Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 40

1.

Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain.

Parisien M, Samoshkin A, Tansley SN, Piltonen MH, Martin LJ, El-Hachem N, Dagostino C, Allegri M, Mogil JS, Khoutorsky A, Diatchenko L.

Pain. 2019 Apr;160(4):932-944. doi: 10.1097/j.pain.0000000000001471.

PMID:
30763288
2.

eIF4E-Dependent Translational Control: A Central Mechanism for Regulation of Pain Plasticity.

Uttam S, Wong C, Price TJ, Khoutorsky A.

Front Genet. 2018 Oct 24;9:470. doi: 10.3389/fgene.2018.00470. eCollection 2018. Review.

3.

Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain.

Megat S, Ray PR, Moy JK, Lou TF, Barragán-Iglesias P, Li Y, Pradhan G, Wanghzou A, Ahmad A, Burton MD, North RY, Dougherty PM, Khoutorsky A, Sonenberg N, Webster KR, Dussor G, Campbell ZT, Price TJ.

J Neurosci. 2019 Jan 16;39(3):393-411. doi: 10.1523/JNEUROSCI.2661-18.2018. Epub 2018 Nov 20.

PMID:
30459229
4.

Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders.

Gantois I, Popic J, Khoutorsky A, Sonenberg N.

Annu Rev Med. 2019 Jan 27;70:167-181. doi: 10.1146/annurev-med-081117-041238. Epub 2018 Oct 26.

PMID:
30365357
5.

Translation deregulation in human disease.

Tahmasebi S, Khoutorsky A, Mathews MB, Sonenberg N.

Nat Rev Mol Cell Biol. 2018 Dec;19(12):791-807. doi: 10.1038/s41580-018-0034-x. Review.

PMID:
30038383
6.

eIF4E Phosphorylation Influences Bdnf mRNA Translation in Mouse Dorsal Root Ganglion Neurons.

Moy JK, Khoutorsky A, Asiedu MN, Dussor G, Price TJ.

Front Cell Neurosci. 2018 Feb 6;12:29. doi: 10.3389/fncel.2018.00029. eCollection 2018.

7.

Translational control of ERK signaling through miRNA/4EHP-directed silencing.

Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N.

Elife. 2018 Feb 7;7. pii: e35034. doi: 10.7554/eLife.35034.

8.

Translational Control Mechanisms in Persistent Pain.

Khoutorsky A, Price TJ.

Trends Neurosci. 2018 Feb;41(2):100-114. doi: 10.1016/j.tins.2017.11.006. Review.

9.

Epiregulin and EGFR interactions are involved in pain processing.

Martin LJ, Smith SB, Khoutorsky A, Magnussen CA, Samoshkin A, Sorge RE, Cho C, Yosefpour N, Sivaselvachandran S, Tohyama S, Cole T, Khuong TM, Mir E, Gibson DG, Wieskopf JS, Sotocinal SG, Austin JS, Meloto CB, Gitt JH, Gkogkas C, Sonenberg N, Greenspan JD, Fillingim RB, Ohrbach R, Slade GD, Knott C, Dubner R, Nackley AG, Ribeiro-da-Silva A, Neely GG, Maixner W, Zaykin DV, Mogil JS, Diatchenko L.

J Clin Invest. 2017 Sep 1;127(9):3353-3366. doi: 10.1172/JCI87406. Epub 2017 Aug 7.

10.

The MNK-eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain.

Moy JK, Khoutorsky A, Asiedu MN, Black BJ, Kuhn JL, Barragán-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio JJ, Mogil JS, Dussor G, Sonenberg N, Price TJ.

J Neurosci. 2017 Aug 2;37(31):7481-7499. doi: 10.1523/JNEUROSCI.0220-17.2017. Epub 2017 Jul 3.

11.

Metformin ameliorates core deficits in a mouse model of fragile X syndrome.

Gantois I, Khoutorsky A, Popic J, Aguilar-Valles A, Freemantle E, Cao R, Sharma V, Pooters T, Nagpal A, Skalecka A, Truong VT, Wiebe S, Groves IA, Jafarnejad SM, Chapat C, McCullagh EA, Gamache K, Nader K, Lacaille JC, Gkogkas CG, Sonenberg N.

Nat Med. 2017 Jun;23(6):674-677. doi: 10.1038/nm.4335. Epub 2017 May 15.

PMID:
28504725
12.

Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes.

Tuttle AH, Tansley S, Dossett K, Tohyama S, Khoutorsky A, Maldonado-Bouchard S, Stein L, Gerstein L, Crawhall-Duk H, Pearl R, Sukosd M, Leger P, Hardt OM, Yachnin D, Austin JS, Chan CM, Pooters T, Groves I, Martin LJ, Sonenberg N, Gkogkas CG, Mogil JS.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5515-5520. doi: 10.1073/pnas.1703477114. Epub 2017 May 8.

13.

Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2.

Tahmasebi S, Jafarnejad SM, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, Bourque G, Yang XJ, Tian B, Stunnenberg HG, Yamanaka Y, Blencowe BJ, Giguère V, Sonenberg N.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12360-12367. Epub 2016 Oct 24.

14.

eIF2α phosphorylation controls thermal nociception.

Khoutorsky A, Sorge RE, Prager-Khoutorsky M, Pawlowski SA, Longo G, Jafarnejad SM, Tahmasebi S, Martin LJ, Pitcher MH, Gkogkas CG, Sharif-Naeini R, Ribeiro-da-Silva A, Bourque CW, Cervero F, Mogil JS, Sonenberg N.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11949-11954. Epub 2016 Oct 3.

15.

mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons.

Skalecka A, Liszewska E, Bilinski R, Gkogkas C, Khoutorsky A, Malik AR, Sonenberg N, Jaworski J.

Dev Neurobiol. 2016 Dec;76(12):1308-1327. doi: 10.1002/dneu.22392. Epub 2016 Apr 7.

16.

Translational control of nociception via 4E-binding protein 1.

Khoutorsky A, Bonin RP, Sorge RE, Gkogkas CG, Pawlowski SA, Jafarnejad SM, Pitcher MH, Alain T, Perez-Sanchez J, Salter EW, Martin L, Ribeiro-da-Silva A, De Koninck Y, Cervero F, Mogil JS, Sonenberg N.

Elife. 2015 Dec 18;4. pii: e12002. doi: 10.7554/eLife.12002.

17.

Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2.

Aguilar-Valles A, Matta-Camacho E, Khoutorsky A, Gkogkas C, Nader K, Lacaille JC, Sonenberg N.

J Neurosci. 2015 Aug 5;35(31):11125-32. doi: 10.1523/JNEUROSCI.4615-14.2015.

18.

mTORC2 Balances AKT Activation and eIF2α Serine 51 Phosphorylation to Promote Survival under Stress.

Tenkerian C, Krishnamoorthy J, Mounir Z, Kazimierczak U, Khoutorsky A, Staschke KA, Kristof AS, Wang S, Hatzoglou M, Koromilas AE.

Mol Cancer Res. 2015 Oct;13(10):1377-88. doi: 10.1158/1541-7786.MCR-15-0184-T. Epub 2015 Jun 30.

19.

Translational control of chronic pain.

Melemedjian OK, Khoutorsky A.

Prog Mol Biol Transl Sci. 2015;131:185-213. doi: 10.1016/bs.pmbts.2014.11.006. Epub 2015 Jan 30. Review.

PMID:
25744674
20.

Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes.

Gkogkas CG, Khoutorsky A, Cao R, Jafarnejad SM, Prager-Khoutorsky M, Giannakas N, Kaminari A, Fragkouli A, Nader K, Price TJ, Konicek BW, Graff JR, Tzinia AK, Lacaille JC, Sonenberg N.

Cell Rep. 2014 Dec 11;9(5):1742-1755. doi: 10.1016/j.celrep.2014.10.064. Epub 2014 Nov 26.

21.

Unique interweaved microtubule scaffold mediates osmosensory transduction via physical interaction with TRPV1.

Prager-Khoutorsky M, Khoutorsky A, Bourque CW.

Neuron. 2014 Aug 20;83(4):866-78. doi: 10.1016/j.neuron.2014.07.023. Epub 2014 Aug 7.

22.

Multifaceted regulation of somatic cell reprogramming by mRNA translational control.

Tahmasebi S, Alain T, Rajasekhar VK, Zhang JP, Prager-Khoutorsky M, Khoutorsky A, Dogan Y, Gkogkas CG, Petroulakis E, Sylvestre A, Ghorbani M, Assadian S, Yamanaka Y, Vinagolu-Baur JR, Teodoro JG, Kim K, Yang XJ, Sonenberg N.

Cell Stem Cell. 2014 May 1;14(5):606-16. doi: 10.1016/j.stem.2014.02.005. Epub 2014 Mar 13.

23.

Reactivation of stalled polyribosomes in synaptic plasticity.

Graber TE, Hébert-Seropian S, Khoutorsky A, David A, Yewdell JW, Lacaille JC, Sossin WS.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16205-10. doi: 10.1073/pnas.1307747110. Epub 2013 Sep 16.

24.

Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling.

Cao R, Robinson B, Xu H, Gkogkas C, Khoutorsky A, Alain T, Yanagiya A, Nevarko T, Liu AC, Amir S, Sonenberg N.

Neuron. 2013 Aug 21;79(4):712-24. doi: 10.1016/j.neuron.2013.06.026.

25.

Pharmacological brake-release of mRNA translation enhances cognitive memory.

Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, Renslo AR, Sonenberg N, Walter P.

Elife. 2013 May 28;2:e00498. doi: 10.7554/eLife.00498.

26.

Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q.

Svitkin YV, Yanagiya A, Karetnikov AE, Alain T, Fabian MR, Khoutorsky A, Perreault S, Topisirovic I, Sonenberg N.

PLoS Biol. 2013;11(5):e1001564. doi: 10.1371/journal.pbio.1001564. Epub 2013 May 21.

27.

Control of synaptic plasticity and memory via suppression of poly(A)-binding protein.

Khoutorsky A, Yanagiya A, Gkogkas CG, Fabian MR, Prager-Khoutorsky M, Cao R, Gamache K, Bouthiette F, Parsyan A, Sorge RE, Mogil JS, Nader K, Lacaille JC, Sonenberg N.

Neuron. 2013 Apr 24;78(2):298-311. doi: 10.1016/j.neuron.2013.02.025.

28.

mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.

Melemedjian OK, Khoutorsky A, Sorge RE, Yan J, Asiedu MN, Valdez A, Ghosh S, Dussor G, Mogil JS, Sonenberg N, Price TJ.

Pain. 2013 Jul;154(7):1080-91. doi: 10.1016/j.pain.2013.03.021. Epub 2013 Mar 15.

29.

Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver.

Chaveroux C, Eichner LJ, Dufour CR, Shatnawi A, Khoutorsky A, Bourque G, Sonenberg N, Giguère V.

Cell Metab. 2013 Apr 2;17(4):586-98. doi: 10.1016/j.cmet.2013.03.003.

30.

The Yin and Yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene.

Sorge RE, LaCroix-Fralish ML, Tuttle AH, Khoutorsky A, Sotocinal SG, Austin JS, Melmed K, Labialle S, Schmidt JV, Wood JN, Naumova AK, Mogil JS.

Genes Brain Behav. 2013 Jun;12(4):405-13. doi: 10.1111/gbb.12030. Epub 2013 Mar 19.

31.

Selective regulation of GluA subunit synthesis and AMPA receptor-mediated synaptic function and plasticity by the translation repressor 4E-BP2 in hippocampal pyramidal cells.

Ran I, Gkogkas CG, Vasuta C, Tartas M, Khoutorsky A, Laplante I, Parsyan A, Nevarko T, Sonenberg N, Lacaille JC.

J Neurosci. 2013 Jan 30;33(5):1872-86. doi: 10.1523/JNEUROSCI.3264-12.2013.

32.

Autism-related deficits via dysregulated eIF4E-dependent translational control.

Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N.

Nature. 2013 Jan 17;493(7432):371-7. doi: 10.1038/nature11628. Epub 2012 Nov 21.

33.

Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain.

Melemedjian OK, Asiedu MN, Tillu DV, Sanoja R, Yan J, Lark A, Khoutorsky A, Johnson J, Peebles KA, Lepow T, Sonenberg N, Dussor G, Price TJ.

Mol Pain. 2011 Sep 21;7:70. doi: 10.1186/1744-8069-7-70.

34.

Formation of hydrophilic nanochannels in the membrane of living cells by the ringlike stable protein-SP1.

Khoutorsky A, Heyman A, Shoseyov O, Spira ME.

Nano Lett. 2011 Jul 13;11(7):2901-4. doi: 10.1021/nl201368w. Epub 2011 Jun 9.

PMID:
21651305
35.

Activity-dependent calpain activation plays a critical role in synaptic facilitation and post-tetanic potentiation.

Khoutorsky A, Spira ME.

Learn Mem. 2009 Jan 29;16(2):129-41. doi: 10.1101/lm.1275709. Print 2009 Feb.

PMID:
19181619
36.

Calpain inhibitors alter the excitable membrane properties of cultured aplysia neurons.

Khoutorsky A, Spira ME.

J Neurophysiol. 2008 Nov;100(5):2784-93. doi: 10.1152/jn.90487.2008. Epub 2008 Aug 6.

37.

Transient leucopenia, thrombocytopenia and anaemia associated with severe acute phenobarbital intoxication in a dog.

Khoutorsky A, Bruchim Y.

J Small Anim Pract. 2008 Jul;49(7):367-9. doi: 10.1111/j.1748-5827.2008.00564.x.

PMID:
18482327
38.

On-line confocal imaging of the events leading to structural dedifferentiation of an axonal segment into a growth cone after axotomy.

Sahly I, Khoutorsky A, Erez H, Prager-Khoutorsky M, Spira ME.

J Comp Neurol. 2006 Feb 10;494(5):705-20.

PMID:
16374810
40.

Effective expression of the green fluorescent fusion proteins in cultured Aplysia neurons.

Sahly I, Erez H, Khoutorsky A, Shapira E, Spira ME.

J Neurosci Methods. 2003 Jun 30;126(2):111-7.

PMID:
12814835

Supplemental Content

Loading ...
Support Center