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Items: 1 to 50 of 224

1.

Mu opioid receptors in the medial habenula contribute to naloxone aversion.

Boulos LJ, Ben Hamida S, Bailly J, Maitra M, Ehrlich AT, Gavériaux-Ruff C, Darcq E, Kieffer BL.

Neuropsychopharmacology. 2019 Apr 20. doi: 10.1038/s41386-019-0395-7. [Epub ahead of print]

PMID:
31005059
2.

Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons.

Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M, Darcq E, Bouvier M, Kieffer BL.

iScience. 2019 Apr 26;14:47-57. doi: 10.1016/j.isci.2019.03.011. Epub 2019 Mar 15.

3.

Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists.

Mann A, Moulédous L, Froment C, O'Neill PR, Dasgupta P, Günther T, Brunori G, Kieffer BL, Toll L, Bruchas MR, Zaveri NT, Schulz S.

Sci Signal. 2019 Mar 26;12(574). pii: eaau8072. doi: 10.1126/scisignal.aau8072.

PMID:
30914485
4.

TouchScreen-based phenotyping: altered stimulus/reward association and lower perseveration to gain a reward in mu opioid receptor knockout mice.

Boulos LJ, Nasseef MT, McNicholas M, Mechling A, Harsan LA, Darcq E, Ben Hamida S, Kieffer BL.

Sci Rep. 2019 Mar 11;9(1):4044. doi: 10.1038/s41598-019-40622-6.

5.

Current strategies toward safer mu opioid receptor drugs for pain management.

Ehrlich AT, Kieffer BL, Darcq E.

Expert Opin Ther Targets. 2019 Apr;23(4):315-326. doi: 10.1080/14728222.2019.1586882. Epub 2019 Mar 15.

PMID:
30802415
6.

Deformation-based Morphometry MRI Reveals Brain Structural Modifications in Living Mu Opioid Receptor Knockout Mice.

Nasseef MT, Devenyi GA, Mechling AE, Harsan LA, Chakravarty MM, Kieffer BL, Darcq E.

Front Psychiatry. 2018 Dec 3;9:643. doi: 10.3389/fpsyt.2018.00643. eCollection 2018.

7.

Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research.

Ehrlich AT, Maroteaux G, Robe A, Venteo L, Nasseef MT, van Kempen LC, Mechawar N, Turecki G, Darcq E, Kieffer BL.

Commun Biol. 2018 Aug 6;1:102. doi: 10.1038/s42003-018-0106-7. eCollection 2018.

8.

Discovery of a Potent, Selective, and Brain-Penetrant Small Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake.

Jin C, Decker AM, Makhijani VH, Besheer J, Darcq E, Kieffer BL, Maitra R.

J Med Chem. 2018 Aug 9;61(15):6748-6758. doi: 10.1021/acs.jmedchem.8b00566. Epub 2018 Jul 30.

9.

Opioid receptors: drivers to addiction?

Darcq E, Kieffer BL.

Nat Rev Neurosci. 2018 Aug;19(8):499-514. doi: 10.1038/s41583-018-0028-x. Review.

PMID:
29934561
10.

The Control of Reward Seeking.

Darcq E, Kieffer BL.

Biol Psychiatry. 2018 Jun 15;83(12):981-983. doi: 10.1016/j.biopsych.2018.04.003. No abstract available.

PMID:
29804588
11.

Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats.

Schmeichel BE, Matzeu A, Koebel P, Vendruscolo LF, Sidhu H, Shahryari R, Kieffer BL, Koob GF, Martin-Fardon R, Contet C.

Neuropsychopharmacology. 2018 Nov;43(12):2373-2382. doi: 10.1038/s41386-018-0054-4. Epub 2018 Apr 6.

PMID:
29703996
12.

Mu-opioid receptors in nociceptive afferents produce a sustained suppression of hyperalgesia in chronic pain.

Severino A, Chen W, Hakimian JK, Kieffer BL, Gaveriaux-Ruff C, Walwyn W, Marvizón JCG.

Pain. 2018 Aug;159(8):1607-1620. doi: 10.1097/j.pain.0000000000001247.

PMID:
29677019
13.

Analysis of the distribution of spinal NOP receptors in a chronic pain model using NOP-eGFP knock-in mice.

Ozawa A, Brunori G, Cippitelli A, Toll N, Schoch J, Kieffer BL, Toll L.

Br J Pharmacol. 2018 Jul;175(13):2662-2675. doi: 10.1111/bph.14225. Epub 2018 May 6.

PMID:
29582417
14.

Increased Alcohol Seeking in Mice Lacking Gpr88 Involves Dysfunctional Mesocorticolimbic Networks.

Ben Hamida S, Mendonça-Netto S, Arefin TM, Nasseef MT, Boulos LJ, McNicholas M, Ehrlich AT, Clarke E, Moquin L, Gratton A, Darcq E, Harsan LA, Maldonado R, Kieffer BL.

Biol Psychiatry. 2018 Aug 1;84(3):202-212. doi: 10.1016/j.biopsych.2018.01.026. Epub 2018 Feb 9. Erratum in: Biol Psychiatry. 2018 Dec 1;84(11):857.

PMID:
29580570
15.

Lack of anticipatory behavior in Gpr88 knockout mice showed by automatized home cage phenotyping.

Maroteaux G, Arefin TM, Harsan LA, Darcq E, Ben Hamida S, Kieffer BL.

Genes Brain Behav. 2018 Nov;17(8):e12473. doi: 10.1111/gbb.12473. Epub 2018 Apr 19.

PMID:
29575471
16.

Focusing on the Opioid System for Addiction Biomarker Discovery.

Belzeaux R, Lalanne L, Kieffer BL, Lutz PE.

Trends Mol Med. 2018 Feb;24(2):206-220. doi: 10.1016/j.molmed.2017.12.004. Epub 2018 Jan 31. Review.

PMID:
29396147
17.

Rare susceptibility variants for bipolar disorder suggest a role for G protein-coupled receptors.

Cruceanu C, Schmouth JF, Torres-Platas SG, Lopez JP, Ambalavanan A, Darcq E, Gross F, Breton B, Spiegelman D, Rochefort D, Hince P, Petite JM, Gauthier J, Lafrenière RG, Dion PA, Greenwood CM, Kieffer BL, Alda M, Turecki G, Rouleau GA.

Mol Psychiatry. 2018 Oct;23(10):2050-2056. doi: 10.1038/mp.2017.223. Epub 2017 Nov 21.

PMID:
29158579
18.

Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing.

Ehrlich AT, Semache M, Bailly J, Wojcik S, Arefin TM, Colley C, Le Gouill C, Gross F, Lukasheva V, Hogue M, Darcq E, Harsan LA, Bouvier M, Kieffer BL.

Brain Struct Funct. 2018 Apr;223(3):1275-1296. doi: 10.1007/s00429-017-1547-3. Epub 2017 Nov 6.

19.

Mu opioid receptors in GABAergic neurons of the forebrain promote alcohol reward and drinking.

Ben Hamida S, Boulos LJ, McNicholas M, Charbogne P, Kieffer BL.

Addict Biol. 2019 Jan;24(1):28-39. doi: 10.1111/adb.12576. Epub 2017 Nov 2.

PMID:
29094432
20.

Remodeling of Sensorimotor Brain Connectivity in Gpr88-Deficient Mice.

Arefin TM, Mechling AE, Meirsman AC, Bienert T, Hübner NS, Lee HL, Ben Hamida S, Ehrlich A, Roquet D, Hennig J, von Elverfeldt D, Kieffer BL, Harsan LA.

Brain Connect. 2017 Oct;7(8):526-540. doi: 10.1089/brain.2017.0486.

21.

GPR88 in A2A receptor-expressing neurons modulates locomotor response to dopamine agonists but not sensorimotor gating.

Meirsman AC, de Kerchove d'Exaerde A, Kieffer BL, Ouagazzal AM.

Eur J Neurosci. 2017 Aug;46(4):2026-2034. doi: 10.1111/ejn.13646. Epub 2017 Aug 2.

22.

κ-Opioid Receptor Activation in Dopamine Neurons Disrupts Behavioral Inhibition.

Abraham AD, Fontaine HM, Song AJ, Andrews MM, Baird MA, Kieffer BL, Land BB, Chavkin C.

Neuropsychopharmacology. 2018 Jan;43(2):362-372. doi: 10.1038/npp.2017.133. Epub 2017 Jun 26.

23.

Characterization of [3H] oxymorphone binding sites in mouse brain: Quantitative autoradiography in opioid receptor knockout mice.

Yoo JH, Borsodi A, Tóth G, Benyhe S, Gaspar R, Matifas A, Kieffer BL, Metaxas A, Kitchen I, Bailey A.

Neurosci Lett. 2017 Mar 16;643:16-21. doi: 10.1016/j.neulet.2017.02.002. Epub 2017 Feb 10.

PMID:
28192197
24.

Mu Opioid Receptors in Gamma-Aminobutyric Acidergic Forebrain Neurons Moderate Motivation for Heroin and Palatable Food.

Charbogne P, Gardon O, Martín-García E, Keyworth HL, Matsui A, Mechling AE, Bienert T, Nasseef T, Robé A, Moquin L, Darcq E, Ben Hamida S, Robledo P, Matifas A, Befort K, Gavériaux-Ruff C, Harsan LA, von Elverfeldt D, Hennig J, Gratton A, Kitchen I, Bailey A, Alvarez VA, Maldonado R, Kieffer BL.

Biol Psychiatry. 2017 May 1;81(9):778-788. doi: 10.1016/j.biopsych.2016.12.022. Epub 2016 Dec 26. Erratum in: Biol Psychiatry. 2018 Dec 1;84(11):857.

25.

BOLD Imaging in Awake Wild-Type and Mu-Opioid Receptor Knock-Out Mice Reveals On-Target Activation Maps in Response to Oxycodone.

Moore K, Madularu D, Iriah S, Yee JR, Kulkarni P, Darcq E, Kieffer BL, Ferris CF.

Front Neurosci. 2016 Nov 3;10:471. eCollection 2016.

26.

Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome.

Mechling AE, Arefin T, Lee HL, Bienert T, Reisert M, Ben Hamida S, Darcq E, Ehrlich A, Gaveriaux-Ruff C, Parent MJ, Rosa-Neto P, Hennig J, von Elverfeldt D, Kieffer BL, Harsan LA.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11603-11608. Epub 2016 Sep 26.

27.

GPR88 in A2AR Neurons Enhances Anxiety-Like Behaviors.

Meirsman AC, Robé A, de Kerchove d'Exaerde A, Kieffer BL.

eNeuro. 2016 Aug 17;3(4). pii: ENEURO.0202-16.2016. doi: 10.1523/ENEURO.0202-16.2016. eCollection 2016 Jul-Aug.

28.

Drug discovery: Designing the ideal opioid.

Kieffer BL.

Nature. 2016 Sep 8;537(7619):170-171. doi: 10.1038/nature19424. Epub 2016 Aug 17. No abstract available.

PMID:
27533037
29.

Translating the Habenula-From Rodents to Humans.

Boulos LJ, Darcq E, Kieffer BL.

Biol Psychiatry. 2017 Feb 15;81(4):296-305. doi: 10.1016/j.biopsych.2016.06.003. Epub 2016 Jun 7. Review.

30.

Leukocyte opioid receptors mediate analgesia via Ca(2+)-regulated release of opioid peptides.

Celik MÖ, Labuz D, Henning K, Busch-Dienstfertig M, Gaveriaux-Ruff C, Kieffer BL, Zimmer A, Machelska H.

Brain Behav Immun. 2016 Oct;57:227-242. doi: 10.1016/j.bbi.2016.04.018. Epub 2016 Apr 30.

PMID:
27139929
31.

Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol.

Becker JAJ, Kieffer BL, Le Merrer J.

Addict Biol. 2017 Sep;22(5):1205-1217. doi: 10.1111/adb.12405. Epub 2016 Apr 28.

32.

Functional and structural characterization of axonal opioid receptors as targets for analgesia.

Mambretti EM, Kistner K, Mayer S, Massotte D, Kieffer BL, Hoffmann C, Reeh PW, Brack A, Asan E, Rittner HL.

Mol Pain. 2016 Mar 1;12. pii: 1744806916628734. doi: 10.1177/1744806916628734. Print 2016.

33.

Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function.

Pradhan AA, Perroy J, Walwyn WM, Smith ML, Vicente-Sanchez A, Segura L, Bana A, Kieffer BL, Evans CJ.

J Neurosci. 2016 Mar 23;36(12):3541-51. doi: 10.1523/JNEUROSCI.4124-15.2016.

34.

Kappa opioid receptor antagonism and chronic antidepressant treatment have beneficial activities on social interactions and grooming deficits during heroin abstinence.

Lalanne L, Ayranci G, Filliol D, Gavériaux-Ruff C, Befort K, Kieffer BL, Lutz PE.

Addict Biol. 2017 Jul;22(4):1010-1021. doi: 10.1111/adb.12392. Epub 2016 Mar 22.

35.

Developmental and adult expression patterns of the G-protein-coupled receptor GPR88 in the rat: Establishment of a dual nuclear-cytoplasmic localization.

Massart R, Mignon V, Stanic J, Munoz-Tello P, Becker JA, Kieffer BL, Darmon M, Sokoloff P, Diaz J.

J Comp Neurol. 2016 Oct 1;524(14):2776-802. doi: 10.1002/cne.23991. Epub 2016 Mar 16.

PMID:
26918661
36.

Emotional Impairment and Persistent Upregulation of mGlu5 Receptor following Morphine Abstinence: Implications of an mGlu5-MOPr Interaction.

Zanos P, Georgiou P, Gonzalez LR, Hourani S, Chen Y, Kitchen I, Kieffer BL, Winsky-Sommerer R, Bailey A.

Int J Neuropsychopharmacol. 2016 Jul 5;19(7). pii: pyw011. doi: 10.1093/ijnp/pyw011. Print 2016 Jul.

37.

Medications between psychiatric and addictive disorders.

Lalanne L, Lutz PE, Trojak B, Lang JP, Kieffer BL, Bacon E.

Prog Neuropsychopharmacol Biol Psychiatry. 2016 Feb 4;65:215-23. doi: 10.1016/j.pnpbp.2015.10.009. Epub 2015 Oct 27. Review.

PMID:
26514592
38.

Impact of chronic morphine on delta opioid receptor-expressing neurons in the mouse hippocampus.

Erbs E, Faget L, Ceredig RA, Matifas A, Vonesch JL, Kieffer BL, Massotte D.

Neuroscience. 2016 Jan 28;313:46-56. doi: 10.1016/j.neuroscience.2015.10.022. Epub 2015 Oct 19.

39.

The oxytocin analogue carbetocin prevents priming-induced reinstatement of morphine-seeking: Involvement of dopaminergic, noradrenergic and MOPr systems.

Georgiou P, Zanos P, Garcia-Carmona JA, Hourani S, Kitchen I, Kieffer BL, Laorden ML, Bailey A.

Eur Neuropsychopharmacol. 2015 Dec;25(12):2459-64. doi: 10.1016/j.euroneuro.2015.09.015. Epub 2015 Oct 9.

PMID:
26475574
40.

Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons.

Ehrich JM, Messinger DI, Knakal CR, Kuhar JR, Schattauer SS, Bruchas MR, Zweifel LS, Kieffer BL, Phillips PE, Chavkin C.

J Neurosci. 2015 Sep 16;35(37):12917-31. doi: 10.1523/JNEUROSCI.2444-15.2015.

41.

Interaction of CRF and kappa opioid systems on GABAergic neurotransmission in the mouse central amygdala.

Kang-Park M, Kieffer BL, Roberts AJ, Siggins GR, Moore SD.

J Pharmacol Exp Ther. 2015 Nov;355(2):206-11. doi: 10.1124/jpet.115.225870. Epub 2015 Sep 8.

42.

Knock-In Mice with NOP-eGFP Receptors Identify Receptor Cellular and Regional Localization.

Ozawa A, Brunori G, Mercatelli D, Wu J, Cippitelli A, Zou B, Xie XS, Williams M, Zaveri NT, Low S, Scherrer G, Kieffer BL, Toll L.

J Neurosci. 2015 Aug 19;35(33):11682-93. doi: 10.1523/JNEUROSCI.5122-14.2015.

43.

Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist.

Meirsman AC, Le Merrer J, Pellissier LP, Diaz J, Clesse D, Kieffer BL, Becker JA.

Biol Psychiatry. 2016 Jun 1;79(11):917-27. doi: 10.1016/j.biopsych.2015.05.020. Epub 2015 Jun 6.

44.

In vivo neuronal co-expression of mu and delta opioid receptors uncovers new therapeutic perspectives.

Erbs E, Faget L, Veinante P, Kieffer BL, Massotte D.

Receptors Clin Investig. 2014 Sep;1(5). pii: 210.

45.

PI3K signaling in the locus coeruleus: a new molecular pathway for ADHD research.

Darcq E, Kieffer BL.

EMBO Mol Med. 2015 Jul;7(7):859-61. doi: 10.15252/emmm.201505266. No abstract available.

46.

The kappa opioid receptor: from addiction to depression, and back.

Lalanne L, Ayranci G, Kieffer BL, Lutz PE.

Front Psychiatry. 2014 Dec 8;5:170. doi: 10.3389/fpsyt.2014.00170. eCollection 2014. Review.

47.

Dissociation of heroin-induced emotional dysfunction from psychomotor activation and physical dependence among inbred mouse strains.

Ayranci G, Befort K, Lalanne L, Kieffer BL, Lutz PE.

Psychopharmacology (Berl). 2015 Jun;232(11):1957-71. doi: 10.1007/s00213-014-3826-5. Epub 2014 Dec 9.

PMID:
25482274
48.

Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizures.

Chung PC, Boehrer A, Stephan A, Matifas A, Scherrer G, Darcq E, Befort K, Kieffer BL.

Behav Brain Res. 2015 Feb 1;278:429-34. doi: 10.1016/j.bbr.2014.10.029. Epub 2014 Oct 30.

49.

A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons.

Chu Sin Chung P, Keyworth HL, Martin-Garcia E, Charbogne P, Darcq E, Bailey A, Filliol D, Matifas A, Scherrer G, Ouagazzal AM, Gaveriaux-Ruff C, Befort K, Maldonado R, Kitchen I, Kieffer BL.

Biol Psychiatry. 2015 Feb 15;77(4):404-15. doi: 10.1016/j.biopsych.2014.07.033. Epub 2014 Aug 27.

50.

VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation.

Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, Tapper AR, Roberto M, Kieffer BL, Sawchenko PE, Koob GF, van der Kooy D, George O.

Nat Neurosci. 2014 Dec;17(12):1751-8. doi: 10.1038/nn.3872. Epub 2014 Nov 17.

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