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SNAP23 depletion enables more SNAP25/calcium channel excitosome formation to increase insulin exocytosis in type 2 diabetes.

Liang T, Qin T, Kang F, Kang Y, Xie L, Zhu D, Dolai S, Greitzer-Antes D, Baker RK, Feng D, Tuduri E, Ostenson CG, Kieffer TJ, Banks K, Pessin JE, Gaisano HY.

JCI Insight. 2020 Feb 13;5(3). pii: 129694. doi: 10.1172/jci.insight.129694.


AAV GCG-EGFP, a new tool to identify glucagon-secreting α-cells.

Tudurí E, Glavas MM, Asadi A, Baker RK, Ellis CE, Soukhatcheva G, Philit M, Huynh FK, Johnson JD, Bruce Verchere C, Kieffer TJ.

Sci Rep. 2019 Jul 25;9(1):10829. doi: 10.1038/s41598-019-46735-2.


Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation.

Petrus P, Fernandez TL, Kwon MM, Huang JL, Lei V, Safikhan NS, Karunakaran S, O'Shannessy DJ, Zheng X, Catrina SB, Albone E, Laine J, Virtanen K, Clee SM, Kieffer TJ, Noll C, Carpentier AC, Johnson JD, Rydén M, Conway EM.

EBioMedicine. 2019 Jun;44:489-501. doi: 10.1016/j.ebiom.2019.05.057. Epub 2019 Jun 17.


Early overnutrition reduces Pdx1 expression and induces β cell failure in Swiss Webster mice.

Glavas MM, Hui Q, Tudurí E, Erener S, Kasteel NL, Johnson JD, Kieffer TJ.

Sci Rep. 2019 Mar 6;9(1):3619. doi: 10.1038/s41598-019-39177-3.


Navigating Two Roads to Glucose Normalization in Diabetes: Automated Insulin Delivery Devices and Cell Therapy.

Latres E, Finan DA, Greenstein JL, Kowalski A, Kieffer TJ.

Cell Metab. 2019 Mar 5;29(3):545-563. doi: 10.1016/j.cmet.2019.02.007. Review.


Vegfa/vegfr2 signaling is necessary for zebrafish islet vessel development, but is dispensable for beta-cell and alpha-cell formation.

Toselli CM, Wilkinson BM, Paterson J, Kieffer TJ.

Sci Rep. 2019 Mar 5;9(1):3594. doi: 10.1038/s41598-019-40136-1.


Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissues.

Pereira S, O'Dwyer SM, Webber TD, Baker RK, So V, Ellis CE, Yoon JS, Mojibian M, Glavas MM, Karunakaran S, Clee SM, Covey SD, Kieffer TJ.

Sci Rep. 2019 Mar 1;9(1):3307. doi: 10.1038/s41598-019-39498-3.


Glucose-dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice.

Shimazu-Kuwahara S, Kanemaru Y, Harada N, Ikeguchi E, Ueda Y, Yamane S, Murata Y, Yasoda A, Kieffer TJ, Inagaki N.

J Diabetes Investig. 2019 Jul;10(4):909-914. doi: 10.1111/jdi.12978. Epub 2018 Dec 27.


Leptin contributes to the beneficial effects of insulin treatment in streptozotocin-diabetic male mice.

Neumann UH, Kwon MM, Baker RK, Kieffer TJ.

Am J Physiol Endocrinol Metab. 2018 Dec 1;315(6):E1264-E1273. doi: 10.1152/ajpendo.00159.2018. Epub 2018 Oct 9.


Enhanced amphetamine-induced motor impulsivity and mild attentional impairment in the leptin-deficient rat model of obesity.

Adams WK, D'souza AM, Sussman JL, Kaur S, Kieffer TJ, Winstanley CA.

Physiol Behav. 2018 Aug 1;192:134-144. doi: 10.1016/j.physbeh.2018.03.027. Epub 2018 Mar 27.


Sex Differences in Maturation of Human Embryonic Stem Cell-Derived β Cells in Mice.

Saber N, Bruin JE, O'Dwyer S, Schuster H, Rezania A, Kieffer TJ.

Endocrinology. 2018 Apr 1;159(4):1827-1841. doi: 10.1210/en.2018-00048.


Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes.

Neumann UH, Ho JSS, Chen S, Tam YYC, Cullis PR, Kieffer TJ.

Mol Metab. 2017 Oct;6(10):1161-1172. doi: 10.1016/j.molmet.2017.06.012. Epub 2017 Jun 22.


Insulin-Deficient Mouse β-Cells Do Not Fully Maturebut Can Be Remedied Through Insulin Replacementby Islet Transplantation.

Ramzy A, Mojibian M, Kieffer TJ.

Endocrinology. 2018 Jan 1;159(1):83-102. doi: 10.1210/en.2017-00263.


In Memoriam-John C. Brown, PhD, DSc, FRSC, 1938-2016: Discoverer of GIP and Motilin.

Kieffer TJ.

Gastroenterology. 2017 Nov;153(5):1169-1171. doi: 10.1053/j.gastro.2017.09.037. Epub 2017 Oct 5. No abstract available.


Beta-cell replacement strategies for diabetes.

Kieffer TJ, Woltjen K, Osafune K, Yabe D, Inagaki N.

J Diabetes Investig. 2017 Oct 6. doi: 10.1111/jdi.12758. [Epub ahead of print] Review.


The glucoregulatory actions of leptin.

D'souza AM, Neumann UH, Glavas MM, Kieffer TJ.

Mol Metab. 2017 May 4;6(9):1052-1065. doi: 10.1016/j.molmet.2017.04.011. eCollection 2017 Sep. Review.


Regenerative medicine and cell-based approaches to restore pancreatic function.

Ellis C, Ramzy A, Kieffer TJ.

Nat Rev Gastroenterol Hepatol. 2017 Oct;14(10):612-628. doi: 10.1038/nrgastro.2017.93. Epub 2017 Aug 16. Review.


Amyloid formation disrupts the balance between interleukin-1β and interleukin-1 receptor antagonist in human islets.

Hui Q, Asadi A, Park YJ, Kieffer TJ, Ao Z, Warnock GL, Marzban L.

Mol Metab. 2017 May 31;6(8):833-844. doi: 10.1016/j.molmet.2017.05.016. eCollection 2017 Aug.


Restoration of Lepr in β cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia.

D'souza AM, Kieffer TJ.

Mol Metab. 2017 Apr 11;6(6):585-593. doi: 10.1016/j.molmet.2017.04.003. eCollection 2017 Jun.


Insulin and Glucagon: Partners for Life.

Holst JJ, Holland W, Gromada J, Lee Y, Unger RH, Yan H, Sloop KW, Kieffer TJ, Damond N, Herrera PL.

Endocrinology. 2017 Apr 1;158(4):696-701. doi: 10.1210/en.2016-1748. Review.


Attenuated secretion of glucose-dependent insulinotropic polypeptide (GIP) does not alleviate hyperphagic obesity and insulin resistance in ob/ob mice.

Shimazu-Kuwahara S, Harada N, Yamane S, Joo E, Sankoda A, Kieffer TJ, Inagaki N.

Mol Metab. 2017 Jan 19;6(3):288-294. doi: 10.1016/j.molmet.2017.01.006. eCollection 2017 Mar.


Profiling of circulating microRNAs in children with recent onset of type 1 diabetes.

Erener S, Marwaha A, Tan R, Panagiotopoulos C, Kieffer TJ.

JCI Insight. 2017 Feb 23;2(4):e89656. doi: 10.1172/jci.insight.89656.


Dipeptidyl peptidase-4 inhibitor treatment induces a greater increase in plasma levels of bioactive GIP than GLP-1 in non-diabetic subjects.

Yanagimachi T, Fujita Y, Takeda Y, Honjo J, Sakagami H, Kitsunai H, Takiyama Y, Abiko A, Makino Y, Kieffer TJ, Haneda M.

Mol Metab. 2016 Dec 31;6(2):226-231. doi: 10.1016/j.molmet.2016.12.009. eCollection 2017 Feb.


Dual role of interleukin-1β in islet amyloid formation and its β-cell toxicity: Implications for type 2 diabetes and islet transplantation.

Park YJ, Warnock GL, Ao Z, Safikhan N, Meloche M, Asadi A, Kieffer TJ, Marzban L.

Diabetes Obes Metab. 2017 May;19(5):682-694. doi: 10.1111/dom.12873. Epub 2017 Feb 27.


Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes.

Zhang D, Wang F, Lal N, Chiu AP, Wan A, Jia J, Bierende D, Flibotte S, Sinha S, Asadi A, Hu X, Taghizadeh F, Pulinilkunnil T, Nislow C, Vlodavsky I, Johnson JD, Kieffer TJ, Hussein B, Rodrigues B.

Diabetes. 2017 Jan;66(1):45-57. doi: 10.2337/db16-0761. Epub 2016 Oct 7.


Suppressing hyperinsulinemia prevents obesity but causes rapid onset of diabetes in leptin-deficient Lepob/ob mice.

D'souza AM, Johnson JD, Clee SM, Kieffer TJ.

Mol Metab. 2016 Sep 21;5(11):1103-1112. doi: 10.1016/j.molmet.2016.09.007. eCollection 2016 Nov.


Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival.

Neumann UH, Ho JSS, Mojibian M, Covey SD, Charron MJ, Kieffer TJ.

Mol Metab. 2016 May 30;5(8):731-736. doi: 10.1016/j.molmet.2016.05.014. eCollection 2016 Aug.


The role of autonomic efferents and uncoupling protein 1 in the glucose-lowering effect of leptin therapy.

Denroche HC, Kwon MM, Glavas MM, Tudurí E, Philippe M, Quong WL, Kieffer TJ.

Mol Metab. 2016 Jun 24;5(8):716-724. doi: 10.1016/j.molmet.2016.06.009. eCollection 2016 Aug.



Kieffer TJ.

J Diabetes Investig. 2016 Apr;7 Suppl 1:3. doi: 10.1111/jdi.12504. No abstract available.


Closing in on Mass Production of Mature Human Beta Cells.

Kieffer TJ.

Cell Stem Cell. 2016 Jun 2;18(6):699-702. doi: 10.1016/j.stem.2016.05.014.


Engineering the gut for insulin replacement to treat diabetes.

Mojibian M, Glavas MM, Kieffer TJ.

J Diabetes Investig. 2016 Apr;7 Suppl 1:87-93. doi: 10.1111/jdi.12479. Epub 2016 Mar 14. Review.


Disrupted Leptin Signaling in the Lateral Hypothalamus and Ventral Premammillary Nucleus Alters Insulin and Glucagon Secretion and Protects Against Diet-Induced Obesity.

Denroche HC, Glavas MM, Tudurí E, Karunakaran S, Quong WL, Philippe M, Britton HM, Clee SM, Kieffer TJ.

Endocrinology. 2016 Jul;157(7):2671-85. doi: 10.1210/en.2015-1998. Epub 2016 May 16.


Statistical approaches and software for clustering islet cell functional heterogeneity.

Wills QF, Boothe T, Asadi A, Ao Z, Warnock GL, Kieffer TJ, Johnson JD.

Islets. 2016 Mar 3;8(2):48-56. doi: 10.1080/19382014.2016.1150664.


T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression.

Patterson SJ, Pesenacker AM, Wang AY, Gillies J, Mojibian M, Morishita K, Tan R, Kieffer TJ, Verchere CB, Panagiotopoulos C, Levings MK.

J Clin Invest. 2016 Mar 1;126(3):1039-51. doi: 10.1172/JCI83987. Epub 2016 Feb 8.


Hypothyroidism Impairs Human Stem Cell-Derived Pancreatic Progenitor Cell Maturation in Mice.

Bruin JE, Saber N, O'Dwyer S, Fox JK, Mojibian M, Arora P, Rezania A, Kieffer TJ.

Diabetes. 2016 May;65(5):1297-309. doi: 10.2337/db15-1439. Epub 2016 Jan 6.


Differentiation of human pluripotent stem cells into β-cells: Potential and challenges.

Quiskamp N, Bruin JE, Kieffer TJ.

Best Pract Res Clin Endocrinol Metab. 2015 Dec;29(6):833-47. doi: 10.1016/j.beem.2015.10.011. Epub 2015 Oct 30. Review.


Insulin Knockout Mice Have Extended Survival but Volatile Blood Glucose Levels on Leptin Therapy.

Neumann UH, Denroche HC, Mojibian M, Covey SD, Kieffer TJ.

Endocrinology. 2016 Mar;157(3):1007-12. doi: 10.1210/en.2015-1890. Epub 2015 Dec 22.


Pancreatic glucose-dependent insulinotropic polypeptide (GIP) (1-30) expression is upregulated in diabetes and PEGylated GIP(1-30) can suppress the progression of low-dose-STZ-induced hyperglycaemia in mice.

Yanagimachi T, Fujita Y, Takeda Y, Honjo J, Atageldiyeva KK, Takiyama Y, Abiko A, Makino Y, Kieffer TJ, Haneda M.

Diabetologia. 2016 Mar;59(3):533-41. doi: 10.1007/s00125-015-3842-y. Epub 2015 Dec 22.


Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice.

Bruin JE, Asadi A, Fox JK, Erener S, Rezania A, Kieffer TJ.

Stem Cell Reports. 2015 Dec 8;5(6):1081-1096. doi: 10.1016/j.stemcr.2015.10.013. Epub 2015 Nov 19.


The Role of ARX in Human Pancreatic Endocrine Specification.

Gage BK, Asadi A, Baker RK, Webber TD, Wang R, Itoh M, Hayashi M, Miyata R, Akashi T, Kieffer TJ.

PLoS One. 2015 Dec 3;10(12):e0144100. doi: 10.1371/journal.pone.0144100. eCollection 2015.


Replacing and safeguarding pancreatic β cells for diabetes.

Bruin JE, Rezania A, Kieffer TJ.

Sci Transl Med. 2015 Dec 2;7(316):316ps23. doi: 10.1126/scitranslmed.aaa9359.


Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation.

Szabat M, Page MM, Panzhinskiy E, Skovsø S, Mojibian M, Fernandez-Tajes J, Bruin JE, Bround MJ, Lee JT, Xu EE, Taghizadeh F, O'Dwyer S, van de Bunt M, Moon KM, Sinha S, Han J, Fan Y, Lynn FC, Trucco M, Borchers CH, Foster LJ, Nislow C, Kieffer TJ, Johnson JD.

Cell Metab. 2016 Jan 12;23(1):179-93. doi: 10.1016/j.cmet.2015.10.016. Epub 2015 Nov 25.


FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1.

Kwon MM, O'Dwyer SM, Baker RK, Covey SD, Kieffer TJ.

Cell Rep. 2015 Nov 24;13(8):1521-7. doi: 10.1016/j.celrep.2015.10.021. Epub 2015 Nov 12.


Long-term, calorie-restricted intake of a high-fat diet in rats reduces impulse control and ventral striatal D2 receptor signalling - two markers of addiction vulnerability.

Adams WK, Sussman JL, Kaur S, D'souza AM, Kieffer TJ, Winstanley CA.

Eur J Neurosci. 2015 Dec;42(12):3095-104. doi: 10.1111/ejn.13117.


Process Analytical Utility of Raman Microspectroscopy in the Directed Differentiation of Human Pancreatic Insulin-Positive Cells.

Konorov SO, Schulze HG, Gage BK, Kieffer TJ, Piret JM, Blades MW, Turner RF.

Anal Chem. 2015 Nov 3;87(21):10762-9. doi: 10.1021/acs.analchem.5b03295. Epub 2015 Oct 20.


Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB.

Berglund LM, Lyssenko V, Ladenvall C, Kotova O, Edsfeldt A, Pilgaard K, Alkayyali S, Brøns C, Forsblom C, Jonsson A, Zetterqvist AV, Nitulescu M, McDavitt CR, Dunér P, Stancáková A, Kuusisto J, Ahlqvist E, Lajer M, Tarnow L, Madsbad S, Rossing P, Kieffer TJ, Melander O, Orho-Melander M, Nilsson P, Groop PH, Vaag A, Lindblad B, Gottsäter A, Laakso M, Goncalves I, Groop L, Gomez MF.

Diabetes. 2016 Jan;65(1):239-54. doi: 10.2337/db15-0122. Epub 2015 Sep 22.


Characterization of Antibodies to Products of Proinsulin Processing Using Immunofluorescence Staining of Pancreas in Multiple Species.

Asadi A, Bruin JE, Kieffer TJ.

J Histochem Cytochem. 2015 Aug;63(8):646-62. doi: 10.1369/0022155415576541.


Treating diet-induced diabetes and obesity with human embryonic stem cell-derived pancreatic progenitor cells and antidiabetic drugs.

Bruin JE, Saber N, Braun N, Fox JK, Mojibian M, Asadi A, Drohan C, O'Dwyer S, Rosman-Balzer DS, Swiss VA, Rezania A, Kieffer TJ.

Stem Cell Reports. 2015 Apr 14;4(4):605-20. doi: 10.1016/j.stemcr.2015.02.011. Epub 2015 Mar 19.


Leptin induces fasting hypoglycaemia in a mouse model of diabetes through the depletion of glycerol.

Denroche HC, Kwon MM, Quong WL, Neumann UH, Kulpa JE, Karunakaran S, Clee SM, Brownsey RW, Covey SD, Kieffer TJ.

Diabetologia. 2015 May;58(5):1100-8. doi: 10.1007/s00125-015-3529-4. Epub 2015 Feb 26.


Overexpression of PAX4 reduces glucagon expression in differentiating hESCs.

Gage BK, Baker RK, Kieffer TJ.

Islets. 2014;6(2):e29236. doi: 10.4161/isl.29236.

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