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Items: 48

1.

Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration.

Grassmann F, Harsch S, Brandl C, Kiel C, Nürnberg P, Toliat MR, Fleckenstein M, Pfau M, Schmitz-Valckenberg S, Holz FG, Chew EY, Swaroop A, Ratnapriya R, Klein ML, Mulyukov Z, Zamiri P, Weber BHF.

JAMA Ophthalmol. 2019 May 23. doi: 10.1001/jamaophthalmol.2019.1318. [Epub ahead of print]

PMID:
31120506
3.

VarQ: A Tool for the Structural and Functional Analysis of Human Protein Variants.

Radusky L, Modenutti C, Delgado J, Bustamante JP, Vishnopolska S, Kiel C, Serrano L, Marti M, Turjanski A.

Front Genet. 2018 Dec 6;9:620. doi: 10.3389/fgene.2018.00620. eCollection 2018.

4.

From oncogenic mutation to dynamic code.

Kolch W, Kiel C.

Science. 2018 Aug 31;361(6405):844-845. doi: 10.1126/science.aau8059. No abstract available.

PMID:
30166473
5.

Y chromosome mosaicism is associated with age-related macular degeneration.

Grassmann F, Kiel C, den Hollander AI, Weeks DE, Lotery A, Cipriani V, Weber BHF; International Age-related Macular Degeneration Genomics Consortium (IAMDGC).

Eur J Hum Genet. 2019 Jan;27(1):36-41. doi: 10.1038/s41431-018-0238-8. Epub 2018 Aug 29.

6.

Systems level expression correlation of Ras GTPase regulators.

Besray Unal E, Kiel C, Benisty H, Campbell A, Pickering K, Blüthgen N, Sansom OJ, Serrano L.

Cell Commun Signal. 2018 Aug 15;16(1):46. doi: 10.1186/s12964-018-0256-8.

7.

Why tibial plateau fractures are overlooked.

Kiel CM, Mikkelsen KL, Krogsgaard MR.

BMC Musculoskelet Disord. 2018 Jul 21;19(1):244. doi: 10.1186/s12891-018-2170-z.

8.

Pleiotropic Effects of Risk Factors in Age-Related Macular Degeneration and Seemingly Unrelated Complex Diseases.

Kiel C, Weber BHF, Grassmann F.

Adv Exp Med Biol. 2018;1074:247-255. doi: 10.1007/978-3-319-75402-4_30.

PMID:
29721950
9.

Interaction Dynamics Determine Signaling and Output Pathway Responses.

Stojanovski K, Ferrar T, Benisty H, Uschner F, Delgado J, Jimenez J, Solé C, de Nadal E, Klipp E, Posas F, Serrano L, Kiel C.

Cell Rep. 2017 Apr 4;19(1):136-149. doi: 10.1016/j.celrep.2017.03.029.

10.

Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits.

Grassmann F, Kiel C, Zimmermann ME, Gorski M, Grassmann V, Stark K; International AMD Genomics Consortium (IAMDGC), Heid IM, Weber BH.

Genome Med. 2017 Mar 27;9(1):29. doi: 10.1186/s13073-017-0418-0.

11.

A Comprehensive View of the β-Arrestinome.

Crépieux P, Poupon A, Langonné-Gallay N, Reiter E, Delgado J, Schaefer MH, Bourquard T, Serrano L, Kiel C.

Front Endocrinol (Lausanne). 2017 Mar 6;8:32. doi: 10.3389/fendo.2017.00032. eCollection 2017.

12.

Simple and complex retinal dystrophies are associated with profoundly different disease networks.

Kiel C, Lastrucci C, Luthert PJ, Serrano L.

Sci Rep. 2017 Jan 31;7:41835. doi: 10.1038/srep41835.

13.

An Eye on Age-Related Macular Degeneration: The Role of MicroRNAs in Disease Pathology.

Berber P, Grassmann F, Kiel C, Weber BH.

Mol Diagn Ther. 2017 Feb;21(1):31-43. doi: 10.1007/s40291-016-0234-z. Review.

14.

The yin-yang of kinase activation and unfolding explains the peculiarity of Val600 in the activation segment of BRAF.

Kiel C, Benisty H, Lloréns-Rico V, Serrano L.

Elife. 2016 Jan 8;5:e12814. doi: 10.7554/eLife.12814.

15.

Tuneable endogenous mammalian target complementation via multiplexed plasmid-based recombineering.

Beltran-Sastre V, Benisty H, Burnier J, Berger I, Serrano L, Kiel C.

Sci Rep. 2015 Nov 27;5:17432. doi: 10.1038/srep17432.

16.

Dissecting the calcium-induced differentiation of human primary keratinocytes stem cells by integrative and structural network analyses.

Toufighi K, Yang JS, Luis NM, Aznar Benitah S, Lehner B, Serrano L, Kiel C.

PLoS Comput Biol. 2015 May 6;11(5):e1004256. doi: 10.1371/journal.pcbi.1004256. eCollection 2015 May.

17.

TAPAS: tools to assist the targeted protein quantification of human alternative splice variants.

Yang JS, Sabidó E, Serrano L, Kiel C.

Bioinformatics. 2014 Oct 15;30(20):2989-90. doi: 10.1093/bioinformatics/btu428. Epub 2014 Jul 4.

PMID:
24996896
18.

Protein conservation and variation suggest mechanisms of cell type-specific modulation of signaling pathways.

Schaefer MH, Yang JS, Serrano L, Kiel C.

PLoS Comput Biol. 2014 Jun 12;10(6):e1003659. doi: 10.1371/journal.pcbi.1003659. eCollection 2014 Jun.

19.

Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.

Kiel C, Serrano L.

Mol Syst Biol. 2014 May 6;10:727. doi: 10.1002/msb.20145092.

20.

Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain.

Piccoli G, Onofri F, Cirnaru MD, Kaiser CJ, Jagtap P, Kastenmüller A, Pischedda F, Marte A, von Zweydorf F, Vogt A, Giesert F, Pan L, Antonucci F, Kiel C, Zhang M, Weinkauf S, Sattler M, Sala C, Matteoli M, Ueffing M, Gloeckner CJ.

Mol Cell Biol. 2014 Jun;34(12):2147-61. doi: 10.1128/MCB.00914-13. Epub 2014 Mar 31.

21.

Assessing the correlation between mutant rhodopsin stability and the severity of retinitis pigmentosa.

McKeone R, Wikstrom M, Kiel C, Rakoczy PE.

Mol Vis. 2014 Feb 7;20:183-99. eCollection 2014.

22.

Integration of protein abundance and structure data reveals competition in the ErbB signaling network.

Kiel C, Verschueren E, Yang JS, Serrano L.

Sci Signal. 2013 Dec 17;6(306):ra109. doi: 10.1126/scisignal.2004560.

PMID:
24345680
23.

Quantification of ErbB network proteins in three cell types using complementary approaches identifies cell-general and cell-type-specific signaling proteins.

Kiel C, Ebhardt HA, Burnier J, Portugal C, Sabidó E, Zimmermann T, Aebersold R, Serrano L.

J Proteome Res. 2014 Jan 3;13(1):300-13. doi: 10.1021/pr400878x. Epub 2013 Dec 9.

PMID:
24313378
24.

Structural data in synthetic biology approaches for studying general design principles of cellular signaling networks.

Kiel C, Serrano L.

Structure. 2012 Nov 7;20(11):1806-13. doi: 10.1016/j.str.2012.10.002. Review.

25.

SAPIN: a framework for the structural analysis of protein interaction networks.

Yang JS, Campagna A, Delgado J, Vanhee P, Serrano L, Kiel C.

Bioinformatics. 2012 Nov 15;28(22):2998-9. doi: 10.1093/bioinformatics/bts539. Epub 2012 Sep 6.

PMID:
22954630
26.

Structural and functional protein network analyses predict novel signaling functions for rhodopsin.

Kiel C, Vogt A, Campagna A, Chatr-aryamontri A, Swiatek-de Lange M, Beer M, Bolz S, Mack AF, Kinkl N, Cesareni G, Serrano L, Ueffing M.

Mol Syst Biol. 2011 Nov 22;7:551. doi: 10.1038/msb.2011.83.

27.

Challenges ahead in signal transduction: MAPK as an example.

Kiel C, Serrano L.

Curr Opin Biotechnol. 2012 Jun;23(3):305-14. doi: 10.1016/j.copbio.2011.10.004. Epub 2011 Oct 28. Review.

PMID:
22036710
28.

Analysis of disease-linked rhodopsin mutations based on structure, function, and protein stability calculations.

Rakoczy EP, Kiel C, McKeone R, Stricher F, Serrano L.

J Mol Biol. 2011 Jan 14;405(2):584-606. doi: 10.1016/j.jmb.2010.11.003. Epub 2010 Nov 19.

PMID:
21094163
29.

Engineering signal transduction pathways.

Kiel C, Yus E, Serrano L.

Cell. 2010 Jan 8;140(1):33-47. doi: 10.1016/j.cell.2009.12.028. Review.

30.

Improved binding of raf to Ras.GDP is correlated with biological activity.

Kiel C, Filchtinski D, Spoerner M, Schreiber G, Kalbitzer HR, Herrmann C.

J Biol Chem. 2009 Nov 13;284(46):31893-902. doi: 10.1074/jbc.M109.031153. Epub 2009 Sep 23.

31.

Cell type-specific importance of ras-c-raf complex association rate constants for MAPK signaling.

Kiel C, Serrano L.

Sci Signal. 2009 Jul 28;2(81):ra38. doi: 10.1126/scisignal.2000397.

32.

Protein design in biological networks: from manipulating the input to modifying the output.

Van der Sloot AM, Kiel C, Serrano L, Stricher F.

Protein Eng Des Sel. 2009 Sep;22(9):537-42. doi: 10.1093/protein/gzp032. Epub 2009 Jul 2. Review.

PMID:
19574296
33.

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.

Markson G, Kiel C, Hyde R, Brown S, Charalabous P, Bremm A, Semple J, Woodsmith J, Duley S, Salehi-Ashtiani K, Vidal M, Komander D, Serrano L, Lehner P, Sanderson CM.

Genome Res. 2009 Oct;19(10):1905-11. doi: 10.1101/gr.093963.109. Epub 2009 Jun 23.

34.

Association rate constants of ras-effector interactions are evolutionarily conserved.

Kiel C, Aydin D, Serrano L.

PLoS Comput Biol. 2008 Dec;4(12):e1000245. doi: 10.1371/journal.pcbi.1000245. Epub 2008 Dec 19.

35.

Toward a comprehensive understanding of phylogenetic relationships among lineages of Acanthaceae s.l. (Lamiales).

McDade LA, Daniel TF, Kiel CA.

Am J Bot. 2008 Sep;95(9):1136-52. doi: 10.3732/ajb.0800096.

36.

Analyzing protein interaction networks using structural information.

Kiel C, Beltrao P, Serrano L.

Annu Rev Biochem. 2008;77:415-41. doi: 10.1146/annurev.biochem.77.062706.133317. Review.

PMID:
18304007
37.

Shaping dots and lines: adding modularity into protein interaction networks using structural information.

Campagna A, Serrano L, Kiel C.

FEBS Lett. 2008 Apr 9;582(8):1231-6. doi: 10.1016/j.febslet.2008.02.019. Epub 2008 Feb 20. Review.

38.

Prediction of Ras-effector interactions using position energy matrices.

Kiel C, Serrano L.

Bioinformatics. 2007 Sep 1;23(17):2226-30. Epub 2007 Jun 28.

PMID:
17599936
39.

Structures in systems biology.

Beltrao P, Kiel C, Serrano L.

Curr Opin Struct Biol. 2007 Jun;17(3):378-84. Epub 2007 Jun 15. Review.

PMID:
17574836
40.

A genome-wide Ras-effector interaction network.

Kiel C, Foglierini M, Kuemmerer N, Beltrao P, Serrano L.

J Mol Biol. 2007 Jul 27;370(5):1020-32. Epub 2007 May 22.

PMID:
17544445
41.

The ubiquitin domain superfold: structure-based sequence alignments and characterization of binding epitopes.

Kiel C, Serrano L.

J Mol Biol. 2006 Jan 27;355(4):821-44. Epub 2005 Nov 8.

PMID:
16310215
42.

Recognizing and defining true Ras binding domains II: in silico prediction based on homology modelling and energy calculations.

Kiel C, Wohlgemuth S, Rousseau F, Schymkowitz J, Ferkinghoff-Borg J, Wittinghofer F, Serrano L.

J Mol Biol. 2005 May 6;348(3):759-75.

PMID:
15826669
43.

Recognizing and defining true Ras binding domains I: biochemical analysis.

Wohlgemuth S, Kiel C, Krämer A, Serrano L, Wittinghofer F, Herrmann C.

J Mol Biol. 2005 May 6;348(3):741-58.

PMID:
15826668
44.

A detailed thermodynamic analysis of ras/effector complex interfaces.

Kiel C, Serrano L, Herrmann C.

J Mol Biol. 2004 Jul 23;340(5):1039-58.

PMID:
15236966
45.

Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex.

Kiel C, Selzer T, Shaul Y, Schreiber G, Herrmann C.

Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9223-8. Epub 2004 Jun 14.

47.

Structural fingerprints of the Ras-GTPase activating proteins neurofibromin and p120GAP.

Ahmadian MR, Kiel C, Stege P, Scheffzek K.

J Mol Biol. 2003 Jun 13;329(4):699-710.

PMID:
12787671
48.

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