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Items: 1 to 50 of 66

1.

Trends in Pretreatment HIV-1 Drug Resistance in Antiretroviral Therapy-naive Adults in South Africa, 2000-2016: A Pooled Sequence Analysis.

Chimukangara B, Lessells RJ, Rhee SY, Giandhari J, Kharsany ABM, Naidoo K, Lewis L, Cawood C, Khanyile D, Ayalew KA, Diallo K, Samuel R, Hunt G, Vandormael A, Stray-Pedersen B, Gordon M, Makadzange T, Kiepiela P, Ramjee G, Ledwaba J, Kalimashe M, Morris L, Parikh UM, Mellors JW, Shafer RW, Katzenstein D, Moodley P, Gupta RK, Pillay D, Abdool Karim SS, de Oliveira T.

EClinicalMedicine. 2019 Mar 18;9:26-34. doi: 10.1016/j.eclinm.2019.03.006. eCollection 2019 Mar.

2.

Role of HIV-specific CD8+ T cells in pediatric HIV cure strategies after widespread early viral escape.

Leitman EM, Thobakgale CF, Adland E, Ansari MA, Raghwani J, Prendergast AJ, Tudor-Williams G, Kiepiela P, Hemelaar J, Brener J, Tsai MH, Mori M, Riddell L, Luzzi G, Jooste P, Ndung'u T, Walker BD, Pybus OG, Kellam P, Naranbhai V, Matthews PC, Gall A, Goulder PJR.

J Exp Med. 2017 Nov 6;214(11):3239-3261. doi: 10.1084/jem.20162123. Epub 2017 Oct 5.

3.

Detecting Mycobacterium tuberculosis using the loop-mediated isothermal amplification test in South Africa.

Reddy S, Ntoyanto S, Sakadavan Y, Reddy T, Mahomed S, Dlamini M, Spooner B, Ramjee G, Coutsoudis A, Ngomane N, Naidoo K, Mlisana K, Kiepiela P.

Int J Tuberc Lung Dis. 2017 Oct 1;21(10):1154-1160. doi: 10.5588/ijtld.16.0863.

PMID:
28911361
4.

Randomised controlled trial testing the effect of cotrimoxazole prophylaxis on morbidity and mortality outcomes in breastfed HIV-exposed uninfected infants: study protocol.

Coutsoudis A, Daniels B, Moodley-Govender E, Ngomane N, Zako L, Spooner E, Kiepiela P, Reddy S, Kuhn L, Ramjee G.

BMJ Open. 2016 Jul 12;6(7):e010656. doi: 10.1136/bmjopen-2015-010656.

5.

PIMA™ point-of-care testing for CD4 counts in predicting antiretroviral initiation in HIV-infected individuals in KwaZulu-Natal, Durban, South Africa.

Skhosana M, Reddy S, Reddy T, Ntoyanto S, Spooner E, Ramjee G, Ngomane N, Coutsoudis A, Kiepiela P.

South Afr J HIV Med. 2016 Jun 24;17(1):444. doi: 10.4102/sajhivmed.v17i1.444. eCollection 2016.

6.

Correction for Thobakgale et al., Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeficiency Virus Type 1 Infection.

Thobakgale CF, Prendergast A, Crawford H, Mkhwanazi N, Ramduth D, Reddy S, Molina C, Mncube Z, Leslie A, Prado J, Chonco F, Mphatshwe W, Tudor-Williams G, Jeena P, Blanckenberg N, Dong K, Kiepiela P, Coovadia H, Ndung'u T, Walker BD, Goulder PJ.

J Virol. 2015 Aug;89(15):8101. doi: 10.1128/JVI.00876-15. Epub 2015 Jul 8. No abstract available.

7.

Characteristics Associated with HIV Drug Resistance Among Women Screening for an HIV Prevention Trial in KwaZulu-Natal, South Africa.

Mensch BS, Gorbach PM, Kelly C, Kiepiela P, Gomez K, Ramjee G, Ganesh S, Morar N, Soto-Torres L, Parikh UM.

AIDS Behav. 2015 Nov;19(11):2076-86. doi: 10.1007/s10461-015-1056-4.

8.

Prevalence of HIV-1 drug resistance among women screening for HIV prevention trials in KwaZulu-Natal, South Africa (MTN-009).

Parikh UM, Kiepiela P, Ganesh S, Gomez K, Horn S, Eskay K, Kelly C, Mensch B, Gorbach P, Soto-Torres L, Ramjee G, Mellors JW; MTN-009 Protocol Team.

PLoS One. 2013 Apr 9;8(4):e59787. doi: 10.1371/journal.pone.0059787. Print 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/8096d24f-06de-4e42-8834-b5d3e116253c. IPTc Taskforce [corrected to MTN-009 Protocol Team].

9.

Use of abacavir in 30 HIV-infected children from Durban, South Africa: report from a pilot study.

Bobat R, Kindra G, Kiepiela P, Reddy S, Jeena PM, Adhikari M, Coovadia HM.

Pediatr Infect Dis J. 2010 Sep;29(9):890. doi: 10.1097/INF.0b013e3181e5a0fe. No abstract available.

PMID:
20720476
10.

Substantial regional differences in human herpesvirus 8 seroprevalence in sub-Saharan Africa: insights on the origin of the "Kaposi's sarcoma belt".

Dollard SC, Butler LM, Jones AM, Mermin JH, Chidzonga M, Chipato T, Shiboski CH, Brander C, Mosam A, Kiepiela P, Hladik W, Martin JN.

Int J Cancer. 2010 Nov 15;127(10):2395-401. doi: 10.1002/ijc.25235.

11.

Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa.

Brumme Z, Wang B, Nair K, Brumme C, de Pierres C, Reddy S, Julg B, Moodley E, Thobakgale C, Lu Z, van der Stok M, Bishop K, Mncube Z, Chonco F, Yuki Y, Frahm N, Brander C, Carrington M, Freedberg K, Kiepiela P, Goulder P, Walker B, Ndung'u T, Losina E.

Clin Infect Dis. 2009 Sep 15;49(6):956-64. doi: 10.1086/605503.

12.

Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.

Thobakgale CF, Prendergast A, Crawford H, Mkhwanazi N, Ramduth D, Reddy S, Molina C, Mncube Z, Leslie A, Prado J, Chonco F, Mphatshwe W, Tudor-Williams G, Jeena P, Blanckenberg N, Dong K, Kiepiela P, Coovadia H, Ndung'u T, Walker BD, Goulder PJ.

J Virol. 2009 Oct;83(19):10234-44. doi: 10.1128/JVI.00921-09. Epub 2009 Jul 15. Erratum in: J Virol. 2015 Aug;89(15):8101.

13.

Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission.

Butler LM, Dorsey G, Hladik W, Rosenthal PJ, Brander C, Neilands TB, Mbisa G, Whitby D, Kiepiela P, Mosam A, Mzolo S, Dollard SC, Martin JN.

J Infect Dis. 2009 Aug 1;200(3):430-8. doi: 10.1086/600103.

14.

Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.

Ramduth D, Day CL, Thobakgale CF, Mkhwanazi NP, de Pierres C, Reddy S, van der Stok M, Mncube Z, Nair K, Moodley ES, Kaufmann DE, Streeck H, Coovadia HM, Kiepiela P, Goulder PJ, Walker BD.

PLoS One. 2009;4(4):e5013. doi: 10.1371/journal.pone.0005013. Epub 2009 Apr 7.

15.

Detection of HIV type 1 gag-specific CD4(+) T cell responses in acutely infected infants.

Ramduth D, Thobakgale CF, Mkhwanazi NP, De Pierres C, Reddy S, van der Stok M, Mncube Z, Mphatswe W, Blanckenberg N, Cengimbo A, Prendergast A, Tudor-Williams G, Dong K, Jeena P, Coovadia HM, Day CL, Kiepiela P, Goulder PJ, Walker BD.

AIDS Res Hum Retroviruses. 2008 Feb;24(2):265-70. doi: 10.1089/aid.2007.0096.

PMID:
18284325
16.

Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.

Ngumbela KC, Day CL, Mncube Z, Nair K, Ramduth D, Thobakgale C, Moodley E, Reddy S, de Pierres C, Mkhwanazi N, Bishop K, van der Stok M, Ismail N, Honeyborne I, Crawford H, Kavanagh DG, Rousseau C, Nickle D, Mullins J, Heckerman D, Korber B, Coovadia H, Kiepiela P, Goulder PJ, Walker BD.

AIDS Res Hum Retroviruses. 2008 Jan;24(1):72-82. doi: 10.1089/aid.2007.0124.

PMID:
18275350
17.

Retraction notice to "Laboratory markers associated with progression of HIV infection [Best Practice & Research Clinical Obstetrics & Gynaecology 19 (2005) 243-254]".

Kiepiela P, Smith AN, Rosenberg E.

Best Pract Res Clin Obstet Gynaecol. 2007 Oct;21(5):883. No abstract available.

PMID:
18061996
18.

Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants.

Thobakgale CF, Ramduth D, Reddy S, Mkhwanazi N, de Pierres C, Moodley E, Mphatswe W, Blanckenberg N, Cengimbo A, Prendergast A, Tudor-Williams G, Dong K, Jeena P, Kindra G, Bobat R, Coovadia H, Kiepiela P, Walker BD, Goulder PJ.

J Virol. 2007 Dec;81(23):12775-84. Epub 2007 Sep 19.

19.

High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis.

Mphatswe W, Blanckenberg N, Tudor-Williams G, Prendergast A, Thobakgale C, Mkhwanazi N, McCarthy N, Walker BD, Kiepiela P, Goulder P.

AIDS. 2007 Jun 19;21(10):1253-61.

PMID:
17545701
20.

Kaposi's sarcoma-associated herpesvirus-specific immune reconstitution and antiviral effect of combined HAART/chemotherapy in HIV clade C-infected individuals with Kaposi's sarcoma.

Bihl F, Mosam A, Henry LN, Chisholm JV 3rd, Dollard S, Gumbi P, Cassol E, Page T, Mueller N, Kiepiela P, Martin JN, Coovadia HM, Scadden DT, Brander C.

AIDS. 2007 Jun 19;21(10):1245-52.

PMID:
17545700
21.

Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.

Crawford H, Prado JG, Leslie A, Hué S, Honeyborne I, Reddy S, van der Stok M, Mncube Z, Brander C, Rousseau C, Mullins JI, Kaslow R, Goepfert P, Allen S, Hunter E, Mulenga J, Kiepiela P, Walker BD, Goulder PJ.

J Virol. 2007 Aug;81(15):8346-51. Epub 2007 May 16.

22.

Effective T-cell responses select human immunodeficiency virus mutants and slow disease progression.

Frater AJ, Brown H, Oxenius A, Günthard HF, Hirschel B, Robinson N, Leslie AJ, Payne R, Crawford H, Prendergast A, Brander C, Kiepiela P, Walker BD, Goulder PJ, McLean A, Phillips RE.

J Virol. 2007 Jun;81(12):6742-51. Epub 2007 Apr 4.

23.

Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections.

Rousseau CM, Learn GH, Bhattacharya T, Nickle DC, Heckerman D, Chetty S, Brander C, Goulder PJ, Walker BD, Kiepiela P, Korber BT, Mullins JI.

J Virol. 2007 May;81(9):4492-500. Epub 2007 Feb 21.

24.

Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.

Honeyborne I, Prendergast A, Pereyra F, Leslie A, Crawford H, Payne R, Reddy S, Bishop K, Moodley E, Nair K, van der Stok M, McCarthy N, Rousseau CM, Addo M, Mullins JI, Brander C, Kiepiela P, Walker BD, Goulder PJ.

J Virol. 2007 Apr;81(7):3667-72. Epub 2007 Jan 24.

25.

CD8+ T-cell responses to different HIV proteins have discordant associations with viral load.

Kiepiela P, Ngumbela K, Thobakgale C, Ramduth D, Honeyborne I, Moodley E, Reddy S, de Pierres C, Mncube Z, Mkhwanazi N, Bishop K, van der Stok M, Nair K, Khan N, Crawford H, Payne R, Leslie A, Prado J, Prendergast A, Frater J, McCarthy N, Brander C, Learn GH, Nickle D, Rousseau C, Coovadia H, Mullins JI, Heckerman D, Walker BD, Goulder P.

Nat Med. 2007 Jan;13(1):46-53. Epub 2006 Dec 17.

PMID:
17173051
26.

Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.

Yu XG, Lichterfeld M, Chetty S, Williams KL, Mui SK, Miura T, Frahm N, Feeney ME, Tang Y, Pereyra F, Labute MX, Pfafferott K, Leslie A, Crawford H, Allgaier R, Hildebrand W, Kaslow R, Brander C, Allen TM, Rosenberg ES, Kiepiela P, Vajpayee M, Goepfert PA, Altfeld M, Goulder PJ, Walker BD.

J Virol. 2007 Feb;81(4):1619-31. Epub 2006 Nov 22.

27.

Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection.

Day CL, Kiepiela P, Leslie AJ, van der Stok M, Nair K, Ismail N, Honeyborne I, Crawford H, Coovadia HM, Goulder PJ, Walker BD, Klenerman P.

J Virol. 2007 Jan;81(1):434-8. Epub 2006 Oct 18.

28.

Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.

Leslie A, Price DA, Mkhize P, Bishop K, Rathod A, Day C, Crawford H, Honeyborne I, Asher TE, Luzzi G, Edwards A, Rousseau CM, Mullins JI, Tudor-Williams G, Novelli V, Brander C, Douek DC, Kiepiela P, Walker BD, Goulder PJ.

J Immunol. 2006 Oct 1;177(7):4699-708. Erratum in: J Immunol. 2006 Dec 15;177(12):8878. Rosseau, Christine M [corrected to Rousseau, Christine M].

29.

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression.

Day CL, Kaufmann DE, Kiepiela P, Brown JA, Moodley ES, Reddy S, Mackey EW, Miller JD, Leslie AJ, DePierres C, Mncube Z, Duraiswamy J, Zhu B, Eichbaum Q, Altfeld M, Wherry EJ, Coovadia HM, Goulder PJ, Klenerman P, Ahmed R, Freeman GJ, Walker BD.

Nature. 2006 Sep 21;443(7109):350-4. Epub 2006 Aug 20.

PMID:
16921384
30.

HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory.

Wherry EJ, Day CL, Draenert R, Miller JD, Kiepiela P, Woodberry T, Brander C, Addo M, Klenerman P, Ahmed R, Walker BD.

Virology. 2006 Sep 30;353(2):366-73. Epub 2006 Jul 24.

31.

Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomes.

Rousseau CM, Birditt BA, McKay AR, Stoddard JN, Lee TC, McLaughlin S, Moore SW, Shindo N, Learn GH, Korber BT, Brander C, Goulder PJ, Kiepiela P, Walker BD, Mullins JI.

J Virol Methods. 2006 Sep;136(1-2):118-25. Epub 2006 May 15.

PMID:
16701907
32.

Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa.

Honeyborne I, Rathod A, Buchli R, Ramduth D, Moodley E, Rathnavalu P, Chetty S, Day C, Brander C, Hildebrand W, Walker BD, Kiepiela P, Goulder PJ.

J Immunol. 2006 Apr 15;176(8):4699-705.

33.

Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.

Martinez-Picado J, Prado JG, Fry EE, Pfafferott K, Leslie A, Chetty S, Thobakgale C, Honeyborne I, Crawford H, Matthews P, Pillay T, Rousseau C, Mullins JI, Brander C, Walker BD, Stuart DI, Kiepiela P, Goulder P.

J Virol. 2006 Apr;80(7):3617-23.

34.

Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.

Frahm N, Kiepiela P, Adams S, Linde CH, Hewitt HS, Sango K, Feeney ME, Addo MM, Lichterfeld M, Lahaie MP, Pae E, Wurcel AG, Roach T, St John MA, Altfeld M, Marincola FM, Moore C, Mallal S, Carrington M, Heckerman D, Allen TM, Mullins JI, Korber BT, Goulder PJ, Walker BD, Brander C.

Nat Immunol. 2006 Feb;7(2):173-8. Epub 2005 Dec 20.

PMID:
16369537
35.

Differential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responses.

Ramduth D, Chetty P, Mngquandaniso NC, Nene N, Harlow JD, Honeyborne I, Ntumba N, Gappoo S, Henry C, Jeena P, Addo MM, Altfeld M, Brander C, Day C, Coovadia H, Kiepiela P, Goulder P, Walker B.

J Infect Dis. 2005 Nov 1;192(9):1588-96. Epub 2005 Sep 30.

PMID:
16206073
36.

HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load.

Frahm N, Adams S, Kiepiela P, Linde CH, Hewitt HS, Lichterfeld M, Sango K, Brown NV, Pae E, Wurcel AG, Altfeld M, Feeney ME, Allen TM, Roach T, St John MA, Daar ES, Rosenberg E, Korber B, Marincola F, Walker BD, Goulder PJ, Brander C.

J Virol. 2005 Aug;79(16):10218-25.

37.

Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.

Leslie A, Kavanagh D, Honeyborne I, Pfafferott K, Edwards C, Pillay T, Hilton L, Thobakgale C, Ramduth D, Draenert R, Le Gall S, Luzzi G, Edwards A, Brander C, Sewell AK, Moore S, Mullins J, Moore C, Mallal S, Bhardwaj N, Yusim K, Phillips R, Klenerman P, Korber B, Kiepiela P, Walker B, Goulder P.

J Exp Med. 2005 Mar 21;201(6):891-902.

38.

Laboratory markers associated with progression of HIV infection.

Kiepiela P, Smith AN, Rosenberg E.

Best Pract Res Clin Obstet Gynaecol. 2005 Apr;19(2):243-54. Epub 2005 Jan 25. Review. Retraction in: Kiepiela P, Smith AN, Rosenberg E. Best Pract Res Clin Obstet Gynaecol. 2007 Oct;21(5):883.

PMID:
15778113
39.

Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.

Kiepiela P, Leslie AJ, Honeyborne I, Ramduth D, Thobakgale C, Chetty S, Rathnavalu P, Moore C, Pfafferott KJ, Hilton L, Zimbwa P, Moore S, Allen T, Brander C, Addo MM, Altfeld M, James I, Mallal S, Bunce M, Barber LD, Szinger J, Day C, Klenerman P, Mullins J, Korber B, Coovadia HM, Walker BD, Goulder PJ.

Nature. 2004 Dec 9;432(7018):769-75.

PMID:
15592417
40.

Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.

Draenert R, Le Gall S, Pfafferott KJ, Leslie AJ, Chetty P, Brander C, Holmes EC, Chang SC, Feeney ME, Addo MM, Ruiz L, Ramduth D, Jeena P, Altfeld M, Thomas S, Tang Y, Verrill CL, Dixon C, Prado JG, Kiepiela P, Martinez-Picado J, Walker BD, Goulder PJ.

J Exp Med. 2004 Apr 5;199(7):905-15.

41.

HIV evolution: CTL escape mutation and reversion after transmission.

Leslie AJ, Pfafferott KJ, Chetty P, Draenert R, Addo MM, Feeney M, Tang Y, Holmes EC, Allen T, Prado JG, Altfeld M, Brander C, Dixon C, Ramduth D, Jeena P, Thomas SA, St John A, Roach TA, Kupfer B, Luzzi G, Edwards A, Taylor G, Lyall H, Tudor-Williams G, Novelli V, Martinez-Picado J, Kiepiela P, Walker BD, Goulder PJ.

Nat Med. 2004 Mar;10(3):282-9. Epub 2004 Feb 8.

PMID:
14770175
42.

Characterisation of the pncA gene in Mycobacterium tuberculosis isolates from Gauteng, South Africa.

Bishop KS, Blumberg L, Trollip AP, Smith AN, Roux L, York DF, Kiepiela P.

Int J Tuberc Lung Dis. 2001 Oct;5(10):952-7.

PMID:
11605890
44.

Rapid screening of Mycobacterium tuberculosis for susceptibility to rifampicin and streptomycin.

McNerney R, Kiepiela P, Bishop KS, Nye PM, Stoker NG.

Int J Tuberc Lung Dis. 2000 Jan;4(1):69-75.

PMID:
10654647
45.

Phylogenetic analysis of Calymmatobacterium granulomatis based on 16S rRNA gene sequences.

Kharsany AB, Hoosen AA, Kiepiela P, Kirby R, Sturm AW.

J Med Microbiol. 1999 Sep;48(9):841-7.

PMID:
10482295
47.

Ultrastructure of Calymmatobacterium granulomatis: comparison of culture with tissue biopsy specimens.

Kharsany AB, Hoosen AA, Naicker T, Kiepiela P, Sturm AW.

J Med Microbiol. 1998 Dec;47(12):1069-73.

PMID:
9856642
48.

Growth and cultural characteristics of Calymmatobacterium granulomatis--the aetiological agent of granuloma inguinale (Donovanosis).

Kharsany AB, Hoosen AA, Kiepiela P, Naicker T, Sturm AW.

J Med Microbiol. 1997 Jul;46(7):579-85.

PMID:
9236742
49.

Ribosomal DNA typing of Haemophilus ducreyi strains: proposal for a novel typing scheme.

Pillay A, Hoosen AA, Kiepiela P, Sturm AW.

J Clin Microbiol. 1996 Oct;34(10):2613-5.

50.

Type II human complement C2 deficiency. Allele-specific amino acid substitutions (Ser189 --> Phe; Gly444 --> Arg) cause impaired C2 secretion.

Wetsel RA, Kulics J, Lokki ML, Kiepiela P, Akama H, Johnson CA, Densen P, Colten HR.

J Biol Chem. 1996 Mar 8;271(10):5824-31.

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