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Items: 1 to 50 of 105

1.

Correction: FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer.

Karadedou CT, Gomes AR, Chen J, Petkovic M, Ho KK, Zwolinska AK, Feltes A, Wong SY, Chan KYK, Cheung YN, Tsang JWH, Brosens JJ, Khoo US, Lam EW.

Oncogene. 2019 Jun;38(25):5111-5112. doi: 10.1038/s41388-019-0770-1.

PMID:
30867566
2.

PTEN PDZ-binding domain suppresses mammary carcinogenesis in the MMTV-PyMT breast cancer model.

Yan M, Wang Y, Wong CW, Or PM, Wong KL, Li L, Many AM, Guan H, Khoo US, Chan AM.

Cancer Lett. 2018 Aug 28;430:67-78. doi: 10.1016/j.canlet.2018.05.012. Epub 2018 May 14.

PMID:
29772266
3.

BQ323636.1, a Novel Splice Variant to NCOR2, as a Predictor for Tamoxifen-Resistant Breast Cancer.

Gong C, Man EPS, Tsoi H, Lee TKW, Lee P, Ma ST, Wong LS, Luk MY, Rakha EA, Green AR, Ellis IO, Lam EW, Cheung KL, Khoo US.

Clin Cancer Res. 2018 Aug 1;24(15):3681-3691. doi: 10.1158/1078-0432.CCR-17-2259. Epub 2018 Feb 2.

4.

Dual-utility NLS drives RNF169-dependent DNA damage responses.

An L, Jiang Y, Ng HH, Man EP, Chen J, Khoo US, Gong Q, Huen MS.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2872-E2881. doi: 10.1073/pnas.1616602114. Epub 2017 Mar 21.

5.

RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment.

Kongsema M, Zona S, Karunarathna U, Cabrera E, Man EP, Yao S, Shibakawa A, Khoo US, Medema RH, Freire R, Lam EW.

Oncogenesis. 2016 Aug 15;5(8):e252. doi: 10.1038/oncsis.2016.57.

6.

BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer.

Gong C, Yao S, Gomes AR, Man EP, Lee HJ, Gong G, Chang S, Kim SB, Fujino K, Kim SW, Park SK, Lee JW, Lee MH; KOHBRA study group, Khoo US, Lam EW.

Oncogenesis. 2016 Apr 4;5:e214. doi: 10.1038/oncsis.2016.23.

7.
8.

Forkhead box K2 modulates epirubicin and paclitaxel sensitivity through FOXO3a in breast cancer.

Nestal de Moraes G, Khongkow P, Gong C, Yao S, Gomes AR, Ji Z, Kandola N, Delbue D, Man EP, Khoo US, Sharrocks AD, Lam EW.

Oncogenesis. 2015 Sep 7;4:e167. doi: 10.1038/oncsis.2015.26.

9.

OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance.

Karunarathna U, Kongsema M, Zona S, Gong C, Cabrera E, Gomes AR, Man EP, Khongkow P, Tsang JW, Khoo US, Medema RH, Freire R, Lam EW.

Oncogene. 2016 Mar 17;35(11):1433-44. doi: 10.1038/onc.2015.208. Epub 2015 Jul 6.

10.

Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance.

Khongkow P, Gomes AR, Gong C, Man EP, Tsang JW, Zhao F, Monteiro LJ, Coombes RC, Medema RH, Khoo US, Lam EW.

Oncogene. 2016 Feb 25;35(8):990-1002. doi: 10.1038/onc.2015.152. Epub 2015 May 11.

11.

Prognostic significance of minichromosome maintenance proteins in breast cancer.

Kwok HF, Zhang SD, McCrudden CM, Yuen HF, Ting KP, Wen Q, Khoo US, Chan KY.

Am J Cancer Res. 2014 Dec 15;5(1):52-71. eCollection 2015.

12.

FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer.

Gong C, Fujino K, Monteiro LJ, Gomes AR, Drost R, Davidson-Smith H, Takeda S, Khoo US, Jonkers J, Sproul D, Lam EW.

Oncogene. 2015 Sep 24;34(39):5012-24. doi: 10.1038/onc.2014.421. Epub 2014 Dec 22.

13.

Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1.

Cai Q, Zhang B, Sung H, Low SK, Kweon SS, Lu W, Shi J, Long J, Wen W, Choi JY, Noh DY, Shen CY, Matsuo K, Teo SH, Kim MK, Khoo US, Iwasaki M, Hartman M, Takahashi A, Ashikawa K, Matsuda K, Shin MH, Park MH, Zheng Y, Xiang YB, Ji BT, Park SK, Wu PE, Hsiung CN, Ito H, Kasuga Y, Kang P, Mariapun S, Ahn SH, Kang HS, Chan KY, Man EP, Iwata H, Tsugane S, Miao H, Liao J, Nakamura Y, Kubo M; DRIVE GAME-ON Consortium, Delahanty RJ, Zhang Y, Li B, Li C, Gao YT, Shu XO, Kang D, Zheng W.

Nat Genet. 2014 Aug;46(8):886-90. doi: 10.1038/ng.3041. Epub 2014 Jul 20.

14.

FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance.

Khongkow P, Karunarathna U, Khongkow M, Gong C, Gomes AR, Yagüe E, Monteiro LJ, Kongsema M, Zona S, Man EP, Tsang JW, Coombes RC, Wu KJ, Khoo US, Medema RH, Freire R, Lam EW.

Oncogene. 2014 Aug 7;33(32):4144-55. doi: 10.1038/onc.2013.457. Epub 2013 Oct 21.

15.

Nuclear Localization Marker of FOXO3a: Can it be Used to Predict Doxorubicin Response?

Gong C, Khoo US.

Front Oncol. 2013 Jun 5;3:149. doi: 10.3389/fonc.2013.00149. eCollection 2013. No abstract available.

16.

Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls.

Zheng W, Zhang B, Cai Q, Sung H, Michailidou K, Shi J, Choi JY, Long J, Dennis J, Humphreys MK, Wang Q, Lu W, Gao YT, Li C, Cai H, Park SK, Yoo KY, Noh DY, Han W, Dunning AM, Benitez J, Vincent D, Bacot F, Tessier D, Kim SW, Lee MH, Lee JW, Lee JY, Xiang YB, Zheng Y, Wang W, Ji BT, Matsuo K, Ito H, Iwata H, Tanaka H, Wu AH, Tseng CC, Van Den Berg D, Stram DO, Teo SH, Yip CH, Kang IN, Wong TY, Shen CY, Yu JC, Huang CS, Hou MF, Hartman M, Miao H, Lee SC, Putti TC, Muir K, Lophatananon A, Stewart-Brown S, Siriwanarangsan P, Sangrajrang S, Shen H, Chen K, Wu PE, Ren Z, Haiman CA, Sueta A, Kim MK, Khoo US, Iwasaki M, Pharoah PD, Wen W, Hall P, Shu XO, Easton DF, Kang D.

Hum Mol Genet. 2013 Jun 15;22(12):2539-50. doi: 10.1093/hmg/ddt089. Epub 2013 Mar 27.

17.

SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer.

Khongkow M, Olmos Y, Gong C, Gomes AR, Monteiro LJ, Yagüe E, Cavaco TB, Khongkow P, Man EP, Laohasinnarong S, Koo CY, Harada-Shoji N, Tsang JW, Coombes RC, Schwer B, Khoo US, Lam EW.

Carcinogenesis. 2013 Jul;34(7):1476-86. doi: 10.1093/carcin/bgt098. Epub 2013 Mar 20.

PMID:
23514751
18.
19.

SpliceArray profiling of breast cancer reveals a novel variant of NCOR2/SMRT that is associated with tamoxifen resistance and control of ERα transcriptional activity.

Zhang L, Gong C, Lau SL, Yang N, Wong OG, Cheung AN, Tsang JW, Chan KY, Khoo US.

Cancer Res. 2013 Jan 1;73(1):246-55. doi: 10.1158/0008-5472.CAN-12-2241. Epub 2012 Nov 1.

20.

Pathway analyses identify TGFBR2 as potential breast cancer susceptibility gene: results from a consortium study among Asians.

Ma X, Beeghly-Fadiel A, Lu W, Shi J, Xiang YB, Cai Q, Shen H, Shen CY, Ren Z, Matsuo K, Khoo US, Iwasaki M, Long J, Zhang B, Ji BT, Zheng Y, Wang W, Hu Z, Liu Y, Wu PE, Shieh YL, Wang S, Xie X, Ito H, Kasuga Y, Chan KY, Iwata H, Tsugane S, Gao YT, Shu XO, Moses HL, Zheng W.

Cancer Epidemiol Biomarkers Prev. 2012 Jul;21(7):1176-84. doi: 10.1158/1055-9965.EPI-12-0118. Epub 2012 Apr 26.

21.

Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer.

Long J, Cai Q, Sung H, Shi J, Zhang B, Choi JY, Wen W, Delahanty RJ, Lu W, Gao YT, Shen H, Park SK, Chen K, Shen CY, Ren Z, Haiman CA, Matsuo K, Kim MK, Khoo US, Iwasaki M, Zheng Y, Xiang YB, Gu K, Rothman N, Wang W, Hu Z, Liu Y, Yoo KY, Noh DY, Han BG, Lee MH, Zheng H, Zhang L, Wu PE, Shieh YL, Chan SY, Wang S, Xie X, Kim SW, Henderson BE, Le Marchand L, Ito H, Kasuga Y, Ahn SH, Kang HS, Chan KY, Iwata H, Tsugane S, Li C, Shu XO, Kang DH, Zheng W.

PLoS Genet. 2012;8(2):e1002532. doi: 10.1371/journal.pgen.1002532. Epub 2012 Feb 23.

22.

Regarding "Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor-positive early breast cancer patients".

Yuen HF, Zhang SD, Wong AS, McCrudden CM, Huang YH, Chan KY, El-Tanani M, Khoo US.

Breast Cancer Res Treat. 2012 Jan;131(1):351-2. doi: 10.1007/s10549-011-1831-5. Epub 2011 Oct 26. No abstract available.

PMID:
22037786
23.

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation.

Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16369-74. doi: 10.1073/pnas.1113483108. Epub 2011 Sep 12.

24.

Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium.

Cai Q, Long J, Lu W, Qu S, Wen W, Kang D, Lee JY, Chen K, Shen H, Shen CY, Sung H, Matsuo K, Haiman CA, Khoo US, Ren Z, Iwasaki M, Gu K, Xiang YB, Choi JY, Park SK, Zhang L, Hu Z, Wu PE, Noh DY, Tajima K, Henderson BE, Chan KY, Su F, Kasuga Y, Wang W, Cheng JR, Yoo KY, Lee JY, Zheng H, Liu Y, Shieh YL, Kim SW, Lee JW, Iwata H, Le Marchand L, Chan SY, Xie X, Tsugane S, Lee MH, Wang S, Li G, Levy S, Huang B, Shi J, Delahanty R, Zheng Y, Li C, Gao YT, Shu XO, Zheng W.

Hum Mol Genet. 2011 Dec 15;20(24):4991-9. doi: 10.1093/hmg/ddr405. Epub 2011 Sep 9.

25.

FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer.

Karadedou CT, Gomes AR, Chen J, Petkovic M, Ho KK, Zwolinska AK, Feltes A, Wong SY, Chan KY, Cheung YN, Tsang JW, Brosens JJ, Khoo US, Lam EW.

Oncogene. 2012 Apr 5;31(14):1845-58. doi: 10.1038/onc.2011.368. Epub 2011 Aug 22. Erratum in: Oncogene. 2019 Jun;38(25):5111-5112.

26.

The role of Pea3 group transcription factors in esophageal squamous cell carcinoma.

Yuen HF, McCrudden CM, Chan KK, Chan YP, Wong ML, Chan KY, Khoo US, Law S, Srivastava G, Lappin TR, Chan KW, El-Tanani M.

Am J Pathol. 2011 Aug;179(2):992-1003. doi: 10.1016/j.ajpath.2011.04.004. Epub 2011 May 31.

27.

Polyomavirus enhancer activator 3 protein promotes breast cancer metastatic progression through Snail-induced epithelial-mesenchymal transition.

Yuen HF, Chan YK, Grills C, McCrudden CM, Gunasekharan V, Shi Z, Wong AS, Lappin TR, Chan KW, Fennell DA, Khoo US, Johnston PG, El-Tanani M.

J Pathol. 2011 May;224(1):78-89. doi: 10.1002/path.2859. Epub 2011 Mar 14.

PMID:
21404275
28.

Replication and functional genomic analyses of the breast cancer susceptibility locus at 6q25.1 generalize its importance in women of chinese, Japanese, and European ancestry.

Cai Q, Wen W, Qu S, Li G, Egan KM, Chen K, Deming SL, Shen H, Shen CY, Gammon MD, Blot WJ, Matsuo K, Haiman CA, Khoo US, Iwasaki M, Santella RM, Zhang L, Fair AM, Hu Z, Wu PE, Signorello LB, Titus-Ernstoff L, Tajima K, Henderson BE, Chan KY, Kasuga Y, Newcomb PA, Zheng H, Cui Y, Wang F, Shieh YL, Iwata H, Le Marchand L, Chan SY, Shrubsole MJ, Trentham-Dietz A, Tsugane S, Garcia-Closas M, Long J, Li C, Shi J, Huang B, Xiang YB, Gao YT, Lu W, Shu XO, Zheng W.

Cancer Res. 2011 Feb 15;71(4):1344-55. doi: 10.1158/0008-5472.CAN-10-2733. Epub 2011 Feb 8.

29.

Association of a single nucleotide polymorphism in the CD209 (DC-SIGN) promoter with SARS severity.

Chan KY, Xu MS, Ching JC, Chan VS, Ip YC, Yam L, Chu CM, Lai ST, So KM, Wong TY, Chung PH, Tam P, Yip SP, Sham P, Lin CL, Leung GM, Peiris JS, Khoo US.

Hong Kong Med J. 2010;16(5 Suppl 4):37-42. No abstract available.

30.

Immunogenetics in SARS: a case-control study.

Ng MH, Cheng SH, Lau KM, Leung GM, Khoo US, Zee BC, Sung JJ.

Hong Kong Med J. 2010;16(5 Suppl 4):29-33. No abstract available.

31.

Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer.

Chen J, Gomes AR, Monteiro LJ, Wong SY, Wu LH, Ng TT, Karadedou CT, Millour J, Ip YC, Cheung YN, Sunters A, Chan KY, Lam EW, Khoo US.

PLoS One. 2010 Aug 20;5(8):e12293. doi: 10.1371/journal.pone.0012293.

32.

Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium.

Long J, Cai Q, Shu XO, Qu S, Li C, Zheng Y, Gu K, Wang W, Xiang YB, Cheng J, Chen K, Zhang L, Zheng H, Shen CY, Huang CS, Hou MF, Shen H, Hu Z, Wang F, Deming SL, Kelley MC, Shrubsole MJ, Khoo US, Chan KY, Chan SY, Haiman CA, Henderson BE, Le Marchand L, Iwasaki M, Kasuga Y, Tsugane S, Matsuo K, Tajima K, Iwata H, Huang B, Shi J, Li G, Wen W, Gao YT, Lu W, Zheng W.

PLoS Genet. 2010 Jun 24;6(6):e1001002. doi: 10.1371/journal.pgen.1001002.

33.

Significance of the myxovirus resistance A (MxA) gene -123C>a single-nucleotide polymorphism in suppressed interferon beta induction of severe acute respiratory syndrome coronavirus infection.

Ching JC, Chan KY, Lee EH, Xu MS, Ting CK, So TM, Sham PC, Leung GM, Peiris JS, Khoo US.

J Infect Dis. 2010 Jun 15;201(12):1899-908. doi: 10.1086/652799.

PMID:
20462354
34.

CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese.

Chan KY, Xu MS, Ching JC, So TM, Lai ST, Chu CM, Yam LY, Wong AT, Chung PH, Chan VS, Lin CL, Sham PC, Leung GM, Peiris JS, Khoo US.

Hum Immunol. 2010 Jul;71(7):702-7. doi: 10.1016/j.humimm.2010.03.006. Epub 2010 May 4.

PMID:
20359516
35.

Functional role of ICAM-3 polymorphism in genetic susceptibility to SARS infection.

Khoo US, Chan KY, Ching JC, Chan VS, Ip YC, Yam L, Chu CM, Lai ST, So KM, Wong TY, Chung PH, Tam P, Yip SP, Sham P, Leung GM, Lin CL, Peiris JS.

Hong Kong Med J. 2009 Oct;15 Suppl 6:26-9. No abstract available.

36.

A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma.

Ngan ES, Lang BH, Liu T, Shum CK, So MT, Lau DK, Leon TY, Cherny SS, Tsai SY, Lo CY, Khoo US, Tam PK, Garcia-Barceló MM.

J Natl Cancer Inst. 2009 Feb 4;101(3):162-75. doi: 10.1093/jnci/djn471. Epub 2009 Jan 27.

PMID:
19176457
37.

Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections.

Khoo US, Chan KY, Chan VS, Ching JC, Yam L, Chu CM, Lai ST, Wong TY, Tam P, Yip SP, Leung GM, Lin CL, Peiris JS.

Hong Kong Med J. 2008 Aug;14 Suppl 4:31-5.

38.

Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women.

Chan KY, Liu W, Long JR, Yip SP, Chan SY, Shu XO, Chua DT, Cheung AN, Ching JC, Cai H, Au GK, Chan M, Foo W, Ngan HY, Gao YT, Ngan ES, Garcia-Barceló MM, Zheng W, Khoo US.

J Med Genet. 2009 Jan;46(1):32-9. doi: 10.1136/jmg.2007.057174. Epub 2008 Sep 9.

39.

Localization of hRad9 in breast cancer.

Chan V, Khoo US, Wong MS, Lau K, Suen D, Li G, Kwong A, Chan TK.

BMC Cancer. 2008 Jul 11;8:196. doi: 10.1186/1471-2407-8-196.

40.

DC-SIGN and L-SIGN: the SIGNs for infection.

Khoo US, Chan KY, Chan VS, Lin CL.

J Mol Med (Berl). 2008 Aug;86(8):861-74. doi: 10.1007/s00109-008-0350-2. Epub 2008 May 6. Review.

PMID:
18458800
41.

Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.

Liao X, Siu MK, Chan KY, Wong ES, Ngan HY, Chan QK, Li AS, Khoo US, Cheung AN.

Int J Cancer. 2008 Jul 15;123(2):296-302. doi: 10.1002/ijc.23494.

42.
43.

A novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung.

Chen Y, Chan VS, Zheng B, Chan KY, Xu X, To LY, Huang FP, Khoo US, Lin CL.

J Exp Med. 2007 Oct 29;204(11):2529-36. Epub 2007 Oct 8.

44.

CpG/CpNpG motifs in the coding region are preferred sites for mutagenesis in the breast cancer susceptibility genes.

Cheung LW, Lee YF, Ng TW, Ching WK, Khoo US, Ng MK, Wong AS.

FEBS Lett. 2007 Oct 2;581(24):4668-74. Epub 2007 Sep 4.

45.

Characterization of the pathogenic mechanism of a novel BRCA2 variant in a Chinese family.

Kwong A, Wong LP, Chan KY, Ma ES, Khoo US, Ford JM.

Fam Cancer. 2008;7(2):125-33. Epub 2007 Jul 27.

PMID:
17657584
46.

Association of ICAM3 genetic variant with severe acute respiratory syndrome.

Chan KY, Ching JC, Xu MS, Cheung AN, Yip SP, Yam LY, Lai ST, Chu CM, Wong AT, Song YQ, Huang FP, Liu W, Chung PH, Leung GM, Chow EY, Chan EY, Chan JC, Ngan HY, Tam P, Chan LC, Sham P, Chan VS, Peiris M, Lin SC, Khoo US.

J Infect Dis. 2007 Jul 15;196(2):271-80. Epub 2007 Jun 5.

PMID:
17570115
47.

A retroperitoneal immature teratoma with rhabdomyoblastic and nephroblastic differentiation.

Fan YS, Khoo US, Chan GS.

Pathology. 2006 Aug;38(4):364-7. No abstract available.

PMID:
16916732
48.

Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility.

Yang CQ, Chan KY, Ngan HY, Khoo US, Chiu PM, Chan QK, Xue WC, Cheung AN.

Carcinogenesis. 2006 Jul;27(7):1502-6. Epub 2006 Mar 30.

PMID:
16574671
49.

Microsatellite instability in mitochondrial genome of common female cancers.

Wang Y, Liu VW, Tsang PC, Chiu PM, Cheung AN, Khoo US, Nagley P, Ngan HY.

Int J Gynecol Cancer. 2006 Jan-Feb;16 Suppl 1:259-66.

PMID:
16515601
50.

Effect of all-trans retinoic acid on tissue dynamics of choriocarcinoma cell lines: an organotypic model.

Chiu PM, Feng HC, Benbrook DM, Ngan HY, Khoo US, Xue WC, Tsao SW, Chan KW, Cheung AN.

J Clin Pathol. 2006 Aug;59(8):845-50. Epub 2006 Feb 6.

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