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Efficacy and safety of dihydroartemisinin-piperaquine for treatment of Plasmodium falciparum uncomplicated malaria in adult patients on antiretroviral therapy in Malawi and Mozambique: an open label non-randomized interventional trial.

Sevene E, Banda CG, Mukaka M, Maculuve S, Macuacua S, Vala A, Piqueras M, Kalilani-Phiri L, Mallewa J, Terlouw DJ, Khoo SH, Lalloo DG, Mwapasa V.

Malar J. 2019 Aug 20;18(1):277. doi: 10.1186/s12936-019-2909-5.


Efficacy and safety of artemether-lumefantrine as treatment for Plasmodium falciparum uncomplicated malaria in adult patients on efavirenz-based antiretroviral therapy in Zambia: an open label non-randomized interventional trial.

Banda CG, Chaponda M, Mukaka M, Mulenga M, Hachizovu S, Kabuya JB, Mulenga J, Sikalima J, Kalilani-Phiri L, Terlouw DJ, Khoo SH, Lalloo DG, Mwapasa V.

Malar J. 2019 May 24;18(1):180. doi: 10.1186/s12936-019-2818-7.


Carbamazepine intervention in a patient with efavirenz-induced liver injury.

Jacobs TG, Burger DM, Pranger AD, Khoo SH, Drenth JPH, van Crevel R.

AIDS. 2019 May 1;33(6):1097-1098. doi: 10.1097/QAD.0000000000002116. No abstract available.


Therapeutic drug monitoring of darunavir/ritonavir in pregnancy.

Murtagh R, Else LJ, Kuan KB, Khoo SH, Jackson V, Patel A, Lawler M, McDonald G, Le Blanc D, Avramovic G, Redmond N, Lambert JS.

Antivir Ther. 2019;24(3):229-233. doi: 10.3851/IMP3291.


Widespread use of herbal medicines by people living with human immunodeficiency virus and contamination of herbal medicines with antiretrovirals in Nigeria.

Gini J, Amara A, Penchala SD, Back DJ, Else L, Egan D, Chiong J, Harri BI, Kabilis ED, Pama PP, Stephen M, Khoo SH.

Int J STD AIDS. 2019 Mar;30(4):371-377. doi: 10.1177/0956462418809749. Epub 2018 Nov 30.


Drug Interactions between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine.

Walimbwa SI, Lamorde M, Waitt C, Kaboggoza J, Else L, Byakika-Kibwika P, Amara A, Gini J, Winterberg M, Chiong J, Tarning J, Khoo SH.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01310-18. doi: 10.1128/AAC.01310-18. Print 2019 Feb.


Impact of Efavirenz-, Ritonavir-Boosted Lopinavir-, and Nevirapine-Based Antiretroviral Regimens on the Pharmacokinetics of Lumefantrine and Safety of Artemether-Lumefantrine in Plasmodium falciparum-Negative HIV-Infected Malawian Adults Stabilized on Antiretroviral Therapy.

Banda CG, Dzinjalamala F, Mukaka M, Mallewa J, Maiden V, Terlouw DJ, Lalloo DG, Khoo SH, Mwapasa V.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01162-18. doi: 10.1128/AAC.01162-18. Print 2018 Nov.


Pharmacokinetics of Piperaquine and Safety Profile of Dihydroartemisinin-Piperaquine Coadministered with Antiretroviral Therapy in Malaria-Uninfected HIV-Positive Malawian Adults.

Banda CG, Dzinjalamala F, Mukaka M, Mallewa J, Maiden V, Terlouw DJ, Lalloo DG, Khoo SH, Mwapasa V.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00634-18. doi: 10.1128/AAC.00634-18. Print 2018 Aug.


Pharmacokinetics and Safety Profile of Artesunate-Amodiaquine Coadministered with Antiretroviral Therapy in Malaria-Uninfected HIV-Positive Malawian Adults.

Banda CG, Dzinjalamala F, Mukaka M, Mallewa J, Maiden V, Terlouw DJ, Lalloo DG, Khoo SH, Mwapasa V.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00412-18. doi: 10.1128/AAC.00412-18. Print 2018 Jul.


Development, validation and utilization of a highly sensitive LC-MS/MS method for quantification of levonorgestrel released from a subdermal implant in human plasma.

Cirrincione LR, Penchala SD, Scarsi KK, Podany AT, Winchester LC, Back DJ, Khoo SH, Fletcher CV, Siccardi M, Else LJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 May 1;1084:106-112. doi: 10.1016/j.jchromb.2018.03.023. Epub 2018 Mar 12.


Genetic Determinants of the Pharmacokinetic Variability of Rifampin in Malawian Adults with Pulmonary Tuberculosis.

Sloan DJ, McCallum AD, Schipani A, Egan D, Mwandumba HC, Ward SA, Waterhouse D, Banda G, Allain TJ, Owen A, Khoo SH, Davies GR.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00210-17. doi: 10.1128/AAC.00210-17. Print 2017 Jul.


Development of an evidence evaluation and synthesis system for drug-drug interactions, and its application to a systematic review of HIV and malaria co-infection.

Seden K, Gibbons S, Marzolini C, Schapiro JM, Burger DM, Back DJ, Khoo SH.

PLoS One. 2017 Mar 23;12(3):e0173509. doi: 10.1371/journal.pone.0173509. eCollection 2017.


Impact of polypharmacy on antiretroviral prescription in people living with HIV.

Guaraldi G, Menozzi M, Zona S, Calcagno A, Silva AR, Santoro A, Malagoli A, Dolci G, Mussi C, Mussini C, Cesari M, Khoo SH.

J Antimicrob Chemother. 2017 Feb;72(2):511-514. doi: 10.1093/jac/dkw437. Epub 2016 Nov 9.


Perceptions of Research Bronchoscopy in Malawian Adults with Pulmonary Tuberculosis: A Cross-Sectional Study.

McCallum AD, Nyirenda D, Lora W, Khoo SH, Sloan DJ, Mwandumba HC, Desmond N, Davies GR.

PLoS One. 2016 Oct 28;11(10):e0165734. doi: 10.1371/journal.pone.0165734. eCollection 2016.


Adequacy of Rifampin Absorption after Jejunostomy Tube Administration.

Stott KE, Singh B, Beadsworth MB, Vaudrey K, Khoo SH, Davies G.

Pharmacotherapy. 2016 Apr;36(4):e23-5. doi: 10.1002/phar.1730. Epub 2016 Apr 6.


First experience of effectiveness and safety of bedaquiline for 18 months within an optimised regimen for XDR-TB.

Lewis JM, Hine P, Walker J, Khoo SH, Taegtmeyer M, Squire SB, Sloan DJ.

Eur Respir J. 2016 May;47(5):1581-4. doi: 10.1183/13993003.01980-2015. Epub 2016 Feb 25. No abstract available.


Choice of antiretroviral drugs for continued treatment scale-up in a public health approach: what more do we need to know?

Vitoria M, Hill AM, Ford NP, Doherty M, Khoo SH, Pozniak AL.

J Int AIDS Soc. 2016 Feb 2;19(1):20504. doi: 10.7448/IAS.19.1.20504. eCollection 2016.


Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial.

McCormack S, Dunn DT, Desai M, Dolling DI, Gafos M, Gilson R, Sullivan AK, Clarke A, Reeves I, Schembri G, Mackie N, Bowman C, Lacey CJ, Apea V, Brady M, Fox J, Taylor S, Antonucci S, Khoo SH, Rooney J, Nardone A, Fisher M, McOwan A, Phillips AN, Johnson AM, Gazzard B, Gill ON.

Lancet. 2016 Jan 2;387(10013):53-60. doi: 10.1016/S0140-6736(15)00056-2. Epub 2015 Sep 9.


Population pharmacokinetics of rifampicin and 25-deacetyl-rifampicin in healthy Asian adults.

Seng KY, Hee KH, Soon GH, Chew N, Khoo SH, Lee LS.

J Antimicrob Chemother. 2015 Dec;70(12):3298-306. doi: 10.1093/jac/dkv268. Epub 2015 Sep 4.


Prevalence and type of drug-drug interactions involving ART in patients attending a specialist HIV outpatient clinic in Kampala, Uganda.

Seden K, Merry C, Hewson R, Siccardi M, Lamorde M, Byakika-Kibwika P, Laker E, Parkes-Ratanshi R, Back DJ, Khoo SH.

J Antimicrob Chemother. 2015 Dec;70(12):3317-22. doi: 10.1093/jac/dkv259. Epub 2015 Aug 18.


Population pharmacokinetic analysis of isoniazid, acetylisoniazid, and isonicotinic acid in healthy volunteers.

Seng KY, Hee KH, Soon GH, Chew N, Khoo SH, Lee LS.

Antimicrob Agents Chemother. 2015 Nov;59(11):6791-9. doi: 10.1128/AAC.01244-15. Epub 2015 Aug 17.


Vitamin D deficiency in Malawian adults with pulmonary tuberculosis: risk factors and treatment outcomes.

Sloan DJ, Mwandumba HC, Kamdolozi M, Shani D, Chisale B, Dutton J, Khoo SH, Allain TJ, Davies GR.

Int J Tuberc Lung Dis. 2015 Aug;19(8):904-11. doi: 10.5588/ijtld.15.0071.


Is infant exposure to antiretroviral drugs during breastfeeding quantitatively important? A systematic review and meta-analysis of pharmacokinetic studies.

Waitt CJ, Garner P, Bonnett LJ, Khoo SH, Else LJ.

J Antimicrob Chemother. 2015 Jul;70(7):1928-41. doi: 10.1093/jac/dkv080. Epub 2015 Apr 8. Review.


Pharmacodynamic Modeling of Bacillary Elimination Rates and Detection of Bacterial Lipid Bodies in Sputum to Predict and Understand Outcomes in Treatment of Pulmonary Tuberculosis.

Sloan DJ, Mwandumba HC, Garton NJ, Khoo SH, Butterworth AE, Allain TJ, Heyderman RS, Corbett EL, Barer MR, Davies GR.

Clin Infect Dis. 2015 Jul 1;61(1):1-8. doi: 10.1093/cid/civ195. Epub 2015 Mar 16.


Steady-state pharmacokinetics of rilpivirine under different meal conditions in HIV-1-infected Ugandan adults.

Lamorde M, Walimbwa S, Byakika-Kibwika P, Katwere M, Mukisa L, Sempa JB, Else L, Back DJ, Khoo SH, Merry C.

J Antimicrob Chemother. 2015 May;70(5):1482-6. doi: 10.1093/jac/dku575. Epub 2015 Feb 3.


Effect of intermittent rifampicin on the pharmacokinetics and safety of raltegravir.

Reynolds HE, Chrdle A, Egan D, Chaponda M, Else L, Chiong J, Back DJ, Khoo SH.

J Antimicrob Chemother. 2015 Feb;70(2):550-4. doi: 10.1093/jac/dku376. Epub 2014 Sep 26.


Quantification of rilpivirine in human plasma, cervicovaginal fluid, rectal fluid and genital/rectal mucosal tissues using liquid chromatography-tandem mass spectrometry.

Else LJ, Tjia J, Jackson A, Penchala SD, Egan D, Boffito M, Khoo SH, Back DJ.

Bioanalysis. 2014;6(14):1907-21. doi: 10.4155/bio.14.59.


Therapeutic drug monitoring of atazanavir/ritonavir in pregnancy.

Else LJ, Jackson V, Brennan M, Back DJ, Khoo SH, Coulter-Smith S, Lambert JS.

HIV Med. 2014 Nov;15(10):604-10. doi: 10.1111/hiv.12164. Epub 2014 May 14.


Recent advances in tuberculosis: New drugs and treatment regimens.

Sloan DJ, Davies GR, Khoo SH.

Curr Respir Med Rev. 2013 Jun 1;9(3):200-210.


Abacavir forms novel cross-linking abacavir protein adducts in patients.

Meng X, Lawrenson AS, Berry NG, Maggs JL, French NS, Back DJ, Khoo SH, Naisbitt DJ, Park BK.

Chem Res Toxicol. 2014 Apr 21;27(4):524-35. doi: 10.1021/tx400406p. Epub 2014 Feb 26.


Open source clinical science for emerging infections.

Dunning JW, Merson L, Rohde GGU, Gao Z, Semple MG, Tran D, Gordon A, Olliaro PL, Khoo SH, Bruzzone R, Horby P, Cobb JP, Longuere KS, Kellam P, Nichol A, Brett S, Everett D, Walsh TS, Hien TT, Yu H, Zambon M, Ruiz-Palacios G, Lang T, Akhvlediani T; ISARIC Working Group 3, ISARIC Council, Hayden FG, Marshall J, Webb S, Angus DC, Shindo N, van der Werf S, Openshaw PJM, Farrar J, Carson G, Baillie JK.

Lancet Infect Dis. 2014 Jan;14(1):8-9. doi: 10.1016/S1473-3099(13)70327-X. No abstract available.


Drug interactions between antiretrovirals and new or emerging direct-acting antivirals in HIV/hepatitis C virus coinfection.

Karageorgopoulos DE, El-Sherif O, Bhagani S, Khoo SH.

Curr Opin Infect Dis. 2014 Feb;27(1):36-45. doi: 10.1097/QCO.0000000000000034. Review.


Population pharmacokinetic and pharmacogenetic analysis of nevirapine in hypersensitive and tolerant HIV-infected patients from Malawi.

Dickinson L, Chaponda M, Carr DF, van Oosterhout JJ, Kumwenda J, Lalloo DG, Pirmohamed M, Heyderman RS, Khoo SH.

Antimicrob Agents Chemother. 2014;58(2):706-12. doi: 10.1128/AAC.02069-13. Epub 2013 Nov 11.


Antiretroviral solid drug nanoparticles with enhanced oral bioavailability: production, characterization, and in vitro-in vivo correlation.

McDonald TO, Giardiello M, Martin P, Siccardi M, Liptrott NJ, Smith D, Roberts P, Curley P, Schipani A, Khoo SH, Long J, Foster AJ, Rannard SP, Owen A.

Adv Healthc Mater. 2014 Mar;3(3):400-11. doi: 10.1002/adhm.201300280. Epub 2013 Sep 1.


Kidney transplantation in HIV-positive adults: the UK experience.

Gathogo EN, Hamzah L, Hilton R, Marshall N, Ashley C, Harber M, Levy JB, Jones R, Boffito M, Khoo SH, Drage M, Bhagani S, Post FA; UK HIV/Kidney Transplantation Study Group (see appendix).

Int J STD AIDS. 2014 Jan;25(1):57-66. doi: 10.1177/0956462413493266. Epub 2013 Jul 19.


Validation of an electrospray ionisation LC-MS/MS method for quantitative analysis of telaprevir and its R-diastereomer.

Penchala SD, Tjia J, El Sherif O, Back DJ, Khoo SH, Else LJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Aug 1;932:100-10. doi: 10.1016/j.jchromb.2013.06.013. Epub 2013 Jun 17.


Interactions between tenofovir and nevirapine in CD4+ T cells and monocyte-derived macrophages restrict their intracellular accumulation.

Liptrott NJ, Curley P, Moss D, Back DJ, Khoo SH, Owen A.

J Antimicrob Chemother. 2013 Nov;68(11):2545-9. doi: 10.1093/jac/dkt225. Epub 2013 Jun 21.


Lower artemether, dihydroartemisinin and lumefantrine concentrations during rifampicin-based tuberculosis treatment.

Lamorde M, Byakika-Kibwika P, Mayito J, Nabukeera L, Ryan M, Hanpithakpong W, Lefèvre G, Back DJ, Khoo SH, Merry C.

AIDS. 2013 Mar 27;27(6):961-5. doi: 10.1097/QAD.0b013e32835cae3b.


The clinical utility of HIV outpatient pharmacist prescreening to reduce medication error and assess adherence.

Seden K, Bradley M, Miller AR, Beadsworth MB, Khoo SH.

Int J STD AIDS. 2013 Mar;24(3):237-41. doi: 10.1177/0956462412472428. Epub 2013 May 6.


Surgically treated cervical myelopathy: a functional outcome comparison study between multilevel anterior cervical decompression fusion with instrumentation and posterior laminoplasty.

Seng C, Tow BP, Siddiqui MA, Srivastava A, Wang L, Yew AK, Yeo W, Khoo SH, Balakrishnan NM, Bin Abd Razak HR, Chen JL, Guo CM, Tan SB, Yue WM.

Spine J. 2013 Jul;13(7):723-31. doi: 10.1016/j.spinee.2013.02.038. Epub 2013 Mar 27.


Association of human leukocyte antigen alleles and nevirapine hypersensitivity in a Malawian HIV-infected population.

Carr DF, Chaponda M, Jorgensen AL, Castro EC, van Oosterhout JJ, Khoo SH, Lalloo DG, Heyderman RS, Alfirevic A, Pirmohamed M.

Clin Infect Dis. 2013 May;56(9):1330-9. doi: 10.1093/cid/cit021. Epub 2013 Jan 29.


Cross-sectional study of prescribing errors in patients admitted to nine hospitals across North West England.

Seden K, Kirkham JJ, Kennedy T, Lloyd M, James S, McManus A, Ritchings A, Simpson J, Thornton D, Gill A, Coleman C, Thorpe B, Khoo SH.

BMJ Open. 2013 Jan 9;3(1). pii: e002036. doi: 10.1136/bmjopen-2012-002036.


Global patient safety and antiretroviral drug-drug interactions in the resource-limited setting.

Seden K, Khoo SH, Back D, Byakika-Kibwika P, Lamorde M, Ryan M, Merry C.

J Antimicrob Chemother. 2013 Jan;68(1):1-3. doi: 10.1093/jac/dks346. Epub 2012 Aug 22. Review.


Optimizing outpatient serial sputum colony counting for studies of tuberculosis treatment in resource-poor settings.

Sloan DJ, Corbett EL, Butterworth AE, Mwandumba HC, Khoo SH, Mdolo A, Shani D, Kamdolozi M, Allen J, Mitchison DA, Coleman DJ, Davies GR.

J Clin Microbiol. 2012 Jul;50(7):2315-20. doi: 10.1128/JCM.00043-12. Epub 2012 May 9.


Estimation of the effect of SLCO1B1 polymorphisms on lopinavir plasma concentration in HIV-infected adults.

Schipani A, Egan D, Dickinson L, Davies G, Boffito M, Youle M, Khoo SH, Back DJ, Owen A.

Antivir Ther. 2012;17(5):861-8. doi: 10.3851/IMP2095. Epub 2012 Apr 4.


Divalent metals and pH alter raltegravir disposition in vitro.

Moss DM, Siccardi M, Murphy M, Piperakis MM, Khoo SH, Back DJ, Owen A.

Antimicrob Agents Chemother. 2012 Jun;56(6):3020-6. doi: 10.1128/AAC.06407-11. Epub 2012 Mar 26.


Patients accessing HIV treatment via sexual health services: what are the risks of the dual case-note system?

Seden K, Mathew T, Bradley M, Ferraro C, Hall E, Beeching NJ, Khoo SH.

Int J STD AIDS. 2012 Feb;23(2):99-104. doi: 10.1258/ijsa.2011.011070.


Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the male and female genital tract.

Else LJ, Taylor S, Back DJ, Khoo SH.

Antivir Ther. 2011;16(8):1149-67. doi: 10.3851/IMP1919. Review.


Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the fetal compartment (placenta and amniotic fluid).

Else LJ, Taylor S, Back DJ, Khoo SH.

Antivir Ther. 2011;16(8):1139-47. doi: 10.3851/IMP1918. Review.


Improved oral bioavailability of lopinavir in melt-extruded tablet formulation reduces impact of third trimester on lopinavir plasma concentrations.

Else LJ, Douglas M, Dickinson L, Back DJ, Khoo SH, Taylor GP.

Antimicrob Agents Chemother. 2012 Feb;56(2):816-24. doi: 10.1128/AAC.05186-11. Epub 2011 Nov 21.

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