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Items: 13

1.

The MSPDBL2 codon 591 polymorphism is associated with lumefantrine in vitro drug responses in Plasmodium falciparum isolates from Kilifi, Kenya.

Ochola-Oyier LI, Okombo J, Mwai L, Kiara SM, Pole L, Tetteh KK, Nzila A, Marsh K.

Antimicrob Agents Chemother. 2015 Mar;59(3):1770-5. doi: 10.1128/AAC.03522-14. Epub 2014 Dec 22.

2.

A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya.

Wendler JP, Okombo J, Amato R, Miotto O, Kiara SM, Mwai L, Pole L, O'Brien J, Manske M, Alcock D, Drury E, Sanders M, Oyola SO, Malangone C, Jyothi D, Miles A, Rockett KA, MacInnis BL, Marsh K, Bejon P, Nzila A, Kwiatkowski DP.

PLoS One. 2014 May 8;9(5):e96486. doi: 10.1371/journal.pone.0096486. eCollection 2014.

3.

Repeat polymorphisms in the low-complexity regions of Plasmodium falciparum ABC transporters and associations with in vitro antimalarial responses.

Okombo J, Abdi AI, Kiara SM, Mwai L, Pole L, Sutherland CJ, Nzila A, Ochola-Oyier LI.

Antimicrob Agents Chemother. 2013 Dec;57(12):6196-204. doi: 10.1128/AAC.01465-13. Epub 2013 Sep 30.

4.

Antimalarial activity of isoquine against Kenyan Plasmodium falciparum clinical isolates and association with polymorphisms in pfcrt and pfmdr1 genes.

Okombo J, Kiara SM, Abdirahman A, Mwai L, Ohuma E, Borrmann S, Nzila A, Ward S.

J Antimicrob Chemother. 2013 Apr;68(4):786-8. doi: 10.1093/jac/dks471. Epub 2012 Nov 20.

PMID:
23169890
5.

Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing.

Manske M, Miotto O, Campino S, Auburn S, Almagro-Garcia J, Maslen G, O'Brien J, Djimde A, Doumbo O, Zongo I, Ouedraogo JB, Michon P, Mueller I, Siba P, Nzila A, Borrmann S, Kiara SM, Marsh K, Jiang H, Su XZ, Amaratunga C, Fairhurst R, Socheat D, Nosten F, Imwong M, White NJ, Sanders M, Anastasi E, Alcock D, Drury E, Oyola S, Quail MA, Turner DJ, Ruano-Rubio V, Jyothi D, Amenga-Etego L, Hubbart C, Jeffreys A, Rowlands K, Sutherland C, Roper C, Mangano V, Modiano D, Tan JC, Ferdig MT, Amambua-Ngwa A, Conway DJ, Takala-Harrison S, Plowe CV, Rayner JC, Rockett KA, Clark TG, Newbold CI, Berriman M, MacInnis B, Kwiatkowski DP.

Nature. 2012 Jul 19;487(7407):375-9. doi: 10.1038/nature11174.

6.

Baseline in vitro activities of the antimalarials pyronaridine and methylene blue against Plasmodium falciparum isolates from Kenya.

Okombo J, Kiara SM, Mwai L, Pole L, Ohuma E, Ochola LI, Nzila A.

Antimicrob Agents Chemother. 2012 Feb;56(2):1105-7. doi: 10.1128/AAC.05454-11. Epub 2011 Nov 28.

7.

Population genetic analysis of Plasmodium falciparum parasites using a customized Illumina GoldenGate genotyping assay.

Campino S, Auburn S, Kivinen K, Zongo I, Ouedraogo JB, Mangano V, Djimde A, Doumbo OK, Kiara SM, Nzila A, Borrmann S, Marsh K, Michon P, Mueller I, Siba P, Jiang H, Su XZ, Amaratunga C, Socheat D, Fairhurst RM, Imwong M, Anderson T, Nosten F, White NJ, Gwilliam R, Deloukas P, MacInnis B, Newbold CI, Rockett K, Clark TG, Kwiatkowski DP.

PLoS One. 2011;6(6):e20251. doi: 10.1371/journal.pone.0020251. Epub 2011 Jun 6.

8.

In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya.

Okombo J, Kiara SM, Rono J, Mwai L, Pole L, Ohuma E, Borrmann S, Ochola LI, Nzila A.

Antimicrob Agents Chemother. 2010 Aug;54(8):3302-7. doi: 10.1128/AAC.00325-10. Epub 2010 Jun 1.

9.

Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.

Nzila A, Rottmann M, Chitnumsub P, Kiara SM, Kamchonwongpaisan S, Maneeruttanarungroj C, Taweechai S, Yeung BK, Goh A, Lakshminarayana SB, Zou B, Wong J, Ma NL, Weaver M, Keller TH, Dartois V, Wittlin S, Brun R, Yuthavong Y, Diagana TT.

Antimicrob Agents Chemother. 2010 Jun;54(6):2603-10. doi: 10.1128/AAC.01526-09. Epub 2010 Mar 29.

10.

In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1.

Mwai L, Kiara SM, Abdirahman A, Pole L, Rippert A, Diriye A, Bull P, Marsh K, Borrmann S, Nzila A.

Antimicrob Agents Chemother. 2009 Dec;53(12):5069-73. doi: 10.1128/AAC.00638-09. Epub 2009 Sep 21.

11.

In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation.

Kiara SM, Okombo J, Masseno V, Mwai L, Ochola I, Borrmann S, Nzila A.

Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8. doi: 10.1128/AAC.00308-09. Epub 2009 Jun 15.

12.

Chloroquine resistance before and after its withdrawal in Kenya.

Mwai L, Ochong E, Abdirahman A, Kiara SM, Ward S, Kokwaro G, Sasi P, Marsh K, Borrmann S, Mackinnon M, Nzila A.

Malar J. 2009 May 18;8:106. doi: 10.1186/1475-2875-8-106.

13.

Characteristics of Plasmodium falciparum dhfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987--2006.

Certain LK, BriceƱo M, Kiara SM, Nzila AM, Watkins WM, Sibley CH.

J Infect Dis. 2008 Jun 15;197(12):1743-51. doi: 10.1086/588198.

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