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Vaso-Occlusion in Sickle Cell Disease: Is Autonomic Dysregulation of the Microvasculature the Trigger?

Veluswamy S, Shah P, Denton CC, Chalacheva P, Khoo MCK, Coates TD.

J Clin Med. 2019 Oct 15;8(10). pii: E1690. doi: 10.3390/jcm8101690. Review.


Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents.

Detterich JA, Liu H, Suriany S, Kato RM, Chalacheva P, Tedla B, Shah PM, Khoo MC, Wood JC, Coates TD, Milne GL, Oh JY, Patel RP, Forman HJ.

Free Radic Biol Med. 2019 Sep;141:408-415. doi: 10.1016/j.freeradbiomed.2019.07.004. Epub 2019 Jul 3.


Phenotype of Ventilatory Control in Children With Moderate to Severe Persistent Asthma and Obstructive Sleep Apnea.

He Z, Armoni Domany K, Nava-Guerra L, Khoo MCK, DiFrancesco M, Xu Y, McConnell K, Hossain MM, Amin R.

Sleep. 2019 Jun 7. pii: zsz130. doi: 10.1093/sleep/zsz130. [Epub ahead of print]


Respiratory modulation of peripheral vasoconstriction: a modeling perspective.

Khoo MCK, Chalacheva P.

J Appl Physiol (1985). 2019 Nov 1;127(5):1177-1186. doi: 10.1152/japplphysiol.00111.2019. Epub 2019 May 16.


Sickle Cell Disease Subjects Have a Distinct Abnormal Autonomic Phenotype Characterized by Peripheral Vasoconstriction With Blunted Cardiac Response to Head-Up Tilt.

Chalacheva P, Kato RM, Shah P, Veluswamy S, Denton CC, Sunwoo J, Thuptimdang W, Wood JC, Detterich JA, Coates TD, Khoo MCK.

Front Physiol. 2019 Apr 11;10:381. doi: 10.3389/fphys.2019.00381. eCollection 2019.


Mental stress causes vasoconstriction in subjects with sickle cell disease and in normal controls.

Shah P, Khaleel M, Thuptimdang W, Sunwoo J, Veluswamy S, Chalacheva P, Kato RM, Detterich J, Wood JC, Zeltzer L, Sposto R, Khoo MCK, Coates TD.

Haematologica. 2020 Jan;105(1):83-90. doi: 10.3324/haematol.2018.211391. Epub 2019 Apr 11.


Sickle cell microvascular paradox-oxygen supply-demand mismatch.

Detterich JA, Kato R, Bush A, Chalacheva P, Ponce D, De Zoysa M, Shah P, Khoo MC, Meiselman HJ, Coates TD, Wood JC.

Am J Hematol. 2019 Jun;94(6):678-688. doi: 10.1002/ajh.25476. Epub 2019 Apr 19.


The effect of adenotonsillectomy on ventilatory control in children with obstructive sleep apnea.

Armoni Domany K, He Z, Nava-Guerra L, Khoo MCK, Xu Y, Hossain MM, DiFrancesco M, McConnell K, Amin RS.

Sleep. 2019 May 1;42(5). pii: zsz045. doi: 10.1093/sleep/zsz045.


Quantifying ventilatory control stability from spontaneous sigh responses during sleep: a comparison of two approaches.

Nava-Guerra L, Edwards BA, Terrill PI, Sands SA, Amin RS, Kemp JS, Khoo MCK.

Physiol Meas. 2018 Nov 22;39(11):114005. doi: 10.1088/1361-6579/aae7a9.


Abnormalities in autonomic function in obese boys at-risk for insulin resistance and obstructive sleep apnea.

Oliveira FMS, Tran WH, Lesser DJ, Bhatia R, Keens TG, Mittelman SD, Davidson Ward SL, Khoo MCK.

Pediatr Res. 2019 May;85(6):790-798. doi: 10.1038/s41390-018-0226-2. Epub 2018 Nov 12.


Upper Airway Narrowing during Central Apnea in Obese Adolescents.

Kato RM, Kim YC, Joshi B, Loloyan S, Wee CP, Wu Z, Tran WH, Keens TG, Khoo MCK, Nayak KS, Davidson Ward SL.

Ann Am Thorac Soc. 2018 Dec;15(12):1465-1471. doi: 10.1513/AnnalsATS.201806-412OC.


A novel cross-correlation methodology for assessing biophysical responses associated with pain.

Sunwoo J, Chalacheva P, Khaleel M, Shah P, Sposto R, Kato RM, Detterich J, Zeltzer LK, Wood JC, Coates TD, Khoo MC.

J Pain Res. 2018 Oct 5;11:2207-2219. doi: 10.2147/JPR.S142582. eCollection 2018.


Assessing ventilatory instability using the response to spontaneous sighs during sleep in preterm infants.

Edwards BA, Nava-Guerra L, Kemp JS, Carroll JL, Khoo MC, Sands SA, Terrill PI, Landry SA, Amin RS.

Sleep. 2018 Nov 1;41(11). doi: 10.1093/sleep/zsy161.


Autonomic nervous system involvement in sickle cell disease.

Coates TD, Chalacheva P, Zeltzer L, Khoo MCK.

Clin Hemorheol Microcirc. 2018;68(2-3):251-262. doi: 10.3233/CH-189011.


Cardioventilatory Control in Preterm-born Children and the Risk of Obstructive Sleep Apnea.

Armoni Domany K, Hossain MM, Nava-Guerra L, Khoo MC, McConnell K, Carroll JL, Xu Y, DiFrancesco M, Amin RS.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):1596-1603. doi: 10.1164/rccm.201708-1700OC.


Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain.

Khaleel M, Puliyel M, Shah P, Sunwoo J, Kato RM, Chalacheva P, Thuptimdang W, Detterich J, Wood JC, Tsao J, Zeltzer L, Sposto R, Khoo MCK, Coates TD.

Am J Hematol. 2017 Nov;92(11):1137-1145. doi: 10.1002/ajh.24858. Epub 2017 Aug 17.


Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease.

Chalacheva P, Khaleel M, Sunwoo J, Shah P, Detterich JA, Kato RM, Thuptimdang W, Meiselman HJ, Sposto R, Tsao J, Wood JC, Zeltzer L, Coates TD, Khoo MCK.

PLoS One. 2017 May 24;12(5):e0178353. doi: 10.1371/journal.pone.0178353. eCollection 2017.


Real-time multislice MRI during continuous positive airway pressure reveals upper airway response to pressure change.

Chen W, Gillett E, Khoo MCK, Davidson Ward SL, Nayak KS.

J Magn Reson Imaging. 2017 Nov;46(5):1400-1408. doi: 10.1002/jmri.25675. Epub 2017 Feb 22.


Model-Derived Markers of Autonomic Cardiovascular Dysfunction in Sleep-Disordered Breathing.

Khoo MCK, Chalacheva P.

Sleep Med Clin. 2016 Dec;11(4):489-501. doi: 10.1016/j.jsmc.2016.07.003. Epub 2016 Oct 27. Review.


Model-based stability assessment of ventilatory control in overweight adolescents with obstructive sleep apnea during NREM sleep.

Nava-Guerra L, Tran WH, Chalacheva P, Loloyan S, Joshi B, Keens TG, Nayak KS, Davidson Ward SL, Khoo MC.

J Appl Physiol (1985). 2016 Jul 1;121(1):185-97. doi: 10.1152/japplphysiol.01081.2015. Epub 2016 May 12.


Modeling of deep breath vasoconstriction reflex.

Chalacheva P, Khoo MC.

Conf Proc IEEE Eng Med Biol Soc. 2015;2015:7792-5. doi: 10.1109/EMBC.2015.7320199.


Modeling of neonatal hemodynamics during PDA closure.

Soleymani S, Khoo MC, Noori S, Seri I.

Conf Proc IEEE Eng Med Biol Soc. 2015;2015:1886-9. doi: 10.1109/EMBC.2015.7318750.


Evaluation of upper airway collapsibility using real-time MRI.

Wu Z, Chen W, Khoo MC, Davidson Ward SL, Nayak KS.

J Magn Reson Imaging. 2016 Jul;44(1):158-67. doi: 10.1002/jmri.25133. Epub 2015 Dec 28.


Dynamic 3-D MR Visualization and Detection of Upper Airway Obstruction During Sleep Using Region-Growing Segmentation.

Javed A, Kim YC, Khoo MC, Ward SL, Nayak KS.

IEEE Trans Biomed Eng. 2016 Feb;63(2):431-7. doi: 10.1109/TBME.2015.2462750. Epub 2015 Aug 3.


Autonomic responses to cold face stimulation in sickle cell disease: a time-varying model analysis.

Chalacheva P, Kato RM, Sangkatumvong S, Detterich J, Bush A, Wood JC, Meiselman H, Coates TD, Khoo MC.

Physiol Rep. 2015 Jul 14;3(7). pii: e12463. doi: 10.14814/phy2.12463. Epub 2015 Jul 14.


Body Fat Composition: A Predictive Factor for Sleep Related Breathing Disorder in Obese Children.

Bhatia R, Lesser DJ, Oliveira FG, Tran WH, Keens TG, Khoo MC, Davidson Ward SL.

J Clin Sleep Med. 2015 Sep 15;11(9):1039-45. doi: 10.5664/jcsm.5022.


Estimating the baroreflex and respiratory modulation of peripheral vascular resistance.

Chalacheva P, Khoo MC.

Conf Proc IEEE Eng Med Biol Soc. 2014;2014:2936-9. doi: 10.1109/EMBC.2014.6944238.


Pediatric sleep-related breathing disorders: advances in imaging and computational modeling.

Davidson Ward SL, Amin R, Arens R, Zhongping Chen, Davis S, Gutmark E, Superfine R, Wong B, Zdanski C, Khoo MC.

IEEE Pulse. 2014 Sep-Oct;5(5):33-9. doi: 10.1109/MPUL.2014.2339293.


An extended model of blood pressure variability: incorporating the respiratory modulation of vascular resistance.

Chalacheva P, Khoo MC.

Conf Proc IEEE Eng Med Biol Soc. 2013;2013:3825-8. doi: 10.1109/EMBC.2013.6610378.


Real-time 3D magnetic resonance imaging of the pharyngeal airway in sleep apnea.

Kim YC, Lebel RM, Wu Z, Ward SL, Khoo MC, Nayak KS.

Magn Reson Med. 2014 Apr;71(4):1501-10. doi: 10.1002/mrm.24808. Epub 2013 Jun 20.


Development of autonomic dysfunction with intermittent hypoxia in a lean murine model.

Chalacheva P, Thum J, Yokoe T, O'Donnell CP, Khoo MC.

Respir Physiol Neurobiol. 2013 Aug 15;188(2):143-51. doi: 10.1016/j.resp.2013.06.002. Epub 2013 Jun 14.


Evaluation of an independent linear model for acoustic noise on a conventional MRI scanner and implications for acoustic noise reduction.

Wu Z, Kim YC, Khoo MC, Nayak KS.

Magn Reson Med. 2014 Apr;71(4):1613-20. doi: 10.1002/mrm.24798. Epub 2013 Jun 11.


Sleep-related changes in autonomic control in obstructive sleep apnea: a model-based perspective.

Khoo MC, Blasi A.

Respir Physiol Neurobiol. 2013 Sep 15;188(3):267-76. doi: 10.1016/j.resp.2013.05.017. Epub 2013 May 23.


Understanding the metabolic syndrome: a modeling perspective.

Khoo MC, Oliveira FM, Cheng L.

IEEE Rev Biomed Eng. 2013;6:143-55. doi: 10.1109/RBME.2012.2232651. Epub 2012 Dec 10. Review.


Autonomic markers of impaired glucose metabolism: effects of sleep-disordered breathing.

Wang W, Redline S, Khoo MC.

J Diabetes Sci Technol. 2012 Sep 1;6(5):1159-71.


Linking engineering and medicine: fostering collaboration skills in interdisciplinary teams.

Khoo MC.

IEEE Pulse. 2012 Jul;3(4):27-9. doi: 10.1109/MPUL.2012.2196832.


Sleep fragmentation and intermittent hypoxemia are associated with decreased insulin sensitivity in obese adolescent Latino males.

Lesser DJ, Bhatia R, Tran WH, Oliveira F, Ortega R, Keens TG, Mittelman SD, Khoo MC, Davidson Ward SL.

Pediatr Res. 2012 Sep;72(3):293-8. doi: 10.1038/pr.2012.73. Epub 2012 Jun 5.


Modeling the autonomic and metabolic effects of obstructive sleep apnea: a simulation study.

Cheng L, Khoo MC.

Front Physiol. 2012 Jan 4;2:111. doi: 10.3389/fphys.2011.00111. eCollection 2011.


Monitoring ultradian changes in cardiorespiratory control in obstructive sleep apnea syndrome.

Khoo MC, Wang W, Chalacheva P.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:1487-90. doi: 10.1109/IEMBS.2011.6090363.


Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease.

Sangkatumvong S, Khoo MC, Kato R, Detterich JA, Bush A, Keens TG, Meiselman HJ, Wood JC, Coates TD.

Am J Respir Crit Care Med. 2011 Aug 15;184(4):474-81. doi: 10.1164/rccm.201103-0537OC.


Autonomic and metabolic effects of OSA in childhood obesity.

Oliveira FM, Tran WH, Lesser D, Bhatia R, Ortega R, Mittelman SD, Keens TG, Davidson Ward SL, Khoo MC.

Conf Proc IEEE Eng Med Biol Soc. 2010;2010:6134-7. doi: 10.1109/IEMBS.2010.5627789.


Time-varying analysis of autonomic control in response to spontaneous sighs in sickle cell anemia.

Sangkatumvong S, Coates TD, Wood JC, Meiselman HJ, Kato R, Detterich JA, Bush A, Khoo MC.

Conf Proc IEEE Eng Med Biol Soc. 2010;2010:1626-9. doi: 10.1109/IEMBS.2010.5626649.


An integrative model of respiratory and cardiovascular control in sleep-disordered breathing.

Cheng L, Ivanova O, Fan HH, Khoo MC.

Respir Physiol Neurobiol. 2010 Nov 30;174(1-2):4-28. doi: 10.1016/j.resp.2010.06.001. Epub 2010 Jun 11. Review.


Sickle cell disease: selected aspects of pathophysiology.

Alexy T, Sangkatumvong S, Connes P, Pais E, Tripette J, Barthelemy JC, Fisher TC, Meiselman HJ, Khoo MC, Coates TD.

Clin Hemorheol Microcirc. 2010;44(3):155-66. doi: 10.3233/CH-2010-1270.


Model-based studies of autonomic and metabolic dysfunction in sleep apnea.

Khoo MC.

Adv Exp Med Biol. 2010;669:275-9. doi: 10.1007/978-1-4419-5692-7_56.


Model-based assessment of cardiovascular autonomic control in children with obstructive sleep apnea.

Chaicharn J, Lin Z, Chen ML, Ward SL, Keens T, Khoo MC.

Sleep. 2009 Jul;32(7):927-38.


Abnormal cardiac autonomic control in sickle cell disease following transient hypoxia.

Sangkatumvong S, Khoo MC, Coates TD.

Conf Proc IEEE Eng Med Biol Soc. 2008;2008:1996-9. doi: 10.1109/IEMBS.2008.4649581.


Association of cardiac autonomic function measures with severity of sleep-disordered breathing in a community-based sample.

Wang W, Tretriluxana S, Redline S, Surovec S, Gottlieb DJ, Khoo MC.

J Sleep Res. 2008 Sep;17(3):251-62. doi: 10.1111/j.1365-2869.2008.00652.x. Epub 2008 Jun 28.


Abnormal autonomic cardiac response to transient hypoxia in sickle cell anemia.

Sangkatumvong S, Coates TD, Khoo MC.

Physiol Meas. 2008 May;29(5):655-68. doi: 10.1088/0967-3334/29/5/010. Epub 2008 May 7.


The effects on cardiovascular autonomic control of repetitive arousal from sleep.

Chaicharn J, Carrington M, Trinder J, Khoo MC.

Sleep. 2008 Jan;31(1):93-103.

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