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Items: 1 to 50 of 74

1.

Aggregation determines the selectivity of membrane-active anticancer and antimicrobial peptides: The case of killerFLIP.

Vaezi Z, Bortolotti A, Luca V, Perilli G, Mangoni ML, Khosravi-Far R, Bobone S, Stella L.

Biochim Biophys Acta Biomembr. 2020 Feb 1;1862(2):183107. doi: 10.1016/j.bbamem.2019.183107. Epub 2019 Oct 31.

PMID:
31678022
2.

A Peroxidase Peroxiredoxin 1-Specific Redox Regulation of the Novel FOXO3 microRNA Target let-7.

Hopkins BL, Nadler M, Skoko JJ, Bertomeu T, Pelosi A, Shafaei PM, Levine K, Schempf A, Pennarun B, Yang B, Datta D, Bucur O, Ndebele K, Oesterreich S, Yang D, Giulia Rizzo M, Khosravi-Far R, Neumann CA.

Antioxid Redox Signal. 2018 Jan 1;28(1):62-77. doi: 10.1089/ars.2016.6871. Epub 2017 May 1.

3.

Changes in membrane lipids drive increased endocytosis following Fas ligation.

Degli Esposti M, Matarrese P, Tinari A, Longo A, Recalchi S, Khosravi-Far R, Malorni W, Misasi R, Garofalo T, Sorice M.

Apoptosis. 2017 May;22(5):681-695. doi: 10.1007/s10495-017-1362-6.

PMID:
28299505
4.

Meta-analysis of transcriptome data identifies a novel 5-gene pancreatic adenocarcinoma classifier.

Bhasin MK, Ndebele K, Bucur O, Yee EU, Otu HH, Plati J, Bullock A, Gu X, Castan E, Zhang P, Najarian R, Muraru MS, Miksad R, Khosravi-Far R, Libermann TA.

Oncotarget. 2016 Apr 26;7(17):23263-81. doi: 10.18632/oncotarget.8139.

5.

A novel caspase 8 selective small molecule potentiates TRAIL-induced cell death.

Bucur O, Gaidos G, Yatawara A, Pennarun B, Rupasinghe C, Roux J, Andrei S, Guo B, Panaitiu A, Pellegrini M, Mierke DF, Khosravi-Far R.

Sci Rep. 2015 May 11;5:9893. doi: 10.1038/srep09893.

6.

PLK1 is a binding partner and a negative regulator of FOXO3 tumor suppressor.

Bucur O, Stancu AL, Muraru MS, Melet A, Petrescu SM, Khosravi-Far R.

Discoveries (Craiova). 2014 Apr-Jun;2(2). pii: e16.

7.

Blocks to thyroid cancer cell apoptosis can be overcome by inhibition of the MAPK and PI3K/AKT pathways.

Gunda V, Bucur O, Varnau J, Vanden Borre P, Bernasconi MJ, Khosravi-Far R, Parangi S.

Cell Death Dis. 2014 Mar 6;5:e1104. doi: 10.1038/cddis.2014.78.

8.

killerFLIP: a novel lytic peptide specifically inducing cancer cell death.

Pennarun B, Gaidos G, Bucur O, Tinari A, Rupasinghe C, Jin T, Dewar R, Song K, Santos MT, Malorni W, Mierke D, Khosravi-Far R.

Cell Death Dis. 2013 Oct 31;4:e894. doi: 10.1038/cddis.2013.401.

9.

Combination of bortezomib and mitotic inhibitors down-modulate Bcr-Abl and efficiently eliminates tyrosine-kinase inhibitor sensitive and resistant Bcr-Abl-positive leukemic cells.

Bucur O, Stancu AL, Goganau I, Petrescu SM, Pennarun B, Bertomeu T, Dewar R, Khosravi-Far R.

PLoS One. 2013 Oct 14;8(10):e77390. doi: 10.1371/journal.pone.0077390. eCollection 2013.

10.

Poor antibody validation is a challenge in biomedical research: a case study for detection of c-FLIP.

Bucur O, Pennarun B, Stancu AL, Nadler M, Muraru MS, Bertomeu T, Khosravi-Far R.

Apoptosis. 2013 Oct;18(10):1154-62. doi: 10.1007/s10495-013-0880-0.

PMID:
23917691
11.

Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications.

Bucur O, Stancu AL, Khosravi-Far R, Almasan A.

Cell Death Dis. 2012 Feb 2;3:e263. doi: 10.1038/cddis.2012.2. No abstract available.

12.

Harnessing the tumor suppressor function of FOXO as an alternative therapeutic approach in cancer.

Singh A, Plati J, Khosravi-Far R.

Curr Drug Targets. 2011 Aug;12(9):1311-21. Review.

PMID:
21443464
13.

Priming of the vascular endothelial growth factor signaling pathway by thrombospondin-1, CD36, and spleen tyrosine kinase.

Kazerounian S, Duquette M, Reyes MA, Lawler JT, Song K, Perruzzi C, Primo L, Khosravi-Far R, Bussolino F, Rabinovitz I, Lawler J.

Blood. 2011 Apr 28;117(17):4658-66. doi: 10.1182/blood-2010-09-305284. Epub 2011 Mar 4.

14.

Apoptotic cell signaling in cancer progression and therapy.

Plati J, Bucur O, Khosravi-Far R.

Integr Biol (Camb). 2011 Apr;3(4):279-96. doi: 10.1039/c0ib00144a. Epub 2011 Feb 22. Review.

15.

Bortezomib treatment causes remission in a Ph+ALL patient and reveals FoxO as a theranostic marker.

Dewar R, Chen ST, Yeckes-Rodin H, Miller K, Khosravi-Far R.

Cancer Biol Ther. 2011 Mar 15;11(6):552-8. Epub 2011 Mar 15.

16.

Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants.

Weisberg E, Choi HG, Ray A, Barrett R, Zhang J, Sim T, Zhou W, Seeliger M, Cameron M, Azam M, Fletcher JA, Debiec-Rychter M, Mayeda M, Moreno D, Kung AL, Janne PA, Khosravi-Far R, Melo JV, Manley PW, Adamia S, Wu C, Gray N, Griffin JD.

Blood. 2010 May 27;115(21):4206-16. doi: 10.1182/blood-2009-11-251751. Epub 2010 Mar 18.

17.

Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT.

Singh A, Ye M, Bucur O, Zhu S, Tanya Santos M, Rabinovitz I, Wei W, Gao D, Hahn WC, Khosravi-Far R.

Mol Biol Cell. 2010 Mar 15;21(6):1140-52. doi: 10.1091/mbc.E09-09-0795. Epub 2010 Jan 28.

18.

Proteasome inhibition causes regression of leukemia and abrogates BCR-ABL-induced evasion of apoptosis in part through regulation of forkhead tumor suppressors.

Jagani Z, Song K, Kutok JL, Dewar MR, Melet A, Santos T, Grassian A, Ghaffari S, Wu C, Yeckes-Rodin H, Ren R, Miller K, Khosravi-Far R.

Cancer Res. 2009 Aug 15;69(16):6546-55. doi: 10.1158/0008-5472.CAN-09-0605. Epub 2009 Aug 4. Erratum in: Cancer Res. 2009 Sep 1;69(17):7130. Rodin, Heather Yeckes [corrected to Yeckes-Rodin, Heather].

19.

A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR.

Ren B, Song K, Parangi S, Jin T, Ye M, Humphreys R, Duquette M, Zhang X, Benhaga N, Lawler J, Khosravi-Far R.

Cancer Res. 2009 May 1;69(9):3856-65. doi: 10.1158/0008-5472.CAN-08-2940. Epub 2009 Apr 14.

20.

Fas death receptor enhances endocytic membrane traffic converging into the Golgi region.

Degli Esposti M, Tour J, Ouasti S, Ivanova S, Matarrese P, Malorni W, Khosravi-Far R.

Mol Biol Cell. 2009 Jan;20(2):600-15. doi: 10.1091/mbc.E08-09-0925. Epub 2008 Nov 26.

21.

Analysis of TNF-related apoptosis-inducing ligand in vivo through bone marrow transduction and transplantation.

Song K, Mariappan R, Khosravi-Far R.

Methods Enzymol. 2008;446:315-31. doi: 10.1016/S0076-6879(08)01619-4.

PMID:
18603131
22.

Methods in enzymolology book on cell death.

Khosravi-Far R, Zakeri Z, Lockshin RA, Piacentini M.

Methods Enzymol. 2008;446:xxi-xxii. doi: 10.1016/S0076-6879(08)01626-1. No abstract available.

PMID:
18603112
23.

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced mitochondrial pathway to apoptosis and caspase activation is potentiated by phospholipid scramblase-3.

Ndebele K, Gona P, Jin TG, Benhaga N, Chalah A, Degli-Esposti M, Khosravi-Far R.

Apoptosis. 2008 Jul;13(7):845-56. doi: 10.1007/s10495-008-0219-4.

24.

Dysregulation of apoptotic signaling in cancer: molecular mechanisms and therapeutic opportunities.

Plati J, Bucur O, Khosravi-Far R.

J Cell Biochem. 2008 Jul 1;104(4):1124-49. doi: 10.1002/jcb.21707. Review.

25.

Endosomal compartment contributes to the propagation of CD95/Fas-mediated signals in type II cells.

Matarrese P, Manganelli V, Garofalo T, Tinari A, Gambardella L, Ndebele K, Khosravi-Far R, Sorice M, Esposti MD, Malorni W.

Biochem J. 2008 Aug 1;413(3):467-78. doi: 10.1042/BJ20071704.

26.

Cancer stem cells and impaired apoptosis.

Jagani Z, Khosravi-Far R.

Adv Exp Med Biol. 2008;615:331-44. doi: 10.1007/978-1-4020-6554-5_15. Review.

PMID:
18437901
27.

Apoptotic pathways in tumor progression and therapy.

Melet A, Song K, Bucur O, Jagani Z, Grassian AR, Khosravi-Far R.

Adv Exp Med Biol. 2008;615:47-79. doi: 10.1007/978-1-4020-6554-5_4. Review.

PMID:
18437891
28.

The mitochondrial death pathway.

Chalah A, Khosravi-Far R.

Adv Exp Med Biol. 2008;615:25-45. doi: 10.1007/978-1-4020-6554-5_3. Review.

PMID:
18437890
29.

Neuropilin-1 modulates p53/caspases axis to promote endothelial cell survival.

Wang L, Dutta SK, Kojima T, Xu X, Khosravi-Far R, Ekker SC, Mukhopadhyay D.

PLoS One. 2007 Nov 14;2(11):e1161.

30.

FoxO tumor suppressors and BCR-ABL-induced leukemia: a matter of evasion of apoptosis.

Jagani Z, Singh A, Khosravi-Far R.

Biochim Biophys Acta. 2008 Jan;1785(1):63-84. Epub 2007 Oct 16. Review.

31.

c-Fos as a proapoptotic agent in TRAIL-induced apoptosis in prostate cancer cells.

Zhang X, Zhang L, Yang H, Huang X, Otu H, Libermann TA, DeWolf WC, Khosravi-Far R, Olumi AF.

Cancer Res. 2007 Oct 1;67(19):9425-34.

32.

CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.

Brown L, Ongusaha PP, Kim HG, Nuti S, Mandinova A, Lee JW, Khosravi-Far R, Aaronson SA, Lee SW.

EMBO J. 2007 Jul 25;26(14):3410-22. Epub 2007 Jun 28.

33.

Death receptor ligation triggers membrane scrambling between Golgi and mitochondria.

Ouasti S, Matarrese P, Paddon R, Khosravi-Far R, Sorice M, Tinari A, Malorni W, Degli Esposti M.

Cell Death Differ. 2007 Mar;14(3):453-61. Epub 2006 Sep 29.

34.
35.

Activation of extracellular signal-regulated protein kinase 5 downregulates FasL upon osmotic stress.

Wang X, Finegan KG, Robinson AC, Knowles L, Khosravi-Far R, Hinchliffe KA, Boot-Handford RP, Tournier C.

Cell Death Differ. 2006 Dec;13(12):2099-108. Epub 2006 May 19.

36.

Quest for molecular markers in adult soft tissue tumors.

Song K, Khosravi-Far R.

Cancer Biol Ther. 2006 Feb;5(2):234-5. Epub 2006 Feb 2. No abstract available.

PMID:
16481736
37.

Regulation of tumor angiogenesis by thrombospondin-1.

Ren B, Yee KO, Lawler J, Khosravi-Far R.

Biochim Biophys Acta. 2006 Apr;1765(2):178-88. Epub 2005 Dec 21. Review.

PMID:
16406676
38.

Tumor necrosis factor-related apoptosis-inducing ligand alters mitochondrial membrane lipids.

Sandra F, Degli Esposti M, Ndebele K, Gona P, Knight D, Rosenquist M, Khosravi-Far R.

Cancer Res. 2005 Sep 15;65(18):8286-97.

39.

Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family.

Persson S, Rosenquist M, Knoblach B, Khosravi-Far R, Sommarin M, Michalak M.

Mol Phylogenet Evol. 2005 Sep;36(3):734-40. No abstract available.

PMID:
15935701
40.

Death receptor signals to mitochondria.

Khosravi-Far R, Esposti MD.

Cancer Biol Ther. 2004 Nov;3(11):1051-7. Epub 2004 Nov 18. Review.

41.

Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer.

Goonesinghe A, Mundy ES, Smith M, Khosravi-Far R, Martinou JC, Esposti MD.

Biochem J. 2005 Apr 1;387(Pt 1):109-18.

42.

Fas-associated protein with death domain (FADD)-independent recruitment of c-FLIPL to death receptor 5.

Jin TG, Kurakin A, Benhaga N, Abe K, Mohseni M, Sandra F, Song K, Kay BK, Khosravi-Far R.

J Biol Chem. 2004 Dec 31;279(53):55594-601. Epub 2004 Oct 14.

44.

Severe hepatic injury in interleukin 18 (IL-18) transgenic mice: a key role for IL-18 in regulating hepatocyte apoptosis in vivo.

Finotto S, Siebler J, Hausding M, Schipp M, Wirtz S, Klein S, Protschka M, Doganci A, Lehr HA, Trautwein C, Khosravi-Far R, Strand D, Lohse A, Galle PR, Blessing M, Neurath MF.

Gut. 2004 Mar;53(3):392-400. Erratum in: Gut. 2004 Jul;53(7):1058. Khosravi-Fahr R [corrected to Khosravi-Far].

45.

Development of human protein reference database as an initial platform for approaching systems biology in humans.

Peri S, Navarro JD, Amanchy R, Kristiansen TZ, Jonnalagadda CK, Surendranath V, Niranjan V, Muthusamy B, Gandhi TK, Gronborg M, Ibarrola N, Deshpande N, Shanker K, Shivashankar HN, Rashmi BP, Ramya MA, Zhao Z, Chandrika KN, Padma N, Harsha HC, Yatish AJ, Kavitha MP, Menezes M, Choudhury DR, Suresh S, Ghosh N, Saravana R, Chandran S, Krishna S, Joy M, Anand SK, Madavan V, Joseph A, Wong GW, Schiemann WP, Constantinescu SN, Huang L, Khosravi-Far R, Steen H, Tewari M, Ghaffari S, Blobe GC, Dang CV, Garcia JG, Pevsner J, Jensen ON, Roepstorff P, Deshpande KS, Chinnaiyan AM, Hamosh A, Chakravarti A, Pandey A.

Genome Res. 2003 Oct;13(10):2363-71.

46.

Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor.

Ghaffari S, Jagani Z, Kitidis C, Lodish HF, Khosravi-Far R.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6523-8. Epub 2003 May 15.

47.

Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain.

Pandey A, Dan I, Kristiansen TZ, Watanabe NM, Voldby J, Kajikawa E, Khosravi-Far R, Blagoev B, Mann M.

Oncogene. 2002 May 30;21(24):3939-48.

48.

The complexity of TNF-related apoptosis-inducing ligand.

Abe K, Kurakin A, Mohseni-Maybodi M, Kay B, Khosravi-Far R.

Ann N Y Acad Sci. 2000;926:52-63. Review.

PMID:
11193041
49.

Role of protein kinase Czeta in Ras-mediated transcriptional activation of vascular permeability factor/vascular endothelial growth factor expression.

Pal S, Datta K, Khosravi-Far R, Mukhopadhyay D.

J Biol Chem. 2001 Jan 26;276(4):2395-403. Epub 2000 Nov 1.

50.

Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells.

Plattner R, Gupta S, Khosravi-Far R, Sato KY, Perucho M, Der CJ, Stanbridge EJ.

Oncogene. 1999 Mar 11;18(10):1807-17.

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