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Items: 1 to 50 of 77

1.

Influence of Maternal Aging on Mitochondrial Heterogeneity, Inheritance, and Function in Oocytes and Preimplantation Embryos.

Woods DC, Khrapko K, Tilly JL.

Genes (Basel). 2018 May 21;9(5). pii: E265. doi: 10.3390/genes9050265. Review.

2.

Impact of exercise on oocyte quality in the POLG mitochondrial DNA mutator mouse.

Faraci C, Annis S, Jin J, Li H, Khrapko K, Woods DC.

Reproduction. 2018 Aug;156(2):185-194. doi: 10.1530/REP-18-0061. Epub 2018 Jun 6.

3.

Data on the time of integration of the human mitochondrial pseudogenes (NUMTs) into the nuclear genome.

Gunbin K, Peshkin L, Popadin K, Annis S, Ackermann RR, Khrapko K.

Data Brief. 2017 May 17;13:536-544. doi: 10.1016/j.dib.2017.05.024. eCollection 2017 Aug.

4.

Integration of mtDNA pseudogenes into the nuclear genome coincides with speciation of the human genus. A hypothesis.

Gunbin K, Peshkin L, Popadin K, Annis S, Ackermann RR, Khrapko K.

Mitochondrion. 2017 May;34:20-23. doi: 10.1016/j.mito.2016.12.001. Epub 2016 Dec 12.

PMID:
27979772
5.

Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis.

Safdar A, Annis S, Kraytsberg Y, Laverack C, Saleem A, Popadin K, Woods DC, Tilly JL, Khrapko K.

Curr Opin Genet Dev. 2016 Jun;38:127-132. doi: 10.1016/j.gde.2016.06.011. Epub 2016 Aug 3. Review.

6.

Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice.

Safdar A, Khrapko K, Flynn JM, Saleem A, De Lisio M, Johnston AP, Kratysberg Y, Samjoo IA, Kitaoka Y, Ogborn DI, Little JP, Raha S, Parise G, Akhtar M, Hettinga BP, Rowe GC, Arany Z, Prolla TA, Tarnopolsky MA.

Skelet Muscle. 2016 Jan 31;6:7. doi: 10.1186/s13395-016-0075-9. eCollection 2016.

7.

ERRATUM TO: Quantitation of Mitochondrial DNA Deletions Via Restriction Digestion/Long-Range Single-Molecule PCR.

Kraytsberg Y, Guo X, Tao S, Kuznetsov A, MacLean C, Ehrlich D, Feldman E, Dombrovsky I, Yang D, Cloutier GJ, Castaneda-Sceppa C, Khrapko K.

Methods Mol Biol. 2016;1351:E1. doi: 10.1007/978-1-4939-3040-1_18. No abstract available.

PMID:
26810329
8.

Quantitation of Mitochondrial DNA Deletions Via Restriction Digestion/Long-Range Single-Molecule PCR.

Kraytsberg Y, Guo X, Tao S, Kuznetsov A, MacLean C, Ehrlich D, Feldman E, Dombrovsky I, Yang D, Cloutier GJ, Castaneda-Sceppa C, Khrapko K.

Methods Mol Biol. 2016;1351:33-46. doi: 10.1007/978-1-4939-3040-1_4. Erratum in: Methods Mol Biol. 2016;1351():E1. McLean, Catherine [Corrected to MacLean, Catherine]. Methods Mol Biol. 2016;1351:E1. McLean, Catherine [Corrected to Maclean, Catherine].

PMID:
26530673
9.

Modeling the aging heart: from local respiratory defects to global rhythm disturbances.

Khrapko K, Trayanova N, Nattel S.

Cell Metab. 2015 May 5;21(5):662-3. doi: 10.1016/j.cmet.2015.04.024.

10.

Mitochondrial DNA mutations and cancer: lessons from the parathyroid.

Popadin K, Gunbin KV, Khrapko K.

Am J Pathol. 2014 Nov;184(11):2852-4. doi: 10.1016/j.ajpath.2014.09.001. Epub 2014 Sep 19. No abstract available.

PMID:
25242389
11.

Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.

Greaves LC, Nooteboom M, Elson JL, Tuppen HA, Taylor GA, Commane DM, Arasaradnam RP, Khrapko K, Taylor RW, Kirkwood TB, Mathers JC, Turnbull DM.

PLoS Genet. 2014 Sep 18;10(9):e1004620. doi: 10.1371/journal.pgen.1004620. eCollection 2014 Sep.

12.

Mitochondrial DNA mutations in aging.

Khrapko K, Turnbull D.

Prog Mol Biol Transl Sci. 2014;127:29-62. doi: 10.1016/B978-0-12-394625-6.00002-7. Review.

PMID:
25149213
13.

When man got his mtDNA deletions?

Popadin K, Safdar A, Kraytsberg Y, Khrapko K.

Aging Cell. 2014 Aug;13(4):579-82. doi: 10.1111/acel.12231. Epub 2014 Jun 4.

14.

In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.

Amabile G, Welner RS, Nombela-Arrieta C, D'Alise AM, Di Ruscio A, Ebralidze AK, Kraytsberg Y, Ye M, Kocher O, Neuberg DS, Khrapko K, Silberstein LE, Tenen DG.

Blood. 2013 Feb 21;121(8):1255-64. doi: 10.1182/blood-2012-06-434407. Epub 2012 Dec 4.

15.

Clonally expanded mitochondrial DNA deletions within the choroid plexus in multiple sclerosis.

Campbell GR, Kraytsberg Y, Krishnan KJ, Ohno N, Ziabreva I, Reeve A, Trapp BD, Newcombe J, Reynolds R, Lassmann H, Khrapko K, Turnbull DM, Mahad DJ.

Acta Neuropathol. 2012 Aug;124(2):209-20. doi: 10.1007/s00401-012-1001-9. Epub 2012 Jun 12.

16.

The timing of mitochondrial DNA mutations in aging.

Khrapko K.

Nat Genet. 2011 Jul 27;43(8):726-7. doi: 10.1038/ng.895. No abstract available.

17.

Distinct patterns of mitochondrial genome diversity in bonobos (Pan paniscus) and humans.

Zsurka G, Kudina T, Peeva V, Hallmann K, Elger CE, Khrapko K, Kunz WS.

BMC Evol Biol. 2010 Sep 2;10:270. doi: 10.1186/1471-2148-10-270.

18.

Repeats, longevity and the sources of mtDNA deletions: evidence from 'deletional spectra'.

Guo X, Popadin KY, Markuzon N, Orlov YL, Kraytsberg Y, Krishnan KJ, Zsurka G, Turnbull DM, Kunz WS, Khrapko K.

Trends Genet. 2010 Aug;26(8):340-3. doi: 10.1016/j.tig.2010.05.006. Epub 2010 Jun 28.

19.

Age-related gene-specific changes of A-to-I mRNA editing in the human brain.

Nicholas A, de Magalhaes JP, Kraytsberg Y, Richfield EK, Levanon EY, Khrapko K.

Mech Ageing Dev. 2010 Jun;131(6):445-7. doi: 10.1016/j.mad.2010.06.001. Epub 2010 Jun 9.

20.

Mitochondrial DNA deletions in mice in men: substantia nigra is much less affected in the mouse.

Guo X, Kudryavtseva E, Bodyak N, Nicholas A, Dombrovsky I, Yang D, Kraytsberg Y, Simon DK, Khrapko K.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1159-62. doi: 10.1016/j.bbabio.2010.04.005. Epub 2010 Apr 11.

21.

Quantification of mitochondrial DNA mutation load.

Greaves LC, Beadle NE, Taylor GA, Commane D, Mathers JC, Khrapko K, Turnbull DM.

Aging Cell. 2009 Sep;8(5):566-72. doi: 10.1111/j.1474-9726.2009.00505.x. Epub 2009 Jul 18.

22.

Quantitative analysis of somatic mitochondrial DNA mutations by single-cell single-molecule PCR.

Kraytsberg Y, Bodyak N, Myerow S, Nicholas A, Ebralidze K, Khrapko K.

Methods Mol Biol. 2009;554:329-69. doi: 10.1007/978-1-59745-521-3_21.

PMID:
19513684
23.

Collection of isolated cells for studying mitochondrial DNA mutations within individual cells.

Kraytsberg Y, Bodyak N, Myerow S, Nicholas A, Ebralidze K, Khrapko K.

Methods Mol Biol. 2009;554:315-27. doi: 10.1007/978-1-59745-521-3_20.

PMID:
19513683
24.

On the timing and the extent of clonal expansion of mtDNA deletions: evidence from single-molecule PCR.

Nicholas A, Kraytsberg Y, Guo X, Khrapko K.

Exp Neurol. 2009 Aug;218(2):316-9. doi: 10.1016/j.expneurol.2009.04.029. Epub 2009 May 6.

25.

Do mtDNA deletions drive premature aging in mtDNA mutator mice?

Kraytsberg Y, Simon DK, Turnbull DM, Khrapko K.

Aging Cell. 2009 Aug;8(4):502-6. doi: 10.1111/j.1474-9726.2009.00484.x. Epub 2009 Apr 22.

26.

Mitochondrial DNA mutations and aging: devils in the details?

Khrapko K, Vijg J.

Trends Genet. 2009 Feb;25(2):91-8. doi: 10.1016/j.tig.2008.11.007. Epub 2008 Dec 26. Review.

27.

Single molecule PCR in mtDNA mutational analysis: Genuine mutations vs. damage bypass-derived artifacts.

Kraytsberg Y, Nicholas A, Caro P, Khrapko K.

Methods. 2008 Dec;46(4):269-73. doi: 10.1016/j.ymeth.2008.10.005. Epub 2008 Oct 26.

28.

Analysis of mutational spectra by denaturing capillary electrophoresis.

Ekstrøm PO, Khrapko K, Li-Sucholeiki XC, Hunter IW, Thilly WG.

Nat Protoc. 2008;3(7):1153-66. doi: 10.1038/nprot.2008.79.

29.

Two ways to make an mtDNA bottleneck.

Khrapko K.

Nat Genet. 2008 Feb;40(2):134-5. doi: 10.1038/ng0208-134. No abstract available.

30.

Are somatic mitochondrial DNA mutations relevant to our health? A challenge for mutation analysis techniques.

Kraytsberg Y, Nicholas A, Khrapko K.

Expert Opin Med Diagn. 2007 Sep;1(1):109-16. doi: 10.1517/17530059.1.1.109.

PMID:
23489273
31.

The complexity of aging: are some aging processes more equal than others?

Khrapko K.

Mech Ageing Dev. 2007 Jul-Aug;128(7-8):463-5. Epub 2007 May 21. Review.

32.

Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S-transferase mRNAs.

Morozova N, Khrapko K, Panee J, Liu W, Harney JW, Berry MJ.

Genes Cells. 2007 May;12(5):561-7.

33.

Mitochondrial DNA mutations and aging: a case closed?

Khrapko K, Vijg J.

Nat Genet. 2007 Apr;39(4):445-6. No abstract available.

PMID:
17392805
34.

Inheritance of mitochondrial DNA recombinants in double-heteroplasmic families: potential implications for phylogenetic analysis.

Zsurka G, Hampel KG, Kudina T, Kornblum C, Kraytsberg Y, Elger CE, Khrapko K, Kunz WS.

Am J Hum Genet. 2007 Feb;80(2):298-305. Epub 2006 Dec 27.

35.

Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging?

Khrapko K, Kraytsberg Y, de Grey AD, Vijg J, Schon EA.

Aging Cell. 2006 Jun;5(3):279-82.

36.

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons.

Kraytsberg Y, Kudryavtseva E, McKee AC, Geula C, Kowall NW, Khrapko K.

Nat Genet. 2006 May;38(5):518-20. Epub 2006 Apr 9.

PMID:
16604072
37.

Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors.

Zheng W, Khrapko K, Coller HA, Thilly WG, Copeland WC.

Mutat Res. 2006 Jul 25;599(1-2):11-20. Epub 2006 Feb 20.

PMID:
16490220
38.

Single-molecule PCR: an artifact-free PCR approach for the analysis of somatic mutations.

Kraytsberg Y, Khrapko K.

Expert Rev Mol Diagn. 2005 Sep;5(5):809-15. Review.

PMID:
16149882
39.

Recombination of mitochondrial DNA in skeletal muscle of individuals with multiple mitochondrial DNA heteroplasmy.

Zsurka G, Kraytsberg Y, Kudina T, Kornblum C, Elger CE, Khrapko K, Kunz WS.

Nat Genet. 2005 Aug;37(8):873-7. Epub 2005 Jul 17.

40.

Clustering of mutant mitochondrial DNA copies suggests stem cells are common in human bronchial epithelium.

Coller HA, Khrapko K, Herrero-Jimenez P, Vatland JA, Li-Sucholeiki XC, Thilly WG.

Mutat Res. 2005 Oct 15;578(1-2):256-71. Epub 2005 Jul 11.

PMID:
16009384
41.

Mitochondrial DNA gene therapy: a gene therapy for aging?

Khrapko K.

Rejuvenation Res. 2005 Spring;8(1):6-8.

PMID:
15798368
42.

Where and when do somatic mtDNA mutations occur?

Khrapko K, Ebralidse K, Kraytsberg Y.

Ann N Y Acad Sci. 2004 Jun;1019:240-4. Review.

PMID:
15247022
43.

Recombination of human mitochondrial DNA.

Kraytsberg Y, Schwartz M, Brown TA, Ebralidse K, Kunz WS, Clayton DA, Vissing J, Khrapko K.

Science. 2004 May 14;304(5673):981. No abstract available.

44.

A microRNA array reveals extensive regulation of microRNAs during brain development.

Krichevsky AM, King KS, Donahue CP, Khrapko K, Kosik KS.

RNA. 2003 Oct;9(10):1274-81. Erratum in: RNA. 2004 Mar;10(3):551.

45.

Mutation and intracellular clonal expansion of mitochondrial genomes: two synergistic components of the aging process?

Kraytsberg Y, Nekhaeva E, Bodyak NB, Khrapko K.

Mech Ageing Dev. 2003 Jan;124(1):49-53. Review.

PMID:
12618006
46.

Clonal expansions of mitochondrial genomes: implications for in vivo mutational spectra.

Khrapko K, Nekhaeva E, Kraytsberg Y, Kunz W.

Mutat Res. 2003 Jan 28;522(1-2):13-9. Review.

PMID:
12517407
47.

Gene expression profiling of the aging mouse cardiac myocytes.

Bodyak N, Kang PM, Hiromura M, Sulijoadikusumo I, Horikoshi N, Khrapko K, Usheva A.

Nucleic Acids Res. 2002 Sep 1;30(17):3788-94.

48.

mtLOH (mitochondrial loss of heteroplasmy), aging, and 'surrogate self'.

Nekhaeva E, Kraytsberg Y, Khrapko K.

Mech Ageing Dev. 2002 Apr 30;123(8):891-8. Review.

PMID:
12044937
49.

Frequent intracellular clonal expansions of somatic mtDNA mutations: significance and mechanisms.

Coller HA, Bodyak ND, Khrapko K.

Ann N Y Acad Sci. 2002 Apr;959:434-47.

PMID:
11976216
50.

Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues.

Nekhaeva E, Bodyak ND, Kraytsberg Y, McGrath SB, Van Orsouw NJ, Pluzhnikov A, Wei JY, Vijg J, Khrapko K.

Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5521-6. Epub 2002 Apr 9.

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