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Items: 1 to 50 of 382

1.

The roles of transmembrane domain helix-III during rhodopsin photoactivation.

Ou WB, Yi T, Kim JM, Khorana HG.

PLoS One. 2011 Feb 25;6(2):e17398. doi: 10.1371/journal.pone.0017398.

2.

Location of the retinal chromophore in the activated state of rhodopsin*.

Ahuja S, Crocker E, Eilers M, Hornak V, Hirshfeld A, Ziliox M, Syrett N, Reeves PJ, Khorana HG, Sheves M, Smith SO.

J Biol Chem. 2009 Apr 10;284(15):10190-201. doi: 10.1074/jbc.M805725200. Epub 2009 Jan 28.

3.

High-level expression, single-step immunoaffinity purification and characterization of human tetraspanin membrane protein CD81.

Takayama H, Chelikani P, Reeves PJ, Zhang S, Khorana HG.

PLoS One. 2008 Jun 4;3(6):e2314. doi: 10.1371/journal.pone.0002314.

4.

Opsin stability and folding: modulation by phospholipid bicelles.

McKibbin C, Farmer NA, Jeans C, Reeves PJ, Khorana HG, Wallace BA, Edwards PC, Villa C, Booth PJ.

J Mol Biol. 2007 Dec 14;374(5):1319-32. Epub 2007 Oct 13.

PMID:
17996895
5.

Opsin stability and folding: the role of Cys185 and abnormal disulfide bond formation in the intradiscal domain.

McKibbin C, Toye AM, Reeves PJ, Khorana HG, Edwards PC, Villa C, Booth PJ.

J Mol Biol. 2007 Dec 14;374(5):1309-18. Epub 2007 Oct 10.

PMID:
17988684
6.

Role of group-conserved residues in the helical core of beta2-adrenergic receptor.

Chelikani P, Hornak V, Eilers M, Reeves PJ, Smith SO, RajBhandary UL, Khorana HG.

Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7027-32. Epub 2007 Apr 16.

7.

Combined solid state and solution NMR studies of alpha,epsilon-15N labeled bovine rhodopsin.

Werner K, Lehner I, Dhiman HK, Richter C, Glaubitz C, Schwalbe H, Klein-Seetharaman J, Khorana HG.

J Biomol NMR. 2007 Apr;37(4):303-12. Epub 2007 Feb 23.

PMID:
17318366
8.

Designer short peptide surfactants stabilize G protein-coupled receptor bovine rhodopsin.

Zhao X, Nagai Y, Reeves PJ, Kiley P, Khorana HG, Zhang S.

Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17707-12. Epub 2006 Nov 10.

9.
10.

Opsin is present as dimers in COS1 cells: identification of amino acids at the dimeric interface.

Kota P, Reeves PJ, Rajbhandary UL, Khorana HG.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3054-9. Epub 2006 Feb 21.

11.

Changes in interhelical hydrogen bonding upon rhodopsin activation.

Patel AB, Crocker E, Reeves PJ, Getmanova EV, Eilers M, Khorana HG, Smith SO.

J Mol Biol. 2005 Apr 8;347(4):803-12.

PMID:
15769471
12.

Light-driven activation of beta 2-adrenergic receptor signaling by a chimeric rhodopsin containing the beta 2-adrenergic receptor cytoplasmic loops.

Kim JM, Hwa J, Garriga P, Reeves PJ, RajBhandary UL, Khorana HG.

Biochemistry. 2005 Feb 22;44(7):2284-92.

PMID:
15709741
13.

Structural origins of constitutive activation in rhodopsin: Role of the K296/E113 salt bridge.

Kim JM, Altenbach C, Kono M, Oprian DD, Hubbell WL, Khorana HG.

Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12508-13. Epub 2004 Aug 11.

14.

Identification of core amino acids stabilizing rhodopsin.

Rader AJ, Anderson G, Isin B, Khorana HG, Bahar I, Klein-Seetharaman J.

Proc Natl Acad Sci U S A. 2004 May 11;101(19):7246-51. Epub 2004 May 3.

15.

Dipolar assisted rotational resonance NMR of tryptophan and tyrosine in rhodopsin.

Crocker E, Patel AB, Eilers M, Jayaraman S, Getmanova E, Reeves PJ, Ziliox M, Khorana HG, Sheves M, Smith SO.

J Biomol NMR. 2004 May;29(1):11-20.

PMID:
15017136
16.

Differential dynamics in the G protein-coupled receptor rhodopsin revealed by solution NMR.

Klein-Seetharaman J, Yanamala NV, Javeed F, Reeves PJ, Getmanova EV, Loewen MC, Schwalbe H, Khorana HG.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3409-13. Epub 2004 Feb 27.

17.

NMR spectroscopy of phosphorylated wild-type rhodopsin: mobility of the phosphorylated C-terminus of rhodopsin in the dark and upon light activation.

Getmanova E, Patel AB, Klein-Seetharaman J, Loewen MC, Reeves PJ, Friedman N, Sheves M, Smith SO, Khorana HG.

Biochemistry. 2004 Feb 3;43(4):1126-33.

PMID:
14744159
18.
19.

Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking.

Hubbell WL, Altenbach C, Hubbell CM, Khorana HG.

Adv Protein Chem. 2003;63:243-90. Review. No abstract available.

PMID:
12629973
21.
22.

Structure and function in rhodopsin: asymmetric reconstitution of rhodopsin in liposomes.

Niu L, Kim JM, Khorana HG.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13409-12. Epub 2002 Oct 7.

23.

Solution NMR spectroscopy of [alpha -15N]lysine-labeled rhodopsin: The single peak observed in both conventional and TROSY-type HSQC spectra is ascribed to Lys-339 in the carboxyl-terminal peptide sequence.

Klein-Seetharaman J, Reeves PJ, Loewen MC, Getmanova EV, Chung J, Schwalbe H, Wright PE, Khorana HG.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3452-7.

26.

Magic angle spinning nuclear magnetic resonance of isotopically labeled rhodopsin.

Eilers M, Ying W, Reeves PJ, Khorana HG, Smith SO.

Methods Enzymol. 2002;343:212-22. No abstract available.

PMID:
11675791
29.

Structure and function in bacteriorhodopsin: the effect of the interhelical loops on the protein folding kinetics.

Allen SJ, Kim JM, Khorana HG, Lu H, Booth PJ.

J Mol Biol. 2001 Apr 27;308(2):423-35.

PMID:
11327777
30.
31.

Solution 19F nuclear Overhauser effects in structural studies of the cytoplasmic domain of mammalian rhodopsin.

Loewen MC, Klein-Seetharaman J, Getmanova EV, Reeves PJ, Schwalbe H, Khorana HG.

Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):4888-92.

34.
35.

Expression and purification of rhodopsin and its mutants from stable mammalian cell lines: application to NMR studies.

Reeves PJ, Klein-Seetharaman J, Getmanova EV, Eilers M, Loewen MC, Smith SO, Khorana HG.

Biochem Soc Trans. 1999 Dec;27(6):950-5. No abstract available.

PMID:
10830134
38.

Rhodopsin kinase: two mAbs binding near the carboxyl terminus cause time-dependent inactivation.

Bruel C, Cha K, Niu L, Reeves PJ, Khorana HG.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3010-5.

39.

Rhodopsin kinase: expression in mammalian cells and a two-step purification.

Bruel C, Cha K, Reeves PJ, Getmanova E, Khorana HG.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3004-9.

40.

A life in science.

Khorana HG.

Science. 2000 Feb 4;287(5454):810. No abstract available.

41.

Time-resolved site-directed spin-labeling studies of bacteriorhodopsin: loop-specific conformational changes in M.

Mollaaghababa R, Steinhoff HJ, Hubbell WL, Khorana HG.

Biochemistry. 2000 Feb 8;39(5):1120-7.

PMID:
10653658
42.

Molecular biology of light transduction by the Mammalian photoreceptor, rhodopsin.

Khorana HG.

J Biomol Struct Dyn. 2000;17 Suppl 1:1-16.

PMID:
22607401
43.

NMR spectroscopy in studies of light-induced structural changes in mammalian rhodopsin: applicability of solution (19)F NMR.

Klein-Seetharaman J, Getmanova EV, Loewen MC, Reeves PJ, Khorana HG.

Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13744-9.

44.
45.

Structural features and light-dependent changes in the sequence 59-75 connecting helices I and II in rhodopsin: a site-directed spin-labeling study.

Altenbach C, Klein-Seetharaman J, Hwa J, Khorana HG, Hubbell WL.

Biochemistry. 1999 Jun 22;38(25):7945-9.

PMID:
10387037
49.

Structural features of the C-terminal domain of bovine rhodopsin: a site-directed spin-labeling study.

Langen R, Cai K, Altenbach C, Khorana HG, Hubbell WL.

Biochemistry. 1999 Jun 22;38(25):7918-24.

PMID:
10387033
50.

Structure and function in rhodopsin: further elucidation of the role of the intradiscal cysteines, Cys-110, -185, and -187, in rhodopsin folding and function.

Hwa J, Reeves PJ, Klein-Seetharaman J, Davidson F, Khorana HG.

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):1932-5.

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