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Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance.

Yamada KJ, Heim CE, Xi X, Attri KS, Wang D, Zhang W, Singh PK, Bronich TK, Kielian T.

PLoS Pathog. 2020 Mar 6;16(3):e1008354. doi: 10.1371/journal.ppat.1008354. eCollection 2020 Mar.


Neutrophils are mediators of metastatic prostate cancer progression in bone.

Costanzo-Garvey DL, Keeley T, Case AJ, Watson GF, Alsamraae M, Yu Y, Su K, Heim CE, Kielian T, Morrissey C, Frieling JS, Cook LM.

Cancer Immunol Immunother. 2020 Feb 29. doi: 10.1007/s00262-020-02527-6. [Epub ahead of print]


Staphylococcus aureus fibronectin binding protein A mediates biofilm development and infection.

Gries CM, Biddle T, Bose JL, Kielian T, Lo DD.

Infect Immun. 2020 Feb 10. pii: IAI.00859-19. doi: 10.1128/IAI.00859-19. [Epub ahead of print]


Large-Scale and Rapid Preparation of Nanofibrous Meshes and Their Application for Drug-Loaded Multilayer Mucoadhesive Patch Fabrication for Mouth Ulcer Treatment.

Wei L, Wu S, Shi W, Aldrich AL, Kielian T, Carlson MA, Sun R, Qin X, Duan B.

ACS Appl Mater Interfaces. 2019 Aug 14;11(32):28740-28751. doi: 10.1021/acsami.9b10379. Epub 2019 Aug 5.


Identification of Potential Cerebrospinal Fluid Biomarkers To Discriminate between Infection and Sterile Inflammation in a Rat Model of Staphylococcus epidermidis Catheter Infection.

Skar GL, Beaver M, Aldrich A, Lagundzin D, Thapa I, Woods N, Ali H, Snowden J, Kielian T.

Infect Immun. 2019 Aug 21;87(9). pii: e00311-19. doi: 10.1128/IAI.00311-19. Print 2019 Sep.


Protease-Mediated Growth of Staphylococcus aureus on Host Proteins Is opp3 Dependent.

Lehman MK, Nuxoll AS, Yamada KJ, Kielian T, Carson SD, Fey PD.

mBio. 2019 Apr 30;10(2). pii: e02553-18. doi: 10.1128/mBio.02553-18.


3D Bioprinted Scaffolds Containing Viable Macrophages and Antibiotics Promote Clearance of Staphylococcus aureus Craniotomy-Associated Biofilm Infection.

Aldrich A, Kuss MA, Duan B, Kielian T.

ACS Appl Mater Interfaces. 2019 Apr 3;11(13):12298-12307. doi: 10.1021/acsami.9b00264. Epub 2019 Mar 21.


Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation.

Zhang W, Guo Y, Kuss M, Shi W, Aldrich AL, Untrauer J, Kielian T, Duan B.

Tissue Eng Part B Rev. 2019 Jun;25(3):225-236. doi: 10.1089/ten.TEB.2018.0309. Epub 2019 May 15. Review.


Lysosomal storage disorders: pathology within the lysosome and beyond.

Kielian T.

J Neurochem. 2019 Mar;148(5):568-572. doi: 10.1111/jnc.14672.


Urease is an essential component of the acid response network of Staphylococcus aureus and is required for a persistent murine kidney infection.

Zhou C, Bhinderwala F, Lehman MK, Thomas VC, Chaudhari SS, Yamada KJ, Foster KW, Powers R, Kielian T, Fey PD.

PLoS Pathog. 2019 Jan 4;15(1):e1007538. doi: 10.1371/journal.ppat.1007538. eCollection 2019 Jan.


Biofilm-Leukocyte Cross-Talk: Impact on Immune Polarization and Immunometabolism.

Yamada KJ, Kielian T.

J Innate Immun. 2019;11(3):280-288. doi: 10.1159/000492680. Epub 2018 Oct 22. Review.


Heterogeneity of Ly6G+ Ly6C+ Myeloid-Derived Suppressor Cell Infiltrates during Staphylococcus aureus Biofilm Infection.

Heim CE, West SC, Ali H, Kielian T.

Infect Immun. 2018 Nov 20;86(12). pii: e00684-18. doi: 10.1128/IAI.00684-18. Print 2018 Dec.


Searching for novel biomarkers using a mouse model of CLN3-Batten disease.

Timm D, Cain JT, Geraets RD, White KA, Koh SY, Kielian T, Pearce DA, Hastings ML, Weimer JM.

PLoS One. 2018 Aug 7;13(8):e0201470. doi: 10.1371/journal.pone.0201470. eCollection 2018.


Astrocytes in juvenile neuronal ceroid lipofuscinosis (CLN3) display metabolic and calcium signaling abnormalities.

Bosch ME, Kielian T.

J Neurochem. 2019 Mar;148(5):612-624. doi: 10.1111/jnc.14545. Epub 2018 Aug 16.


Caspase 1 activity influences juvenile Batten disease (CLN3) pathogenesis.

Burkovetskaya M, Bosch ME, Karpuk N, Fallet R, Kielian T.

J Neurochem. 2019 Mar;148(5):652-668. doi: 10.1111/jnc.14480. Epub 2018 Aug 9.


Arginase-1 Expression in Myeloid Cells Regulates Staphylococcus aureus Planktonic but Not Biofilm Infection.

Yamada KJ, Heim CE, Aldrich AL, Gries CM, Staudacher AG, Kielian T.

Infect Immun. 2018 Jun 21;86(7). pii: e00206-18. doi: 10.1128/IAI.00206-18. Print 2018 Jul.


Human prosthetic joint infections are associated with myeloid-derived suppressor cells (MDSCs): Implications for infection persistence.

Heim CE, Vidlak D, Odvody J, Hartman CW, Garvin KL, Kielian T.

J Orthop Res. 2018 Jun;36(6):1605-1613. doi: 10.1002/jor.23806. Epub 2017 Dec 5.


SaeRS Is Responsive to Cellular Respiratory Status and Regulates Fermentative Biofilm Formation in Staphylococcus aureus.

Mashruwala AA, Gries CM, Scherr TD, Kielian T, Boyd JM.

Infect Immun. 2017 Jul 19;85(8). pii: e00157-17. doi: 10.1128/IAI.00157-17. Print 2017 Aug.


Age-dependent alterations in neuronal activity in the hippocampus and visual cortex in a mouse model of Juvenile Neuronal Ceroid Lipofuscinosis (CLN3).

Burkovetskaya M, Karpuk N, Kielian T.

Neurobiol Dis. 2017 Apr;100:19-29. doi: 10.1016/j.nbd.2016.12.022. Epub 2016 Dec 30.


Staphylococcal Biofilms and Immune Polarization During Prosthetic Joint Infection.

Gries CM, Kielian T.

J Am Acad Orthop Surg. 2017 Feb;25 Suppl 1:S20-S24. doi: 10.5435/JAAOS-D-16-00636. Review.


Efficacy of phosphodiesterase-4 inhibitors in juvenile Batten disease (CLN3).

Aldrich A, Bosch ME, Fallet R, Odvody J, Burkovetskaya M, Rama Rao KV, Cooper JD, Drack AV, Kielian T.

Ann Neurol. 2016 Dec;80(6):909-923. doi: 10.1002/ana.24815. Epub 2016 Nov 23.


Cyclic di-AMP Released from Staphylococcus aureus Biofilm Induces a Macrophage Type I Interferon Response.

Gries CM, Bruger EL, Moormeier DE, Scherr TD, Waters CM, Kielian T.

Infect Immun. 2016 Nov 18;84(12):3564-3574. Print 2016 Dec.


Self-Complementary AAV9 Gene Delivery Partially Corrects Pathology Associated with Juvenile Neuronal Ceroid Lipofuscinosis (CLN3).

Bosch ME, Aldrich A, Fallet R, Odvody J, Burkovetskaya M, Schuberth K, Fitzgerald JA, Foust KD, Kielian T.

J Neurosci. 2016 Sep 14;36(37):9669-82. doi: 10.1523/JNEUROSCI.1635-16.2016.


Nox2-derived oxidative stress results in inefficacy of antibiotics against post-influenza S. aureus pneumonia.

Sun K, Yajjala VK, Bauer C, Talmon GA, Fischer KJ, Kielian T, Metzger DW.

J Exp Med. 2016 Aug 22;213(9):1851-64. doi: 10.1084/jem.20150514. Epub 2016 Aug 15.


Infectious Dose Dictates the Host Response during Staphylococcus aureus Orthopedic-Implant Biofilm Infection.

Vidlak D, Kielian T.

Infect Immun. 2016 Jun 23;84(7):1957-1965. doi: 10.1128/IAI.00117-16. Print 2016 Jul.


Moving towards effective therapeutic strategies for Neuronal Ceroid Lipofuscinosis.

Geraets RD, Koh Sy, Hastings ML, Kielian T, Pearce DA, Weimer JM.

Orphanet J Rare Dis. 2016 Apr 16;11:40. doi: 10.1186/s13023-016-0414-2. Review.


Resistance to Acute Macrophage Killing Promotes Airway Fitness of Prevalent Community-Acquired Staphylococcus aureus Strains.

Yajjala VK, Thomas VC, Bauer C, Scherr TD, Fischer KJ, Fey PD, Bayles KW, Kielian T, Sun K.

J Immunol. 2016 May 15;196(10):4196-203. doi: 10.4049/jimmunol.1600081. Epub 2016 Apr 6.


Multifaceted roles of neuroinflammation: the need to consider both sides of the coin.

Kielian T.

J Neurochem. 2016 Jan;136 Suppl 1:5-9. doi: 10.1111/jnc.13530. Review. No abstract available.


Neuroinflammatory paradigms in lysosomal storage diseases.

Bosch ME, Kielian T.

Front Neurosci. 2015 Oct 30;9:417. doi: 10.3389/fnins.2015.00417. eCollection 2015. Review.


Neuron-astrocyte interactions in neurodegenerative diseases: Role of neuroinflammation.

Rama Rao KV, Kielian T.

Clin Exp Neuroimmunol. 2015 Aug;6(3):245-263. Epub 2015 Aug 3.


MyD88 in lung resident cells governs airway inflammatory and pulmonary function responses to organic dust treatment.

Poole JA, Wyatt TA, Romberger DJ, Staab E, Simet S, Reynolds SJ, Sisson JH, Kielian T.

Respir Res. 2015 Sep 16;16:111. doi: 10.1186/s12931-015-0272-9.


Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin.

Scherr TD, Hanke ML, Huang O, James DB, Horswill AR, Bayles KW, Fey PD, Torres VJ, Kielian T.

mBio. 2015 Aug 25;6(4). pii: e01021-15. doi: 10.1128/mBio.01021-15.


Interleukin-10 production by myeloid-derived suppressor cells contributes to bacterial persistence during Staphylococcus aureus orthopedic biofilm infection.

Heim CE, Vidlak D, Kielian T.

J Leukoc Biol. 2015 Dec;98(6):1003-13. doi: 10.1189/jlb.4VMA0315-125RR. Epub 2015 Jul 31.


Astrocytes and lysosomal storage diseases.

Rama Rao KV, Kielian T.

Neuroscience. 2016 May 26;323:195-206. doi: 10.1016/j.neuroscience.2015.05.061. Epub 2015 May 30. Review.


IL-12 promotes myeloid-derived suppressor cell recruitment and bacterial persistence during Staphylococcus aureus orthopedic implant infection.

Heim CE, Vidlak D, Scherr TD, Hartman CW, Garvin KL, Kielian T.

J Immunol. 2015 Apr 15;194(8):3861-3872. doi: 10.4049/jimmunol.1402689. Epub 2015 Mar 11.


Rot is a key regulator of Staphylococcus aureus biofilm formation.

Mootz JM, Benson MA, Heim CE, Crosby HA, Kavanaugh JS, Dunman PM, Kielian T, Torres VJ, Horswill AR.

Mol Microbiol. 2015 Apr;96(2):388-404. doi: 10.1111/mmi.12943. Epub 2015 Feb 26.


Hemichannels in neurodegenerative diseases: is there a link to pathology?

Bosch M, Kielian T.

Front Cell Neurosci. 2014 Aug 20;8:242. doi: 10.3389/fncel.2014.00242. eCollection 2014.


Transformation of human cathelicidin LL-37 into selective, stable, and potent antimicrobial compounds.

Wang G, Hanke ML, Mishra B, Lushnikova T, Heim CE, Chittezham Thomas V, Bayles KW, Kielian T.

ACS Chem Biol. 2014 Sep 19;9(9):1997-2002. doi: 10.1021/cb500475y. Epub 2014 Jul 30.


Neuroinflammation: good, bad, or indifferent?

Kielian T.

J Neurochem. 2014 Jul;130(1):1-3. doi: 10.1111/jnc.12755. Epub 2014 May 24. No abstract available.


Evidence for aberrant astrocyte hemichannel activity in Juvenile Neuronal Ceroid Lipofuscinosis (JNCL).

Burkovetskaya M, Karpuk N, Xiong J, Bosch M, Boska MD, Takeuchi H, Suzumura A, Kielian T.

PLoS One. 2014 Apr 15;9(4):e95023. doi: 10.1371/journal.pone.0095023. eCollection 2014.


Myeloid-derived suppressor cells contribute to Staphylococcus aureus orthopedic biofilm infection.

Heim CE, Vidlak D, Scherr TD, Kozel JA, Holzapfel M, Muirhead DE, Kielian T.

J Immunol. 2014 Apr 15;192(8):3778-92. doi: 10.4049/jimmunol.1303408. Epub 2014 Mar 19.


Hiding in Plain Sight: Interplay between Staphylococcal Biofilms and Host Immunity.

Scherr TD, Heim CE, Morrison JM, Kielian T.

Front Immunol. 2014 Feb 5;5:37. doi: 10.3389/fimmu.2014.00037. eCollection 2014. Review.


Critical role for the AIM2 inflammasome during acute CNS bacterial infection.

Hanamsagar R, Aldrich A, Kielian T.

J Neurochem. 2014 May;129(4):704-11. doi: 10.1111/jnc.12669. Epub 2014 Feb 19.


Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation.

Snowden JN, Beaver M, Beenken K, Smeltzer M, Horswill AR, Kielian T.

PLoS One. 2013 Dec 30;8(12):e84089. doi: 10.1371/journal.pone.0084089. eCollection 2013.


A mouse model of Staphylococcus catheter-associated biofilm infection.

Heim CE, Hanke ML, Kielian T.

Methods Mol Biol. 2014;1106:183-91. doi: 10.1007/978-1-62703-736-5_17.


Mouse model of post-arthroplasty Staphylococcus epidermidis joint infection.

Scherr TD, Lindgren KE, Schaeffer CR, Hanke ML, Hartman CW, Kielian T.

Methods Mol Biol. 2014;1106:173-81. doi: 10.1007/978-1-62703-736-5_16.


Global transcriptome analysis of Staphylococcus aureus biofilms in response to innate immune cells.

Scherr TD, Roux CM, Hanke ML, Angle A, Dunman PM, Kielian T.

Infect Immun. 2013 Dec;81(12):4363-76. doi: 10.1128/IAI.00819-13. Epub 2013 Sep 16.


Microglia in juvenile neuronal ceroid lipofuscinosis are primed toward a pro-inflammatory phenotype.

Xiong J, Kielian T.

J Neurochem. 2013 Oct;127(2):245-58. doi: 10.1111/jnc.12385. Epub 2013 Aug 22.


Compartmentalization of immune responses during Staphylococcus aureus cranial bone flap infection.

Cheatle J, Aldrich A, Thorell WE, Boska MD, Kielian T.

Am J Pathol. 2013 Aug;183(2):450-8. doi: 10.1016/j.ajpath.2013.04.031. Epub 2013 Jun 7.


Myeloid differentiation factor 88-dependent signaling is critical for acute organic dust-induced airway inflammation in mice.

Bauer C, Kielian T, Wyatt TA, Romberger DJ, West WW, Gleason AM, Poole JA.

Am J Respir Cell Mol Biol. 2013 Jun;48(6):781-9. doi: 10.1165/rcmb.2012-0479OC.

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