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The HDAC3 enzymatic activity regulates skeletal muscle fuel metabolism.

Song S, Wen Y, Tong H, Loro E, Gong Y, Liu J, Hong S, Li L, Khurana TS, Chu M, Sun Z.

J Mol Cell Biol. 2019 Feb 1;11(2):133-143. doi: 10.1093/jmcb/mjy066.


Elongated mitochondrial constrictions and fission in muscle fatigue.

Lavorato M, Loro E, Debattisti V, Khurana TS, Franzini-Armstrong C.

J Cell Sci. 2018 Dec 5;131(23). pii: jcs221028. doi: 10.1242/jcs.221028.


Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15RA.

Loro E, Bisetto S, Khurana TS.

J Cell Sci. 2018 Nov 2;131(21). pii: jcs218313. doi: 10.1242/jcs.218313.


Functional improvement of dystrophic muscle by repression of utrophin: let-7c interaction.

Mishra MK, Loro E, Sengupta K, Wilton SD, Khurana TS.

PLoS One. 2017 Oct 18;12(10):e0182676. doi: 10.1371/journal.pone.0182676. eCollection 2017.


In Vivo Evaluation of the Mechanical and Viscoelastic Properties of the Rat Tongue.

Loro E, Wang SH, Schwab RJ, Khurana TS.

J Vis Exp. 2017 Jul 6;(125). doi: 10.3791/56006.


IL15RA is required for osteoblast function and bone mineralization.

Loro E, Ramaswamy G, Chandra A, Tseng WJ, Mishra MK, Shore EM, Khurana TS.

Bone. 2017 Oct;103:20-30. doi: 10.1016/j.bone.2017.06.003. Epub 2017 Jun 6.


DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress.

Simonson B, Subramanya V, Chan MC, Zhang A, Franchino H, Ottaviano F, Mishra MK, Knight AC, Hunt D, Ghiran I, Khurana TS, Kontaridis MI, Rosenzweig A, Das S.

Sci Signal. 2017 Feb 28;10(468). pii: eaaf5967. doi: 10.1126/scisignal.aaf5967.


Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion.

Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, Ding G, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill BD, Molina H, Khurana TS, Rabinowitz JD, Lazar MA, Sun Z.

Nat Med. 2017 Feb;23(2):223-234. doi: 10.1038/nm.4245. Epub 2016 Dec 19.


Development of Experimental Myopia in Chicks in a Natural Environment.

Stone RA, Cohen Y, McGlinn AM, Davison S, Casavant S, Shaffer J, Khurana TS, Pardue MT, Iuvone PM.

Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4779-89. doi: 10.1167/iovs.16-19310.


Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle.

Frederick DW, Loro E, Liu L, Davila A Jr, Chellappa K, Silverman IM, Quinn WJ 3rd, Gosai SJ, Tichy ED, Davis JG, Mourkioti F, Gregory BD, Dellinger RW, Redpath P, Migaud ME, Nakamaru-Ogiso E, Rabinowitz JD, Khurana TS, Baur JA.

Cell Metab. 2016 Aug 9;24(2):269-82. doi: 10.1016/j.cmet.2016.07.005.


The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α.

Arsenault PR, Song D, Chung YJ, Khurana TS, Lee FS.

Mol Cell Biol. 2016 Aug 26;36(18):2328-43. doi: 10.1128/MCB.00090-16. Print 2016 Sep 15.


Pharmacotherapy to protect the neuromuscular junction after acute organophosphorus pesticide poisoning.

Bird SB, Krajacic P, Sawamoto K, Bunya N, Loro E, Khurana TS.

Ann N Y Acad Sci. 2016 Jun;1374(1):86-93. doi: 10.1111/nyas.13111. Epub 2016 Jun 3. Review.


IL-15Rα is a determinant of muscle fuel utilization, and its loss protects against obesity.

Loro E, Seifert EL, Moffat C, Romero F, Mishra MK, Sun Z, Krajacic P, Anokye-Danso F, Summer RS, Ahima RS, Khurana TS.

Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R835-44. doi: 10.1152/ajpregu.00505.2014. Epub 2015 Aug 12.


Expression of calcium-buffering proteins in rat intrinsic laryngeal muscles.

Ferretti R, Marques MJ, Khurana TS, Santo Neto H.

Physiol Rep. 2015 Jun;3(6). pii: e12409. doi: 10.14814/phy2.12409.


Exercise protocol induces muscle, tendon, and bone adaptations in the rat shoulder.

Rooney SI, Loro E, Sarver JJ, Peltz CD, Hast MW, Tseng WJ, Kuntz AF, Liu XS, Khurana TS, Soslowsky LJ.

Muscles Ligaments Tendons J. 2015 Feb 5;4(4):413-9. eCollection 2014 Oct-Dec.


A mouse model for dominant collagen VI disorders: heterozygous deletion of Col6a3 Exon 16.

Pan TC, Zhang RZ, Arita M, Bogdanovich S, Adams SM, Gara SK, Wagener R, Khurana TS, Birk DE, Chu ML.

J Biol Chem. 2014 Apr 11;289(15):10293-307. doi: 10.1074/jbc.M114.549311. Epub 2014 Feb 22.


FER-1/Dysferlin promotes cholinergic signaling at the neuromuscular junction in C. elegans and mice.

Krajacic P, Pistilli EE, Tanis JE, Khurana TS, Lamitina ST.

Biol Open. 2013 Oct 15;2(11):1245-52. doi: 10.1242/bio.20135637. eCollection 2013.


The nuclear receptor Rev-erbα controls circadian thermogenic plasticity.

Gerhart-Hines Z, Feng D, Emmett MJ, Everett LJ, Loro E, Briggs ER, Bugge A, Hou C, Ferrara C, Seale P, Pryma DA, Khurana TS, Lazar MA.

Nature. 2013 Nov 21;503(7476):410-413. doi: 10.1038/nature12642. Epub 2013 Oct 27.


A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism.

Arsenault PR, Pei F, Lee R, Kerestes H, Percy MJ, Keith B, Simon MC, Lappin TR, Khurana TS, Lee FS.

J Biol Chem. 2013 Nov 22;288(47):33571-84. doi: 10.1074/jbc.M113.482364. Epub 2013 Oct 11.


Ventilatory chemosensory drive is blunted in the mdx mouse model of Duchenne Muscular Dystrophy (DMD).

Mosqueira M, Baby SM, Lahiri S, Khurana TS.

PLoS One. 2013 Jul 29;8(7):e69567. doi: 10.1371/journal.pone.0069567. Print 2013.


Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation.

Tan Q, Kerestes H, Percy MJ, Pietrofesa R, Chen L, Khurana TS, Christofidou-Solomidou M, Lappin TR, Lee FS.

J Biol Chem. 2013 Jun 14;288(24):17134-44. doi: 10.1074/jbc.M112.444059. Epub 2013 May 2.


COL6A3 protein deficiency in mice leads to muscle and tendon defects similar to human collagen VI congenital muscular dystrophy.

Pan TC, Zhang RZ, Markova D, Arita M, Zhang Y, Bogdanovich S, Khurana TS, Bönnemann CG, Birk DE, Chu ML.

J Biol Chem. 2013 May 17;288(20):14320-31. doi: 10.1074/jbc.M112.433078. Epub 2013 Apr 5.


Duchenne muscular dystrophy drug discovery - the application of utrophin promoter activation screening.

Moorwood C, Khurana TS.

Expert Opin Drug Discov. 2013 May;8(5):569-81. doi: 10.1517/17460441.2013.777040. Epub 2013 Mar 9. Review.


Pharmacology of myopia and potential role for intrinsic retinal circadian rhythms.

Stone RA, Pardue MT, Iuvone PM, Khurana TS.

Exp Eye Res. 2013 Sep;114:35-47. doi: 10.1016/j.exer.2013.01.001. Epub 2013 Jan 8. Review.


A cell-based high-throughput screening assay for posttranscriptional utrophin upregulation.

Moorwood C, Soni N, Patel G, Wilton SD, Khurana TS.

J Biomol Screen. 2013 Apr;18(4):400-6. doi: 10.1177/1087057112465648. Epub 2012 Oct 30.


Expression profiling reveals novel hypoxic biomarkers in peripheral blood of adult mice exposed to chronic hypoxia.

Mosqueira M, Willmann G, Zeiger U, Khurana TS.

PLoS One. 2012;7(5):e37497. doi: 10.1371/journal.pone.0037497. Epub 2012 May 22.


Translational regulation of utrophin by miRNAs.

Basu U, Lozynska O, Moorwood C, Patel G, Wilton SD, Khurana TS.

PLoS One. 2011;6(12):e29376. doi: 10.1371/journal.pone.0029376. Epub 2011 Dec 27.


Drug discovery for Duchenne muscular dystrophy via utrophin promoter activation screening.

Moorwood C, Lozynska O, Suri N, Napper AD, Diamond SL, Khurana TS.

PLoS One. 2011;6(10):e26169. doi: 10.1371/journal.pone.0026169. Epub 2011 Oct 20.


Loss of IL-15 receptor α alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles.

Pistilli EE, Bogdanovich S, Garton F, Yang N, Gulbin JP, Conner JD, Anderson BG, Quinn LS, North K, Ahima RS, Khurana TS.

J Clin Invest. 2011 Aug;121(8):3120-32. doi: 10.1172/JCI44945. Epub 2011 Jul 18.


Image defocus and altered retinal gene expression in chick: clues to the pathogenesis of ametropia.

Stone RA, McGlinn AM, Baldwin DA, Tobias JW, Iuvone PM, Khurana TS.

Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5765-77. doi: 10.1167/iovs.10-6727.


Biglycan recruits utrophin to the sarcolemma and counters dystrophic pathology in mdx mice.

Amenta AR, Yilmaz A, Bogdanovich S, McKechnie BA, Abedi M, Khurana TS, Fallon JR.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):762-7. doi: 10.1073/pnas.1013067108. Epub 2010 Dec 27.


Chronic hypoxia impairs muscle function in the Drosophila model of Duchenne's muscular dystrophy (DMD).

Mosqueira M, Willmann G, Ruohola-Baker H, Khurana TS.

PLoS One. 2010 Oct 20;5(10):e13450. doi: 10.1371/journal.pone.0013450.


Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition.

Goncalves MD, Pistilli EE, Balduzzi A, Birnbaum MJ, Lachey J, Khurana TS, Ahima RS.

PLoS One. 2010 Sep 15;5(9):e12707. doi: 10.1371/journal.pone.0012707.


Effects on colour discrimination during long term exposure to high altitudes on Mt Everest.

Willmann G, Ivanov IV, Fischer MD, Lahiri S, Pokharel RK, Werner A, Khurana TS.

Br J Ophthalmol. 2010 Oct;94(10):1393-7. doi: 10.1136/bjo.2009.178491. Epub 2010 Aug 23.


Superior calcium homeostasis of extraocular muscles.

Zeiger U, Mitchell CH, Khurana TS.

Exp Eye Res. 2010 Nov;91(5):613-22. doi: 10.1016/j.exer.2010.07.019. Epub 2010 Aug 7.


Identification of the neuromuscular junction transcriptome of extraocular muscle by laser capture microdissection.

Ketterer C, Zeiger U, Budak MT, Rubinstein NA, Khurana TS.

Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4589-99. doi: 10.1167/iovs.09-4893. Epub 2010 Apr 14.


Gene profiling in experimental models of eye growth: clues to myopia pathogenesis.

Stone RA, Khurana TS.

Vision Res. 2010 Nov 23;50(23):2322-33. doi: 10.1016/j.visres.2010.03.021. Epub 2010 Apr 2. Review.


The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice.

Hickey MM, Richardson T, Wang T, Mosqueira M, Arguiri E, Yu H, Yu QC, Solomides CC, Morrisey EE, Khurana TS, Christofidou-Solomidou M, Simon MC.

J Clin Invest. 2010 Mar;120(3):827-39. doi: 10.1172/JCI36362. Epub 2010 Feb 8.


Distinctive patterns of microRNA expression in extraocular muscles.

Zeiger U, Khurana TS.

Physiol Genomics. 2010 May;41(3):289-96. doi: 10.1152/physiolgenomics.00169.2009. Epub 2010 Feb 9.


Pretreatment with a soluble activin type IIB receptor/Fc fusion protein improves hypoxia-induced muscle dysfunction.

Pistilli EE, Bogdanovich S, Mosqueira M, Lachey J, Seehra J, Khurana TS.

Am J Physiol Regul Integr Comp Physiol. 2010 Jan;298(1):R96-R103. doi: 10.1152/ajpregu.00138.2009. Epub 2009 Oct 28.


C. elegans dysferlin homolog fer-1 is expressed in muscle, and fer-1 mutations initiate altered gene expression of muscle enriched genes.

Krajacic P, Hermanowski J, Lozynska O, Khurana TS, Lamitina T.

Physiol Genomics. 2009 Dec 30;40(1):8-14. doi: 10.1152/physiolgenomics.00106.2009. Epub 2009 Sep 15.


The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity.

Akpan I, Goncalves MD, Dhir R, Yin X, Pistilli EE, Bogdanovich S, Khurana TS, Ucran J, Lachey J, Ahima RS.

Int J Obes (Lond). 2009 Nov;33(11):1265-73. doi: 10.1038/ijo.2009.162. Epub 2009 Aug 11.


Differential expression of utrophin-A and -B promoters in the central nervous system (CNS) of normal and dystrophic mdx mice.

Baby SM, Bogdanovich S, Willmann G, Basu U, Lozynska O, Khurana TS.

Brain Pathol. 2010 Mar;20(2):323-42. doi: 10.1111/j.1750-3639.2009.00275.x. Epub 2009 May 22.


Influence of hyperthyroid conditions on gene expression in extraocular muscles of rats.

Postler TS, Budak MT, Khurana TS, Rubinstein NA.

Physiol Genomics. 2009 May 13;37(3):231-8. doi: 10.1152/physiolgenomics.00023.2009. Epub 2009 Mar 10.


Transcriptional and functional differences in stem cell populations isolated from extraocular and limb muscles.

Pacheco-Pinedo EC, Budak MT, Zeiger U, Jørgensen LH, Bogdanovich S, Schrøder HD, Rubinstein NA, Khurana TS.

Physiol Genomics. 2009 Mar 3;37(1):35-42. doi: 10.1152/physiolgenomics.00051.2008. Epub 2008 Dec 30.


Myostatin blockade improves function but not histopathology in a murine model of limb-girdle muscular dystrophy 2C.

Bogdanovich S, McNally EM, Khurana TS.

Muscle Nerve. 2008 Mar;37(3):308-16.


Combination of peptide OFFGEL fractionation and label-free quantitation facilitated proteomics profiling of extraocular muscle.

Fraterman S, Zeiger U, Khurana TS, Rubinstein NA, Wilm M.

Proteomics. 2007 Sep;7(18):3404-16.


Heregulin-induced epigenetic regulation of the utrophin-A promoter.

Basu U, Gyrd-Hansen M, Baby SM, Lozynska O, Krag TO, Jensen CJ, Frödin M, Khurana TS.

FEBS Lett. 2007 Sep 4;581(22):4153-8. Epub 2007 Jul 23.


Form-deprivation myopia in chick induces limited changes in retinal gene expression.

McGlinn AM, Baldwin DA, Tobias JW, Budak MT, Khurana TS, Stone RA.

Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3430-6.


Ets-2 repressor factor silences extrasynaptic utrophin by N-box mediated repression in skeletal muscle.

Perkins KJ, Basu U, Budak MT, Ketterer C, Baby SM, Lozynska O, Lunde JA, Jasmin BJ, Rubinstein NA, Khurana TS.

Mol Biol Cell. 2007 Aug;18(8):2864-72. Epub 2007 May 16.

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