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Interleukin 4 is inactivated via selective disulfide-bond reduction by extracellular thioredoxin.

Plugis NM, Weng N, Zhao Q, Palanski BA, Maecker HT, Habtezion A, Khosla C.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8781-8786. doi: 10.1073/pnas.1805288115. Epub 2018 Aug 13.


Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.

Li X, Sevillano N, La Greca F, Deis L, Liu YC, Deller MC, Mathews II, Matsui T, Cane DE, Craik CS, Khosla C.

J Am Chem Soc. 2018 May 30;140(21):6518-6521. doi: 10.1021/jacs.8b02100. Epub 2018 May 18.


HEx: A heterologous expression platform for the discovery of fungal natural products.

Harvey CJB, Tang M, Schlecht U, Horecka J, Fischer CR, Lin HC, Li J, Naughton B, Cherry J, Miranda M, Li YF, Chu AM, Hennessy JR, Vandova GA, Inglis D, Aiyar RS, Steinmetz LM, Davis RW, Medema MH, Sattely E, Khosla C, St Onge RP, Tang Y, Hillenmeyer ME.

Sci Adv. 2018 Apr 11;4(4):eaar5459. doi: 10.1126/sciadv.aar5459. eCollection 2018 Apr.


Cystamine and Disulfiram Inhibit Human Transglutaminase 2 via an Oxidative Mechanism.

Palanski BA, Khosla C.

Biochemistry. 2018 Jun 19;57(24):3359-3363. doi: 10.1021/acs.biochem.8b00204. Epub 2018 Mar 28.


Endoplasmic reticulum-resident protein 57 (ERp57) oxidatively inactivates human transglutaminase 2.

Yi MC, Melkonian AV, Ousey JA, Khosla C.

J Biol Chem. 2018 Feb 23;293(8):2640-2649. doi: 10.1074/jbc.RA117.001382. Epub 2018 Jan 5.


Genetic Mapping and Biochemical Basis of Yellow Feather Pigmentation in Budgerigars.

Cooke TF, Fischer CR, Wu P, Jiang TX, Xie KT, Kuo J, Doctorov E, Zehnder A, Khosla C, Chuong CM, Bustamante CD.

Cell. 2017 Oct 5;171(2):427-439.e21. doi: 10.1016/j.cell.2017.08.016.


Biosynthesis and structure-activity relationships of the lipid a family of glycolipids.

Xiao X, Sankaranarayanan K, Khosla C.

Curr Opin Chem Biol. 2017 Oct;40:127-137. doi: 10.1016/j.cbpa.2017.07.008. Epub 2017 Sep 20. Review.


The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography.

Mathews II, Allison K, Robbins T, Lyubimov AY, Uervirojnangkoorn M, Brunger AT, Khosla C, DeMirci H, McPhillips SE, Hollenbeck M, Soltis M, Cohen AE.

Biochemistry. 2017 Sep 12;56(36):4751-4756. doi: 10.1021/acs.biochem.7b00711. Epub 2017 Aug 31.


Transglutaminase 2 in pulmonary and cardiac tissue remodeling in experimental pulmonary hypertension.

Penumatsa KC, Toksoz D, Warburton RR, Kharnaf M, Preston IR, Kapur NK, Khosla C, Hill NS, Fanburg BL.

Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L752-L762. doi: 10.1152/ajplung.00170.2017. Epub 2017 Aug 3.


Latiglutenase Improves Symptoms in Seropositive Celiac Disease Patients While on a Gluten-Free Diet.

Syage JA, Murray JA, Green PHR, Khosla C.

Dig Dis Sci. 2017 Sep;62(9):2428-2432. doi: 10.1007/s10620-017-4687-7. Epub 2017 Jul 28.


Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay.

Xie X, Garg A, Khosla C, Cane DE.

J Am Chem Soc. 2017 Jul 19;139(28):9507-9510. doi: 10.1021/jacs.7b05502. Epub 2017 Jul 7.


A B-Cell Gene Signature Correlates With the Extent of Gluten-Induced Intestinal Injury in Celiac Disease.

Garber ME, Saldanha A, Parker JS, Jones WD, Kaukinen K, Laurila K, Lähdeaho ML, Khatri P, Khosla C, Adelman DC, Mäki M.

Cell Mol Gastroenterol Hepatol. 2017 Jan 28;4(1):1-17. doi: 10.1016/j.jcmgh.2017.01.011. eCollection 2017 Jul.


Human pyrimidine nucleotide biosynthesis as a target for antiviral chemotherapy.

Okesli A, Khosla C, Bassik MC.

Curr Opin Biotechnol. 2017 Dec;48:127-134. doi: 10.1016/j.copbio.2017.03.010. Epub 2017 Apr 27. Review.


Real-Time in Vivo Detection of H2O2 Using Hyperpolarized 13C-Thiourea.

Wibowo A, Park JM, Liu SC, Khosla C, Spielman DM.

ACS Chem Biol. 2017 Jul 21;12(7):1737-1742. doi: 10.1021/acschembio.7b00130. Epub 2017 Jun 5.


Elucidation of the Stereospecificity of C-Methyltransferases from trans-AT Polyketide Synthases.

Xie X, Khosla C, Cane DE.

J Am Chem Soc. 2017 May 3;139(17):6102-6105. doi: 10.1021/jacs.7b02911. Epub 2017 Apr 25.


Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli.

Vandova GA, O'Brien RV, Lowry B, Robbins TF, Fischer CR, Davis RW, Khosla C, Harvey CJ, Hillenmeyer ME.

J Antibiot (Tokyo). 2017 Jul;70(7):859-863. doi: 10.1038/ja.2017.38. Epub 2017 Apr 12. No abstract available.


Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease.

Bouziat R, Hinterleitner R, Brown JJ, Stencel-Baerenwald JE, Ikizler M, Mayassi T, Meisel M, Kim SM, Discepolo V, Pruijssers AJ, Ernest JD, Iskarpatyoti JA, Costes LM, Lawrence I, Palanski BA, Varma M, Zurenski MA, Khomandiak S, McAllister N, Aravamudhan P, Boehme KW, Hu F, Samsom JN, Reinecker HC, Kupfer SS, Guandalini S, Semrad CE, Abadie V, Khosla C, Barreiro LB, Xavier RJ, Ng A, Dermody TS, Jabri B.

Science. 2017 Apr 7;356(6333):44-50. doi: 10.1126/science.aah5298.


Celiac Disease: Lessons for and from Chemical Biology.

Khosla C.

ACS Chem Biol. 2017 Jun 16;12(6):1455-1459. doi: 10.1021/acschembio.6b01155. Epub 2017 May 22. Review.


Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis.

Xie X, Garg A, Khosla C, Cane DE.

J Am Chem Soc. 2017 Mar 1;139(8):3283-3292. doi: 10.1021/jacs.7b00278. Epub 2017 Feb 14.


Thioredoxin-1 Selectively Activates Transglutaminase 2 in the Extracellular Matrix of the Small Intestine: IMPLICATIONS FOR CELIAC DISEASE.

Plugis NM, Palanski BA, Weng CH, Albertelli M, Khosla C.

J Biol Chem. 2017 Feb 3;292(5):2000-2008. doi: 10.1074/jbc.M116.767988. Epub 2016 Dec 21.


Intracellular TG2 Activity Increases Microtubule Stability but is not Sufficient to Prompt Neurite Growth.

Guo S, Palanski BA, Kloeck C, Khosla C, Cui B.

Neurosci Bull. 2017 Feb;33(1):103-106. doi: 10.1007/s12264-016-0075-0. Epub 2016 Nov 4. No abstract available.


Cholestyramine as a promising, strong anion exchange resin for direct capture of genetic biomarkers from raw pancreatic fluids.

Hilmer AJ, Jeffrey RB, Park WG, Khosla C.

Biotechnol Bioeng. 2017 Apr;114(4):934-938. doi: 10.1002/bit.26207. Epub 2016 Nov 17.


Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase.

Robbins T, Kapilivsky J, Cane DE, Khosla C.

Biochemistry. 2016 Aug 16;55(32):4476-84. doi: 10.1021/acs.biochem.6b00639. Epub 2016 Aug 3.


Partial In Vitro Reconstitution of an Orphan Polyketide Synthase Associated with Clinical Cases of Nocardiosis.

Kuo J, Lynch SR, Liu CW, Xiao X, Khosla C.

ACS Chem Biol. 2016 Sep 16;11(9):2636-41. doi: 10.1021/acschembio.6b00489. Epub 2016 Aug 5.


Structure and mechanism of assembly line polyketide synthases.

Robbins T, Liu YC, Cane DE, Khosla C.

Curr Opin Struct Biol. 2016 Dec;41:10-18. doi: 10.1016/ Epub 2016 Jun 5. Review.


Protein-Protein Interactions, Not Substrate Recognition, Dominate the Turnover of Chimeric Assembly Line Polyketide Synthases.

Klaus M, Ostrowski MP, Austerjost J, Robbins T, Lowry B, Cane DE, Khosla C.

J Biol Chem. 2016 Jul 29;291(31):16404-15. doi: 10.1074/jbc.M116.730531. Epub 2016 May 31.


Editorial overview: Next-generation therapeutics: Breaking new ground and making a difference for patients.

Khosla C, Baryza J.

Curr Opin Chem Biol. 2016 Jun;32:58-9. doi: 10.1016/j.cbpa.2016.04.017. Epub 2016 May 17. No abstract available.


Recognition of acyl carrier proteins by ketoreductases in assembly line polyketide synthases.

Ostrowski MP, Cane DE, Khosla C.

J Antibiot (Tokyo). 2016 Jul;69(7):507-10. doi: 10.1038/ja.2016.41. Epub 2016 Apr 27.


Thiol-Disulfide Exchange Reactions in the Mammalian Extracellular Environment.

Yi MC, Khosla C.

Annu Rev Chem Biomol Eng. 2016 Jun 7;7:197-222. doi: 10.1146/annurev-chembioeng-080615-033553. Epub 2016 Mar 17. Review.


Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification.

Deans RM, Morgens DW, Ökesli A, Pillay S, Horlbeck MA, Kampmann M, Gilbert LA, Li A, Mateo R, Smith M, Glenn JS, Carette JE, Khosla C, Bassik MC.

Nat Chem Biol. 2016 May;12(5):361-6. doi: 10.1038/nchembio.2050. Epub 2016 Mar 28.


A Turnstile Mechanism for the Controlled Growth of Biosynthetic Intermediates on Assembly Line Polyketide Synthases.

Lowry B, Li X, Robbins T, Cane DE, Khosla C.

ACS Cent Sci. 2016 Jan 27;2(1):14-20. Epub 2016 Jan 6.


Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues.

Xie X, Garg A, Keatinge-Clay AT, Khosla C, Cane DE.

Biochemistry. 2016 Mar 1;55(8):1179-86. doi: 10.1021/acs.biochem.6b00024. Epub 2016 Feb 12.


Gluten Introduction, Breastfeeding, and Celiac Disease: Back to the Drawing Board.

Lebwohl B, Murray JA, Verdú EF, Crowe SE, Dennis M, Fasano A, Green PH, Guandalini S, Khosla C.

Am J Gastroenterol. 2016 Jan;111(1):12-4. doi: 10.1038/ajg.2015.219. Epub 2015 Aug 11.


Quo vadis, enzymology?

Khosla C.

Nat Chem Biol. 2015 Jul;11(7):438-41. doi: 10.1038/nchembio.1844. No abstract available.


Therapeutic approaches for celiac disease.

Plugis NM, Khosla C.

Best Pract Res Clin Gastroenterol. 2015 Jun;29(3):503-21. doi: 10.1016/j.bpg.2015.04.005. Epub 2015 May 9. Review.


An unprecedented dual antagonist and agonist of human Transglutaminase 2.

Yi MC, Palanski BA, Quintero SA, Plugis NM, Khosla C.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4922-4926. doi: 10.1016/j.bmcl.2015.05.006. Epub 2015 May 15.


Rationale for Using Social Media to Collect Patient-Reported Outcomes in Patients with Celiac Disease.

Park K, Harris M, Khavari N, Khosla C.

J Gastrointest Dig Syst. 2014 Feb;4(1). pii: 166.


Role of FNAC in the Preoperative Diagnosis of Salivary Gland Lesions.

Fernandes H, D'souza CR, Khosla C, George L, Katte NH.

J Clin Diagn Res. 2014 Sep;8(9):FC01-3. doi: 10.7860/JCDR/2014/6735.4809. Epub 2014 Sep 20.


Discovery of potent and specific dihydroisoxazole inhibitors of human transglutaminase 2.

Klöck C, Herrera Z, Albertelli M, Khosla C.

J Med Chem. 2014 Nov 13;57(21):9042-64. doi: 10.1021/jm501145a. Epub 2014 Oct 31.


Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation.

Penumatsa KC, Toksoz D, Warburton RR, Hilmer AJ, Liu T, Khosla C, Comhair SA, Fanburg BL.

Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L576-85. doi: 10.1152/ajplung.00162.2014. Epub 2014 Aug 15.


Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchange.

Garg A, Xie X, Keatinge-Clay A, Khosla C, Cane DE.

J Am Chem Soc. 2014 Jul 23;136(29):10190-3. doi: 10.1021/ja5056998. Epub 2014 Jul 10.


Dihydroisoxazole inhibitors of Anopheles gambiae seminal transglutaminase AgTG3.

Le BV, Klöck C, Schatz A, Nguyen JB, Kakani EG, Catteruccia F, Khosla C, Baxter RH.

Malar J. 2014 Jun 2;13:210. doi: 10.1186/1475-2875-13-210.


Use of transmission electron microscopy to identify nanocrystals of challenging protein targets.

Stevenson HP, Makhov AM, Calero M, Edwards AL, Zeldin OB, Mathews II, Lin G, Barnes CO, Santamaria H, Ross TM, Soltis SM, Khosla C, Nagarajan V, Conway JF, Cohen AE, Calero G.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8470-5. doi: 10.1073/pnas.1400240111. Epub 2014 May 28.


Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases.

Dunn BJ, Watts KR, Robbins T, Cane DE, Khosla C.

Biochemistry. 2014 Jun 17;53(23):3796-806. doi: 10.1021/bi5004316. Epub 2014 Jun 9.


Assembly line polyketide synthases: mechanistic insights and unsolved problems.

Khosla C, Herschlag D, Cane DE, Walsh CT.

Biochemistry. 2014 May 13;53(18):2875-83. doi: 10.1021/bi500290t. Epub 2014 May 1. Review.


Generation of food-grade recombinant Lactobacillus casei delivering Myxococcus xanthus prolyl endopeptidase.

Alvarez-Sieiro P, Martin MC, Redruello B, Del Rio B, Ladero V, Palanski BA, Khosla C, Fernandez M, Alvarez MA.

Appl Microbiol Biotechnol. 2014 Aug;98(15):6689-700. doi: 10.1007/s00253-014-5730-7. Epub 2014 Apr 22.


Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthase.

Edwards AL, Matsui T, Weiss TM, Khosla C.

J Mol Biol. 2014 May 29;426(11):2229-45. doi: 10.1016/j.jmb.2014.03.015. Epub 2014 Apr 2.


The initiation ketosynthase (FabH) is the sole rate-limiting enzyme of the fatty acid synthase of Synechococcus sp. PCC 7002.

Kuo J, Khosla C.

Metab Eng. 2014 Mar;22:53-9. doi: 10.1016/j.ymben.2013.12.008. Epub 2014 Jan 3.


Computational identification and analysis of orphan assembly-line polyketide synthases.

O'Brien RV, Davis RW, Khosla C, Hillenmeyer ME.

J Antibiot (Tokyo). 2014 Jan;67(1):89-97. doi: 10.1038/ja.2013.125. Epub 2013 Dec 4.

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