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Items: 1 to 50 of 165


ADAMTS10-mediated tissue disruption in Weill-Marchesani syndrome.

Mularczyk EJ, Singh M, Godwin ARF, Galli F, Humphreys N, Adamson AD, Mironov A, Cain SA, Sengle G, Boot-Handford RP, Cossu G, Kielty CM, Baldock C.

Hum Mol Genet. 2018 Nov 1;27(21):3675-3687. doi: 10.1093/hmg/ddy276.


Recombinant Extracellular Matrix Protein Fragments Support Human Embryonic Stem Cell Chondrogenesis.

Cheng A, Cain SA, Tian P, Baldwin AK, Uppanan P, Kielty CM, Kimber SJ.

Tissue Eng Part A. 2018 Jun;24(11-12):968-978. doi: 10.1089/ten.TEA.2017.0285. Epub 2018 Feb 7.


Extracellular Matrix Molecule-Based Capture of Mesenchymal Stromal Cells Under Flow.

Massam-Wu T, Cain SA, Kielty CM.

Methods Mol Biol. 2018;1722:249-260. doi: 10.1007/978-1-4939-7553-2_16.


Fell-Muir Lecture: Fibrillin microfibrils: structural tensometers of elastic tissues?

Kielty CM.

Int J Exp Pathol. 2017 Aug;98(4):172-190. doi: 10.1111/iep.12239. Epub 2017 Sep 14. Review.


Liposome-Indocyanine Green Nanoprobes for Optical Labeling and Tracking of Human Mesenchymal Stem Cells Post-Transplantation In Vivo.

Mazza M, Lozano N, Vieira DB, Buggio M, Kielty C, Kostarelos K.

Adv Healthc Mater. 2017 Nov;6(21). doi: 10.1002/adhm.201700374. Epub 2017 Aug 4.


Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro.

Redondo-Castro E, Cunningham C, Miller J, Martuscelli L, Aoulad-Ali S, Rothwell NJ, Kielty CM, Allan SM, Pinteaux E.

Stem Cell Res Ther. 2017 Apr 17;8(1):79. doi: 10.1186/s13287-017-0531-4.


ADAMTS-10 and -6 differentially regulate cell-cell junctions and focal adhesions.

Cain SA, Mularczyk EJ, Singh M, Massam-Wu T, Kielty CM.

Sci Rep. 2016 Oct 25;6:35956. doi: 10.1038/srep35956.


Independent multimerization of Latent TGFβ Binding Protein-1 stabilized by cross-linking and enhanced by heparan sulfate.

Troilo H, Steer R, Collins RF, Kielty CM, Baldock C.

Sci Rep. 2016 Sep 28;6:34347. doi: 10.1038/srep34347.


Mutations in LTBP3 cause acromicric dysplasia and geleophysic dysplasia.

McInerney-Leo AM, Le Goff C, Leo PJ, Kenna TJ, Keith P, Harris JE, Steer R, Bole-Feysot C, Nitschke P, Kielty C, Brown MA, Zankl A, Duncan EL, Cormier-Daire V.

J Med Genet. 2016 Jul;53(7):457-64. doi: 10.1136/jmedgenet-2015-103647. Epub 2016 Apr 11.


A high-content platform to characterise human induced pluripotent stem cell lines.

Leha A, Moens N, Meleckyte R, Culley OJ, Gervasio MK, Kerz M, Reimer A, Cain SA, Streeter I, Folarin A, Stegle O, Kielty CM; HipSci Consortium, Durbin R, Watt FM, Danovi D.

Methods. 2016 Mar 1;96:85-96. doi: 10.1016/j.ymeth.2015.11.012. Epub 2015 Nov 25.


Comparative quantification of the surfaceome of human multipotent mesenchymal progenitor cells.

Holley RJ, Tai G, Williamson AJ, Taylor S, Cain SA, Richardson SM, Merry CL, Whetton AD, Kielty CM, Canfield AE.

Stem Cell Reports. 2015 Mar 10;4(3):473-88. doi: 10.1016/j.stemcr.2015.01.007. Epub 2015 Feb 13.


Immobilisation of a fibrillin-1 fragment enhances the biocompatibility of PTFE.

Hajian H, Wise SG, Bax DV, Kondyurin A, Waterhouse A, Dunn LL, Kielty CM, Yu Y, Weiss AS, Bilek MM, Bannon PG, Ng MK.

Colloids Surf B Biointerfaces. 2014 Apr 1;116:544-52. doi: 10.1016/j.colsurfb.2014.01.042. Epub 2014 Feb 4.


Leri's pleonosteosis, a congenital rheumatic disease, results from microduplication at 8q22.1 encompassing GDF6 and SDC2 and provides insight into systemic sclerosis pathogenesis.

Banka S, Cain SA, Carim S, Daly SB, Urquhart JE, Erdem G, Harris J, Bottomley M, Donnai D, Kerr B, Kingston H, Superti-Furga A, Unger S, Ennis H, Worthington J, Herrick AL, Merry CL, Yue WW, Kielty CM, Newman WG.

Ann Rheum Dis. 2015 Jun;74(6):1249-56. doi: 10.1136/annrheumdis-2013-204309. Epub 2014 Jan 17.


Epithelial-mesenchymal status influences how cells deposit fibrillin microfibrils.

Baldwin AK, Cain SA, Lennon R, Godwin A, Merry CL, Kielty CM.

J Cell Sci. 2014 Jan 1;127(Pt 1):158-71. doi: 10.1242/jcs.134270. Epub 2013 Nov 4.


Activation of brain endothelial cells by interleukin-1 is regulated by the extracellular matrix after acute brain injury.

Summers L, Kangwantas K, Rodriguez-Grande B, Denes A, Penny J, Kielty C, Pinteaux E.

Mol Cell Neurosci. 2013 Nov;57:93-103. doi: 10.1016/j.mcn.2013.10.007. Epub 2013 Oct 24.


Mesenchymal stromal cells: inhibiting PDGF receptors or depleting fibronectin induces mesodermal progenitors with endothelial potential.

Ball SG, Worthington JJ, Canfield AE, Merry CL, Kielty CM.

Stem Cells. 2014 Mar;32(3):694-705. doi: 10.1002/stem.1538.


Elastic fibres in health and disease.

Baldwin AK, Simpson A, Steer R, Cain SA, Kielty CM.

Expert Rev Mol Med. 2013 Aug 20;15:e8. doi: 10.1017/erm.2013.9. Review.


Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.

Cain SA, McGovern A, Baldwin AK, Baldock C, Kielty CM.

PLoS One. 2012;7(11):e48634. doi: 10.1371/journal.pone.0048634. Epub 2012 Nov 2.


Collagen VI, conformation of A-domain arrays and microfibril architecture.

Beecher N, Roseman AM, Jowitt TA, Berry R, Troilo H, Kammerer RA, Shuttleworth CA, Kielty CM, Baldock C.

J Biol Chem. 2011 Nov 18;286(46):40266-75. doi: 10.1074/jbc.M111.265595. Epub 2011 Sep 9.


Mesenchymal stem cell migration is regulated by fibronectin through α5β1-integrin-mediated activation of PDGFR-β and potentiation of growth factor signals.

Veevers-Lowe J, Ball SG, Shuttleworth A, Kielty CM.

J Cell Sci. 2011 Apr 15;124(Pt 8):1288-300. doi: 10.1242/jcs.076935. Epub 2011 Mar 23.


Density of human bone marrow stromal cells regulates commitment to vascular lineages.

Whyte JL, Ball SG, Shuttleworth CA, Brennan K, Kielty CM.

Stem Cell Res. 2011 May;6(3):238-50. doi: 10.1016/j.scr.2011.02.001. Epub 2011 Feb 17.


Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta.

Massam-Wu T, Chiu M, Choudhury R, Chaudhry SS, Baldwin AK, McGovern A, Baldock C, Shuttleworth CA, Kielty CM.

J Cell Sci. 2010 Sep 1;123(Pt 17):3006-18. doi: 10.1242/jcs.073437. Epub 2010 Aug 10.


Microfibrils and fibrillin-1 induce integrin-mediated signaling, proliferation and migration in human endothelial cells.

Mariko B, Ghandour Z, Raveaud S, Quentin M, Usson Y, Verdetti J, Huber P, Kielty C, Faury G.

Am J Physiol Cell Physiol. 2010 Nov;299(5):C977-87. doi: 10.1152/ajpcell.00377.2009. Epub 2010 Aug 4.


Adhesion to the extracellular matrix is required for interleukin-1 beta actions leading to reactive phenotype in rat astrocytes.

Summers L, Kangwantas K, Nguyen L, Kielty C, Pinteaux E.

Mol Cell Neurosci. 2010 Jul;44(3):272-81. doi: 10.1016/j.mcn.2010.03.013. Epub 2010 Apr 7.


Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells.

Ball SG, Bayley C, Shuttleworth CA, Kielty CM.

Biochem J. 2010 Mar 15;427(1):29-40. doi: 10.1042/BJ20091512.


Platelet-derived growth factor receptors regulate mesenchymal stem cell fate: implications for neovascularization.

Ball SG, Shuttleworth CA, Kielty CM.

Expert Opin Biol Ther. 2010 Jan;10(1):57-71. doi: 10.1517/14712590903379510. Review.


Structural effects of fibulin 5 missense mutations associated with age-related macular degeneration and cutis laxa.

Jones RP, Ridley C, Jowitt TA, Wang MC, Howard M, Bobola N, Wang T, Bishop PN, Kielty CM, Baldock C, Lotery AJ, Trump D.

Invest Ophthalmol Vis Sci. 2010 May;51(5):2356-62. doi: 10.1167/iovs.09-4620. Epub 2009 Dec 10.


Defining elastic fiber interactions by molecular fishing: an affinity purification and mass spectrometry approach.

Cain SA, McGovern A, Small E, Ward LJ, Baldock C, Shuttleworth A, Kielty CM.

Mol Cell Proteomics. 2009 Dec;8(12):2715-32. doi: 10.1074/mcp.M900008-MCP200. Epub 2009 Sep 15.


Development of a microtiter plate-based glycosaminoglycan array for the investigation of glycosaminoglycan-protein interactions.

Marson A, Robinson DE, Brookes PN, Mulloy B, Wiles M, Clark SJ, Fielder HL, Collinson LJ, Cain SA, Kielty CM, McArthur S, Buttle DJ, Short RD, Whittle JD, Day AJ.

Glycobiology. 2009 Dec;19(12):1537-46. doi: 10.1093/glycob/cwp132. Epub 2009 Sep 3.


Fibulin 5 forms a compact dimer in physiological solutions.

Jones RP, Wang MC, Jowitt TA, Ridley C, Mellody KT, Howard M, Wang T, Bishop PN, Lotery AJ, Kielty CM, Baldock C, Trump D.

J Biol Chem. 2009 Sep 18;284(38):25938-43. doi: 10.1074/jbc.M109.011627. Epub 2009 Jul 17.


Differential regulation of elastic fiber formation by fibulin-4 and -5.

Choudhury R, McGovern A, Ridley C, Cain SA, Baldwin A, Wang MC, Guo C, Mironov A Jr, Drymoussi Z, Trump D, Shuttleworth A, Baldock C, Kielty CM.

J Biol Chem. 2009 Sep 4;284(36):24553-67. doi: 10.1074/jbc.M109.019364. Epub 2009 Jul 1.


Adhesion to fibronectin regulates interleukin-1 beta expression in microglial cells.

Summers L, Kielty C, Pinteaux E.

Mol Cell Neurosci. 2009 Jun;41(2):148-55. doi: 10.1016/j.mcn.2009.02.007. Epub 2009 Feb 26.


ECM macromolecules: rotary shadowing and transmission electron microscopy.

Sherratt MJ, Meadows RS, Graham HK, Kielty CM, Holmes DF.

Methods Mol Biol. 2009;522:175-81. doi: 10.1007/978-1-59745-413-1_11.


ECM macromolecules: height-mapping and nano-mechanics using atomic force microscopy.

Hodson NW, Kielty CM, Sherratt MJ.

Methods Mol Biol. 2009;522:123-41. doi: 10.1007/978-1-59745-413-1_7.


Mass-mapping of ECM macromolecules by scanning transmission electron microscopy.

Sherratt MJ, Graham HK, Kielty CM, Holmes DF.

Methods Mol Biol. 2009;522:151-61. doi: 10.1007/978-1-59745-413-1_9.


Heparan sulfate regulates fibrillin-1 N- and C-terminal interactions.

Cain SA, Baldwin AK, Mahalingam Y, Raynal B, Jowitt TA, Shuttleworth CA, Couchman JR, Kielty CM.

J Biol Chem. 2008 Oct 3;283(40):27017-27. doi: 10.1074/jbc.M803373200. Epub 2008 Jul 31.


Fibrillin-1 microfibril deposition is dependent on fibronectin assembly.

Kinsey R, Williamson MR, Chaudhry S, Mellody KT, McGovern A, Takahashi S, Shuttleworth CA, Kielty CM.

J Cell Sci. 2008 Aug 15;121(Pt 16):2696-704. doi: 10.1242/jcs.029819. Epub 2008 Jul 24.


Biomolecular analysis of elastic fibre molecules.

Cain SA, Raynal B, Hodson N, Shuttleworth A, Kielty CM.

Methods. 2008 May;45(1):42-52. doi: 10.1016/j.ymeth.2008.01.005.


The effects of stretch on vascular smooth muscle cell phenotype in vitro.

Halka AT, Turner NJ, Carter A, Ghosh J, Murphy MO, Kirton JP, Kielty CM, Walker MG.

Cardiovasc Pathol. 2008 Mar-Apr;17(2):98-102. doi: 10.1016/j.carpath.2007.03.001. Epub 2007 May 11. Review.


Mesenchymal stem cells and neovascularization: role of platelet-derived growth factor receptors.

Ball SG, Shuttleworth CA, Kielty CM.

J Cell Mol Med. 2007 Sep-Oct;11(5):1012-30. Review.


The role of endothelial cell attachment to elastic fibre molecules in the enhancement of monolayer formation and retention, and the inhibition of smooth muscle cell recruitment.

Williamson MR, Shuttleworth A, Canfield AE, Black RA, Kielty CM.

Biomaterials. 2007 Dec;28(35):5307-18. Epub 2007 Sep 11.


Applying elastic fibre biology in vascular tissue engineering.

Kielty CM, Stephan S, Sherratt MJ, Williamson M, Shuttleworth CA.

Philos Trans R Soc Lond B Biol Sci. 2007 Aug 29;362(1484):1293-312. Review.


Fibulin-5 binds human smooth-muscle cells through alpha5beta1 and alpha4beta1 integrins, but does not support receptor activation.

Lomas AC, Mellody KT, Freeman LJ, Bax DV, Shuttleworth CA, Kielty CM.

Biochem J. 2007 Aug 1;405(3):417-28.


Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.

Ball SG, Shuttleworth CA, Kielty CM.

J Cell Biol. 2007 May 7;177(3):489-500. Epub 2007 Apr 30.


Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation.

Bax DV, Mahalingam Y, Cain S, Mellody K, Freeman L, Younger K, Shuttleworth CA, Humphries MJ, Couchman JR, Kielty CM.

J Cell Sci. 2007 Apr 15;120(Pt 8):1383-92. Epub 2007 Mar 20.


Fibrillin-1 regulates the bioavailability of TGFbeta1.

Chaudhry SS, Cain SA, Morgan A, Dallas SL, Shuttleworth CA, Kielty CM.

J Cell Biol. 2007 Jan 29;176(3):355-67. Epub 2007 Jan 22.


The morphology of adsorbed extracellular matrix assemblies is critically dependent on solution calcium concentration.

Sherratt MJ, Baldock C, Morgan A, Kielty CM.

Matrix Biol. 2007 Apr;26(3):156-66. Epub 2006 Nov 7.


Platelet-derived growth factor receptor-alpha is a key determinant of smooth muscle alpha-actin filaments in bone marrow-derived mesenchymal stem cells.

Ball SG, Shuttleworth CA, Kielty CM.

Int J Biochem Cell Biol. 2007;39(2):379-91. Epub 2006 Sep 24.


Cell-matrix biology in vascular tissue engineering.

Stephan S, Ball SG, Williamson M, Bax DV, Lomas A, Shuttleworth CA, Kielty CM.

J Anat. 2006 Oct;209(4):495-502. Review.

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