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Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq.

Li W, Huang Y, Sargsyan D, Khor TO, Guo Y, Shu L, Yang AY, Zhang C, Paredes-Gonzalez X, Verzi M, Hart RP, Kong AN.

Cell Biosci. 2018 Jan 12;8:3. doi: 10.1186/s13578-018-0201-y. eCollection 2018.


PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

Meehan TF, Conte N, Goldstein T, Inghirami G, Murakami MA, Brabetz S, Gu Z, Wiser JA, Dunn P, Begley DA, Krupke DM, Bertotti A, Bruna A, Brush MH, Byrne AT, Caldas C, Christie AL, Clark DA, Dowst H, Dry JR, Doroshow JH, Duchamp O, Evrard YA, Ferretti S, Frese KK, Goodwin NC, Greenawalt D, Haendel MA, Hermans E, Houghton PJ, Jonkers J, Kemper K, Khor TO, Lewis MT, Lloyd KCK, Mason J, Medico E, Neuhauser SB, Olson JM, Peeper DS, Rueda OM, Seong JK, Trusolino L, Vinolo E, Wechsler-Reya RJ, Weinstock DM, Welm A, Weroha SJ, Amant F, Pfister SM, Kool M, Parkinson H, Butte AJ, Bult CJ.

Cancer Res. 2017 Nov 1;77(21):e62-e66. doi: 10.1158/0008-5472.CAN-17-0582.


Dibenzoylmethane Protects Against CCl4-Induced Acute Liver Injury by Activating Nrf2 via JNK, AMPK, and Calcium Signaling.

Cao M, Wang H, Guo L, Yang S, Liu C, Khor TO, Yu S, Kong AN.

AAPS J. 2017 Nov;19(6):1703-1714. doi: 10.1208/s12248-017-0133-1. Epub 2017 Aug 21.


Comparative mutational landscape analysis of patient-derived tumour xenografts.

Brait M, Izumchenko E, Kagohara LT, Long S, Wysocki PT, Faherty B, Fertig EJ, Khor TO, Bruckheimer E, Baia G, Ciznadija D, Sloma I, Ben-Zvi I, Paz K, Sidransky D.

Br J Cancer. 2017 Feb 14;116(4):515-523. doi: 10.1038/bjc.2016.450. Epub 2017 Jan 24.


Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194.

Zhang C, Shu L, Kim H, Khor TO, Wu R, Li W, Kong AN.

Mol Nutr Food Res. 2016 Jun;60(6):1427-36. doi: 10.1002/mnfr.201500918. Epub 2016 May 17.


Pharmacokinetics and pharmacodynamics of 3,3'-diindolylmethane (DIM) in regulating gene expression of phase II drug metabolizing enzymes.

Wu TY, Huang Y, Zhang C, Su ZY, Boyanapalli S, Khor TO, Wang H, Lin H, Gounder M, Kagan L, Androulakis IP, Kong AN.

J Pharmacokinet Pharmacodyn. 2015 Aug;42(4):401-8. doi: 10.1007/s10928-015-9421-5. Epub 2015 Jul 3.


Epigenetic DNA methylation of antioxidative stress regulator NRF2 in human prostate cancer.

Khor TO, Fuentes F, Shu L, Paredes-Gonzalez X, Yang AY, Liu Y, Smiraglia DJ, Yegnasubramanian S, Nelson WG, Kong AN.

Cancer Prev Res (Phila). 2014 Dec;7(12):1186-97. doi: 10.1158/1940-6207.CAPR-14-0127. Epub 2014 Sep 29.


Nrf2 null enhances UVB-induced skin inflammation and extracellular matrix damages.

Saw CL, Yang AY, Huang MT, Liu Y, Lee JH, Khor TO, Su ZY, Shu L, Lu Y, Conney AH, Kong AN.

Cell Biosci. 2014 Aug 5;4:39. doi: 10.1186/2045-3701-4-39. eCollection 2014.


Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane.

Su ZY, Zhang C, Lee JH, Shu L, Wu TY, Khor TO, Conney AH, Lu YP, Kong AN.

Cancer Prev Res (Phila). 2014 Mar;7(3):319-29. doi: 10.1158/1940-6207.CAPR-13-0313-T. Epub 2014 Jan 17.


Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1 cell line and in vivo TRAMP prostate tumors.

Wu TY, Khor TO, Su ZY, Saw CL, Shu L, Cheung KL, Huang Y, Yu S, Kong AN.

AAPS J. 2013 Jul;15(3):864-74. doi: 10.1208/s12248-013-9493-3. Epub 2013 May 9.


Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and anti-inflammation.

Saw CL, Wu Q, Su ZY, Wang H, Yang Y, Xu X, Huang Y, Khor TO, Kong AN.

Biopharm Drug Dispos. 2013 Sep;34(6):303-11. doi: 10.1002/bdd.1846. Epub 2013 May 23.


Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation.

Su ZY, Khor TO, Shu L, Lee JH, Saw CL, Wu TY, Huang Y, Suh N, Yang CS, Conney AH, Wu Q, Kong AN.

Chem Res Toxicol. 2013 Mar 18;26(3):477-85. doi: 10.1021/tx300524p. Epub 2013 Mar 8.


Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation.

Zhang C, Su ZY, Khor TO, Shu L, Kong AN.

Biochem Pharmacol. 2013 May 1;85(9):1398-404. doi: 10.1016/j.bcp.2013.02.010. Epub 2013 Feb 14.


Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression.

Lee JH, Khor TO, Shu L, Su ZY, Fuentes F, Kong AN.

Pharmacol Ther. 2013 Feb;137(2):153-71. doi: 10.1016/j.pharmthera.2012.09.008. Epub 2012 Oct 3. Review.


Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes.

Wang H, Khor TO, Yang Q, Huang Y, Wu TY, Saw CL, Lin W, Androulakis IP, Kong AN.

Mol Pharm. 2012 Oct 1;9(10):2819-27. Epub 2012 Sep 11.


Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation.

Cheung KL, Lee JH, Khor TO, Wu TY, Li GX, Chan J, Yang CS, Kong AN.

Mol Carcinog. 2014 Jan;53(1):77-84. doi: 10.1002/mc.21950. Epub 2012 Aug 21.


A perspective on dietary phytochemicals and cancer chemoprevention: oxidative stress, nrf2, and epigenomics.

Su ZY, Shu L, Khor TO, Lee JH, Fuentes F, Kong AN.

Top Curr Chem. 2013;329:133-62. doi: 10.1007/128_2012_340. Review.


Pharmacodynamics of ginsenosides: antioxidant activities, activation of Nrf2, and potential synergistic effects of combinations.

Saw CL, Yang AY, Cheng DC, Boyanapalli SS, Su ZY, Khor TO, Gao S, Wang J, Jiang ZH, Kong AN.

Chem Res Toxicol. 2012 Aug 20;25(8):1574-80. doi: 10.1021/tx2005025. Epub 2012 Aug 9.


Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability.

Wang H, Khor TO, Shu L, Su ZY, Fuentes F, Lee JH, Kong AN.

Anticancer Agents Med Chem. 2012 Dec;12(10):1281-305. Review.


A γ-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation.

Huang Y, Khor TO, Shu L, Saw CL, Wu TY, Suh N, Yang CS, Kong AN.

J Nutr. 2012 May;142(5):818-23. doi: 10.3945/jn.111.153114. Epub 2012 Mar 28.


Dietary tocopherols inhibit cell proliferation, regulate expression of ERα, PPARγ, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia.

Smolarek AK, So JY, Thomas PE, Lee HJ, Paul S, Dombrowski A, Wang CX, Saw CL, Khor TO, Kong AN, Reuhl K, Lee MJ, Yang CS, Suh N.

Mol Carcinog. 2013 Jul;52(7):514-25. doi: 10.1002/mc.21886. Epub 2012 Mar 2.


Epigenetic CpG demethylation of the promoter and reactivation of the expression of Neurog1 by curcumin in prostate LNCaP cells.

Shu L, Khor TO, Lee JH, Boyanapalli SS, Huang Y, Wu TY, Saw CL, Cheung KL, Kong AN.

AAPS J. 2011 Dec;13(4):606-14. doi: 10.1208/s12248-011-9300-y. Epub 2011 Sep 22.


In vivo pharmacodynamics of indole-3-carbinol in the inhibition of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: involvement of Nrf2 and cell cycle/apoptosis signaling pathways.

Wu TY, Saw CL, Khor TO, Pung D, Boyanapalli SS, Kong AN.

Mol Carcinog. 2012 Oct;51(10):761-70. doi: 10.1002/mc.20841. Epub 2011 Aug 11.


Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation.

Khor TO, Huang Y, Wu TY, Shu L, Lee J, Kong AN.

Biochem Pharmacol. 2011 Nov 1;82(9):1073-8. doi: 10.1016/j.bcp.2011.07.065. Epub 2011 Jul 20.


Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane.

Saw CL, Huang MT, Liu Y, Khor TO, Conney AH, Kong AN.

Mol Carcinog. 2011 Jun;50(6):479-86. doi: 10.1002/mc.20725. Epub 2010 Dec 28.


Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition.

Lin W, Hong JL, Shen G, Wu RT, Wang Y, Huang MT, Newmark HL, Huang Q, Khor TO, Heimbach T, Kong AN.

Biopharm Drug Dispos. 2011 Mar;32(2):65-75. doi: 10.1002/bdd.734. Epub 2010 Dec 16.


Inhibitory Effect of a γ-Tocopherol-Rich Mixture of Tocopherols on the Formation and Growth of LNCaP Prostate Tumors in Immunodeficient Mice.

Zheng X, Cui XX, Khor TO, Huang Y, Dipaola RS, Goodin S, Lee MJ, Yang CS, Kong AN, Conney AH.

Cancers (Basel). 2011 Sep 28;3(4):3762-72. doi: 10.3390/cancers3043762.


Pharmacodynamics of fish oil: protective effects against prostate cancer in TRAMP mice fed with a high fat western diet.

Saw CL, Wu TY, Paredes-Gonzalez X, Khor TO, Pung D, Kong AN.

Asian Pac J Cancer Prev. 2011;12(12):3331-4.


Anti-inflammatory/Anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and licorice Glycyrrhiza uralensis.

Wu TY, Khor TO, Saw CL, Loh SC, Chen AI, Lim SS, Park JH, Cai L, Kong AN.

AAPS J. 2011 Mar;13(1):1-13. doi: 10.1208/s12248-010-9239-4. Epub 2010 Oct 22.


Role of Nrf2 in suppressing LPS-induced inflammation in mouse peritoneal macrophages by polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid.

Wang H, Khor TO, Saw CL, Lin W, Wu T, Huang Y, Kong AN.

Mol Pharm. 2010 Dec 6;7(6):2185-93. doi: 10.1021/mp100199m. Epub 2010 Oct 6.


Phytochemicals: cancer chemoprevention and suppression of tumor onset and metastasis.

Shu L, Cheung KL, Khor TO, Chen C, Kong AN.

Cancer Metastasis Rev. 2010 Sep;29(3):483-502. doi: 10.1007/s10555-010-9239-y. Review.


Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells.

Nair S, Barve A, Khor TO, Shen GX, Lin W, Chan JY, Cai L, Kong AN.

Acta Pharmacol Sin. 2010 Sep;31(9):1223-40. doi: 10.1038/aps.2010.147. Epub 2010 Aug 23.


Mixed tocotrienols inhibit prostate carcinogenesis in TRAMP mice.

Barve A, Khor TO, Reuhl K, Reddy B, Newmark H, Kong AN.

Nutr Cancer. 2010;62(6):789-94. doi: 10.1080/01635581003605896.


Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice.

Yu S, Khor TO, Cheung KL, Li W, Wu TY, Huang Y, Foster BA, Kan YW, Kong AN.

PLoS One. 2010 Jan 5;5(1):e8579. doi: 10.1371/journal.pone.0008579.


Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM.

Cheung KL, Khor TO, Huang MT, Kong AN.

Carcinogenesis. 2010 May;31(5):880-5. doi: 10.1093/carcin/bgp285. Epub 2009 Dec 3.


Dietary feeding of dibenzoylmethane inhibits prostate cancer in transgenic adenocarcinoma of the mouse prostate model.

Khor TO, Yu S, Barve A, Hao X, Hong JL, Lin W, Foster B, Huang MT, Newmark HL, Kong AN.

Cancer Res. 2009 Sep 1;69(17):7096-102. doi: 10.1158/0008-5472.CAN-09-0597. Epub 2009 Aug 25.


Anti-NF-kappaB and anti-inflammatory activities of synthetic isothiocyanates: effect of chemical structures and cellular signaling.

Prawan A, Saw CL, Khor TO, Keum YS, Yu S, Hu L, Kong AN.

Chem Biol Interact. 2009 May 15;179(2-3):202-11. doi: 10.1016/j.cbi.2008.12.014. Epub 2008 Dec 30.


Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer.

Khor TO, Huang MT, Prawan A, Liu Y, Hao X, Yu S, Cheung WK, Chan JY, Reddy BS, Yang CS, Kong AN.

Cancer Prev Res (Phila). 2008 Aug;1(3):187-91. doi: 10.1158/1940-6207.CAPR-08-0028. Epub 2008 Mar 31.


Gamma-tocopherol-enriched mixed tocopherol diet inhibits prostate carcinogenesis in TRAMP mice.

Barve A, Khor TO, Nair S, Reuhl K, Suh N, Reddy B, Newmark H, Kong AN.

Int J Cancer. 2009 Apr 1;124(7):1693-9. doi: 10.1002/ijc.24106.


Dietary cancer chemopreventive agents - targeting inflammation and Nrf2 signaling pathway.

Khor TO, Yu S, Kong AN.

Planta Med. 2008 Oct;74(13):1540-7. doi: 10.1055/s-0028-1088303. Epub 2008 Oct 20. Review.


Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation.

Cheung KL, Khor TO, Kong AN.

Pharm Res. 2009 Jan;26(1):224-31. doi: 10.1007/s11095-008-9734-9. Epub 2008 Oct 8.


Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism.

Yu S, Shen G, Khor TO, Kim JH, Kong AN.

Mol Cancer Ther. 2008 Sep;7(9):2609-20. doi: 10.1158/1535-7163.MCT-07-2400.


Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway.

Lin W, Wu RT, Wu T, Khor TO, Wang H, Kong AN.

Biochem Pharmacol. 2008 Oct 15;76(8):967-73. doi: 10.1016/j.bcp.2008.07.036. Epub 2008 Aug 7.


Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis.

Li W, Khor TO, Xu C, Shen G, Jeong WS, Yu S, Kong AN.

Biochem Pharmacol. 2008 Dec 1;76(11):1485-9. doi: 10.1016/j.bcp.2008.07.017. Epub 2008 Jul 23. Review.


PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway.

Cheung KL, Khor TO, Yu S, Kong AN.

AAPS J. 2008 Jun;10(2):277-81. doi: 10.1208/s12248-008-9032-9. Epub 2008 May 13.


Murine prostate cancer inhibition by dietary phytochemicals--curcumin and phenyethylisothiocyanate.

Barve A, Khor TO, Hao X, Keum YS, Yang CS, Reddy B, Kong AN.

Pharm Res. 2008 Sep;25(9):2181-9. doi: 10.1007/s11095-008-9574-7. Epub 2008 Apr 25.


Pharmacogenomic profile of soy isoflavone concentrate in the prostate of Nrf2 deficient and wild-type mice.

Barve A, Khor TO, Nair S, Lin W, Yu S, Jain MR, Chan JY, Kong AN.

J Pharm Sci. 2008 Oct;97(10):4528-45. doi: 10.1002/jps.21311.


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