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Items: 1 to 50 of 106

1.

Modeling Motor Neuron Resilience in ALS Using Stem Cells.

Allodi I, Nijssen J, Benitez JA, Schweingruber C, Fuchs A, Bonvicini G, Cao M, Kiehn O, Hedlund E.

Stem Cell Reports. 2019 Jun 11;12(6):1329-1341. doi: 10.1016/j.stemcr.2019.04.009. Epub 2019 May 9.

2.

Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity.

Zhang MD, Su J, Adori C, Cinquina V, Malenczyk K, Girach F, Peng C, Ernfors P, Löw P, Borgius L, Kiehn O, Watanabe M, Uhlén M, Mitsios N, Mulder J, Harkany T, Hökfelt T.

J Clin Invest. 2018 Aug 31;128(9):3757-3768. doi: 10.1172/JCI120913. Epub 2018 Jul 30.

3.

Sacral Spinal Cord Transection and Isolated Sacral Cord Preparation to Study Chronic Spinal Cord Injury in Adult Mice.

Bellardita C, Marcantoni M, Löw P, Kiehn O.

Bio Protoc. 2018 Apr 5;8(7):e2784. doi: 10.21769/BioProtoc.2784.

4.

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types.

Häring M, Zeisel A, Hochgerner H, Rinwa P, Jakobsson JET, Lönnerberg P, La Manno G, Sharma N, Borgius L, Kiehn O, Lagerström MC, Linnarsson S, Ernfors P.

Nat Neurosci. 2018 Jun;21(6):869-880. doi: 10.1038/s41593-018-0141-1. Epub 2018 Apr 23.

PMID:
29686262
5.

Midbrain circuits that set locomotor speed and gait selection.

Caggiano V, Leiras R, Goñi-Erro H, Masini D, Bellardita C, Bouvier J, Caldeira V, Fisone G, Kiehn O.

Nature. 2018 Jan 25;553(7689):455-460. doi: 10.1038/nature25448. Epub 2018 Jan 17.

6.

Probenecid Inhibits α-Adrenergic Receptor-Mediated Vasoconstriction in the Human Leg Vasculature.

Nyberg M, Piil P, Kiehn OT, Maagaard C, Jørgensen TS, Egelund J, Isakson BE, Nielsen MS, Gliemann L, Hellsten Y.

Hypertension. 2018 Jan;71(1):151-159. doi: 10.1161/HYPERTENSIONAHA.117.10251. Epub 2017 Oct 30.

7.

Spatiotemporal correlation of spinal network dynamics underlying spasms in chronic spinalized mice.

Bellardita C, Caggiano V, Leiras R, Caldeira V, Fuchs A, Bouvier J, Löw P, Kiehn O.

Elife. 2017 Feb 13;6. pii: e23011. doi: 10.7554/eLife.23011.

8.

Spinal Hb9::Cre-derived excitatory interneurons contribute to rhythm generation in the mouse.

Caldeira V, Dougherty KJ, Borgius L, Kiehn O.

Sci Rep. 2017 Jan 27;7:41369. doi: 10.1038/srep41369.

9.

Decoding the organization of spinal circuits that control locomotion.

Kiehn O.

Nat Rev Neurosci. 2016 Apr;17(4):224-38. doi: 10.1038/nrn.2016.9. Epub 2016 Mar 3. Review.

10.

Descending Command Neurons in the Brainstem that Halt Locomotion.

Bouvier J, Caggiano V, Leiras R, Caldeira V, Bellardita C, Balueva K, Fuchs A, Kiehn O.

Cell. 2015 Nov 19;163(5):1191-1203. doi: 10.1016/j.cell.2015.10.074.

11.

Editorial overview: Motor circuits and action.

Kiehn O, Churchland MM.

Curr Opin Neurobiol. 2015 Aug;33:v-vi. doi: 10.1016/j.conb.2015.06.004. Epub 2015 Jun 30. No abstract available.

PMID:
26141430
12.

Phenotypic characterization of speed-associated gait changes in mice reveals modular organization of locomotor networks.

Bellardita C, Kiehn O.

Curr Biol. 2015 Jun 1;25(11):1426-36. doi: 10.1016/j.cub.2015.04.005. Epub 2015 May 7.

13.

The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO₂.

Ruffault PL, D'Autréaux F, Hayes JA, Nomaksteinsky M, Autran S, Fujiyama T, Hoshino M, Hägglund M, Kiehn O, Brunet JF, Fortin G, Goridis C.

Elife. 2015 Apr 13;4. doi: 10.7554/eLife.07051.

14.

Organization of left-right coordination of neuronal activity in the mammalian spinal cord: Insights from computational modelling.

Shevtsova NA, Talpalar AE, Markin SN, Harris-Warrick RM, Kiehn O, Rybak IA.

J Physiol. 2015 Jun 1;593(11):2403-26. doi: 10.1113/JP270121.

15.

[2014 Nobel Prize in Physiology or Medicine. The Nobel laureates have explored the internal GPS of the brain].

Forssberg H, Kiehn O.

Lakartidningen. 2014 Oct 8-14;111(41):1766-7. Swedish. No abstract available.

16.

Spinal glutamatergic neurons defined by EphA4 signaling are essential components of normal locomotor circuits.

Borgius L, Nishimaru H, Caldeira V, Kunugise Y, Löw P, Reig R, Itohara S, Iwasato T, Kiehn O.

J Neurosci. 2014 Mar 12;34(11):3841-53. doi: 10.1523/JNEUROSCI.4992-13.2014.

17.

Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury.

Zhang MD, Tortoriello G, Hsueh B, Tomer R, Ye L, Mitsios N, Borgius L, Grant G, Kiehn O, Watanabe M, Uhlén M, Mulder J, Deisseroth K, Harkany T, Hökfelt TG.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):E1149-58. doi: 10.1073/pnas.1402318111. Epub 2014 Mar 10.

18.

Locomotor rhythm generation linked to the output of spinal shox2 excitatory interneurons.

Dougherty KJ, Zagoraiou L, Satoh D, Rozani I, Doobar S, Arber S, Jessell TM, Kiehn O.

Neuron. 2013 Nov 20;80(4):920-33. doi: 10.1016/j.neuron.2013.08.015.

19.

Modelling genetic reorganization in the mouse spinal cord affecting left-right coordination during locomotion.

Rybak IA, Shevtsova NA, Kiehn O.

J Physiol. 2013 Nov 15;591(22):5491-508. doi: 10.1113/jphysiol.2013.261115. Epub 2013 Sep 30.

20.

Dual-mode operation of neuronal networks involved in left-right alternation.

Talpalar AE, Bouvier J, Borgius L, Fortin G, Pierani A, Kiehn O.

Nature. 2013 Aug 1;500(7460):85-8. doi: 10.1038/nature12286. Epub 2013 Jun 30.

PMID:
23812590
21.

Optogenetic dissection reveals multiple rhythmogenic modules underlying locomotion.

Hägglund M, Dougherty KJ, Borgius L, Itohara S, Iwasato T, Kiehn O.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11589-94. doi: 10.1073/pnas.1304365110. Epub 2013 Jun 24.

22.

Identification of minimal neuronal networks involved in flexor-extensor alternation in the mammalian spinal cord.

Talpalar AE, Endo T, Löw P, Borgius L, Hägglund M, Dougherty KJ, Ryge J, Hnasko TS, Kiehn O.

Neuron. 2011 Sep 22;71(6):1071-84. doi: 10.1016/j.neuron.2011.07.011. Epub 2011 Sep 21.

23.

Medial septal dysfunction by Aβ-induced KCNQ channel-block in glutamatergic neurons.

Leão RN, Colom LV, Borgius L, Kiehn O, Fisahn A.

Neurobiol Aging. 2012 Sep;33(9):2046-61. doi: 10.1016/j.neurobiolaging.2011.07.013. Epub 2011 Sep 9.

PMID:
21907458
24.

Change in the balance of excitatory and inhibitory midline fiber crossing as an explanation for the hopping phenotype in EphA4 knockout mice.

Restrepo CE, Margaryan G, Borgius L, Lundfald L, Sargsyan D, Kiehn O.

Eur J Neurosci. 2011 Oct;34(7):1102-12. doi: 10.1111/j.1460-9568.2011.07838.x. Epub 2011 Sep 7.

PMID:
21899605
25.

The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance.

Holz A, Kollmus H, Ryge J, Niederkofler V, Dias J, Ericson J, Stoeckli ET, Kiehn O, Arnold HH.

Development. 2010 Dec;137(24):4249-60. doi: 10.1242/dev.053819. Epub 2010 Nov 10.

26.

Development and functional organization of spinal locomotor circuits.

Kiehn O.

Curr Opin Neurobiol. 2011 Feb;21(1):100-9. doi: 10.1016/j.conb.2010.09.004. Review.

PMID:
20889331
27.

Glutamatergic mechanisms for speed control and network operation in the rodent locomotor CpG.

Talpalar AE, Kiehn O.

Front Neural Circuits. 2010 Aug 6;4. pii: 19. doi: 10.3389/fncir.2010.00019. eCollection 2010.

28.

A transgenic mouse line for molecular genetic analysis of excitatory glutamatergic neurons.

Borgius L, Restrepo CE, Leao RN, Saleh N, Kiehn O.

Mol Cell Neurosci. 2010 Nov;45(3):245-57. doi: 10.1016/j.mcn.2010.06.016. Epub 2010 Jul 1.

PMID:
20600924
29.

Functional organization of V2a-related locomotor circuits in the rodent spinal cord.

Dougherty KJ, Kiehn O.

Ann N Y Acad Sci. 2010 Jun;1198:85-93. doi: 10.1111/j.1749-6632.2010.05502.x. Review.

PMID:
20536923
30.

Transcriptional regulation of gene expression clusters in motor neurons following spinal cord injury.

Ryge J, Winther O, Wienecke J, Sandelin A, Westerdahl AC, Hultborn H, Kiehn O.

BMC Genomics. 2010 Jun 9;11:365. doi: 10.1186/1471-2164-11-365.

31.

Probing spinal circuits controlling walking in mammals.

Kiehn O, Dougherty KJ, Hägglund M, Borgius L, Talpalar A, Restrepo CE.

Biochem Biophys Res Commun. 2010 May 21;396(1):11-8. doi: 10.1016/j.bbrc.2010.02.107. Review.

PMID:
20494103
32.

Activation of groups of excitatory neurons in the mammalian spinal cord or hindbrain evokes locomotion.

Hägglund M, Borgius L, Dougherty KJ, Kiehn O.

Nat Neurosci. 2010 Feb;13(2):246-52. doi: 10.1038/nn.2482. Epub 2010 Jan 17.

PMID:
20081850
33.

Firing and cellular properties of V2a interneurons in the rodent spinal cord.

Dougherty KJ, Kiehn O.

J Neurosci. 2010 Jan 6;30(1):24-37. doi: 10.1523/JNEUROSCI.4821-09.2010.

34.

Global gene expression analysis of rodent motor neurons following spinal cord injury associates molecular mechanisms with development of postinjury spasticity.

Wienecke J, Westerdahl AC, Hultborn H, Kiehn O, Ryge J.

J Neurophysiol. 2010 Feb;103(2):761-78. doi: 10.1152/jn.00609.2009. Epub 2009 Nov 25.

35.

Transmitter-phenotypes of commissural interneurons in the lumbar spinal cord of newborn mice.

Restrepo CE, Lundfald L, Szabó G, Erdélyi F, Zeilhofer HU, Glover JC, Kiehn O.

J Comp Neurol. 2009 Nov 10;517(2):177-92. doi: 10.1002/cne.22144.

PMID:
19731323
36.

Genetic ablation of V2a ipsilateral interneurons disrupts left-right locomotor coordination in mammalian spinal cord.

Crone SA, Quinlan KA, Zagoraiou L, Droho S, Restrepo CE, Lundfald L, Endo T, Setlak J, Jessell TM, Kiehn O, Sharma K.

Neuron. 2008 Oct 9;60(1):70-83. doi: 10.1016/j.neuron.2008.08.009.

37.

Gene expression profiling of two distinct neuronal populations in the rodent spinal cord.

Ryge J, Westerdahl AC, Alstrøm P, Kiehn O.

PLoS One. 2008;3(10):e3415. doi: 10.1371/journal.pone.0003415. Epub 2008 Oct 15.

38.

Asymmetric operation of the locomotor central pattern generator in the neonatal mouse spinal cord.

Endo T, Kiehn O.

J Neurophysiol. 2008 Dec;100(6):3043-54. doi: 10.1152/jn.90729.2008. Epub 2008 Oct 1.

39.

Phenotype of V2-derived interneurons and their relationship to the axon guidance molecule EphA4 in the developing mouse spinal cord.

Lundfald L, Restrepo CE, Butt SJ, Peng CY, Droho S, Endo T, Zeilhofer HU, Sharma K, Kiehn O.

Eur J Neurosci. 2007 Dec;26(11):2989-3002.

PMID:
18028107
40.

Excitatory components of the mammalian locomotor CPG.

Kiehn O, Quinlan KA, Restrepo CE, Lundfald L, Borgius L, Talpalar AE, Endo T.

Brain Res Rev. 2008 Jan;57(1):56-63. Epub 2007 Nov 7. Review.

PMID:
17988744
41.

Segmental, synaptic actions of commissural interneurons in the mouse spinal cord.

Quinlan KA, Kiehn O.

J Neurosci. 2007 Jun 13;27(24):6521-30.

42.

Locomotor circuits in the mammalian spinal cord.

Kiehn O.

Annu Rev Neurosci. 2006;29:279-306. Review.

PMID:
16776587
43.

Activity of Renshaw cells during locomotor-like rhythmic activity in the isolated spinal cord of neonatal mice.

Nishimaru H, Restrepo CE, Kiehn O.

J Neurosci. 2006 May 17;26(20):5320-8. Erratum in: J Neurosci. 2006 May 24;26(21):table of contents.

44.

V1 spinal neurons regulate the speed of vertebrate locomotor outputs.

Gosgnach S, Lanuza GM, Butt SJ, Saueressig H, Zhang Y, Velasquez T, Riethmacher D, Callaway EM, Kiehn O, Goulding M.

Nature. 2006 Mar 9;440(7081):215-9.

PMID:
16525473
45.

EphA4 defines a class of excitatory locomotor-related interneurons.

Butt SJ, Lundfald L, Kiehn O.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14098-103. Epub 2005 Sep 19.

46.

Regulation of EphA 4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function.

Egea J, Nissen UV, Dufour A, Sahin M, Greer P, Kullander K, Mrsic-Flogel TD, Greenberg ME, Kiehn O, Vanderhaeghen P, Klein R.

Neuron. 2005 Aug 18;47(4):515-28.

47.

Glial and neuronal connexin expression patterns in the rat spinal cord during development and following injury.

Lee IH, Lindqvist E, Kiehn O, Widenfalk J, Olson L.

J Comp Neurol. 2005 Aug 15;489(1):1-10.

PMID:
15977163
48.

Mammalian motor neurons corelease glutamate and acetylcholine at central synapses.

Nishimaru H, Restrepo CE, Ryge J, Yanagawa Y, Kiehn O.

Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5245-9. Epub 2005 Mar 21.

49.

Central pattern generators deciphered by molecular genetics.

Kiehn O, Kullander K.

Neuron. 2004 Feb 5;41(3):317-21. Review.

50.

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