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Items: 29

1.

The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry.

Kiema TR, Thapa CJ, Laitaoja M, Schmitz W, Maksimainen MM, Fukao T, Rouvinen J, Jänis J, Wierenga RK.

Biochem J. 2019 Jan 25;476(2):307-332. doi: 10.1042/BCJ20180788.

PMID:
30573650
2.

De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: Carbon source preferences and metabolic flux redistributions.

Millerioux Y, Mazet M, Bouyssou G, Allmann S, Kiema TR, Bertiaux E, Fouillen L, Thapa C, Biran M, Plazolles N, Dittrich-Domergue F, Crouzols A, Wierenga RK, Rotureau B, Moreau P, Bringaud F.

PLoS Pathog. 2018 May 29;14(5):e1007116. doi: 10.1371/journal.ppat.1007116. eCollection 2018 May.

3.

Structural enzymology comparisons of multifunctional enzyme, type-1 (MFE1): the flexibility of its dehydrogenase part.

Kasaragod P, Midekessa GB, Sridhar S, Schmitz W, Kiema TR, Hiltunen JK, Wierenga RK.

FEBS Open Bio. 2017 Nov 6;7(12):1830-1842. doi: 10.1002/2211-5463.12337. eCollection 2017 Dec.

4.

Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1.

Harijan RK, Kiema TR, Syed SM, Qadir I, Mazet M, Bringaud F, Michels PAM, Wierenga RK.

Protein Eng Des Sel. 2017 Mar 1;30(3):225-233. doi: 10.1093/protein/gzw080.

PMID:
28062645
5.

Crystal structures of two monomeric triosephosphate isomerase variants identified via a directed-evolution protocol selecting for L-arabinose isomerase activity.

Krause M, Kiema TR, Neubauer P, Wierenga RK.

Acta Crystallogr F Struct Biol Commun. 2016 Jun;72(Pt 6):490-9. doi: 10.1107/S2053230X16007548. Epub 2016 May 23.

6.

The SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolism.

Harijan RK, Mazet M, Kiema TR, Bouyssou G, Alexson SE, Bergmann U, Moreau P, Michels PA, Bringaud F, Wierenga RK.

Proteins. 2016 Aug;84(8):1075-96. doi: 10.1002/prot.25054. Epub 2016 May 9.

PMID:
27093562
7.

Structural characterization of a mitochondrial 3-ketoacyl-CoA (T1)-like thiolase from Mycobacterium smegmatis.

Janardan N, Harijan RK, Kiema TR, Wierenga RK, Murthy MR.

Acta Crystallogr D Biol Crystallogr. 2015 Dec 1;71(Pt 12):2479-93. doi: 10.1107/S1399004715019331. Epub 2015 Nov 27.

PMID:
26627655
8.

The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities.

Kiema TR, Harijan RK, Strozyk M, Fukao T, Alexson SE, Wierenga RK.

Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3212-25. doi: 10.1107/S1399004714023827. Epub 2014 Nov 22.

PMID:
25478839
9.

Phylogenetic relationships and classification of thiolases and thiolase-like proteins of Mycobacterium tuberculosis and Mycobacterium smegmatis.

Anbazhagan P, Harijan RK, Kiema TR, Janardan N, Murthy MR, Michels PA, Juffer AH, Wierenga RK.

Tuberculosis (Edinb). 2014 Jul;94(4):405-12. doi: 10.1016/j.tube.2014.03.003. Epub 2014 Apr 4.

PMID:
24825023
10.

Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop.

Harijan RK, Kiema TR, Karjalainen MP, Janardan N, Murthy MR, Weiss MS, Michels PA, Wierenga RK.

Biochem J. 2013 Oct 1;455(1):119-30. doi: 10.1042/BJ20130669.

PMID:
23909465
11.

The characterization and evolutionary relationships of a trypanosomal thiolase.

Mazet M, Harijan RK, Kiema TR, Haapalainen AM, Morand P, Morales J, Bringaud F, Wierenga RK, Michels PA.

Int J Parasitol. 2011 Oct;41(12):1273-83. doi: 10.1016/j.ijpara.2011.07.009. Epub 2011 Aug 26.

PMID:
21907205
12.

Crystal structure of liganded rat peroxisomal multifunctional enzyme type 1: a flexible molecule with two interconnected active sites.

Kasaragod P, Venkatesan R, Kiema TR, Hiltunen JK, Wierenga RK.

J Biol Chem. 2010 Jul 30;285(31):24089-98. doi: 10.1074/jbc.M110.117606. Epub 2010 May 12.

13.

Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding.

Takala H, Nurminen E, Nurmi SM, Aatonen M, Strandin T, Takatalo M, Kiema T, Gahmberg CG, Ylänne J, Fagerholm SC.

Blood. 2008 Sep 1;112(5):1853-62. doi: 10.1182/blood-2007-12-127795. Epub 2008 Jun 12.

14.

Structure of three tandem filamin domains reveals auto-inhibition of ligand binding.

Lad Y, Kiema T, Jiang P, Pentikäinen OT, Coles CH, Campbell ID, Calderwood DA, Ylänne J.

EMBO J. 2007 Sep 5;26(17):3993-4004. Epub 2007 Aug 9.

15.

Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer.

Sjekloća L, Pudas R, Sjöblom B, Konarev P, Carugo O, Rybin V, Kiema TR, Svergun D, Ylänne J, Djinović Carugo K.

J Mol Biol. 2007 May 11;368(4):1011-23. Epub 2007 Feb 20.

PMID:
17379241
16.

The molecular basis of filamin binding to integrins and competition with talin.

Kiema T, Lad Y, Jiang P, Oxley CL, Baldassarre M, Wegener KL, Campbell ID, Ylänne J, Calderwood DA.

Mol Cell. 2006 Feb 3;21(3):337-47.

17.

Structural studies of MFE-1: the 1.9 A crystal structure of the dehydrogenase part of rat peroxisomal MFE-1.

Taskinen JP, Kiema TR, Hiltunen JK, Wierenga RK.

J Mol Biol. 2006 Jan 27;355(4):734-46. Epub 2005 Nov 18.

PMID:
16330050
18.

Structural basis for vertebrate filamin dimerization.

Pudas R, Kiema TR, Butler PJ, Stewart M, Ylänne J.

Structure. 2005 Jan;13(1):111-9.

19.

Organization of the multifunctional enzyme type 1: interaction between N- and C-terminal domains is required for the hydratase-1/isomerase activity.

Kiema TR, Taskinen JP, Pirilä PL, Koivuranta KT, Wierenga RK, Hiltunen JK.

Biochem J. 2002 Oct 15;367(Pt 2):433-41.

20.

Crystallization and characterization of the dehydrogenase domain from rat peroxisomal multifunctional enzyme type 1.

Taskinen JP, Kiema TR, Koivuranta KT, Wierenga RK, Hiltunen JK.

Acta Crystallogr D Biol Crystallogr. 2002 Apr;58(Pt 4):690-3. Epub 2002 Mar 22.

PMID:
11914498
21.

Mutagenic and enzymological studies of the hydratase and isomerase activities of 2-enoyl-CoA hydratase-1.

Kiema TR, Engel CK, Schmitz W, Filppula SA, Wierenga RK, Hiltunen JK.

Biochemistry. 1999 Mar 9;38(10):2991-9.

PMID:
10074351
22.

Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells.

Haapasalo A, Saarelainen T, Moshnyakov M, Arumäe U, Kiema TR, Saarma M, Wong G, Castrén E.

Oncogene. 1999 Feb 11;18(6):1285-96.

23.

Variants of renin-angiotensin system genes and echocardiographic left ventricular mass.

Kauma H, Ikäheimo M, Savolainen MJ, Kiema TR, Rantala AO, Lilja M, Reunanen A, Kesäniemi YA.

Eur Heart J. 1998 Jul;19(7):1109-17.

PMID:
9717047
26.

Variation at the angiotensin-converting enzyme gene and angiotensinogen gene loci in relation to blood pressure.

Kiema TR, Kauma H, Rantala AO, Lilja M, Reunanen A, Kesäniemi YA, Savolainen MJ.

Hypertension. 1996 Dec;28(6):1070-5.

PMID:
8952598
27.

Association between angiotensin converting enzyme gene polymorphism and carotid atherosclerosis.

Kauma H, Päivänsalo M, Savolainen MJ, Rantala AO, Kiema TR, Lilja M, Reunanen A, Kesäniemi YA.

J Hypertens. 1996 Oct;14(10):1183-7.

PMID:
8906516
28.
29.

Neurotrophins and their receptors in rat peripheral trigeminal system during maxillary nerve growth.

Arumäe U, Pirvola U, Palgi J, Kiema TR, Palm K, Moshnyakov M, Ylikoski J, Saarma M.

J Cell Biol. 1993 Sep;122(5):1053-65.

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