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Items: 1 to 50 of 272

1.

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells.

Radtke S, Perez AM, Venkataraman R, Reddy S, Haworth KG, Humbert O, Kiem HP, Peterson CW.

J Vis Exp. 2019 Feb 15;(144). doi: 10.3791/58933.

PMID:
30829324
2.

The response to lymphodepletion impacts PFS in aggressive non-Hodgkin lymphoma patients treated with CD19 CAR-T cells.

Hirayama AV, Gauthier J, Hay KA, Voutsinas JM, Wu Q, Gooley T, Li D, Cherian S, Chen X, Pender BS, Hawkins RM, Vakil A, Steinmetz RN, Acharya UH, Cassaday RD, Chapuis AG, Dhawale TM, Hendrie PC, Kiem HP, Lynch RC, Ramos J, Shadman M, Till BG, Riddell SR, Maloney DG, Turtle CJ.

Blood. 2019 Feb 19. pii: blood-2018-11-887067. doi: 10.1182/blood-2018-11-887067. [Epub ahead of print]

PMID:
30782611
3.

Factors associated with durable EFS in adult B-cell ALL patients achieving MRD-negative CR after CD19 CAR-T cells.

Hay KA, Gauthier J, Hirayama AV, Voutsinas JM, Wu Q, Li D, Gooley TA, Cherian S, Chen X, Pender BS, Hawkins RM, Vakil A, Steinmetz RN, Schoch G, Chapuis AG, Till BG, Kiem HP, Ramos JD, Shadman M, Cassaday RD, Acharya UH, Riddell SR, Maloney DG, Turtle CJ.

Blood. 2019 Feb 6. pii: blood-2018-11-883710. doi: 10.1182/blood-2018-11-883710. [Epub ahead of print]

PMID:
30728140
4.

TALEN-Mediated Gene Editing of HBG in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction.

Lux CT, Pattabhi S, Berger M, Nourigat C, Flowers DA, Negre O, Humbert O, Yang JG, Lee C, Jacoby K, Bernstein I, Kiem HP, Scharenberg A, Rawlings DJ.

Mol Ther Methods Clin Dev. 2018 Dec 31;12:175-183. doi: 10.1016/j.omtm.2018.12.008. eCollection 2019 Mar 15.

5.

Human hematopoietic stem cell maintenance and myeloid cell development in next-generation humanized mouse models.

Sippel TR, Radtke S, Olsen TM, Kiem HP, Rongvaux A.

Blood Adv. 2019 Feb 12;3(3):268-274. doi: 10.1182/bloodadvances.2018023887. No abstract available.

6.

MISTRG mice support engraftment and assessment of nonhuman primate hematopoietic stem and progenitor cells.

Radtke S, Chan YY, Sippel TR, Kiem HP, Rongvaux A.

Exp Hematol. 2019 Feb;70:31-41.e1. doi: 10.1016/j.exphem.2018.12.003. Epub 2018 Dec 25.

PMID:
30590092
7.

Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice.

Kuhlmann AS, Haworth KG, Barber-Axthelm IM, Ironside C, Giese MA, Peterson CW, Kiem HP.

Mol Ther. 2019 Jan 2;27(1):164-177. doi: 10.1016/j.ymthe.2018.09.017. Epub 2018 Sep 27.

PMID:
30391142
8.

Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation.

Colonna L, Peterson CW, Schell JB, Carlson JM, Tkachev V, Brown M, Yu A, Reddy S, Obenza WM, Nelson V, Polacino PS, Mack H, Hu SL, Zeleski K, Hoffman M, Olvera J, Furlan SN, Zheng H, Taraseviciute A, Hunt DJ, Betz K, Lane JF, Vogel K, Hotchkiss CE, Moats C, Baldessari A, Murnane RD, English C, Astley CA, Wangari S, Agricola B, Ahrens J, Iwayama N, May A, Stensland L, Huang MW, Jerome KR, Kiem HP, Kean LS.

Nat Commun. 2018 Oct 25;9(1):4438. doi: 10.1038/s41467-018-06736-7.

9.

Engineering resistance to CD33-targeted immunotherapy in normal hematopoiesis by CRISPR/Cas9-deletion of CD33 exon 2.

Humbert O, Laszlo GS, Sichel S, Ironside C, Haworth KG, Bates OM, Beddoe ME, Carrillo RR, Kiem HP, Walter RB.

Leukemia. 2019 Mar;33(3):762-808. doi: 10.1038/s41375-018-0277-8. Epub 2018 Oct 5. No abstract available.

PMID:
30291334
10.

Sorting Out the Best: Enriching Hematopoietic Stem Cells for Gene Therapy and Editing.

Radtke S, Humbert O, Kiem HP.

Mol Ther. 2018 Oct 3;26(10):2328-2329. doi: 10.1016/j.ymthe.2018.08.025. Epub 2018 Sep 13. No abstract available.

PMID:
30220614
11.

Screening Clinical Cell Products for Replication Competent Retrovirus: The National Gene Vector Biorepository Experience.

Cornetta K, Duffy L, Feldman SA, Mackall CL, Davila ML, Curran KJ, Junghans RP, Tang JY, Kochenderfer JN, O'Cearbhaill R, Archer G, Kiem HP, Shah NN, Delbrook C, Kaplan R, Brentjens RJ, Rivière I, Sadelain M, Rosenberg SA.

Mol Ther Methods Clin Dev. 2018 Aug 17;10:371-378. doi: 10.1016/j.omtm.2018.08.006. eCollection 2018 Sep 21.

12.

Minimal conditioning in Fanconi anemia promotes multi-lineage marrow engraftment at 10-fold lower cell doses.

Haworth KG, Ironside C, Ramirez MA, Weitz S, Beard BC, Schwartz JD, Adair JE, Kiem HP.

J Gene Med. 2018 Oct;20(10-11):e3050. doi: 10.1002/jgm.3050. Epub 2018 Oct 1.

PMID:
30129972
13.

Efficient Enrichment of Gene-Modified Primary T Cells via CCR5-Targeted Integration of Mutant Dihydrofolate Reductase.

Paul B, Ibarra GSR, Hubbard N, Einhaus T, Astrakhan A, Rawlings DJ, Kiem HP, Peterson CW.

Mol Ther Methods Clin Dev. 2018 Apr 5;9:347-357. doi: 10.1016/j.omtm.2018.04.002. eCollection 2018 Jun 15.

14.

HIV infection results in clonal expansions containing integrations within pathogenesis-related biological pathways.

Haworth KG, Schefter LE, Norgaard ZK, Ironside C, Adair JE, Kiem HP.

JCI Insight. 2018 Jul 12;3(13). pii: 99127. doi: 10.1172/jci.insight.99127.

15.

Novel lineage depletion preserves autologous blood stem cells for gene therapy of Fanconi anemia complementation group A.

Adair JE, Chandrasekaran D, Sghia-Hughes G, Haworth KG, Woolfrey AE, Burroughs LM, Choi GY, Becker PS, Kiem HP.

Haematologica. 2018 Nov;103(11):1806-1814. doi: 10.3324/haematol.2018.194571. Epub 2018 Jul 5.

16.

Chimeric antigen receptor T-cell approaches to HIV cure.

Kuhlmann AS, Peterson CW, Kiem HP.

Curr Opin HIV AIDS. 2018 Sep;13(5):446-453. doi: 10.1097/COH.0000000000000485.

PMID:
29878913
17.

Rapid immune reconstitution of SCID-X1 canines after G-CSF/AMD3100 mobilization and in vivo gene therapy.

Humbert O, Chan F, Rajawat YS, Torgerson TR, Burtner CR, Hubbard NW, Humphrys D, Norgaard ZK, O'Donnell P, Adair JE, Trobridge GD, Scharenberg AM, Felsburg PJ, Rawlings DJ, Kiem HP.

Blood Adv. 2018 May 8;2(9):987-999. doi: 10.1182/bloodadvances.2018016451.

18.

Next-Generation Conditioning for Bone Marrow Transplantation: Paving the Way for CAR-T Cell-Based Conditioning.

Haworth KG, Kiem HP.

Mol Ther. 2018 May 2;26(5):1167-1168. doi: 10.1016/j.ymthe.2018.04.011. No abstract available.

PMID:
29685383
19.

Differential impact of transplantation on peripheral and tissue-associated viral reservoirs: Implications for HIV gene therapy.

Peterson CW, Wang J, Deleage C, Reddy S, Kaur J, Polacino P, Reik A, Huang ML, Jerome KR, Hu SL, Holmes MC, Estes JD, Kiem HP.

PLoS Pathog. 2018 Apr 19;14(4):e1006956. doi: 10.1371/journal.ppat.1006956. eCollection 2018 Apr.

20.

Corrigendum: Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury.

Velardi E, Tsai JJ, Radtke S, Cooper K, Argyropoulos KV, Jae-Hung S, Young LF, Lazrak A, Smith OM, Lieberman S, Kreines F, Shono Y, Wertheimer T, Jenq RR, Hanash AM, Narayan P, Lei Z, Moore MA, Kiem HP, van den Brink MRM, Dudakov JA.

Nat Med. 2018 Apr 10;24(4):525. doi: 10.1038/nm0418-525b.

PMID:
29634695
21.

Correction: Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS.

Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG.

PLoS Pathog. 2018 Mar 12;14(3):e1006891. doi: 10.1371/journal.ppat.1006891. eCollection 2018 Mar.

22.

Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury.

Velardi E, Tsai JJ, Radtke S, Cooper K, Argyropoulos KV, Jae-Hung S, Young LF, Lazrak A, Smith OM, Lieberman S, Kreines F, Shono Y, Wertheimer T, Jenq RR, Hanash AM, Narayan P, Lei Z, Moore MA, Kiem HP, van den Brink MRM, Dudakov JA.

Nat Med. 2018 Feb;24(2):239-246. doi: 10.1038/nm.4470. Epub 2018 Jan 8. Erratum in: Nat Med. 2018 Apr 10;24(4):525.

23.

Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS.

Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG.

PLoS Pathog. 2017 Dec 28;13(12):e1006753. doi: 10.1371/journal.ppat.1006753. eCollection 2017 Dec. Erratum in: PLoS Pathog. 2018 Mar 12;14 (3):e1006891.

24.

A Nonhuman Primate Transplantation Model to Evaluate Hematopoietic Stem Cell Gene Editing Strategies for β-Hemoglobinopathies.

Humbert O, Peterson CW, Norgaard ZK, Radtke S, Kiem HP.

Mol Ther Methods Clin Dev. 2017 Nov 21;8:75-86. doi: 10.1016/j.omtm.2017.11.005. eCollection 2018 Mar 16.

25.

Cell and Gene Therapy for HIV Cure.

Peterson CW, Kiem HP.

Curr Top Microbiol Immunol. 2018;417:211-248. doi: 10.1007/82_2017_71.

PMID:
29256135
26.

A Combined In Vivo HSC Transduction/Selection Approach Results in Efficient and Stable Gene Expression in Peripheral Blood Cells in Mice.

Wang H, Richter M, Psatha N, Li C, Kim J, Liu J, Ehrhardt A, Nilsson SK, Cao B, Palmer D, Ng P, Izsvák Z, Haworth KG, Kiem HP, Papayannopoulou T, Lieber A.

Mol Ther Methods Clin Dev. 2017 Nov 10;8:52-64. doi: 10.1016/j.omtm.2017.11.004. eCollection 2018 Mar 16.

27.

A distinct hematopoietic stem cell population for rapid multilineage engraftment in nonhuman primates.

Radtke S, Adair JE, Giese MA, Chan YY, Norgaard ZK, Enstrom M, Haworth KG, Schefter LE, Kiem HP.

Sci Transl Med. 2017 Nov 1;9(414). pii: eaan1145. doi: 10.1126/scitranslmed.aan1145.

PMID:
29093179
28.

Hematopoietic Stem Cell Approaches to Cancer.

Adair JE, Kubek SP, Kiem HP.

Hematol Oncol Clin North Am. 2017 Oct;31(5):897-912. doi: 10.1016/j.hoc.2017.06.012. Review.

PMID:
28895855
29.

In Vivo Hematopoietic Stem Cell Transduction.

Richter M, Stone D, Miao C, Humbert O, Kiem HP, Papayannopoulou T, Lieber A.

Hematol Oncol Clin North Am. 2017 Oct;31(5):771-785. doi: 10.1016/j.hoc.2017.06.001. Review.

30.

Nanoparticle Biokinetics in Mice and Nonhuman Primates.

Chiarelli PA, Revia RA, Stephen ZR, Wang K, Jeon M, Nelson V, Kievit FM, Sham J, Ellenbogen RG, Kiem HP, Zhang M.

ACS Nano. 2017 Sep 26;11(9):9514-9524. doi: 10.1021/acsnano.7b05377. Epub 2017 Sep 18.

31.

Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers.

Moffett HF, Coon ME, Radtke S, Stephan SB, McKnight L, Lambert A, Stoddard BL, Kiem HP, Stephan MT.

Nat Commun. 2017 Aug 30;8(1):389. doi: 10.1038/s41467-017-00505-8.

32.

CCR5-edited gene therapies for HIV cure: Closing the door to viral entry.

Haworth KG, Peterson CW, Kiem HP.

Cytotherapy. 2017 Nov;19(11):1325-1338. doi: 10.1016/j.jcyt.2017.05.013. Epub 2017 Jul 24. Review.

PMID:
28751153
33.

In Vivo Murine-Matured Human CD3+ Cells as a Preclinical Model for T Cell-Based Immunotherapies.

Haworth KG, Ironside C, Norgaard ZK, Obenza WM, Adair JE, Kiem HP.

Mol Ther Methods Clin Dev. 2017 May 17;6:17-30. doi: 10.1016/j.omtm.2017.05.004. eCollection 2017 Sep 15.

34.

Refining Current Scientific Priorities and Identifying New Scientific Gaps in HIV-Related Heart, Lung, Blood, and Sleep Research.

Twigg HL 3rd, Crystal R, Currier J, Ridker P, Berliner N, Kiem HP, Rutherford G, Zou S, Glynn S, Wong R, Peprah E, Engelgau M, Creazzo T, Colombini-Hatch S, Caler E.

AIDS Res Hum Retroviruses. 2017 Sep;33(9):889-897. doi: 10.1089/AID.2017.0026. Epub 2017 Jun 26.

35.

Autologous Stem Cell Transplantation Disrupts Adaptive Immune Responses during Rebound Simian/Human Immunodeficiency Virus Viremia.

Reeves DB, Peterson CW, Kiem HP, Schiffer JT.

J Virol. 2017 Jun 9;91(13). pii: e00095-17. doi: 10.1128/JVI.00095-17. Print 2017 Jul 1.

36.

Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector.

Singh S, Khan I, Khim S, Seymour B, Sommer K, Wielgosz M, Norgaard Z, Kiem HP, Adair J, Liggitt D, Nienhuis A, Rawlings DJ.

Mol Ther Methods Clin Dev. 2016 Dec 18;4:1-16. doi: 10.1016/j.omtm.2016.11.001. eCollection 2017 Mar 17.

37.

Endothelial Cells Promote Expansion of Long-Term Engrafting Marrow Hematopoietic Stem and Progenitor Cells in Primates.

Gori JL, Butler JM, Kunar B, Poulos MG, Ginsberg M, Nolan DJ, Norgaard ZK, Adair JE, Rafii S, Kiem HP.

Stem Cells Transl Med. 2017 Mar;6(3):864-876. doi: 10.5966/sctm.2016-0240. Epub 2016 Oct 14.

38.

Loss of immune homeostasis dictates SHIV rebound after stem-cell transplantation.

Peterson CW, Benne C, Polacino P, Kaur J, McAllister CE, Filali-Mouhim A, Obenza W, Pecor TA, Huang ML, Baldessari A, Murnane RD, Woolfrey AE, Jerome KR, Hu SL, Klatt NR, DeRosa S, Sékaly RP, Kiem HP.

JCI Insight. 2017 Feb 23;2(4):e91230. doi: 10.1172/jci.insight.91230.

39.

Lessons Learned from Two Decades of Clinical Trial Experience in Gene Therapy for Fanconi Anemia.

Adair JE, Sevilla J, Heredia CD, Becker PS, Kiem HP, Bueren J.

Curr Gene Ther. 2017;16(5):338-348. doi: 10.2174/1566523217666170119113029. Review.

PMID:
28103787
40.

Virion Structure of Black Queen Cell Virus, a Common Honeybee Pathogen.

Spurny R, Přidal A, Pálková L, Kiem HK, de Miranda JR, Plevka P.

J Virol. 2017 Feb 28;91(6). pii: e02100-16. doi: 10.1128/JVI.02100-16. Print 2017 Mar 15.

41.

Dose-adapted post-transplant cyclophosphamide for HLA-haploidentical transplantation in Fanconi anemia.

Thakar MS, Bonfim C, Walters MC, Storb R, Pasquini R, Burroughs L, Sandmaier BM, Woolfrey A, Kiem HP.

Bone Marrow Transplant. 2017 Apr;52(4):570-573. doi: 10.1038/bmt.2016.301. Epub 2017 Jan 9.

42.

Devouring the Hematopoietic Stem Cell: Setting the Table for Marrow Cell Transplantation.

Cowan MJ, Kiem HP.

Mol Ther. 2016 Nov;24(11):1892-1894. doi: 10.1038/mt.2016.193. No abstract available.

43.

Cell-Delivered Entry Inhibitors for HIV-1: CCR5 Downregulation and Blocking Virus/Membrane Fusion in Defending the Host Cell Population.

Symonds G, Bartlett JS, Kiem HP, Tsie M, Breton L.

AIDS Patient Care STDS. 2016 Dec;30(12):545-550.

PMID:
27905841
44.

Haploidentical Bone Marrow Transplantation with Post-Transplant Cyclophosphamide for Children and Adolescents with Fanconi Anemia.

Bonfim C, Ribeiro L, Nichele S, Loth G, Bitencourt M, Koliski A, Kuwahara C, Fabro AL, Pereira NF, Pilonetto D, Thakar M, Kiem HP, Page K, Fuchs EJ, Eapen M, Pasquini R.

Biol Blood Marrow Transplant. 2017 Feb;23(2):310-317. doi: 10.1016/j.bbmt.2016.11.006. Epub 2016 Nov 7.

45.

In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors.

Richter M, Saydaminova K, Yumul R, Krishnan R, Liu J, Nagy EE, Singh M, Izsvák Z, Cattaneo R, Uckert W, Palmer D, Ng P, Haworth KG, Kiem HP, Ehrhardt A, Papayannopoulou T, Lieber A.

Blood. 2016 Nov 3;128(18):2206-2217. Epub 2016 Aug 23.

46.

A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?

Lederman MM, Cannon PM, Currier JS, June CH, Kiem HP, Kuritzkes DR, Lewin SR, Margolis DM, McCune JM, Mellors JW, Schacker TW, Sekaly RP, Tebas P, Walker BD, Douek DC.

Pathog Immun. 2016 Spring;1(1):154-164.

47.

Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy.

Adair JE, Waters T, Haworth KG, Kubek SP, Trobridge GD, Hocum JD, Heimfeld S, Kiem HP.

Nat Commun. 2016 Oct 20;7:13173. doi: 10.1038/ncomms13173.

48.

Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.

Romano Ibarra GS, Paul B, Sather BD, Younan PM, Sommer K, Kowalski JP, Hale M, Stoddard B, Jarjour J, Astrakhan A, Kiem HP, Rawlings DJ.

Mol Ther Nucleic Acids. 2016 Aug 23;5(8):e352. doi: 10.1038/mtna.2016.56.

49.

Rethinking the Regulatory Infrastructure for Human Gene Transfer Clinical Trials.

Jenkins CL, Bagarazzi ML, Kiem HP, Levine AJ, Ando D, June CH, Reid T, Emery DW.

Mol Ther. 2016 Aug;24(7):1173-7. doi: 10.1038/mt.2016.133. No abstract available.

50.

Marrow grafts from HLA-identical siblings for severe aplastic anemia: does limiting the number of transplanted marrow cells reduce the risk of chronic GvHD?

Gallo S, Woolfrey AE, Burroughs LM, Storer BE, Flowers ME, Hari P, Pulsipher MA, Heimfeld S, Kiem HP, Sandmaier BM, Storb R.

Bone Marrow Transplant. 2016 Dec;51(12):1573-1578. doi: 10.1038/bmt.2016.198. Epub 2016 Aug 1.

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