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Items: 29


Notch-mediated lateral induction is necessary to maintain vestibular prosensory identity during inner ear development.

Brown RM 2nd, Nelson JC, Zhang H, Kiernan AE, Groves AK.

Dev Biol. 2020 Mar 5. pii: S0012-1606(20)30075-0. doi: 10.1016/j.ydbio.2020.02.015. [Epub ahead of print]


SOX2 is required for inner ear growth and cochlear nonsensory formation before sensory development.

Steevens AR, Glatzer JC, Kellogg CC, Low WC, Santi PA, Kiernan AE.

Development. 2019 Jun 21;146(13). pii: dev170522. doi: 10.1242/dev.170522.


Ciliary margin-derived BMP4 does not have a major role in ocular development.

Rausch RL, Libby RT, Kiernan AE.

PLoS One. 2018 May 8;13(5):e0197048. doi: 10.1371/journal.pone.0197048. eCollection 2018.


Trabecular meshwork morphogenesis: A comparative analysis of wildtype and anterior segment dysgenesis mouse models.

Rausch RL, Libby RT, Kiernan AE.

Exp Eye Res. 2018 May;170:81-91. doi: 10.1016/j.exer.2018.02.011. Epub 2018 Feb 13.


Deletion of a Long-Range Dlx5 Enhancer Disrupts Inner Ear Development in Mice.

Johnson KR, Gagnon LH, Tian C, Longo-Guess CM, Low BE, Wiles MV, Kiernan AE.

Genetics. 2018 Mar;208(3):1165-1179. doi: 10.1534/genetics.117.300447. Epub 2018 Jan 3.


SOX2 is required for inner ear neurogenesis.

Steevens AR, Sookiasian DL, Glatzer JC, Kiernan AE.

Sci Rep. 2017 Jun 22;7(1):4086. doi: 10.1038/s41598-017-04315-2.


Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.

Fernandes KA, Harder JM, Williams PA, Rausch RL, Kiernan AE, Nair KS, Anderson MG, John SW, Howell GR, Libby RT.

Exp Eye Res. 2015 Dec;141:42-56. doi: 10.1016/j.exer.2015.06.019. Epub 2015 Jun 24. Review.


Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells.

Savoy-Burke G, Gilels FA, Pan W, Pratt D, Que J, Gan L, White PM, Kiernan AE.

PLoS One. 2014 Sep 29;9(9):e108160. doi: 10.1371/journal.pone.0108160. eCollection 2014.


LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochlea.

Deng M, Luo XJ, Pan L, Yang H, Xie X, Liang G, Huang L, Hu F, Kiernan AE, Gan L.

J Neurosci. 2014 Jul 23;34(30):10072-7. doi: 10.1523/JNEUROSCI.0352-14.2014.


Ectopic expression of activated notch or SOX2 reveals similar and unique roles in the development of the sensory cell progenitors in the mammalian inner ear.

Pan W, Jin Y, Chen J, Rottier RJ, Steel KP, Kiernan AE.

J Neurosci. 2013 Oct 9;33(41):16146-57. doi: 10.1523/JNEUROSCI.3150-12.2013.


Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye.

Zhou Y, Tanzie C, Yan Z, Chen S, Duncan M, Gaudenz K, Li H, Seidel C, Lewis B, Moran A, Libby RT, Kiernan AE, Xie T.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8966-71. doi: 10.1073/pnas.1218145110. Epub 2013 May 15.


Notch signaling during cell fate determination in the inner ear.

Kiernan AE.

Semin Cell Dev Biol. 2013 May;24(5):470-9. doi: 10.1016/j.semcdb.2013.04.002. Epub 2013 Apr 8. Review.


Mutanlallemand (mtl) and Belly Spot and Deafness (bsd) are two new mutations of Lmx1a causing severe cochlear and vestibular defects.

Steffes G, Lorente-Cánovas B, Pearson S, Brooker RH, Spiden S, Kiernan AE, Guénet JL, Steel KP.

PLoS One. 2012;7(11):e51065. doi: 10.1371/journal.pone.0051065. Epub 2012 Nov 30.


Notch signaling is required for the generation of hair cells and supporting cells in the mammalian inner ear.

Pan W, Jin Y, Stanger B, Kiernan AE.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15798-803. doi: 10.1073/pnas.1003089107. Epub 2010 Aug 23.


Genetic background modifies inner ear and eye phenotypes of jag1 heterozygous mice.

Kiernan AE, Li R, Hawes NL, Churchill GA, Gridley T.

Genetics. 2007 Sep;177(1):307-11.


The paintfill method as a tool for analyzing the three-dimensional structure of the inner ear.

Kiernan AE.

Brain Res. 2006 May 26;1091(1):270-6. Epub 2006 Apr 5.


The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear.

Kiernan AE, Xu J, Gridley T.

PLoS Genet. 2006 Jan;2(1):e4. Epub 2006 Jan 13.


The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.

Kiernan AE, Cordes R, Kopan R, Gossler A, Gridley T.

Development. 2005 Oct;132(19):4353-62. Epub 2005 Sep 1.


Sox2 is required for sensory organ development in the mammalian inner ear.

Kiernan AE, Pelling AL, Leung KK, Tang AS, Bell DM, Tease C, Lovell-Badge R, Steel KP, Cheah KS.

Nature. 2005 Apr 21;434(7036):1031-5.


Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice.

Hulander M, Kiernan AE, Blomqvist SR, Carlsson P, Samuelsson EJ, Johansson BR, Steel KP, Enerbäck S.

Development. 2003 May;130(9):2013-25.


ENU mutagenesis reveals a highly mutable locus on mouse Chromosome 4 that affects ear morphogenesis.

Kiernan AE, Erven A, Voegeling S, Peters J, Nolan P, Hunter J, Bacon Y, Steel KP, Brown SD, Guénet JL.

Mamm Genome. 2002 Mar;13(3):142-8.


The Wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects.

Alavizadeh A, Kiernan AE, Nolan P, Lo C, Steel KP, Bucan M.

Dev Biol. 2001 Jun 1;234(1):244-60.


The Notch ligand Jagged1 is required for inner ear sensory development.

Kiernan AE, Ahituv N, Fuchs H, Balling R, Avraham KB, Steel KP, Hrabé de Angelis M.

Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3873-8. Epub 2001 Mar 20.


The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti.

Tsai H, Hardisty RE, Rhodes C, Kiernan AE, Roby P, Tymowska-Lalanne Z, Mburu P, Rastan S, Hunter AJ, Brown SD, Steel KP.

Hum Mol Genet. 2001 Mar 1;10(5):507-12.


Molecular genetics of pattern formation in the inner ear: do compartment boundaries play a role?

Brigande JV, Kiernan AE, Gao X, Iten LE, Fekete DM.

Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11700-6.


Tailchaser (Tlc): a new mouse mutation affecting hair bundle differentiation and hair cell survival.

Kiernan AE, Zalzman M, Fuchs H, Hrabe de Angelis M, Balling R, Steel KP, Avraham KB.

J Neurocytol. 1999 Oct-Nov;28(10-11):969-85.


Mouse homologues for human deafness.

Kiernan AE, Steel KP.

Adv Otorhinolaryngol. 2000;56:233-43. Review. No abstract available.


In vivo gene transfer into the embryonic inner ear using retroviral vectors.

Kiernan AE, Fekete DM.

Audiol Neurootol. 1997 Jan-Apr;2(1-2):12-24. Review.


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