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ZHO-1, an intrinsic MBL from the environmental Gram-negative species Zhongshania aliphaticivorans.

Kieffer N, Guzmán-Puche J, Poirel L, Kang HJ, Jeon CO, Nordmann P.

J Antimicrob Chemother. 2019 Feb 18. pii: dkz057. doi: 10.1093/jac/dkz057. [Epub ahead of print]


Increased Resistance to Carbapenems in Proteus mirabilis Mediated by Amplication of the blaVIM-1-Carrying and IS26-Associated Class 1 Integron.

Bontron S, Poirel L, Kieffer N, Savov E, Trifonova A, Todorova I, Kueffer G, Nordmann P.

Microb Drug Resist. 2019 Jan 24. doi: 10.1089/mdr.2018.0365. [Epub ahead of print]


Stability of cefiderocol against clinically significant broad-spectrum oxacillinases.

Poirel L, Kieffer N, Nordmann P.

Int J Antimicrob Agents. 2018 Dec;52(6):866-867. doi: 10.1016/j.ijantimicag.2018.11.005. Epub 2018 Nov 8. No abstract available.


Acquisition of Extended-Spectrum β-Lactamase GES-6 Leading to Resistance to Ceftolozane-Tazobactam Combination in Pseudomonas aeruginosa.

Poirel L, Ortiz De La Rosa JM, Kieffer N, Dubois V, Jayol A, Nordmann P.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01809-18. doi: 10.1128/AAC.01809-18. Print 2019 Jan.


Antimicrobial Resistance in Escherichia coli.

Poirel L, Madec JY, Lupo A, Schink AK, Kieffer N, Nordmann P, Schwarz S.

Microbiol Spectr. 2018 Jul;6(4). doi: 10.1128/microbiolspec.ARBA-0026-2017. Review.


Screening and Characterization of Multidrug-Resistant Gram-Negative Bacteria from a Remote African Area, São Tomé and Príncipe.

Poirel L, Aires-de-Sousa M, Kudyba P, Kieffer N, Nordmann P.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e01021-18. doi: 10.1128/AAC.01021-18. Print 2018 Sep.


Evaluation of the Rapid Polymyxin NP test and its industrial version for the detection of polymyxin-resistant Enterobacteriaceae.

Jayol A, Kieffer N, Poirel L, Guérin F, Güneser D, Cattoir V, Nordmann P.

Diagn Microbiol Infect Dis. 2018 Oct;92(2):90-94. doi: 10.1016/j.diagmicrobio.2018.05.006. Epub 2018 May 16.


Genetic and Functional Characterization of an MCR-3-Like Enzyme-Producing Escherichia coli Isolate Recovered from Swine in Brazil.

Kieffer N, Nordmann P, Moreno AM, Zanolli Moreno L, Chaby R, Breton A, Tissières P, Poirel L.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00278-18. doi: 10.1128/AAC.00278-18. Print 2018 Jul.


Colistin-resistant carbapenemase-producing isolates among Klebsiella spp. and Acinetobacter baumannii in Tripoli, Libya.

Kieffer N, Ahmed MO, Elramalli AK, Daw MA, Poirel L, Álvarez R, Nordmann P.

J Glob Antimicrob Resist. 2018 Jun;13:37-39. doi: 10.1016/j.jgar.2018.02.020. Epub 2018 Mar 9. No abstract available.


Transposition of Tn1213 Encoding the PER-1 Extended-Spectrum β-Lactamase.

Mancini S, Poirel L, Kieffer N, Nordmann P.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02453-17. doi: 10.1128/AAC.02453-17. Print 2018 Mar.


High Rate of MCR-1-Producing Escherichia coli and Klebsiella pneumoniae among Pigs, Portugal.

Kieffer N, Aires-de-Sousa M, Nordmann P, Poirel L.

Emerg Infect Dis. 2017 Dec;23(12):2023-2029. doi: 10.3201/eid2312.170883.


MCR-2-mediated plasmid-borne polymyxin resistance most likely originates from Moraxella pluranimalium.

Poirel L, Kieffer N, Fernandez-Garayzabal JF, Vela AI, Larpin Y, Nordmann P.

J Antimicrob Chemother. 2017 Oct 1;72(10):2947-2949. doi: 10.1093/jac/dkx225. No abstract available.


Co-production of MCR-1 and extended-spectrum β-lactamase in Escherichia coli recovered from urinary tract infections in Switzerland.

Kieffer N, Poirel L, Clerc O, Lienhard R, Nordmann P.

Infection. 2018 Feb;46(1):143-144. doi: 10.1007/s15010-017-1080-6. Epub 2017 Oct 19. No abstract available.


Antimicrobial activity of octenidine against multidrug-resistant Gram-negative pathogens.

Alvarez-Marin R, Aires-de-Sousa M, Nordmann P, Kieffer N, Poirel L.

Eur J Clin Microbiol Infect Dis. 2017 Dec;36(12):2379-2383. doi: 10.1007/s10096-017-3070-0. Epub 2017 Aug 19.


Evaluation of the RAPIDEC® CARBA NP and β-CARBA® tests for rapid detection of Carbapenemase-producing Enterobacteriaceae.

Mancini S, Kieffer N, Poirel L, Nordmann P.

Diagn Microbiol Infect Dis. 2017 Aug;88(4):293-297. doi: 10.1016/j.diagmicrobio.2017.05.006. Epub 2017 May 13.


First report of OXA-181 and NDM-1 from a clinical Klebsiella pneumoniae isolate from Nigeria.

Uwaezuoke NS, Kieffer N, Iregbu KC, Nordmann P.

Int J Infect Dis. 2017 Aug;61:1-2. doi: 10.1016/j.ijid.2017.05.004. Epub 2017 May 16. No abstract available.


In Vitro Study of ISApl1-Mediated Mobilization of the Colistin Resistance Gene mcr-1.

Poirel L, Kieffer N, Nordmann P.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00127-17. doi: 10.1128/AAC.00127-17. Print 2017 Jul.


Moraxella Species as Potential Sources of MCR-Like Polymyxin Resistance Determinants.

Kieffer N, Nordmann P, Poirel L.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e00129-17. doi: 10.1128/AAC.00129-17. Print 2017 Jun.


Very low prevalence of MCR-1/MCR-2 plasmid-mediated colistin resistance in urinary tract Enterobacteriaceae in Switzerland.

Liassine N, Assouvie L, Descombes MC, Tendon VD, Kieffer N, Poirel L, Nordmann P.

Int J Infect Dis. 2016 Oct;51:4-5. doi: 10.1016/j.ijid.2016.08.008. Epub 2016 Aug 17. No abstract available.


Sequence Type 48 Escherichia coli Carrying the blaCTX-M-1 IncI1/ST3 Plasmid in Drinking Water in France.

Madec JY, Haenni M, Ponsin C, Kieffer N, Rion E, Gassilloud B.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6430-2. doi: 10.1128/AAC.01135-16. Print 2016 Oct.


Features of the mcr-1 Cassette Related to Colistin Resistance.

Zurfluh K, Kieffer N, Poirel L, Nordmann P, Stephan R.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6438-9. doi: 10.1128/AAC.01519-16. Print 2016 Oct. No abstract available.


High Prevalence of Carbapenemase-Producing Enterobacteriaceae among Hospitalized Children in Luanda, Angola.

Kieffer N, Nordmann P, Aires-de-Sousa M, Poirel L.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6189-92. doi: 10.1128/AAC.01201-16. Print 2016 Oct.


Genetic Features of MCR-1-Producing Colistin-Resistant Escherichia coli Isolates in South Africa.

Poirel L, Kieffer N, Brink A, Coetze J, Jayol A, Nordmann P.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):4394-7. doi: 10.1128/AAC.00444-16. Print 2016 Jul.


Plasmid-Mediated Colistin-Resistant Escherichia coli in Bacteremia in Switzerland.

Nordmann P, Lienhard R, Kieffer N, Clerc O, Poirel L.

Clin Infect Dis. 2016 May 15;62(10):1322-3. doi: 10.1093/cid/ciw124. Epub 2016 Mar 1. No abstract available.


VIM-1, VIM-34, and IMP-8 Carbapenemase-Producing Escherichia coli Strains Recovered from a Portuguese River.

Kieffer N, Poirel L, Bessa LJ, Barbosa-Vasconcelos A, da Costa PM, Nordmann P.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2585-6. doi: 10.1128/AAC.02632-15. Print 2016 Apr. No abstract available.


Plasmid-mediated carbapenem and colistin resistance in a clinical isolate of Escherichia coli.

Poirel L, Kieffer N, Liassine N, Thanh D, Nordmann P.

Lancet Infect Dis. 2016 Mar;16(3):281. doi: 10.1016/S1473-3099(16)00006-2. Epub 2016 Jan 8. No abstract available.


Co-occurrence of extended spectrum β lactamase and MCR-1 encoding genes on plasmids.

Haenni M, Poirel L, Kieffer N, Châtre P, Saras E, Métayer V, Dumoulin R, Nordmann P, Madec JY.

Lancet Infect Dis. 2016 Mar;16(3):281-2. doi: 10.1016/S1473-3099(16)00007-4. Epub 2016 Jan 8. No abstract available.


In vitro evaluation of dual carbapenem combinations against carbapenemase-producing Enterobacteriaceae.

Poirel L, Kieffer N, Nordmann P.

J Antimicrob Chemother. 2016 Jan;71(1):156-61. doi: 10.1093/jac/dkv294. Epub 2015 Sep 27.


Inhibition of αIIbβ3 Ligand Binding by an αIIb Peptide that Clasps the Hybrid Domain to the βI Domain of β3.

Lee WH, Schaffner-Reckinger E, Tsoukatos DC, Aylward K, Moussis V, Tsikaris V, Trypou P, Egot M, Baruch D, Kieffer N, Bachelot-Loza C.

PLoS One. 2015 Sep 2;10(9):e0134952. doi: 10.1371/journal.pone.0134952. eCollection 2015.


Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor.

Koutsioumpa M, Poimenidi E, Pantazaka E, Theodoropoulou C, Skoura A, Megalooikonomou V, Kieffer N, Courty J, Mizumoto S, Sugahara K, Papadimitriou E.

Mol Cancer. 2015 Feb 3;14:19. doi: 10.1186/s12943-015-0287-3.


Pleiotrophin-induced endothelial cell migration is regulated by xanthine oxidase-mediated generation of reactive oxygen species.

Tsirmoula S, Lamprou M, Hatziapostolou M, Kieffer N, Papadimitriou E.

Microvasc Res. 2015 Mar;98:74-81. doi: 10.1016/j.mvr.2015.01.001. Epub 2015 Jan 10.


Emergence of colistin resistance in Klebsiella pneumoniae from veterinary medicine.

Kieffer N, Poirel L, Nordmann P, Madec JY, Haenni M.

J Antimicrob Chemother. 2015 Apr;70(4):1265-7. doi: 10.1093/jac/dku485. Epub 2014 Nov 26. No abstract available.


Interplay between αvβ3 integrin and nucleolin regulates human endothelial and glioma cell migration.

Koutsioumpa M, Polytarchou C, Courty J, Zhang Y, Kieffer N, Mikelis C, Skandalis SS, Hellman U, Iliopoulos D, Papadimitriou E.

J Biol Chem. 2013 Jan 4;288(1):343-54. doi: 10.1074/jbc.M112.387076. Epub 2012 Nov 16.


Levamisole-induced occlusive necrotising vasculitis in cocaine abusers: an unusual cause of skin necrosis and neutropenia.

Belfonte CD, Shanmugam VK, Kieffer N, Coker S, Boucree S, Kerr G.

Int Wound J. 2013 Oct;10(5):590-6. doi: 10.1111/j.1742-481X.2012.01027.x. Epub 2012 Jun 21.


Redox control of the survival of healthy and diseased cells.

Zhang Y, Du Y, Le W, Wang K, Kieffer N, Zhang J.

Antioxid Redox Signal. 2011 Dec 1;15(11):2867-908. doi: 10.1089/ars.2010.3685. Epub 2011 Jun 11. Review.


Recent advances in the understanding of the molecular mechanisms regulating platelet integrin αIIbβ3 activation.

Tao L, Zhang Y, Xi X, Kieffer N.

Protein Cell. 2010 Jul;1(7):627-37. doi: 10.1007/s13238-010-0089-8. Epub 2010 Jul 29. Review.


PML/RARalpha fusion protein transactivates the tissue factor promoter through a GAGC-containing element without direct DNA association.

Yan J, Wang K, Dong L, Liu H, Chen W, Xi W, Ding Q, Kieffer N, Caen JP, Chen S, Chen Z, Xi X.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3716-21. doi: 10.1073/pnas.0915006107. Epub 2010 Feb 3.


Overexpression of the partially activated alpha(IIb)beta3D723H integrin salt bridge mutant downregulates RhoA activity and induces microtubule-dependent proplatelet-like extensions in Chinese hamster ovary cells.

Schaffner-Reckinger E, Salsmann A, Debili N, Bellis J, De Mey J, Vainchenker W, Ouwehand WH, Kieffer N.

J Thromb Haemost. 2009 Jul;7(7):1207-17. doi: 10.1111/j.1538-7836.2009.03494.x. Epub 2009 May 22.


The novel S527F mutation in the integrin beta3 chain induces a high affinity alphaIIbbeta3 receptor by hindering adoption of the bent conformation.

Vanhoorelbeke K, De Meyer SF, Pareyn I, Melchior C, Plançon S, Margue C, Pradier O, Fondu P, Kieffer N, Springer TA, Deckmyn H.

J Biol Chem. 2009 May 29;284(22):14914-20. doi: 10.1074/jbc.M809167200. Epub 2009 Mar 27.


Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta.

Mikelis C, Sfaelou E, Koutsioumpa M, Kieffer N, Papadimitriou E.

FASEB J. 2009 May;23(5):1459-69. doi: 10.1096/fj.08-117564. Epub 2009 Jan 13.


Testicular cancer in Luxembourg: incidence and outcome in relation to the different histo-pathological types (1980-2004).

Scheiden R, Hein T, Wagener C, Kieffer N, Lamy S, Capesius C.

Bull Soc Sci Med Grand Duche Luxemb. 2008;(4):521-39.


The CXC-chemokine CXCL4 interacts with integrins implicated in angiogenesis.

Aidoudi S, Bujakowska K, Kieffer N, Bikfalvi A.

PLoS One. 2008 Jul 16;3(7):e2657. doi: 10.1371/journal.pone.0002657.


The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridges.

Rodius S, Chaloin O, Moes M, Schaffner-Reckinger E, Landrieu I, Lippens G, Lin M, Zhang J, Kieffer N.

J Biol Chem. 2008 Aug 29;283(35):24212-23. doi: 10.1074/jbc.M709704200. Epub 2008 Jun 23.


RGT, a synthetic peptide corresponding to the integrin beta 3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin alpha IIb beta 3 with Src kinase.

Su X, Mi J, Yan J, Flevaris P, Lu Y, Liu H, Ruan Z, Wang X, Kieffer N, Chen S, Du X, Xi X.

Blood. 2008 Aug 1;112(3):592-602. doi: 10.1182/blood-2007-09-110437. Epub 2008 Apr 8.


A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the alphaIIbbeta3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia.

Ghevaert C, Salsmann A, Watkins NA, Schaffner-Reckinger E, Rankin A, Garner SF, Stephens J, Smith GA, Debili N, Vainchenker W, de Groot PG, Huntington JA, Laffan M, Kieffer N, Ouwehand WH.

Blood. 2008 Apr 1;111(7):3407-14. Epub 2007 Dec 7.


The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton.

Moes M, Rodius S, Coleman SJ, Monkley SJ, Goormaghtigh E, Tremuth L, Kox C, van der Holst PP, Critchley DR, Kieffer N.

J Biol Chem. 2007 Jun 8;282(23):17280-8. Epub 2007 Apr 11.


Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis.

Schmitz M, Grignard G, Margue C, Dippel W, Capesius C, Mossong J, Nathan M, Giacchi S, Scheiden R, Kieffer N.

Int J Cancer. 2007 Mar 15;120(6):1284-92.


Effect of PEX, a noncatalytic metalloproteinase fragment with integrin-binding activity, on experimental Chlamydophila pneumoniae infection.

Caronzolo D, Lucini V, Pannacci M, Grosso S, Kieffer N, Bello L, Bikfalvi A, Scaglione F.

Antimicrob Agents Chemother. 2006 Oct;50(10):3277-82.


Involvement of the RNAse L gene in prostate cancer.

Kieffer N, Schmitz M, Scheiden R, Nathan M, Faber JC.

Bull Soc Sci Med Grand Duche Luxemb. 2006;(1):21-8. Review.


Thyroid cancer in Luxembourg: a national population-based data report (1983-1999).

Scheiden R, Keipes M, Bock C, Dippel W, Kieffer N, Capesius C.

BMC Cancer. 2006 Apr 24;6:102.

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