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Target engagement and intracellular delivery of mono- and bivalent LDL receptor-binding peptide-cargo conjugates: Implications for the rational design of new targeted drug therapies.

Varini K, Lécorché P, Sonnette R, Gassiot F, Broc B, Godard M, David M, Faucon A, Abouzid K, Ferracci G, Temsamani J, Khrestchatisky M, Jacquot G.

J Control Release. 2019 Nov 28;314:141-161. doi: 10.1016/j.jconrel.2019.10.033. Epub 2019 Oct 20.


Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer's Disease Pathogenesis in a Transgenic Mouse Model.

Baranger K, van Gijsel-Bonnello M, Stephan D, Carpentier W, Rivera S, Khrestchatisky M, Gharib B, De Reggi M, Benech P.

Neurotherapeutics. 2019 Jul 2. doi: 10.1007/s13311-019-00754-z. [Epub ahead of print]


gH625-liposomes as tool for pituitary adenylate cyclase-activating polypeptide brain delivery.

Iachetta G, Falanga A, Molino Y, Masse M, Jabès F, Mechioukhi Y, Laforgia V, Khrestchatisky M, Galdiero S, Valiante S.

Sci Rep. 2019 Jun 24;9(1):9183. doi: 10.1038/s41598-019-45137-8.


Metalloproteinases and their tissue inhibitors in Alzheimer's disease and other neurodegenerative disorders.

Rivera S, García-González L, Khrestchatisky M, Baranger K.

Cell Mol Life Sci. 2019 Aug;76(16):3167-3191. doi: 10.1007/s00018-019-03178-2. Epub 2019 Jun 13. Review.


High levels of serum soluble TWEAK are associated with neuroinflammation during multiple sclerosis.

Maarouf A, Stephan D, Ranjeva MP, Ranjeva JP, Pelletier J, Audoin B, Khrestchatisky M, Desplat-Jégo S.

J Transl Med. 2019 Feb 20;17(1):51. doi: 10.1186/s12967-019-1789-3.


Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking.

Paumier JM, Py NA, García-González L, Bernard A, Stephan D, Louis L, Checler F, Khrestchatisky M, Baranger K, Rivera S.

FASEB J. 2019 Feb;33(2):2910-2927. doi: 10.1096/fj.201801076R. Epub 2018 Oct 17.


Syngeneic Transplantation of Olfactory Ectomesenchymal Stem Cells Restores Learning and Memory Abilities in a Rat Model of Global Cerebral Ischemia.

Veron AD, Bienboire-Frosini C, Girard SD, Sadelli K, Stamegna JC, Khrestchatisky M, Alexis J, Pageat P, Asproni P, Mengoli M, Roman FS.

Stem Cells Int. 2018 May 10;2018:2683969. doi: 10.1155/2018/2683969. eCollection 2018.


Correction: Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer's disease: Alleviation by pantethine.

van Gijsel-Bonnello M, Baranger K, Benech P, Rivera S, Khrestchatisky M, de Reggi M, Gharib B.

PLoS One. 2018 Mar 14;13(3):e0194586. doi: 10.1371/journal.pone.0194586. eCollection 2018.


Identification and characterization of highly versatile peptide-vectors that bind non-competitively to the low-density lipoprotein receptor for in vivo targeting and delivery of small molecules and protein cargos.

David M, Lécorché P, Masse M, Faucon A, Abouzid K, Gaudin N, Varini K, Gassiot F, Ferracci G, Jacquot G, Vlieghe P, Khrestchatisky M.

PLoS One. 2018 Feb 27;13(2):e0191052. doi: 10.1371/journal.pone.0191052. eCollection 2018.


Grafts of Olfactory Stem Cells Restore Breathing and Motor Functions after Rat Spinal Cord Injury.

Stamegna JC, Sadelli K, Escoffier G, Girard SD, Veron AD, Bonnet A, Khrestchatisky M, Gauthier P, Roman FS.

J Neurotrauma. 2018 Aug 1;35(15):1765-1780. doi: 10.1089/neu.2017.5383. Epub 2018 Apr 30.


Isolation and characterization of olfactory ecto-mesenchymal stem cells from eight mammalian genera.

Veron AD, Bienboire-Frosini C, Feron F, Codecasa E, Deveze A, Royer D, Watelet P, Asproni P, Sadelli K, Chabaud C, Stamegna JC, Fagot J, Khrestchatisky M, Cozzi A, Roman FS, Pageat P, Mengoli M, Girard SD.

BMC Vet Res. 2018 Jan 17;14(1):17. doi: 10.1186/s12917-018-1342-2.


Correction to: Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.

Greenwood J, Hammarlund-Udenaes M, Jones HC, Stitt AW, Vandenbroucke RE, Romero IA, Campbell M, Fricker G, Brodin B, Manninga H, Gaillard PJ, Schwaninger M, Webster C, Wicher KB, Khrestchatisky M.

Fluids Barriers CNS. 2018 Jan 12;15(1):3. doi: 10.1186/s12987-017-0086-x.


Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017.

Greenwood J, Hammarlund-Udenaes M, Jones HC, Stitt AW, Vandenbroucke RE, Romero IA, Campbell M, Fricker G, Brodin B, Manninga H, Gaillard PJ, Schwaninger M, Webster C, Wicher KB, Khrestchatisky M.

Fluids Barriers CNS. 2017 Nov 7;14(1):31. doi: 10.1186/s12987-017-0079-9. Erratum in: Fluids Barriers CNS. 2018 Jan 12;15(1):3.


Identification of LRP-1 as an endocytosis and recycling receptor for β1-integrin in thyroid cancer cells.

Theret L, Jeanne A, Langlois B, Hachet C, David M, Khrestchatisky M, Devy J, Hervé E, Almagro S, Dedieu S.

Oncotarget. 2017 Aug 10;8(45):78614-78632. doi: 10.18632/oncotarget.20201. eCollection 2017 Oct 3.


Chronic treatments with a 5-HT4 receptor agonist decrease amyloid pathology in the entorhinal cortex and learning and memory deficits in the 5xFAD mouse model of Alzheimer's disease.

Baranger K, Giannoni P, Girard SD, Girot S, Gaven F, Stephan D, Migliorati M, Khrestchatisky M, Bockaert J, Marchetti-Gauthier E, Rivera S, Claeysen S, Roman FS.

Neuropharmacology. 2017 Nov;126:128-141. doi: 10.1016/j.neuropharm.2017.08.031. Epub 2017 Aug 26.


From Blood to Lesioned Brain: An In Vitro Study on Migration Mechanisms of Human Nasal Olfactory Stem Cells.

Girard SD, Virard I, Lacassagne E, Paumier JM, Lahlou H, Jabes F, Molino Y, Stephan D, Baranger K, Belghazi M, Deveze A, Khrestchatisky M, Nivet E, Roman FS, Féron F.

Stem Cells Int. 2017;2017:1478606. doi: 10.1155/2017/1478606. Epub 2017 Jun 18.


Global cerebral ischemia in rats leads to amnesia due to selective neuronal death followed by astroglial scar formation in the CA1 layer.

Sadelli K, Stamegna JC, Girard SD, Baril N, Escoffier G, Brus M, Véron AD, Khrestchatisky M, Roman FS.

Neurobiol Learn Mem. 2017 May;141:168-178. doi: 10.1016/j.nlm.2017.04.004. Epub 2017 Apr 21.


Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer's disease: Alleviation by pantethine.

van Gijsel-Bonnello M, Baranger K, Benech P, Rivera S, Khrestchatisky M, de Reggi M, Gharib B.

PLoS One. 2017 Apr 14;12(4):e0175369. doi: 10.1371/journal.pone.0175369. eCollection 2017. Erratum in: PLoS One. 2018 Mar 14;13(3):e0194586.


MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro.

Baranger K, Bonnet AE, Girard SD, Paumier JM, García-González L, Elmanaa W, Bernard A, Charrat E, Stephan D, Bauer C, Moschke K, Lichtenthaler SF, Roman FS, Checler F, Khrestchatisky M, Rivera S.

Front Mol Neurosci. 2017 Jan 10;9:163. doi: 10.3389/fnmol.2016.00163. eCollection 2016.


Use of LDL receptor-targeting peptide vectors for in vitro and in vivo cargo transport across the blood-brain barrier.

Molino Y, David M, Varini K, Jabès F, Gaudin N, Fortoul A, Bakloul K, Masse M, Bernard A, Drobecq L, Lécorché P, Temsamani J, Jacquot G, Khrestchatisky M.

FASEB J. 2017 May;31(5):1807-1827. doi: 10.1096/fj.201600827R. Epub 2017 Jan 20.


Optimization and in Vivo Validation of Peptide Vectors Targeting the LDL Receptor.

Jacquot G, Lécorché P, Malcor JD, Laurencin M, Smirnova M, Varini K, Malicet C, Gassiot F, Abouzid K, Faucon A, David M, Gaudin N, Masse M, Ferracci G, Dive V, Cisternino S, Khrestchatisky M.

Mol Pharm. 2016 Dec 5;13(12):4094-4105. Epub 2016 Oct 11.


MT5-MMP, just a new APP processing proteinase in Alzheimer's disease?

Baranger K, Khrestchatisky M, Rivera S.

J Neuroinflammation. 2016 Jun 28;13(1):167. doi: 10.1186/s12974-016-0633-4.


The FVB/N mice: A well suited strain to study learning and memory processes using olfactory cues.

Girard SD, Escoffier G, Khrestchatisky M, Roman FS.

Behav Brain Res. 2016 Jan 1;296:254-259. doi: 10.1016/j.bbr.2015.09.004. Epub 2015 Sep 10.


Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders.

Féron F, Gepner B, Lacassagne E, Stephan D, Mesnage B, Blanchard MP, Boulanger N, Tardif C, Devèze A, Rousseau S, Suzuki K, Izpisua Belmonte JC, Khrestchatisky M, Nivet E, Erard-Garcia M.

Mol Psychiatry. 2016 Sep;21(9):1215-24. doi: 10.1038/mp.2015.106. Epub 2015 Aug 4.


MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.

Baranger K, Marchalant Y, Bonnet AE, Crouzin N, Carrete A, Paumier JM, Py NA, Bernard A, Bauer C, Charrat E, Moschke K, Seiki M, Vignes M, Lichtenthaler SF, Checler F, Khrestchatisky M, Rivera S.

Cell Mol Life Sci. 2016 Jan;73(1):217-36. doi: 10.1007/s00018-015-1992-1. Epub 2015 Jul 23.


Cholecalciferol (vitamin D₃) improves functional recovery when delivered during the acute phase after a spinal cord trauma.

Gueye Y, Marqueste T, Maurel F, Khrestchatisky M, Decherchi P, Feron F.

J Steroid Biochem Mol Biol. 2015 Nov;154:23-31. doi: 10.1016/j.jsbmb.2015.06.007. Epub 2015 Jul 6.


Pantethine Alters Lipid Composition and Cholesterol Content of Membrane Rafts, With Down-Regulation of CXCL12-Induced T Cell Migration.

van Gijsel-Bonnello M, Acar N, Molino Y, Bretillon L, Khrestchatisky M, de Reggi M, Gharib B.

J Cell Physiol. 2015 Oct;230(10):2415-25. doi: 10.1002/jcp.24971.


Endogenous and synthetic MMP inhibitors in CNS physiopathology.

Baranger K, Rivera S, Liechti FD, Grandgirard D, Bigas J, Seco J, Tarrago T, Leib SL, Khrestchatisky M.

Prog Brain Res. 2014;214:313-51. doi: 10.1016/B978-0-444-63486-3.00014-1. Review.


Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-amyloidogenic role of MT1-MMP.

Py NA, Bonnet AE, Bernard A, Marchalant Y, Charrat E, Checler F, Khrestchatisky M, Baranger K, Rivera S.

Front Aging Neurosci. 2014 Sep 18;6:247. doi: 10.3389/fnagi.2014.00247. eCollection 2014.


Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease.

Landel V, Baranger K, Virard I, Loriod B, Khrestchatisky M, Rivera S, Benech P, Féron F.

Mol Neurodegener. 2014 Sep 11;9:33. doi: 10.1186/1750-1326-9-33.


Low-density lipoprotein receptor-related protein-1 mediates endocytic clearance of tissue inhibitor of metalloproteinases-1 and promotes its cytokine-like activities.

Thevenard J, Verzeaux L, Devy J, Etique N, Jeanne A, Schneider C, Hachet C, Ferracci G, David M, Martiny L, Charpentier E, Khrestchatisky M, Rivera S, Dedieu S, Emonard H.

PLoS One. 2014 Jul 30;9(7):e103839. doi: 10.1371/journal.pone.0103839. eCollection 2014.


Setting-up an in vitro model of rat blood-brain barrier (BBB): a focus on BBB impermeability and receptor-mediated transport.

Molino Y, Jabès F, Lacassagne E, Gaudin N, Khrestchatisky M.

J Vis Exp. 2014 Jun 28;(88):e51278. doi: 10.3791/51278.


Dynamic expression of the polysialyltransferase in adult rat hippocampus performing an olfactory associative task.

Manrique C, Migliorati M, Gilbert V, Brezun JM, Chaillan FA, Truchet B, Khrestchatisky M, Guiraudie-Capraz G, Roman FS.

Hippocampus. 2014 Aug;24(8):979-89. doi: 10.1002/hipo.22284. Epub 2014 Apr 29.


A unique method for the isolation of nasal olfactory stem cells in living rats.

Stamegna JC, Girard SD, Veron A, Sicard G, Khrestchatisky M, Feron F, Roman FS.

Stem Cell Res. 2014 May;12(3):673-9. doi: 10.1016/j.scr.2014.02.010. Epub 2014 Mar 12.


Onset of hippocampus-dependent memory impairments in 5XFAD transgenic mouse model of Alzheimer's disease.

Girard SD, Jacquet M, Baranger K, Migliorati M, Escoffier G, Bernard A, Khrestchatisky M, Féron F, Rivera S, Roman FS, Marchetti E.

Hippocampus. 2014 Jul;24(7):762-72. doi: 10.1002/hipo.22267. Epub 2014 Mar 14.


Tissue inhibitor of matrix metalloproteinases-1 loaded poly(lactic-co-glycolic acid) nanoparticles for delivery across the blood-brain barrier.

Chaturvedi M, Molino Y, Sreedhar B, Khrestchatisky M, Kaczmarek L.

Int J Nanomedicine. 2014 Jan 20;9:575-88. doi: 10.2147/IJN.S54750. eCollection 2014.


Is TWEAK a Biomarker for Autoimmune/Chronic Inflammatory Diseases?

Bertin D, Stephan D, Khrestchatisky M, Desplat-Jégo S.

Front Immunol. 2013 Dec 27;4:489. doi: 10.3389/fimmu.2013.00489. Review.


Area-specific alterations of synaptic plasticity in the 5XFAD mouse model of Alzheimer's disease: dissociation between somatosensory cortex and hippocampus.

Crouzin N, Baranger K, Cavalier M, Marchalant Y, Cohen-Solal C, Roman FS, Khrestchatisky M, Rivera S, Féron F, Vignes M.

PLoS One. 2013 Sep 17;8(9):e74667. doi: 10.1371/journal.pone.0074667. eCollection 2013.


Cholecalciferol (vitamin D₃) improves myelination and recovery after nerve injury.

Chabas JF, Stephan D, Marqueste T, Garcia S, Lavaut MN, Nguyen C, Legre R, Khrestchatisky M, Decherchi P, Feron F.

PLoS One. 2013 May 31;8(5):e65034. doi: 10.1371/journal.pone.0065034. Print 2013.


TWEAK/Fn14 pathway modulates properties of a human microvascular endothelial cell model of blood brain barrier.

Stephan D, Sbai O, Wen J, Couraud PO, Putterman C, Khrestchatisky M, Desplat-Jégo S.

J Neuroinflammation. 2013 Jan 15;10:9. doi: 10.1186/1742-2094-10-9.


Role of matrix metalloproteinases in migration and neurotrophic properties of nasal olfactory stem and ensheathing cells.

Ould-Yahoui A, Sbai O, Baranger K, Bernard A, Gueye Y, Charrat E, Clément B, Gigmes D, Dive V, Girard SD, Féron F, Khrestchatisky M, Rivera S.

Cell Transplant. 2013;22(6):993-1010. doi: 10.3727/096368912X657468. Epub 2012 Oct 3.


Evidence for early cognitive impairment related to frontal cortex in the 5XFAD mouse model of Alzheimer's disease.

Girard SD, Baranger K, Gauthier C, Jacquet M, Bernard A, Escoffier G, Marchetti E, Khrestchatisky M, Rivera S, Roman FS.

J Alzheimers Dis. 2013;33(3):781-96. doi: 10.3233/JAD-2012-120982.


LRP-1--CD44, a new cell surface complex regulating tumor cell adhesion.

Perrot G, Langlois B, Devy J, Jeanne A, Verzeaux L, Almagro S, Sartelet H, Hachet C, Schneider C, Sick E, David M, Khrestchatisky M, Emonard H, Martiny L, Dedieu S.

Mol Cell Biol. 2012 Aug;32(16):3293-307. doi: 10.1128/MCB.00228-12. Epub 2012 Jun 18.


Medicinal chemistry based approaches and nanotechnology-based systems to improve CNS drug targeting and delivery.

Vlieghe P, Khrestchatisky M.

Med Res Rev. 2013 May;33(3):457-516. doi: 10.1002/med.21252. Epub 2012 Mar 20. Review.


Chemical optimization of new ligands of the low-density lipoprotein receptor as potential vectors for central nervous system targeting.

Malcor JD, Payrot N, David M, Faucon A, Abouzid K, Jacquot G, Floquet N, Debarbieux F, Rougon G, Martinez J, Khrestchatisky M, Vlieghe P, Lisowski V.

J Med Chem. 2012 Mar 8;55(5):2227-41. doi: 10.1021/jm2014919. Epub 2012 Feb 14.


Can the benefits of cannabinoid receptor stimulation on neuroinflammation, neurogenesis and memory during normal aging be useful in AD prevention?

Marchalant Y, Baranger K, Wenk GL, Khrestchatisky M, Rivera S.

J Neuroinflammation. 2012 Jan 16;9:10. doi: 10.1186/1742-2094-9-10.


The potential role of metalloproteinases in neurogenesis in the gerbil hippocampus following global forebrain ischemia.

Wójcik-Stanaszek L, Sypecka J, Szymczak P, Ziemka-Nalecz M, Khrestchatisky M, Rivera S, Zalewska T.

PLoS One. 2011;6(7):e22465. doi: 10.1371/journal.pone.0022465. Epub 2011 Jul 25.


Engraftment of human nasal olfactory stem cells restores neuroplasticity in mice with hippocampal lesions.

Nivet E, Vignes M, Girard SD, Pierrisnard C, Baril N, Devèze A, Magnan J, Lanté F, Khrestchatisky M, Féron F, Roman FS.

J Clin Invest. 2011 Jul;121(7):2808-20. doi: 10.1172/JCI44489. Epub 2011 Jun 13.


Vitamin D₃ improves respiratory adjustment to fatigue and H-reflex responses in paraplegic adult rats.

Bianco J, Gueye Y, Marqueste T, Alluin O, Risso JJ, Garcia S, Lavault MN, Khrestchatisky M, Feron F, Decherchi P.

Neuroscience. 2011 Aug 11;188:182-92. doi: 10.1016/j.neuroscience.2011.04.066. Epub 2011 May 7.


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