactions in mismatch repair.

Alani E, Lee JY, Schofield MJ, Kijas AW, Hsieh P, Yang W.

J Biol Chem. 2003 May 2;278(18):16088-94. Epub 2003 Feb 11.

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