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Items: 1 to 50 of 97


Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales.

Guo Y, Li D, Zhang S, Yang Y, Liu JJ, Wang X, Liu C, Milkie DE, Moore RP, Tulu US, Kiehart DP, Hu J, Lippincott-Schwartz J, Betzig E, Li D.

Cell. 2018 Nov 15;175(5):1430-1442.e17. doi: 10.1016/j.cell.2018.09.057. Epub 2018 Oct 25.


Contractile protein biochemistry in the Pollard Lab in Baltimore.

Kiehart DP, Cooper JA.

Biophys Rev. 2018 Dec;10(6):1483-1485. doi: 10.1007/s12551-018-0477-5. Epub 2018 Nov 8. Review.


Unified biophysical mechanism for cell-shape oscillations and cell ingression.

Lo WC, Madrak C, Kiehart DP, Edwards GS.

Phys Rev E. 2018 Jun;97(6-1):062414. doi: 10.1103/PhysRevE.97.062414.


Mathematical models of dorsal closure.

Aristotelous AC, Crawford JM, Edwards GS, Kiehart DP, Venakides S.

Prog Biophys Mol Biol. 2018 Sep;137:111-131. doi: 10.1016/j.pbiomolbio.2018.05.009. Epub 2018 May 29. Review.


Identifying Genetic Players in Cell Sheet Morphogenesis Using a Drosophila Deficiency Screen for Genes on Chromosome 2R Involved in Dorsal Closure.

Mortensen RD, Moore RP, Fogerson SM, Chiou HY, Obinero CV, Prabhu NK, Wei AH, Crawford JM, Kiehart DP.

G3 (Bethesda). 2018 Jul 2;8(7):2361-2387. doi: 10.1534/g3.118.200233.


Cell Sheet Morphogenesis: Dorsal Closure in Drosophila melanogaster as a Model System.

Kiehart DP, Crawford JM, Aristotelous A, Venakides S, Edwards GS.

Annu Rev Cell Dev Biol. 2017 Oct 6;33:169-202. doi: 10.1146/annurev-cellbio-111315-125357. Review.


Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue.

Cao J, Wang J, Jackman CP, Cox AH, Trembley MA, Balowski JJ, Cox BD, De Simone A, Dickson AL, Di Talia S, Small EM, Kiehart DP, Bursac N, Poss KD.

Dev Cell. 2017 Sep 25;42(6):600-615.e4. doi: 10.1016/j.devcel.2017.08.024.


Quantifying dorsal closure in three dimensions.

Lu H, Sokolow A, Kiehart DP, Edwards GS.

Mol Biol Cell. 2016 Dec 15;27(25):3948-3955. Epub 2016 Oct 26.


MRCK-1 Drives Apical Constriction in C. elegans by Linking Developmental Patterning to Force Generation.

Marston DJ, Higgins CD, Peters KA, Cupp TD, Dickinson DJ, Pani AM, Moore RP, Cox AH, Kiehart DP, Goldstein B.

Curr Biol. 2016 Aug 22;26(16):2079-89. doi: 10.1016/j.cub.2016.06.010. Epub 2016 Jul 21.


Remodeling Tissue Interfaces and the Thermodynamics of Zipping during Dorsal Closure in Drosophila.

Lu H, Sokolow A, Kiehart DP, Edwards GS.

Biophys J. 2015 Dec 1;109(11):2406-17. doi: 10.1016/j.bpj.2015.10.017.


Moving Inward: Establishing the Mammalian Inner Cell Mass.

Goldstein B, Kiehart DP.

Dev Cell. 2015 Aug 24;34(4):385-6. doi: 10.1016/j.devcel.2015.08.007.


Epithelial morphogenesis: apoptotic forces drive cell shape changes.

Kiehart DP.

Dev Cell. 2015 Mar 9;32(5):532-3. doi: 10.1016/j.devcel.2015.02.020.


Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution.

Chen BC, Legant WR, Wang K, Shao L, Milkie DE, Davidson MW, Janetopoulos C, Wu XS, Hammer JA 3rd, Liu Z, English BP, Mimori-Kiyosue Y, Romero DP, Ritter AT, Lippincott-Schwartz J, Fritz-Laylin L, Mullins RD, Mitchell DM, Bembenek JN, Reymann AC, Böhme R, Grill SW, Wang JT, Seydoux G, Tulu US, Kiehart DP, Betzig E.

Science. 2014 Oct 24;346(6208):1257998. doi: 10.1126/science.1257998. Epub 2014 Oct 23.


Complete canthi removal reveals that forces from the amnioserosa alone are sufficient to drive dorsal closure in Drosophila.

Wells AR, Zou RS, Tulu US, Sokolow AC, Crawford JM, Edwards GS, Kiehart DP.

Mol Biol Cell. 2014 Nov 5;25(22):3552-68. doi: 10.1091/mbc.E14-07-1190. Epub 2014 Sep 24.


Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure.

Hunter GL, Crawford JM, Genkins JZ, Kiehart DP.

Development. 2014 Jan;141(2):325-34. doi: 10.1242/dev.097097. Epub 2013 Dec 4.


Cell ingression and apical shape oscillations during dorsal closure in Drosophila.

Sokolow A, Toyama Y, Kiehart DP, Edwards GS.

Biophys J. 2012 Mar 7;102(5):969-79. doi: 10.1016/j.bpj.2012.01.027. Epub 2012 Mar 6.


Triggering a cell shape change by exploiting preexisting actomyosin contractions.

Roh-Johnson M, Shemer G, Higgins CD, McClellan JH, Werts AD, Tulu US, Gao L, Betzig E, Kiehart DP, Goldstein B.

Science. 2012 Mar 9;335(6073):1232-5. doi: 10.1126/science.1217869. Epub 2012 Feb 9.


Division of labor: subsets of dorsal-appendage-forming cells control the shape of the entire tube.

Boyle MJ, French RL, Cosand KA, Dorman JB, Kiehart DP, Berg CA.

Dev Biol. 2010 Oct 1;346(1):68-79. doi: 10.1016/j.ydbio.2010.07.018. Epub 2010 Jul 24.


Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis.

Franke JD, Montague RA, Kiehart DP.

Dev Biol. 2010 Sep 15;345(2):117-32. doi: 10.1016/j.ydbio.2010.06.028. Epub 2010 Jun 28.


Drosophila morphogenesis: tissue force laws and the modeling of dorsal closure.

Layton AT, Toyama Y, Yang GQ, Edwards GS, Kiehart DP, Venakides S.

HFSP J. 2009 Dec;3(6):441-60. doi: 10.2976/1.3266062. Epub 2009 Dec 15.


Actomyosin purse strings: renewable resources that make morphogenesis robust and resilient.

Rodriguez-Diaz A, Toyama Y, Abravanel DL, Wiemann JM, Wells AR, Tulu US, Edwards GS, Kiehart DP.

HFSP J. 2008 Aug;2(4):220-37. doi: 10.2976/1.2955565. Epub 2008 Jul 23.


Apoptotic force and tissue dynamics during Drosophila embryogenesis.

Toyama Y, Peralta XG, Wells AR, Kiehart DP, Edwards GS.

Science. 2008 Sep 19;321(5896):1683-6. doi: 10.1126/science.1157052.


Myosin VIIA, important for human auditory function, is necessary for Drosophila auditory organ development.

Todi SV, Sivan-Loukianova E, Jacobs JS, Kiehart DP, Eberl DF.

PLoS One. 2008 May 7;3(5):e2115. doi: 10.1371/journal.pone.0002115.


Emergent properties during dorsal closure in Drosophila morphogenesis.

Peralta XG, Toyama Y, Kiehart DP, Edwards GS.

Phys Biol. 2008 Apr 10;5(1):015004. doi: 10.1088/1478-3975/5/1/015004.


An MYH9 human disease model in flies: site-directed mutagenesis of the Drosophila non-muscle myosin II results in hypomorphic alleles with dominant character.

Franke JD, Montague RA, Rickoll WL, Kiehart DP.

Hum Mol Genet. 2007 Dec 15;16(24):3160-73. Epub 2007 Sep 26.


Upregulation of forces and morphogenic asymmetries in dorsal closure during Drosophila development.

Peralta XG, Toyama Y, Hutson MS, Montague R, Venakides S, Kiehart DP, Edwards GS.

Biophys J. 2007 Apr 1;92(7):2583-96. Epub 2007 Jan 11.


Quantitative microinjection of Drosophila embryos: general strategy.

Kiehart DP, Crawford JM, Montague RA.

CSH Protoc. 2007 Apr 1;2007:pdb.top5. doi: 10.1101/pdb.top5.


Quantitative microinjection of Drosophila embryos.

Kiehart DP, Crawford JM, Montague RA.

CSH Protoc. 2007 Apr 1;2007:pdb.prot4718. doi: 10.1101/pdb.prot4718.


Collection, dechorionation, and preparation of Drosophila embryos for quantitative microinjection.

Kiehart DP, Crawford JM, Montague RA.

CSH Protoc. 2007 Apr 1;2007:pdb.prot4717. doi: 10.1101/pdb.prot4717.


Native nonmuscle myosin II stability and light chain binding in Drosophila melanogaster.

Franke JD, Boury AL, Gerald NJ, Kiehart DP.

Cell Motil Cytoskeleton. 2006 Oct;63(10):604-22.


Dimerized Drosophila myosin VIIa: a processive motor.

Yang Y, Kovács M, Sakamoto T, Zhang F, Kiehart DP, Sellers JR.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5746-51. Epub 2006 Apr 3.


JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.

Homsy JG, Jasper H, Peralta XG, Wu H, Kiehart DP, Bohmann D.

Dev Dyn. 2006 Feb;235(2):427-34.


Myosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in Drosophila.

Todi SV, Franke JD, Kiehart DP, Eberl DF.

Curr Biol. 2005 May 10;15(9):862-8.


Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA.

Kiehart DP, Franke JD, Chee MK, Montague RA, Chen TL, Roote J, Ashburner M.

Genetics. 2004 Nov;168(3):1337-52.


Rod mutations associated with MYH9-related disorders disrupt nonmuscle myosin-IIA assembly.

Franke JD, Dong F, Rickoll WL, Kelley MJ, Kiehart DP.

Blood. 2005 Jan 1;105(1):161-9. Epub 2004 Aug 31.


bullwinkle is required for epithelial morphogenesis during Drosophila oogenesis.

Dorman JB, James KE, Fraser SE, Kiehart DP, Berg CA.

Dev Biol. 2004 Mar 15;267(2):320-41.


Myosins motor Miranda.

Kiehart DP.

Mol Cell. 2003 Dec;12(6):1346-7.


Forces for morphogenesis investigated with laser microsurgery and quantitative modeling.

Hutson MS, Tokutake Y, Chang MS, Bloor JW, Venakides S, Kiehart DP, Edwards GS.

Science. 2003 Apr 4;300(5616):145-9. Epub 2003 Feb 6.


Real-time imaging of morphogenetic movements in Drosophila using Gal4-UAS-driven expression of GFP fused to the actin-binding domain of moesin.

Dutta D, Bloor JW, Ruiz-Gomez M, VijayRaghavan K, Kiehart DP.

Genesis. 2002 Sep-Oct;34(1-2):146-51. No abstract available.


Actin dynamics: the arp2/3 complex branches out.

Kiehart DP, Franke JD.

Curr Biol. 2002 Aug 20;12(16):R557-9.


Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants.

Ohashi T, Kiehart DP, Erickson HP.

J Cell Sci. 2002 Mar 15;115(Pt 6):1221-9.


Role of myosin-II phosphorylation in V12Cdc42-mediated disruption of Drosophila cellularization.

Crawford JM, Su Z, Varlamova O, Bresnick AR, Kiehart DP.

Eur J Cell Biol. 2001 Mar;80(3):240-4.


Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family.

Champagne MB, Edwards KA, Erickson HP, Kiehart DP.

J Mol Biol. 2000 Jul 21;300(4):759-77.


Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis.

Halsell SR, Chu BI, Kiehart DP.

Genetics. 2000 Jul;155(3):1253-65. Erratum in: Genetics 2000 Sep;156(1):following 468.

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