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J Virol. 1992 Feb;66(2):1202-6.

Finite life span of hybrids formed by fusion of different simian virus 40-immortalized human cell lines.

Author information

1
Children's Medical Research Foundation, Camperdown, New South Wales, Australia.

Abstract

Simian virus 40 (SV40) genes are able to induce immortalization of normal human cells after a culture crisis during which unknown cellular genetic changes presumably occur. To determine whether these genetic changes are always identical, we performed somatic cell hybridization analysis of an SV40-immortalized human bronchial epithelial cell line, BET-1A. Fusion of BET-1A with an SV40-immortalized fibroblast cell line resulted in hybrids that senesced, indicating that these cell lines are in different complementation groups for immortalization.

PMID:
1309897
PMCID:
PMC240827
[Indexed for MEDLINE]
Free PMC Article

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