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Inclusion of pregnant women in antiretroviral drug research: what is needed to move forwards?

Fairlie L, Waitt C, Lockman S, Moorhouse M, Abrams EJ, Clayden P, Boffito M, Khoo S, Rees H, Cournil A, Venter WF, Serenata C, Chersich M.

J Int AIDS Soc. 2019 Sep;22(9):e25372. doi: 10.1002/jia2.25372.


Pharmacokinetics of maraviroc in plasma and breastmilk in a treatment-experienced perinatally HIV-1 infected women.

Feiterna-Sperling C, Krüger R, Amara A, Khoo S, Waitt C.

AIDS. 2019 Sep 2. doi: 10.1097/QAD.0000000000002360. [Epub ahead of print] No abstract available.


Efficacy and safety of dihydroartemisinin-piperaquine for treatment of Plasmodium falciparum uncomplicated malaria in adult patients on antiretroviral therapy in Malawi and Mozambique: an open label non-randomized interventional trial.

Sevene E, Banda CG, Mukaka M, Maculuve S, Macuacua S, Vala A, Piqueras M, Kalilani-Phiri L, Mallewa J, Terlouw DJ, Khoo SH, Lalloo DG, Mwapasa V.

Malar J. 2019 Aug 20;18(1):277. doi: 10.1186/s12936-019-2909-5.


Polypharmacy and drug-drug interactions in HIV-infected subjects in the region of Madrid, Spain: a population-based study.

López-Centeno B, Badenes-Olmedo C, Mataix-Sanjuan Á, McAllister K, Bellón JM, Gibbons S, Balsalobre P, Pérez-Latorre L, Benedí J, Marzolini C, Aranguren-Oyarzábal A, Khoo S, Calvo-Alcántara MJ, Berenguer J.

Clin Infect Dis. 2019 Aug 20. pii: ciz811. doi: 10.1093/cid/ciz811. [Epub ahead of print]


TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]): An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral Therapy.

Pushpakom S, Kolamunnage-Dona R, Taylor C, Foster T, Spowart C, García-Fiñana M, Kemp GJ, Jaki T, Khoo S, Williamson P, Pirmohamed M; TAILoR Study Group .

Clin Infect Dis. 2019 Jul 3. pii: ciz589. doi: 10.1093/cid/ciz589. [Epub ahead of print]


Aspects of extraversion and their associations with psychopathology.

Watson D, Ellickson-Larew S, Stanton K, Levin-Aspenson HF, Khoo S, Stasik-O'Brien SM, Clark LA.

J Abnorm Psychol. 2019 Aug 15. doi: 10.1037/abn0000459. [Epub ahead of print]


Clinical Pharmacodynamics, Pharmacokinetics, and Drug Interaction Profile of Doravirine.

Boyle A, Moss CE, Marzolini C, Khoo S.

Clin Pharmacokinet. 2019 Aug 7. doi: 10.1007/s40262-019-00806-9. [Epub ahead of print] Review.


Towards developing and validating Quality Physical Education in schools-The Asian physical education professionals' voice.

Ho WKY, Ahmed MD, Khoo S, Tan CH, Dehkordi MR, Gallardo M, Lee K, Yamaguchi Y, Tao Y, Shu C.

PLoS One. 2019 Aug 1;14(8):e0218158. doi: 10.1371/journal.pone.0218158. eCollection 2019.


Suboptimal treatment of dyslipidemia in patients with nonalcoholic fatty liver disease.

Khoo S, Wong VW, Goh GB, Fan J, Chan WK, Seto WK, Chow WC.

J Gastroenterol Hepatol. 2019 Jul 23. doi: 10.1111/jgh.14794. [Epub ahead of print]


Pharmacokinetics (PK) of ethinylestradiol/levonorgestrel co-administered with atazanavir/cobicistat.

Elliot ER, Bisdomini E, Penchala SD, Khoo S, Nwokolo N, Boffito M.

HIV Res Clin Pract. 2019 Jul 23:1-10. doi: 10.1080/25787489.2019.1638077. [Epub ahead of print]


Leveraging crowdsourcing to accelerate global health solutions.

Davis S, Button-Simons K, Bensellak T, Ahsen EM, Checkley L, Foster GJ, Su X, Moussa A, Mapiye D, Khoo SK, Nosten F, Anderson TJC, Vendrely K, Bletz J, Yu T, Panji S, Ghouila A, Mulder N, Norman T, Kern S, Meyer P, Stolovitzky G, Ferdig MT, Siwo GH.

Nat Biotechnol. 2019 Aug;37(8):848-850. doi: 10.1038/s41587-019-0180-5. No abstract available.


Telmisartan to reduce insulin resistance in HIV-positive individuals on combination antiretroviral therapy: the TAILoR dose-ranging Phase II RCT.

Pushpakom S, Kolamunnage-Dona R, Taylor C, Foster T, Spowart C, Garcia-Finana M, Kemp GJ, Jaki T, Khoo S, Williamson P, Pirmohamed M.

Southampton (UK): NIHR Journals Library; 2019 Jul.


Optimizing responses to drug safety signals in pregnancy: the example of dolutegravir and neural tube defects.

Mofenson LM, Pozniak AL, Wambui J, Raizes E, Ciaranello A, Clayden P, Ehrenkranz P, Fakoya A, Hill A, Khoo S, Mahaka I, Modi S, Moore C, Phillips A, Siberry G, Sikwese K, Thorne C, Watts HD, Doherty M, Ford NP.

J Int AIDS Soc. 2019 Jul;22(7):e25352. doi: 10.1002/jia2.25352.


Intraoperative Computed Tomography Scan for Orbital Fracture Reconstruction.

Nazimi AJ, Khoo SC, Nabil S, Nordin R, Lan TH, Rajandram RK, Rajaran JR.

J Craniofac Surg. 2019 Jun 20. doi: 10.1097/SCS.0000000000005667. [Epub ahead of print]


Effectiveness of near-peer simulation for managing the acutely deteriorating patient among residents of an internal medicine junior residency programme.

Shen X, Tay BWR, Tan BY, Ngiam NJ, Mok JSR, Mok SF, Yap ES, Khoo SM.

Singapore Med J. 2019 Jun 14. doi: 10.11622/smedj.2019056. [Epub ahead of print]


A Multiple Dose Phase 1 Assessment of Rilpivirine Long Acting in a Model of Preexposure Prophylaxis Against HIV.

Cranston RD, Dezzutti CS, Siegel A, Engstrom J, Shetler C, Richardson-Harman N, Abebe KZ, Back D, Else L, Egan D, Khoo S, Egan JE, Stall R, Williams P, Brand RM, Parikh UM, McGowan I.

AIDS Res Hum Retroviruses. 2019 Sep;35(9):794-804. doi: 10.1089/AID.2018.0265. Epub 2019 Jul 16.


Reply to Banda et al., "Interpretation of Drug Interactions between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine".

Walimbwa S, Lamorde M, Waitt C, Amara A, Khoo S.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00593-19. doi: 10.1128/AAC.00593-19. Print 2019 Jun. No abstract available.


Efficacy and safety of artemether-lumefantrine as treatment for Plasmodium falciparum uncomplicated malaria in adult patients on efavirenz-based antiretroviral therapy in Zambia: an open label non-randomized interventional trial.

Banda CG, Chaponda M, Mukaka M, Mulenga M, Hachizovu S, Kabuya JB, Mulenga J, Sikalima J, Kalilani-Phiri L, Terlouw DJ, Khoo SH, Lalloo DG, Mwapasa V.

Malar J. 2019 May 24;18(1):180. doi: 10.1186/s12936-019-2818-7.


Management of primary hyperparathyroidism in pregnancy: a case series.

McCarthy A, Howarth S, Khoo S, Hale J, Oddy S, Halsall D, Fish B, Mariathasan S, Andrews K, Oyibo SO, Samyraju M, Gajewska-Knapik K, Park SM, Wood D, Moran C, Casey RT.

Endocrinol Diabetes Metab Case Rep. 2019 May 16;2019. pii: EDM190039. doi: 10.1530/EDM-19-0039. [Epub ahead of print]


The medial prefrontal cortex is required for responding to alcohol-predictive cues but only in the absence of alcohol delivery.

Khoo SY, Sciascia JM, Pettorelli A, Maddux JN, Chaudhri N.

J Psychopharmacol. 2019 Jul;33(7):842-854. doi: 10.1177/0269881119844180. Epub 2019 May 9.


Dry surgical field minor salivary gland harvest using a chalazion clamp for sicca syndrome.

Wijaya C, Ramli RR, Khoo SG.

J Laryngol Otol. 2019 May;133(5):419-423. doi: 10.1017/S002221511900077X. Epub 2019 Apr 22.


Peri-Infarct Upregulation of the Oxytocin Receptor in Vascular Dementia.

McKay EC, Beck JS, Khoo SK, Dykema KJ, Cottingham SL, Winn ME, Paulson HL, Lieberman AP, Counts SE.

J Neuropathol Exp Neurol. 2019 May 1;78(5):436-452. doi: 10.1093/jnen/nlz023.


Predictors of treatment initiation, completion, and selection among youth offered trauma-informed care.

Ghafoori B, Garfin DR, Ramírez J, Khoo SF.

Psychol Trauma. 2019 Apr 11. doi: 10.1037/tra0000460. [Epub ahead of print]


Carbamazepine intervention in a patient with efavirenz-induced liver injury.

Jacobs TG, Burger DM, Pranger AD, Khoo SH, Drenth JPH, van Crevel R.

AIDS. 2019 May 1;33(6):1097-1098. doi: 10.1097/QAD.0000000000002116. No abstract available.


The Utility of Efavirenz-based Prophylaxis Against HIV Infection. A Systems Pharmacological Analysis.

Duwal S, Seeler D, Dickinson L, Khoo S, von Kleist M.

Front Pharmacol. 2019 Mar 13;10:199. doi: 10.3389/fphar.2019.00199. eCollection 2019.


Development of highly potent glucocorticoids for steroid-resistant severe asthma.

He Y, Shi J, Nguyen QT, You E, Liu H, Ren X, Wu Z, Li J, Qiu W, Khoo SK, Yang T, Yi W, Sun F, Xi Z, Huang X, Melcher K, Min B, Xu HE.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6932-6937. doi: 10.1073/pnas.1816734116. Epub 2019 Mar 20.


Cerebrospinal fluid exposure of cenicriviroc in HIV-positive individuals with cognitive impairment.

Alagaratnam J, Dilly-Penchala S, Challenger E, Else L, Legg K, Petersen C, Jones B, Kulasegaram R, Seyedkazemi S, Lefebvre E, Khoo S, Winston A.

Br J Clin Pharmacol. 2019 May;85(5):1039-1040. doi: 10.1111/bcp.13878. Epub 2019 Mar 4. No abstract available.


Pharmacokinetics of dolutegravir with and without darunavir/cobicistat in healthy volunteers.

Elliot ER, Cerrone M, Challenger E, Else L, Amara A, Bisdomini E, Khoo S, Owen A, Boffito M.

J Antimicrob Chemother. 2019 May 1;74(5):1466. doi: 10.1093/jac/dky571. No abstract available.


Impact of pharmacogenetics and pregnancy on tenofovir and emtricitabine pharmacokinetics.

Gini J, Olagunju A, Dickinson L, Waitt C, Neary M, Else LJ, Siccardi M, Khoo S.

Pharmacogenomics. 2019 Mar;20(4):217-223. doi: 10.2217/pgs-2018-0111. Epub 2019 Feb 15.


Context and topography determine the role of basolateral amygdala metabotropic glutamate receptor 5 in appetitive Pavlovian responding.

Khoo SY, LeCocq MR, Deyab GE, Chaudhri N.

Neuropsychopharmacology. 2019 Aug;44(9):1524-1533. doi: 10.1038/s41386-019-0335-6. Epub 2019 Feb 8.


Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing.

Khoo SK, Read J, Franks K, Zhang G, Bizzintino J, Coleman L, McCrae C, Öberg L, Troy NM, Prastanti F, Everard J, Oo S, Borland ML, Maciewicz RA, Le Souëf PN, Laing IA, Bosco A.

J Immunol. 2019 Mar 15;202(6):1845-1858. doi: 10.4049/jimmunol.1800178. Epub 2019 Feb 11.


Therapeutic drug monitoring of darunavir/ritonavir in pregnancy.

Murtagh R, Else LJ, Kuan KB, Khoo SH, Jackson V, Patel A, Lawler M, McDonald G, Le Blanc D, Avramovic G, Redmond N, Lambert JS.

Antivir Ther. 2019;24(3):229-233. doi: 10.3851/IMP3291.


Mechanistic framework predicts drug-class specific utility of antiretrovirals for HIV prophylaxis.

Duwal S, Dickinson L, Khoo S, von Kleist M.

PLoS Comput Biol. 2019 Jan 30;15(1):e1006740. doi: 10.1371/journal.pcbi.1006740. eCollection 2019 Jan.


HIV-Related Arterial Stiffness in Malawian Adults Is Associated With the Proportion of PD-1-Expressing CD8+ T Cells and Reverses With Antiretroviral Therapy.

Kelly C, Mwandumba HC, Heyderman RS, Jambo K, Kamng'ona R, Chammudzi M, Sheha I, Peterson I, Rapala A, Mallewa J, Walker AS, Klein N, Khoo S.

J Infect Dis. 2019 May 24;219(12):1948-1958. doi: 10.1093/infdis/jiz015.


Pharmacogenetics and pharmacokinetics of CNS penetration of efavirenz and its metabolites.

Decloedt EH, Sinxadi PZ, van Zyl GU, Wiesner L, Khoo S, Joska JA, Haas DW, Maartens G.

J Antimicrob Chemother. 2019 Mar 1;74(3):699-709. doi: 10.1093/jac/dky481.


Widespread use of herbal medicines by people living with human immunodeficiency virus and contamination of herbal medicines with antiretrovirals in Nigeria.

Gini J, Amara A, Penchala SD, Back DJ, Else L, Egan D, Chiong J, Harri BI, Kabilis ED, Pama PP, Stephen M, Khoo SH.

Int J STD AIDS. 2019 Mar;30(4):371-377. doi: 10.1177/0956462418809749. Epub 2018 Nov 30.


Pharmacogenetics of artemether-lumefantrine influence on nevirapine disposition: Clinically significant drug-drug interaction?

Abdullahi ST, Olagunju A, Soyinka JO, Bolarinwa RA, Olarewaju OJ, Bakare-Odunola MT, Owen A, Khoo S.

Br J Clin Pharmacol. 2019 Mar;85(3):540-550. doi: 10.1111/bcp.13821. Epub 2019 Jan 2.


Validation and clinical application of a novel LC-MS method for quantification of dolutegravir in breast milk.

Gini J, Penchala SD, Amara A, Challenger E, Egan D, Waitt C, Lamorde M, Orrell C, Myer L, Khoo S, Else LJ.

Bioanalysis. 2018 Nov 19. doi: 10.4155/bio-2018-0085. [Epub ahead of print]


Drug Interactions between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine.

Walimbwa SI, Lamorde M, Waitt C, Kaboggoza J, Else L, Byakika-Kibwika P, Amara A, Gini J, Winterberg M, Chiong J, Tarning J, Khoo SH.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01310-18. doi: 10.1128/AAC.01310-18. Print 2019 Feb.


Pharmacokinetics of dolutegravir with and without darunavir/cobicistat in healthy volunteers.

Elliot ER, Cerrone M, Else L, Amara A, Bisdomini E, Khoo S, Owen A, Boffito M.

J Antimicrob Chemother. 2019 Jan 1;74(1):149-156. doi: 10.1093/jac/dky384.


Two cases of monkeypox imported to the United Kingdom, September 2018.

Vaughan A, Aarons E, Astbury J, Balasegaram S, Beadsworth M, Beck CR, Chand M, O'Connor C, Dunning J, Ghebrehewet S, Harper N, Howlett-Shipley R, Ihekweazu C, Jacobs M, Kaindama L, Katwa P, Khoo S, Lamb L, Mawdsley S, Morgan D, Palmer R, Phin N, Russell K, Said B, Simpson A, Vivancos R, Wade M, Walsh A, Wilburn J.

Euro Surveill. 2018 Sep;23(38). doi: 10.2807/1560-7917.ES.2018.23.38.1800509.


Synthesis of a Base-Stabilized Silicon(I)-Iron(II) Complex for Hydroboration of Carbonyl Compounds.

Khoo S, Cao J, Ng F, So CW.

Inorg Chem. 2018 Oct 15;57(20):12452-12455. doi: 10.1021/acs.inorgchem.8b01760. Epub 2018 Sep 24.


Impact of Efavirenz-, Ritonavir-Boosted Lopinavir-, and Nevirapine-Based Antiretroviral Regimens on the Pharmacokinetics of Lumefantrine and Safety of Artemether-Lumefantrine in Plasmodium falciparum-Negative HIV-Infected Malawian Adults Stabilized on Antiretroviral Therapy.

Banda CG, Dzinjalamala F, Mukaka M, Mallewa J, Maiden V, Terlouw DJ, Lalloo DG, Khoo SH, Mwapasa V.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01162-18. doi: 10.1128/AAC.01162-18. Print 2018 Nov.


Establishing content validity and fidelity of a novel paediatric intussusception air enema reduction simulator.

Nataraja RM, Khoo S, Ditchfield M, Webb NR.

ANZ J Surg. 2019 Sep;89(9):1133-1137. doi: 10.1111/ans.14747. Epub 2018 Aug 22.


Synthesis of a Dimeric Base-Stabilized Cobaltosilylene Complex for Catalytic C-H Bond Functionalization and C-C Bond Formation.

Khoo S, Cao J, Yang MC, Shan YL, Su MD, So CW.

Chemistry. 2018 Sep 25;24(54):14329-14334. doi: 10.1002/chem.201803410. Epub 2018 Sep 14.


High prevalence and long duration of nervous system and psychiatric adverse drug reactions in Ugandan patients taking efavirenz 600 mg daily.

Seden K, Kiiza D, Laker E, Arinaitwe WJ, Waitt C, Lamorde M, Khoo S.

J Antimicrob Chemother. 2018 Nov 1;73(11):3158-3161. doi: 10.1093/jac/dky298.


Polymorphisms of tenofovir disoproxil fumarate transporters and risk of kidney tubular dysfunction in HIV-positive patients: genetics of tenofovir transporters.

Danjuma MI, Egan D, Abubeker IY, Post F, Khoo S.

Int J STD AIDS. 2018 Aug 2:956462418786562. doi: 10.1177/0956462418786562. [Epub ahead of print]


Dynamic characterisation of Össur Flex-Run prosthetic feet for a more informed prescription.

Noroozi S, Ong ZC, Khoo SY, Aslani N, Sewell P.

Prosthet Orthot Int. 2019 Feb;43(1):62-70. doi: 10.1177/0309364618789449. Epub 2018 Jul 27.


Cord Blood IL-12 Confers Protection to Clinical Malaria in Early Childhood Life.

Song Y, Aguilar R, Guo J, Manaca MN, Nhabomba A, Berthoud TK, Khoo SK, Wiertsema S, Barbosa A, Quintó L, Laing IA, Mayor A, Guinovart C, Alonso PL, LeSouëf PN, Dobaño C, Zhang GB.

Sci Rep. 2018 Jul 18;8(1):10860. doi: 10.1038/s41598-018-29179-y.


Cross-sectional analysis of ethnic differences in fall prevalence in urban dwellers aged 55 years and over in the Malaysian Elders Longitudinal Research study.

Alex D, Khor HM, Chin AV, Hairi NN, Othman S, Khoo SPK, Bahyah Kamaruzzaman S, Tan MP.

BMJ Open. 2018 Jul 17;8(7):e019579. doi: 10.1136/bmjopen-2017-019579.

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