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Items: 16


Mirabegron elicits rat corpus cavernosum relaxation and increases in vivo erectile response.

de Oliveira MG, Rojas-Moscoso JA, Bertollotto GM, Candido TZ, Kiguti LRA, Pupo AS, Antunes E, De Nucci G, Mónica FZ.

Eur J Pharmacol. 2019 Sep 5;858:172447. doi: 10.1016/j.ejphar.2019.172447. Epub 2019 Jun 19.


Contractile Effects of Serotonin (5-HT) in the Rat Cauda Epididymis: Expression and Functional Characterization of 5-HT Receptors.

Mueller A, Kiguti LRA, Silva EJR, Pupo AS.

J Pharmacol Exp Ther. 2019 Apr;369(1):98-106. doi: 10.1124/jpet.118.254110. Epub 2019 Feb 6.


Contraction of Rat Cauda Epididymis Smooth Muscle to α1-Adrenoceptor Activation Is Mediated by α1A-Adrenoceptors.

Pacini ESA, Castilho ACS, Hebeler-Barbosa F, Pupo AS, Kiguti LRA.

J Pharmacol Exp Ther. 2018 Jul;366(1):21-28. doi: 10.1124/jpet.117.246710. Epub 2018 Apr 23.


Gender-specific impairment of in vitro sinoatrial node chronotropic responses and of myocardial ischemia tolerance in rats exposed prenatally to betamethasone.

Kiguti LRA, Borges CS, Mueller A, Silva KP, Polo CM, Rosa JL, Silva PV, Missassi G, Valencise L, Kempinas WG, Pupo AS.

Toxicol Appl Pharmacol. 2017 Nov 1;334:66-74. doi: 10.1016/j.taap.2017.09.002. Epub 2017 Sep 5.


Cardiac hyporesponsiveness in severe sepsis is associated with nitric oxide-dependent activation of G protein receptor kinase.

Dal-Secco D, DalBó S, Lautherbach NES, Gava FN, Celes MRN, Benedet PO, Souza AH, Akinaga J, Lima V, Silva KP, Kiguti LRA, Rossi MA, Kettelhut IC, Pupo AS, Cunha FQ, Assreuy J.

Am J Physiol Heart Circ Physiol. 2017 Jul 1;313(1):H149-H163. doi: 10.1152/ajpheart.00052.2016. Epub 2017 May 19.


How important is the α1-adrenoceptor in primate and rodent proximal urethra? Sex differences in the contribution of α1-adrenoceptor to urethral contractility.

Alexandre EC, de Oliveira MG, Campos R, Kiguti LR, Calmasini FB, Silva FH, Grant AD, Yoshimura N, Antunes E.

Am J Physiol Renal Physiol. 2017 Jun 1;312(6):F1026-F1034. doi: 10.1152/ajprenal.00013.2017. Epub 2017 Mar 15.


Long-term adverse effects on reproductive function in male rats exposed prenatally to the glucocorticoid betamethasone.

Borges CD, Dias AF, Silva PV, Rosa JL, Guerra MT, Silva RF, Kiguti LR, Pupo AS, Kempinas WG.

Toxicology. 2017 Feb 1;376:15-22. doi: 10.1016/j.tox.2016.04.005. Epub 2016 Apr 27.


The Coadministration of N-Acetylcysteine Ameliorates the Effects of Arsenic Trioxide on the Male Mouse Genital System.

da Silva RF, Borges Cdos S, Villela E Silva P, Missassi G, Kiguti LR, Pupo AS, Barbosa Junior F, Anselmo-Franci JA, Kempinas Wde G.

Oxid Med Cell Longev. 2016;2016:4257498. doi: 10.1155/2016/4257498. Epub 2015 Dec 29.


Cissus sicyoides: Pharmacological Mechanisms Involved in the Anti-Inflammatory and Antidiarrheal Activities.

Beserra FP, Santos Rde C, Périco LL, Rodrigues VP, Kiguti LR, Saldanha LL, Pupo AS, da Rocha LR, Dokkedal AL, Vilegas W, Hiruma-Lima CA.

Int J Mol Sci. 2016 Jan 23;17(2). pii: E149. doi: 10.3390/ijms17020149.


Mirabegron relaxes urethral smooth muscle by a dual mechanism involving β3 -adrenoceptor activation and α1 -adrenoceptor blockade.

Alexandre EC, Kiguti LR, Calmasini FB, Silva FH, da Silva KP, Ferreira R, Ribeiro CA, Mónica FZ, Pupo AS, Antunes E.

Br J Pharmacol. 2016 Feb;173(3):415-28. doi: 10.1111/bph.13367. Epub 2016 Jan 15.


Antidiarrheal and intestinal antiinflammatory activities of a methanolic extract of Qualea parviflora Mart. in experimental models.

Mazzolin LP, Kiguti LR, da Maia EO, Fernandes LT, da Rocha LR, Vilegas W, Pupo AS, Di Stasi LC, Hiruma-Lima CA.

J Ethnopharmacol. 2013 Dec 12;150(3):1016-23. doi: 10.1016/j.jep.2013.10.006. Epub 2013 Oct 21.


Slimmer or fertile? Pharmacological mechanisms involved in reduced sperm quality and fertility in rats exposed to the anorexigen sibutramine.

Borges CS, Missassi G, Pacini ES, Kiguti LR, Sanabria M, Silva RF, Banzato TP, Perobelli JE, Pupo AS, Kempinas WG.

PLoS One. 2013 Jun 12;8(6):e66091. doi: 10.1371/journal.pone.0066091. Print 2013.


Differential phosphorylation, desensitization, and internalization of α1A-adrenoceptors activated by norepinephrine and oxymetazoline.

Akinaga J, Lima V, Kiguti LR, Hebeler-Barbosa F, Alcántara-Hernández R, García-Sáinz JA, Pupo AS.

Mol Pharmacol. 2013 Apr;83(4):870-81. doi: 10.1124/mol.112.082313. Epub 2013 Jan 30.


Acceleration of sperm transit time and reduction of sperm reserves in the epididymis of rats exposed to sibutramine.

Bellentani FF, Fernandes GS, Perobelli JE, Pacini ES, Kiguti LR, Pupo AS, Kempinas WD.

J Androl. 2011 Nov-Dec;32(6):718-24. doi: 10.2164/jandrol.111.013466. Epub 2011 Jul 15.


The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors.

Nojimoto FD, Mueller A, Hebeler-Barbosa F, Akinaga J, Lima V, Kiguti LR, Pupo AS.

Neuropharmacology. 2010 Jul-Aug;59(1-2):49-57. doi: 10.1016/j.neuropharm.2010.03.015. Epub 2010 Apr 2.


Multiple effects of sibutramine on ejaculation and on vas deferens and seminal vesicle contractility.

Nojimoto FD, Piffer RC, Kiguti LR, Lameu C, de Camargo AC, Pereira OC, Pupo AS.

Toxicol Appl Pharmacol. 2009 Sep 15;239(3):233-40. doi: 10.1016/j.taap.2009.05.021. Epub 2009 May 29.


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