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A recombinant platform for flavivirus vaccines and diagnostics using chimeras of a new insect-specific virus.

Hobson-Peters J, Harrison JJ, Watterson D, Hazlewood JE, Vet LJ, Newton ND, Warrilow D, Colmant AMG, Taylor C, Huang B, Piyasena TBH, Chow WK, Setoh YX, Tang B, Nakayama E, Yan K, Amarilla AA, Wheatley S, Moore PR, Finger M, Kurucz N, Modhiran N, Young PR, Khromykh AA, Bielefeldt-Ohmann H, Suhrbier A, Hall RA.

Sci Transl Med. 2019 Dec 11;11(522). pii: eaax7888. doi: 10.1126/scitranslmed.aax7888.


Chimeric viruses of the insect-specific flavivirus Palm Creek with structural proteins of vertebrate-infecting flaviviruses identify barriers to replication of insect-specific flaviviruses in vertebrate cells.

Piyasena TBH, Newton ND, Hobson-Peters J, Vet LJ, Setoh YX, Bielefeldt-Ohmann H, Khromykh AA, Hall RA.

J Gen Virol. 2019 Nov;100(11):1580-1586. doi: 10.1099/jgv.0.001326.


West Nile virus infection and interferon alpha treatment alter the spectrum and the levels of coding and noncoding host RNAs secreted in extracellular vesicles.

Slonchak A, Clarke B, Mackenzie J, Amarilla AA, Setoh YX, Khromykh AA.

BMC Genomics. 2019 Jun 10;20(1):474. doi: 10.1186/s12864-019-5835-6.


Author Correction: Infectious DNAs derived from insect-specific flavivirus genomes enable identification of pre- and post-entry host restrictions in vertebrate cells.

Piyasena TBH, Setoh YX, Hobson-Peters J, Newton ND, Bielefeldt-Ohmann H, McLean BJ, Vet LJ, Khromykh AA, Hall RA.

Sci Rep. 2019 Jun 5;9(1):8431. doi: 10.1038/s41598-019-44657-7.


Determinants of Zika virus host tropism uncovered by deep mutational scanning.

Setoh YX, Amarilla AA, Peng NYG, Griffiths RE, Carrera J, Freney ME, Nakayama E, Ogawa S, Watterson D, Modhiran N, Nanyonga FE, Torres FJ, Slonchak A, Periasamy P, Prow NA, Tang B, Harrison J, Hobson-Peters J, Cuddihy T, Cooper-White J, Hall RA, Young PR, Mackenzie JM, Wolvetang E, Bloom JD, Suhrbier A, Khromykh AA.

Nat Microbiol. 2019 May;4(5):876-887. doi: 10.1038/s41564-019-0399-4. Epub 2019 Mar 18.


CCR2 Plays a Protective Role in Rocio Virus-Induced Encephalitis by Promoting Macrophage Infiltration Into the Brain.

Amarilla AA, Santos-Junior NN, Figueiredo ML, Luiz JPM, Fumagalli MJ, Colón DF, Lippi V, Alfonso HL, Lima-Junior DS, Trabuco AC, Spinieli RL, Desidera AC, Leite-Panissi CRA, Lauretti F, Mendoza SES, Silva CLA, Rego EM, Galvao-Lima LJ, Bassi GS, Penharvel Martíns SLB, Manrique WG, Alves-Filho JC, Cunha FQ, Peng NYG, Modhiran N, Setoh YX, Khromykh AA, Figueiredo LTM, Aquino VH.

J Infect Dis. 2019 May 24;219(12):2015-2025. doi: 10.1093/infdis/jiz029.


Contemporary Anti-Ebola Drug Discovery Approaches and Platforms.

Schneider-Futschik EK, Hoyer D, Khromykh AA, Baell JB, Marsh GA, Baker MA, Li J, Velkov T.

ACS Infect Dis. 2019 Jan 11;5(1):35-48. doi: 10.1021/acsinfecdis.8b00285. Epub 2018 Dec 20. Review.


Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses.

Setoh YX, Peng NY, Nakayama E, Amarilla AA, Prow NA, Suhrbier A, Khromykh AA.

Viruses. 2018 Oct 3;10(10). pii: E541. doi: 10.3390/v10100541.


Subgenomic flaviviral RNAs: What do we know after the first decade of research.

Slonchak A, Khromykh AA.

Antiviral Res. 2018 Nov;159:13-25. doi: 10.1016/j.antiviral.2018.09.006. Epub 2018 Sep 11. Review.


Ilheus and Saint Louis encephalitis viruses elicit cross-protection against a lethal Rocio virus challenge in mice.

Amarilla AA, Fumagalli MJ, Figueiredo ML, Lima-Junior DS, Santos-Junior NN, Alfonso HL, Lippi V, Trabuco AC, Lauretti F, Muller VD, Colón DF, Luiz JPM, Suhrbier A, Setoh YX, Khromykh AA, Figueiredo LTM, Aquino VH.

PLoS One. 2018 Jun 13;13(6):e0199071. doi: 10.1371/journal.pone.0199071. eCollection 2018.


A vaccinia-based single vector construct multi-pathogen vaccine protects against both Zika and chikungunya viruses.

Prow NA, Liu L, Nakayama E, Cooper TH, Yan K, Eldi P, Hazlewood JE, Tang B, Le TT, Setoh YX, Khromykh AA, Hobson-Peters J, Diener KR, Howley PM, Hayball JD, Suhrbier A.

Nat Commun. 2018 Mar 26;9(1):1230. doi: 10.1038/s41467-018-03662-6.


Helicase Domain of West Nile Virus NS3 Protein Plays a Role in Inhibition of Type I Interferon Signalling.

Setoh YX, Periasamy P, Peng NYG, Amarilla AA, Slonchak A, Khromykh AA.

Viruses. 2017 Nov 2;9(11). pii: E326. doi: 10.3390/v9110326.


Characterization of Recombinant Flaviviridae Viruses Possessing a Small Reporter Tag.

Tamura T, Fukuhara T, Uchida T, Ono C, Mori H, Sato A, Fauzyah Y, Okamoto T, Kurosu T, Setoh YX, Imamura M, Tautz N, Sakoda Y, Khromykh AA, Chayama K, Matsuura Y.

J Virol. 2018 Jan 2;92(2). pii: e01582-17. doi: 10.1128/JVI.01582-17. Print 2018 Jan 15.


Differential Diagnosis of Flavivirus Infections in Horses Using Viral Envelope Protein Domain III Antigens in Enzyme-Linked Immunosorbent Assay.

Piyasena TBH, Setoh YX, Hobson-Peters J, Prow NA, Bielefeldt-Ohmann H, Khromykh AA, Perera D, Cardosa MJ, Kirkland PD, Hall RA.

Vector Borne Zoonotic Dis. 2017 Dec;17(12):825-835. doi: 10.1089/vbz.2017.2172. Epub 2017 Oct 30.


Full genome sequence of Rocio virus reveal substantial variations from the prototype Rocio virus SPH 34675 sequence.

Setoh YX, Amarilla AA, Peng NY, Slonchak A, Periasamy P, Figueiredo LTM, Aquino VH, Khromykh AA.

Arch Virol. 2018 Jan;163(1):255-258. doi: 10.1007/s00705-017-3561-4. Epub 2017 Sep 22.


Cell fusing agent virus and dengue virus mutually interact in Aedes aegypti cell lines.

Zhang G, Asad S, Khromykh AA, Asgari S.

Sci Rep. 2017 Jul 31;7(1):6935. doi: 10.1038/s41598-017-07279-5.


Infectious DNAs derived from insect-specific flavivirus genomes enable identification of pre- and post-entry host restrictions in vertebrate cells.

Piyasena TBH, Setoh YX, Hobson-Peters J, Newton ND, Bielefeldt-Ohmann H, McLean BJ, Vet LJ, Khromykh AA, Hall RA.

Sci Rep. 2017 Jun 7;7(1):2940. doi: 10.1038/s41598-017-03120-1. Erratum in: Sci Rep. 2019 Jun 5;9(1):8431.


De Novo Generation and Characterization of New Zika Virus Isolate Using Sequence Data from a Microcephaly Case.

Setoh YX, Prow NA, Peng N, Hugo LE, Devine G, Hazlewood JE, Suhrbier A, Khromykh AA.

mSphere. 2017 May 17;2(3). pii: e00190-17. doi: 10.1128/mSphereDirect.00190-17. eCollection 2017 May-Jun.


Chimeric viruses between Rocio and West Nile: the role for Rocio prM-E proteins in virulence and inhibition of interferon-α/β signaling.

Amarilla AA, Setoh YX, Periasamy P, Peng NY, Pali G, Figueiredo LT, Khromykh AA, Aquino VH.

Sci Rep. 2017 Mar 20;7:44642. doi: 10.1038/srep44642.


Genetic characterization of Cacipacoré virus from ticks collected in São Paulo State, Brazil.

de Figueiredo GG, Amarilla AA, de Souza WM, Fumagalli MJ, de Figueiredo MLG, Szabó MPJ, Badra SJ, Setoh YX, Khromykh AA, Aquino VH, Figueiredo LTM.

Arch Virol. 2017 Jun;162(6):1783-1786. doi: 10.1007/s00705-017-3279-3. Epub 2017 Feb 20.


Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG.

Pyankov OV, Setoh YX, Bodnev SA, Edmonds JH, Pyankova OG, Pyankov SA, Pali G, Belford S, Lu L, La M, Lovrecz G, Volchkova VA, Chappell KJ, Watterson D, Marsh G, Young PR, Agafonov AA, Farmer JF, Volchkov VE, Suhrbier A, Khromykh AA.

Sci Rep. 2017 Feb 3;7:41537. doi: 10.1038/srep41537.


Virulence and Evolution of West Nile Virus, Australia, 1960-2012.

Prow NA, Edmonds JH, Williams DT, Setoh YX, Bielefeldt-Ohmann H, Suen WW, Hobson-Peters J, van den Hurk AF, Pyke AT, Hall-Mendelin S, Northill JA, Johansen CA, Warrilow D, Wang J, Kirkland PD, Doggett S, Andrade CC, Brault AC, Khromykh AA, Hall RA.

Emerg Infect Dis. 2016 Aug;22(8):1353-62. doi: 10.3201/eid2208.151719.


The in vitro and in vivo antiviral properties of combined monoterpene alcohols against West Nile virus infection.

Pliego Zamora A, Edmonds JH, Reynolds MJ, Khromykh AA, Ralph SJ.

Virology. 2016 Aug;495:18-32. doi: 10.1016/j.virol.2016.04.021. Epub 2016 May 3.


The I22V and L72S substitutions in West Nile virus prM protein promote enhanced prM/E heterodimerisation and nucleocapsid incorporation.

Setoh YX, Tan CS, Prow NA, Hobson-Peters J, Young PR, Khromykh AA, Hall RA.

Virol J. 2015 May 7;12:72. doi: 10.1186/s12985-015-0303-7.


Comparison of attenuated and virulent West Nile virus strains in human monocyte-derived dendritic cells as a model of initial human infection.

Rawle DJ, Setoh YX, Edmonds JH, Khromykh AA.

Virol J. 2015 Mar 22;12:46. doi: 10.1186/s12985-015-0279-3.


Viral RNA intermediates as targets for detection and discovery of novel and emerging mosquito-borne viruses.

O'Brien CA, Hobson-Peters J, Yam AW, Colmant AM, McLean BJ, Prow NA, Watterson D, Hall-Mendelin S, Warrilow D, Ng ML, Khromykh AA, Hall RA.

PLoS Negl Trop Dis. 2015 Mar 23;9(3):e0003629. doi: 10.1371/journal.pntd.0003629. eCollection 2015 Mar.


A Kunjin Replicon Virus-like Particle Vaccine Provides Protection Against Ebola Virus Infection in Nonhuman Primates.

Pyankov OV, Bodnev SA, Pyankova OG, Solodkyi VV, Pyankov SA, Setoh YX, Volchkova VA, Suhrbier A, Volchkov VV, Agafonov AA, Khromykh AA.

J Infect Dis. 2015 Oct 1;212 Suppl 2:S368-71. doi: 10.1093/infdis/jiv019. Epub 2015 Mar 2.


Post-translational regulation and modifications of flavivirus structural proteins.

Roby JA, Setoh YX, Hall RA, Khromykh AA.

J Gen Virol. 2015 Jul;96(Pt 7):1551-69. doi: 10.1099/vir.0.000097. Epub 2015 Feb 23. Review.


Functional non-coding RNAs derived from the flavivirus 3' untranslated region.

Clarke BD, Roby JA, Slonchak A, Khromykh AA.

Virus Res. 2015 Aug 3;206:53-61. doi: 10.1016/j.virusres.2015.01.026. Epub 2015 Feb 7. Review.


Systematic analysis of viral genes responsible for differential virulence between American and Australian West Nile virus strains.

Setoh YX, Prow NA, Rawle DJ, Tan CS, Edmonds JH, Hall RA, Khromykh AA.

J Gen Virol. 2015 Jun;96(Pt 6):1297-308. doi: 10.1099/vir.0.000069. Epub 2015 Jan 27.


Last 20 aa of the West Nile virus NS1' protein are responsible for its retention in cells and the formation of unique heat-stable dimers.

Young LB, Melian EB, Setoh YX, Young PR, Khromykh AA.

J Gen Virol. 2015 May;96(Pt 5):1042-54. doi: 10.1099/vir.0.000053. Epub 2015 Jan 22.


Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection.

Poo YS, Rudd PA, Gardner J, Wilson JA, Larcher T, Colle MA, Le TT, Nakaya HI, Warrilow D, Allcock R, Bielefeldt-Ohmann H, Schroder WA, Khromykh AA, Lopez JA, Suhrbier A.

PLoS Negl Trop Dis. 2014 Dec 4;8(12):e3354. doi: 10.1371/journal.pntd.0003354. eCollection 2014 Dec.


Programmed ribosomal frameshift alters expression of west nile virus genes and facilitates virus replication in birds and mosquitoes.

Melian EB, Hall-Mendelin S, Du F, Owens N, Bosco-Lauth AM, Nagasaki T, Rudd S, Brault AC, Bowen RA, Hall RA, van den Hurk AF, Khromykh AA.

PLoS Pathog. 2014 Nov 6;10(11):e1004447. doi: 10.1371/journal.ppat.1004447. eCollection 2014 Nov.


Increased expression of capsid protein in trans enhances production of single-round infectious particles by West Nile virus DNA vaccine candidate.

Roby JA, Bielefeldt-Ohmann H, Prow NA, Chang DC, Hall RA, Khromykh AA.

J Gen Virol. 2014 Oct;95(Pt 10):2176-91. doi: 10.1099/vir.0.064121-0. Epub 2014 Jun 23.


Expression of mosquito microRNA Aae-miR-2940-5p is downregulated in response to West Nile virus infection to restrict viral replication.

Slonchak A, Hussain M, Torres S, Asgari S, Khromykh AA.

J Virol. 2014 Aug;88(15):8457-67. doi: 10.1128/JVI.00317-14. Epub 2014 May 14.


Wolbachia infection modifies the profile, shuttling and structure of microRNAs in a mosquito cell line.

Mayoral JG, Etebari K, Hussain M, Khromykh AA, Asgari S.

PLoS One. 2014 Apr 23;9(4):e96107. doi: 10.1371/journal.pone.0096107. eCollection 2014.


Loop de loop: viral RNA evades IFIT1 targeting.

Roby JA, Clarke BD, Khromykh AA.

Trends Microbiol. 2014 Apr;22(4):171-3. doi: 10.1016/j.tim.2014.02.014. Epub 2014 Mar 13.


Noncoding subgenomic flavivirus RNA: multiple functions in West Nile virus pathogenesis and modulation of host responses.

Roby JA, Pijlman GP, Wilusz J, Khromykh AA.

Viruses. 2014 Jan 27;6(2):404-27. doi: 10.3390/v6020404. Review.


NS1' colocalizes with NS1 and can substitute for NS1 in West Nile virus replication.

Young LB, Melian EB, Khromykh AA.

J Virol. 2013 Aug;87(16):9384-90. doi: 10.1128/JVI.01101-13. Epub 2013 Jun 12.


An interaction between the methyltransferase and RNA dependent RNA polymerase domains of the West Nile virus NS5 protein.

Tan CS, Hobson-Peters JM, Stoermer MJ, Fairlie DP, Khromykh AA, Hall RA.

J Gen Virol. 2013 Sep;94(Pt 9):1961-71. doi: 10.1099/vir.0.054395-0. Epub 2013 Jun 5.


A novel bacterium-free method for generation of flavivirus infectious DNA by circular polymerase extension reaction allows accurate recapitulation of viral heterogeneity.

Edmonds J, van Grinsven E, Prow N, Bosco-Lauth A, Brault AC, Bowen RA, Hall RA, Khromykh AA.

J Virol. 2013 Feb;87(4):2367-72. doi: 10.1128/JVI.03162-12. Epub 2012 Dec 12.


Effect of Wolbachia on replication of West Nile virus in a mosquito cell line and adult mosquitoes.

Hussain M, Lu G, Torres S, Edmonds JH, Kay BH, Khromykh AA, Asgari S.

J Virol. 2013 Jan;87(2):851-8. doi: 10.1128/JVI.01837-12. Epub 2012 Oct 31.


West Nile virus NS2A protein facilitates virus-induced apoptosis independently of interferon response.

Melian EB, Edmonds JH, Nagasaki TK, Hinzman E, Floden N, Khromykh AA.

J Gen Virol. 2013 Feb;94(Pt 2):308-13. doi: 10.1099/vir.0.047076-0. Epub 2012 Oct 31.


Noncoding flavivirus RNA displays RNA interference suppressor activity in insect and Mammalian cells.

Schnettler E, Sterken MG, Leung JY, Metz SW, Geertsema C, Goldbach RW, Vlak JM, Kohl A, Khromykh AA, Pijlman GP.

J Virol. 2012 Dec;86(24):13486-500. doi: 10.1128/JVI.01104-12. Epub 2012 Oct 3.


A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability.

Moon SL, Anderson JR, Kumagai Y, Wilusz CJ, Akira S, Khromykh AA, Wilusz J.

RNA. 2012 Nov;18(11):2029-40. doi: 10.1261/rna.034330.112. Epub 2012 Sep 24.


Identification of residues in West Nile virus pre-membrane protein that influence viral particle secretion and virulence.

Setoh YX, Prow NA, Hobson-Peters J, Lobigs M, Young PR, Khromykh AA, Hall RA.

J Gen Virol. 2012 Sep;93(Pt 9):1965-75. doi: 10.1099/vir.0.044453-0. Epub 2012 Jul 4.


Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock.

Rudd PA, Wilson J, Gardner J, Larcher T, Babarit C, Le TT, Anraku I, Kumagai Y, Loo YM, Gale M Jr, Akira S, Khromykh AA, Suhrbier A.

J Virol. 2012 Sep;86(18):9888-98. doi: 10.1128/JVI.00956-12. Epub 2012 Jul 3.


Characterization of virulent West Nile virus Kunjin strain, Australia, 2011.

Frost MJ, Zhang J, Edmonds JH, Prow NA, Gu X, Davis R, Hornitzky C, Arzey KE, Finlaison D, Hick P, Read A, Hobson-Peters J, May FJ, Doggett SL, Haniotis J, Russell RC, Hall RA, Khromykh AA, Kirkland PD.

Emerg Infect Dis. 2012 May;18(5):792-800. doi: 10.3201/eid1805.111720.

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