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Items: 1 to 50 of 145

1.

3-18F-fluoropropane-1-thiol and 18F-PEG4-1-thiol: Versatile prosthetic groups for radiolabeling maleimide functionalized peptides.

Jacobson O, Wang Z, Yu G, Ma Y, Chen X, Kiesewetter DO.

Bioorg Med Chem. 2019 Oct 1;27(19):115041. doi: 10.1016/j.bmc.2019.08.002. Epub 2019 Aug 5.

PMID:
31402203
2.

Organosilica-Based Hollow Mesoporous Bilirubin Nanoparticles for Antioxidation-Activated Self-Protection and Tumor-Specific Deoxygenation-Driven Synergistic Therapy.

Shan L, Fan W, Wang W, Tang W, Yang Z, Wang Z, Liu Y, Shen Z, Dai Y, Cheng S, Jacobson O, Zhai K, Hu J, Ma Y, Kiesewetter DO, Gao G, Chen X.

ACS Nano. 2019 Aug 27;13(8):8903-8916. doi: 10.1021/acsnano.9b02477. Epub 2019 Aug 6.

PMID:
31374171
3.

In situ polymerization on nanoscale metal-organic frameworks for enhanced physiological stability and stimulus-responsive intracellular drug delivery.

Liu Y, Gong CS, Dai Y, Yang Z, Yu G, Liu Y, Zhang M, Lin L, Tang W, Zhou Z, Zhu G, Chen J, Jacobson O, Kiesewetter DO, Wang Z, Chen X.

Biomaterials. 2019 Oct;218:119365. doi: 10.1016/j.biomaterials.2019.119365. Epub 2019 Jul 15.

PMID:
31344642
4.

Tumor Microenvironment-Activated Ultrasensitive Nanoprobes for Specific Detection of Intratumoral Glutathione by Ratiometric Photoacoustic Imaging.

Tang L, Yu F, Tang B, Yang Z, Fan W, Zhang M, Wang Z, Jacobson O, Zhou Z, Li L, Liu Y, Kiesewetter DO, Tang W, He L, Ma Y, Niu G, Zhang X, Chen X.

ACS Appl Mater Interfaces. 2019 Aug 7;11(31):27558-27567. doi: 10.1021/acsami.9b08100. Epub 2019 Jul 29.

PMID:
31317730
5.

Improving the Theranostic Potential of Exendin 4 by Reducing the Renal Radioactivity through Brush Border Membrane Enzyme-Mediated Degradation.

Zhang M, Jacobson O, Kiesewetter DO, Ma Y, Wang Z, Lang L, Tang L, Kang F, Deng H, Yang W, Niu G, Wang J, Chen X.

Bioconjug Chem. 2019 Jun 19;30(6):1745-1753. doi: 10.1021/acs.bioconjchem.9b00280. Epub 2019 Jun 5.

PMID:
31181890
6.

An Albumin Sandwich Enhances in Vivo Circulation and Stability of Metabolically Labile Peptides.

Tian R, Zhu S, Zeng Q, Lang L, Ma Y, Kiesewetter DO, Liu Y, Fu X, Lau J, Zhu G, Jacobson O, Wang Z, Dai Y, Yu G, Brooks BR, Liu G, Niu G, Chen X.

Bioconjug Chem. 2019 Jun 19;30(6):1711-1723. doi: 10.1021/acs.bioconjchem.9b00258. Epub 2019 Jun 6.

PMID:
31082207
7.

A Logic-Gated Modular Nanovesicle Enables Programmable Drug Release for On-Demand Chemotherapy.

Tang L, Yang Z, Zhou Z, Ma Y, Kiesewetter DO, Wang Z, Fan W, Zhu S, Zhang M, Tian R, Lang L, Niu G, Zhang X, Chen X.

Theranostics. 2019 Feb 14;9(5):1358-1368. doi: 10.7150/thno.32106. eCollection 2019.

8.

In Situ Dendritic Cell Vaccine for Effective Cancer Immunotherapy.

Yang W, Zhu G, Wang S, Yu G, Yang Z, Lin L, Zhou Z, Liu Y, Dai Y, Zhang F, Shen Z, Liu Y, He Z, Lau J, Niu G, Kiesewetter DO, Hu S, Chen X.

ACS Nano. 2019 Mar 26;13(3):3083-3094. doi: 10.1021/acsnano.8b08346. Epub 2019 Mar 7.

PMID:
30835435
9.

Rational design of a super-contrast NIR-II fluorophore affords high-performance NIR-II molecular imaging guided microsurgery.

Tian R, Ma H, Yang Q, Wan H, Zhu S, Chandra S, Sun H, Kiesewetter DO, Niu G, Liang Y, Chen X.

Chem Sci. 2018 Oct 10;10(1):326-332. doi: 10.1039/c8sc03751e. eCollection 2019 Jan 7.

10.

Antidiabetic Effect of Abextide, a Long-Acting Exendin-4 Analogue in Cynomolgus Monkeys.

Niu G, Wang G, Lau J, Lang L, Jacobson O, Ma Y, Kiesewetter DO, Zhang S, Chen X.

Adv Healthc Mater. 2019 Jun;8(12):e1800686. doi: 10.1002/adhm.201800686. Epub 2018 Oct 9.

PMID:
30300471
11.

Single Low-Dose Injection of Evans Blue Modified PSMA-617 Radioligand Therapy Eliminates Prostate-Specific Membrane Antigen Positive Tumors.

Wang Z, Tian R, Niu G, Ma Y, Lang L, Szajek LP, Kiesewetter DO, Jacobson O, Chen X.

Bioconjug Chem. 2018 Sep 19;29(9):3213-3221. doi: 10.1021/acs.bioconjchem.8b00556. Epub 2018 Aug 22.

PMID:
30105912
12.

Automated radiosynthesis of [18F]FBEM, a sulfhydryl site specific labeling agent for peptides and proteins.

Lim K, Ropchan J, Kiesewetter DO, Chen X, Huang Y.

Appl Radiat Isot. 2018 Oct;140:294-299. doi: 10.1016/j.apradiso.2018.07.033. Epub 2018 Jul 29.

PMID:
30098587
13.

Repurposing Cyanine NIR-I Dyes Accelerates Clinical Translation of Near-Infrared-II (NIR-II) Bioimaging.

Zhu S, Hu Z, Tian R, Yung BC, Yang Q, Zhao S, Kiesewetter DO, Niu G, Sun H, Antaris AL, Chen X.

Adv Mater. 2018 Jul 9:e1802546. doi: 10.1002/adma.201802546. [Epub ahead of print]

PMID:
29985542
14.

Radioligand Therapy of Prostate Cancer with a Long-Lasting Prostate-Specific Membrane Antigen Targeting Agent 90Y-DOTA-EB-MCG.

Wang Z, Jacobson O, Tian R, Mease RC, Kiesewetter DO, Niu G, Pomper MG, Chen X.

Bioconjug Chem. 2018 Jul 18;29(7):2309-2315. doi: 10.1021/acs.bioconjchem.8b00292. Epub 2018 Jun 15.

15.

Chronic neuropathic pain reduces opioid receptor availability with associated anhedonia in rat.

Thompson SJ, Pitcher MH, Stone LS, Tarum F, Niu G, Chen X, Kiesewetter DO, Schweinhardt P, Bushnell MC.

Pain. 2018 Sep;159(9):1856-1866. doi: 10.1097/j.pain.0000000000001282.

16.

A paclitaxel prodrug with bifunctional folate and albumin binding moieties for both passive and active targeted cancer therapy.

Shan L, Zhuo X, Zhang F, Dai Y, Zhu G, Yung BC, Fan W, Zhai K, Jacobson O, Kiesewetter DO, Ma Y, Gao G, Chen X.

Theranostics. 2018 Feb 16;8(7):2018-2030. doi: 10.7150/thno.24382. eCollection 2018.

17.

Evans Blue Attachment Enhances Somatostatin Receptor Subtype-2 Imaging and Radiotherapy.

Tian R, Jacobson O, Niu G, Kiesewetter DO, Wang Z, Zhu G, Ma Y, Liu G, Chen X.

Theranostics. 2018 Jan 1;8(3):735-745. doi: 10.7150/thno.23491. eCollection 2018.

18.

Engineered Zn(II)-Dipicolylamine-Gold Nanorod Provides Effective Prostate Cancer Treatment by Combining siRNA Delivery and Photothermal Therapy.

Min KH, Kim YH, Wang Z, Kim J, Kim JS, Kim SH, Kim K, Kwon IC, Kiesewetter DO, Chen X.

Theranostics. 2017 Sep 26;7(17):4240-4254. doi: 10.7150/thno.22435. eCollection 2017.

19.

Quantification of Tumor Vascular Permeability and Blood Volume by Positron Emission Tomography.

Chen H, Tong X, Lang L, Jacobson O, Yung BC, Yang X, Bai R, Kiesewetter DO, Ma Y, Wu H, Niu G, Chen X.

Theranostics. 2017 Jun 14;7(9):2363-2376. doi: 10.7150/thno.19898. eCollection 2017.

20.

PET-Guided Evaluation and Optimization of Internalized Antibody-Drug Conjugates Targeting Erythropoietin-Producing Hepatoma A2 Receptor.

Jacobson O, Li Q, Chen H, Niu G, Kiesewetter DO, Xu L, Cook K, Yang G, Dall'Acqua W, Tsui P, Peng L, Chen X.

J Nucl Med. 2017 Nov;58(11):1838-1844. doi: 10.2967/jnumed.117.192245. Epub 2017 May 25.

21.

Correction to "Novel 19F Activatable Probe for the Detection of Matrix Metalloprotease-2 Activity by MRI/MRS".

Yue X, Wang Z, Zhu L, Wang Y, Qian C, Ma Y, Kiesewetter DO, Niu G, Chen X.

Mol Pharm. 2017 Apr 3;14(4):1317-1318. doi: 10.1021/acs.molpharmaceut.7b00150. Epub 2017 Mar 9. No abstract available.

22.

Novel "Add-On" Molecule Based on Evans Blue Confers Superior Pharmacokinetics and Transforms Drugs to Theranostic Agents.

Chen H, Jacobson O, Niu G, Weiss ID, Kiesewetter DO, Liu Y, Ma Y, Wu H, Chen X.

J Nucl Med. 2017 Apr;58(4):590-597. doi: 10.2967/jnumed.116.182097. Epub 2016 Nov 22.

23.

Size Dependent Kinetics of Gold Nanorods in EPR Mediated Tumor Delivery.

Tong X, Wang Z, Sun X, Song J, Jacobson O, Niu G, Kiesewetter DO, Chen X.

Theranostics. 2016 Sep 9;6(12):2039-2051. eCollection 2016.

24.

Albumin-Binding Evans Blue Derivatives for Diagnostic Imaging and Production of Long-Acting Therapeutics.

Jacobson O, Kiesewetter DO, Chen X.

Bioconjug Chem. 2016 Oct 19;27(10):2239-2247. doi: 10.1021/acs.bioconjchem.6b00487. Epub 2016 Oct 6.

PMID:
27682195
25.

Monitoring Tumor Hypoxia Using (18)F-FMISO PET and Pharmacokinetics Modeling after Photodynamic Therapy.

Tong X, Srivatsan A, Jacobson O, Wang Y, Wang Z, Yang X, Niu G, Kiesewetter DO, Zheng H, Chen X.

Sci Rep. 2016 Aug 22;6:31551. doi: 10.1038/srep31551.

26.

A photothermally responsive nanoprobe for bioimaging based on Edman degradation.

Liu Y, Wang Z, Zhang H, Lang L, Ma Y, He Q, Lu N, Huang P, Liu Y, Song J, Liu Z, Gao S, Ma Q, Kiesewetter DO, Chen X.

Nanoscale. 2016 May 19;8(20):10553-7. doi: 10.1039/c6nr01400c.

27.

Chemical Conjugation of Evans Blue Derivative: A Strategy to Develop Long-Acting Therapeutics through Albumin Binding.

Chen H, Wang G, Lang L, Jacobson O, Kiesewetter DO, Liu Y, Ma Y, Zhang X, Wu H, Zhu L, Niu G, Chen X.

Theranostics. 2016 Jan 1;6(2):243-53. doi: 10.7150/thno.14322. eCollection 2016.

28.

Glucagon-Like Peptide-1 Receptor PET/CT with 68Ga-NOTA-Exendin-4 for Detecting Localized Insulinoma: A Prospective Cohort Study.

Luo Y, Pan Q, Yao S, Yu M, Wu W, Xue H, Kiesewetter DO, Zhu Z, Li F, Zhao Y, Chen X.

J Nucl Med. 2016 May;57(5):715-20. doi: 10.2967/jnumed.115.167445. Epub 2016 Jan 21.

29.

68Ga-NOTA-Exendin-4 PET/CT in Localization of an Occult Insulinoma and Appearance of Coexisting Esophageal Carcinoma.

Luo Y, Li N, Kiesewetter DO, Chen X, Li F.

Clin Nucl Med. 2016 Apr;41(4):341-3. doi: 10.1097/RLU.0000000000001087.

30.

Stable Evans Blue Derived Exendin-4 Peptide for Type 2 Diabetes Treatment.

Liu Y, Wang G, Zhang H, Ma Y, Lang L, Jacobson O, Kiesewetter DO, Zhu L, Gao S, Ma Q, Chen X.

Bioconjug Chem. 2016 Jan 20;27(1):54-8. doi: 10.1021/acs.bioconjchem.5b00625. Epub 2015 Dec 10.

31.

Boramino acid as a marker for amino acid transporters.

Liu Z, Chen H, Chen K, Shao Y, Kiesewetter DO, Niu G, Chen X.

Sci Adv. 2015 Sep 11;1(8):e1500694. doi: 10.1126/sciadv.1500694. eCollection 2015 Sep.

32.

NIR-Responsive On-Demand Release of CO from Metal Carbonyl-Caged Graphene Oxide Nanomedicine.

He Q, Kiesewetter DO, Qu Y, Fu X, Fan J, Huang P, Liu Y, Zhu G, Liu Y, Qian Z, Chen X.

Adv Mater. 2015 Nov;27(42):6741-6. doi: 10.1002/adma.201502762. Epub 2015 Sep 24.

33.

18F-Labeled Single-Stranded DNA Aptamer for PET Imaging of Protein Tyrosine Kinase-7 Expression.

Jacobson O, Weiss ID, Wang L, Wang Z, Yang X, Dewhurst A, Ma Y, Zhu G, Niu G, Kiesewetter DO, Vasdev N, Liang SH, Chen X.

J Nucl Med. 2015 Nov;56(11):1780-1785. doi: 10.2967/jnumed.115.160960. Epub 2015 Aug 27.

34.

One-step (18)F labeling of biomolecules using organotrifluoroborates.

Liu Z, Lin KS, BĂ©nard F, Pourghiasian M, Kiesewetter DO, Perrin DM, Chen X.

Nat Protoc. 2015 Sep;10(9):1423-32. doi: 10.1038/nprot.2015.090. Epub 2015 Aug 27.

35.

Al[18F]NOTA-T140 Peptide for Noninvasive Visualization of CXCR4 Expression.

Yan X, Niu G, Wang Z, Yang X, Kiesewetter DO, Jacobson O, Shen B, Chen X.

Mol Imaging Biol. 2016 Feb;18(1):135-42. doi: 10.1007/s11307-015-0872-2.

36.

Novel Method for Radiolabeling and Dimerizing Thiolated Peptides Using (18)F-Hexafluorobenzene.

Jacobson O, Yan X, Ma Y, Niu G, Kiesewetter DO, Chen X.

Bioconjug Chem. 2015 Oct 21;26(10):2016-20. doi: 10.1021/acs.bioconjchem.5b00278. Epub 2015 Jun 24.

37.

Design of a functional cyclic HSV1-TK reporter and its application to PET imaging of apoptosis.

Wang Z, Wang F, Hida N, Kiesewetter DO, Tian J, Niu G, Chen X.

Nat Protoc. 2015 May;10(5):807-21. doi: 10.1038/nprot.2015.048. Epub 2015 Apr 30.

38.

Quantitative Evaluation of Tumor Early Response to a Vascular-Disrupting Agent with Dynamic PET.

Guo N, Zhang F, Zhang X, Guo J, Lang L, Kiesewetter DO, Niu G, Li Q, Chen X.

Mol Imaging Biol. 2015 Dec;17(6):865-73. doi: 10.1007/s11307-015-0854-4.

39.

PET imaging of tenascin-C with a radiolabeled single-stranded DNA aptamer.

Jacobson O, Yan X, Niu G, Weiss ID, Ma Y, Szajek LP, Shen B, Kiesewetter DO, Chen X.

J Nucl Med. 2015 Apr;56(4):616-21. doi: 10.2967/jnumed.114.149484. Epub 2015 Feb 19.

40.

Intrinsically radioactive [64Cu]CuInS/ZnS quantum dots for PET and optical imaging: improved radiochemical stability and controllable Cerenkov luminescence.

Guo W, Sun X, Jacobson O, Yan X, Min K, Srivatsan A, Niu G, Kiesewetter DO, Chang J, Chen X.

ACS Nano. 2015 Jan 27;9(1):488-95. doi: 10.1021/nn505660r. Epub 2015 Jan 2.

41.

In vivo albumin labeling and lymphatic imaging.

Wang Y, Lang L, Huang P, Wang Z, Jacobson O, Kiesewetter DO, Ali IU, Teng G, Niu G, Chen X.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):208-13. doi: 10.1073/pnas.1414821112. Epub 2014 Dec 22.

42.

Bioinspired nanocomplex for spatiotemporal imaging of sequential mRNA expression in differentiating neural stem cells.

Wang Z, Zhang R, Wang Z, Wang HF, Wang Y, Zhao J, Wang F, Li W, Niu G, Kiesewetter DO, Chen X.

ACS Nano. 2014 Dec 23;8(12):12386-96. doi: 10.1021/nn505047n. Epub 2014 Dec 12.

43.

Fluorine-18 radiochemistry, labeling strategies and synthetic routes.

Jacobson O, Kiesewetter DO, Chen X.

Bioconjug Chem. 2015 Jan 21;26(1):1-18. doi: 10.1021/bc500475e. Epub 2014 Dec 12. Review.

44.

68Ga-NOTA-exendin-4 PET/CT in detection of occult insulinoma and evaluation of physiological uptake.

Luo Y, Yu M, Pan Q, Wu W, Zhang T, Kiesewetter DO, Zhu Z, Li F, Chen X, Zhao Y.

Eur J Nucl Med Mol Imaging. 2015 Mar;42(3):531-2. doi: 10.1007/s00259-014-2946-9. Epub 2014 Nov 15. No abstract available.

45.

Novel 19F activatable probe for the detection of matrix metalloprotease-2 activity by MRI/MRS.

Yue X, Wang Z, Zhu L, Wang Y, Qian C, Ma Y, Kiesewetter DO, Niu G, Chen X.

Mol Pharm. 2014 Nov 3;11(11):4208-17. doi: 10.1021/mp500443x. Epub 2014 Oct 13. Erratum in: Mol Pharm. 2017 Apr 3;14(4):1317-1318.

46.

[(18)F]DPA-714 PET imaging of AMD3100 treatment in a mouse model of stroke.

Wang Y, Yue X, Kiesewetter DO, Wang Z, Lu J, Niu G, Teng G, Chen X.

Mol Pharm. 2014 Oct 6;11(10):3463-70. doi: 10.1021/mp500234d. Epub 2014 Sep 4.

47.

Chelator-free (64)Cu-integrated gold nanomaterials for positron emission tomography imaging guided photothermal cancer therapy.

Sun X, Huang X, Yan X, Wang Y, Guo J, Jacobson O, Liu D, Szajek LP, Zhu W, Niu G, Kiesewetter DO, Sun S, Chen X.

ACS Nano. 2014 Aug 26;8(8):8438-46.

48.

In Vivo Labeling of Serum Albumin for PET.

Niu G, Lang L, Kiesewetter DO, Ma Y, Sun Z, Guo N, Guo J, Wu C, Chen X.

J Nucl Med. 2014 Jul;55(7):1150-6. doi: 10.2967/jnumed.114.139642. Epub 2014 May 19.

49.

One-pot two-step radiosynthesis of a new (18)F-labeled thiol reactive prosthetic group and its conjugate for insulinoma imaging.

Yue X, Yan X, Wu C, Niu G, Ma Y, Jacobson O, Shen B, Kiesewetter DO, Chen X.

Mol Pharm. 2014 Nov 3;11(11):3875-84. doi: 10.1021/mp5001857. Epub 2014 May 12.

50.

A symmetrical fluorous dendron-cyanine dye-conjugated bimodal nanoprobe for quantitative 19F MRI and NIR fluorescence bioimaging.

Wang Z, Yue X, Wang Y, Qian C, Huang P, Lizak M, Niu G, Wang F, Rong P, Kiesewetter DO, Ma Y, Chen X.

Adv Healthc Mater. 2014 Aug;3(8):1326-33. doi: 10.1002/adhm.201400088. Epub 2014 May 2.

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