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Items: 1 to 50 of 79

1.

Activation of Polyamine Catabolism by N¹,N11-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype.

Ivanova ON, Snezhkina AV, Krasnov GS, Valuev-Elliston VT, Khomich OA, Khomutov AR, Keinanen TA, Alhonen L, Bartosch B, Kudryavtseva AV, Kochetkov SN, Ivanov AV.

Cells. 2018 Dec 18;7(12). pii: E275. doi: 10.3390/cells7120275.

2.

Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators.

Keinänen TA, Grigorenko N, Khomutov AR, Huang Q, Uimari A, Alhonen L, Hyvönen MT, Vepsäläinen J.

Biosci Rep. 2018 Aug 29;38(4). pii: BSR20180527. doi: 10.1042/BSR20180527. Print 2018 Aug 31.

3.

On the Reaction of Carbonyl Diphosphonic Acid with Hydroxylamine and O-alkylhydroxylamines: Unexpected Degradation of P-C-P Bridge.

Khomich OA, Yanvarev DV, Novikov RA, Kornev AB, Puljulla E, Vepsäläinen J, Khomutov AR, Kochetkov SN.

Molecules. 2017 Jun 23;22(7). pii: E1040. doi: 10.3390/molecules22071040.

4.

Hepatitis C virus alters metabolism of biogenic polyamines by affecting expression of key enzymes of their metabolism.

Smirnova OA, Keinanen TA, Ivanova ON, Hyvonen MT, Khomutov AR, Kochetkov SN, Bartosch B, Ivanov AV.

Biochem Biophys Res Commun. 2017 Feb 5;483(2):904-909. doi: 10.1016/j.bbrc.2017.01.032. Epub 2017 Jan 9.

PMID:
28082202
5.

Triethylenetetramine modulates polyamine and energy metabolism and inhibits cancer cell proliferation.

Hyvönen MT, Ucal S, Pasanen M, Peräniemi S, Weisell J, Khomutov M, Khomutov AR, Vepsäläinen J, Alhonen L, Keinänen TA.

Biochem J. 2016 May 15;473(10):1433-41. doi: 10.1042/BCJ20160134. Epub 2016 Mar 21.

PMID:
27001865
6.

[Enantioselective Synthesis of (R)- and (S)-3-Methylspermidines].

Khomutov MA, Keinanen TA, Hyvonen MT, Weisell J, Vepsalainen J, Alhonen L, Kochetkov SN, Khomutov AR.

Bioorg Khim. 2015 Sep-Oct;41(5):612-8. Russian.

PMID:
26762100
7.

Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.

Hyvönen MT, Khomutov M, Petit M, Weisell J, Kochetkov SN, Alhonen L, Vepsäläinen J, Khomutov AR, Keinänen TA.

ACS Chem Biol. 2015 Jun 19;10(6):1417-24. doi: 10.1021/cb500938e. Epub 2015 Feb 27.

PMID:
25689365
8.

Hydroxylamine derivatives for regulation of spermine and spermidine metabolism.

Khomutov MA, Weisell J, Hyvönen M, Keinänen TA, Vepsäläinen J, Alhonen L, Khomutov AR, Kochetkov SN.

Biochemistry (Mosc). 2013 Dec;78(13):1431-46. doi: 10.1134/S0006297913130051. Review.

9.

Selective regulation of polyamine metabolism with methylated polyamine analogues.

Keinänen TA, Hyvönen MT, Alhonen L, Vepsäläinen J, Khomutov AR.

Amino Acids. 2014 Mar;46(3):605-20. Epub 2013 Oct 10. Review.

PMID:
24022706
10.

Charge deficient analogues of the natural polyamines.

Weisell J, Hyvönen MT, Alhonen L, Vepsäläinen J, Keinänen TA, Khomutov AR.

Curr Pharm Des. 2014;20(2):262-77. Review.

PMID:
23701551
11.

Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A.

Hyvönen MT, Koponen T, Weisell J, Pietilä M, Khomutov AR, Vepsäläinen J, Alhonen L, Keinänen TA.

Biochem J. 2013 Aug 1;453(3):467-74. doi: 10.1042/BJ20130263.

PMID:
23672317
12.

Biogenic polyamines spermine and spermidine activate RNA polymerase and inhibit RNA helicase of hepatitis C virus.

Korovina AN, Tunitskaya VL, Khomutov MA, Simonian AR, Khomutov AR, Ivanov AV, Kochetkov SN.

Biochemistry (Mosc). 2012 Oct;77(10):1172-80. doi: 10.1134/S0006297912100094.

13.

Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N(1)-acetyltransferase and thialysine acetyltransferase.

Hyvönen MT, Weisell J, Khomutov AR, Alhonen L, Vepsäläinen J, Keinänen TA.

Drug Metab Dispos. 2013 Jan;41(1):30-2. doi: 10.1124/dmd.112.047274. Epub 2012 Sep 28.

PMID:
23024204
14.

Inhibition of DNA gyrase by levofloxacin and related fluorine-containing heterocyclic compounds.

Tunitskaya VL, Khomutov AR, Kochetkov SN, Kotovskaya SK, Charushin VN.

Acta Naturae. 2011 Oct;3(4):94-9.

15.

Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine.

Jin HT, Lämsä T, Nordback PH, Hyvönen MT, Grigorenko N, Khomutov AR, Nordback I, Räty S, Pörsti I, Alhonen L, Sand J.

Pharmacol Rep. 2011;63(4):999-1008.

16.

Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.

Hyvönen MT, Keinänen TA, Khomutov M, Simonian A, Vepsäläinen J, Park JH, Khomutov AR, Alhonen L, Park MH.

Amino Acids. 2012 Feb;42(2-3):685-95. doi: 10.1007/s00726-011-0984-1. Epub 2011 Aug 23.

17.

Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase.

Hyvönen MT, Uimari A, Vepsäläinen J, Khomutov AR, Keinänen TA, Alhonen L.

Amino Acids. 2012 Feb;42(2-3):485-93. doi: 10.1007/s00726-011-1027-7. Epub 2011 Aug 2.

PMID:
21809078
18.

The use of novel C-methylated spermidine derivatives to investigate the regulation of polyamine metabolism.

Hyvönen MT, Keinänen TA, Khomutov M, Simonian A, Weisell J, Kochetkov SN, Vepsäläinen J, Alhonen L, Khomutov AR.

J Med Chem. 2011 Jul 14;54(13):4611-8. doi: 10.1021/jm200293r. Epub 2011 Jun 3.

PMID:
21639123
19.

A rapid and robust assay for the determination of the amino acid hypusine as a possible biomarker for a high-throughput screening of antimalarials and for the diagnosis and therapy of different diseases.

Kaiser A, Khomutov AR, Simonian A, Agostinelli E.

Amino Acids. 2012 May;42(5):1651-9. doi: 10.1007/s00726-011-0859-5. Epub 2011 Mar 1.

PMID:
21360085
20.

Methylated polyamines as research tools.

Khomutov AR, Weisell J, Khomutov MA, Grigorenko NA, Simonian AR, Häkkinen MR, Keinänen TA, Hyvönen MT, Alhonen L, Kochetkov SN, Vepsäläinen J.

Methods Mol Biol. 2011;720:449-61. doi: 10.1007/978-1-61779-034-8_29.

PMID:
21318892
21.

Synthesis and biological characterization of novel charge-deficient spermine analogues.

Weisell J, Hyvönen MT, Häkkinen MR, Grigorenko NA, Pietilä M, Lampinen A, Kochetkov SN, Alhonen L, Vepsäläinen J, Keinänen TA, Khomutov AR.

J Med Chem. 2010 Aug 12;53(15):5738-48. doi: 10.1021/jm100439p.

PMID:
20684609
22.

Acute pancreatitis induced by activated polyamine catabolism is associated with coagulopathy: effects of alpha-methylated polyamine analogs on hemostasis.

Hyvönen MT, Sinervirta R, Keinänen TA, Fashe T, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L.

Pancreatology. 2010;10(2-3):208-21. doi: 10.1159/000243730. Epub 2010 May 7.

PMID:
20453551
23.

Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases.

Häkkinen MR, Hyvönen MT, Auriola S, Casero RA Jr, Vepsäläinen J, Khomutov AR, Alhonen L, Keinänen TA.

Amino Acids. 2010 Feb;38(2):369-81. doi: 10.1007/s00726-009-0429-2. Epub 2009 Dec 10.

24.

alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage.

Hyvönen MT, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Keinänen TA, Alhonen L.

Amino Acids. 2010 Feb;38(2):575-81. doi: 10.1007/s00726-009-0418-5. Epub 2009 Dec 3.

PMID:
19956991
25.

Cutaneous application of alpha-methylspermidine activates the growth of resting hair follicles in mice.

Fashe TM, Keinänen TA, Grigorenko NA, Khomutov AR, Jänne J, Alhonen L, Pietilä M.

Amino Acids. 2010 Feb;38(2):583-90. doi: 10.1007/s00726-009-0421-x. Epub 2009 Dec 3.

PMID:
19956989
26.

Novel isosteric charge-deficient spermine analogue--1,12-diamino-3,6,9-triazadodecane: synthesis, pK(a) measurement and biological activity.

Weisell J, Hyvönen MT, Vepsäläinen J, Alhonen L, Keinänen TA, Khomutov AR, Soininen P.

Amino Acids. 2010 Feb;38(2):501-7. doi: 10.1007/s00726-009-0409-6. Epub 2009 Dec 2.

PMID:
19953281
27.

DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage.

Nayvelt I, Hyvönen MT, Alhonen L, Pandya I, Thomas T, Khomutov AR, Vepsäläinen J, Patel R, Keinänen TA, Thomas TJ.

Biomacromolecules. 2010 Jan 11;11(1):97-105. doi: 10.1021/bm900958c.

PMID:
19919070
28.

Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes.

Vuohelainen S, Pirinen E, Cerrada-Gimenez M, Keinänen TA, Uimari A, Pietilä M, Khomutov AR, Jänne J, Alhonen L.

J Cell Mol Med. 2010 Jun;14(6B):1683-92. doi: 10.1111/j.1582-4934.2009.00808.x. Epub 2009 Jun 16.

29.

Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues.

Hyvönen MT, Howard MT, Anderson CB, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J, Keinänen TA.

Biochem J. 2009 Aug 13;422(2):321-8. doi: 10.1042/BJ20090737.

PMID:
19522702
30.

[Methylated analogues of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism].

Khomutov AR, Keinanen TA, Grigorenko NA, Hyvonen MT, Uimari A, Pietila M, Cerrada-Gimenez M, Simonian AR, Khomutov MA, Verspalainen J, Alhonen L, Janne J.

Mol Biol (Mosk). 2009 Mar-Apr;43(2):274-85. Russian.

PMID:
19425496
31.

Novel agmatine analogue, gamma-guanidinooxypropylamine (GAPA) efficiently inhibits proliferation of Leishmania donovani by depletion of intracellular polyamine levels.

Singh S, Jhingran A, Sharma A, Simonian AR, Soininen P, Vepsalainen J, Khomutov AR, Madhubala R.

Biochem Biophys Res Commun. 2008 Oct 10;375(1):168-72. doi: 10.1016/j.bbrc.2008.07.143. Epub 2008 Aug 8.

PMID:
18692480
32.

A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate.

Jin HT, Lämsä T, Hyvönen MT, Sand J, Räty S, Grigorenko N, Khomutov AR, Herzig KH, Alhonen L, Nordback I.

Surgery. 2008 Jul;144(1):49-56. doi: 10.1016/j.surg.2008.03.029.

PMID:
18571584
33.

Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS.

Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S.

J Pharm Biomed Anal. 2008 Sep 29;48(2):414-21. doi: 10.1016/j.jpba.2008.02.019. Epub 2008 Feb 26.

PMID:
18394842
34.

Analysis of underivatized polyamines by reversed phase liquid chromatography with electrospray tandem mass spectrometry.

Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S.

J Pharm Biomed Anal. 2007 Nov 30;45(4):625-34. Epub 2007 Sep 7.

PMID:
17945452
35.

Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.

Hyvönen MT, Keinänen TA, Cerrada-Gimenez M, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J.

J Biol Chem. 2007 Nov 30;282(48):34700-6. Epub 2007 Sep 27.

36.

Alpha-methylated polyamines as potential drugs and experimental tools in enzymology.

Keinänen TA, Järvinen A, Uimari A, Vepsäläinen J, Khomutov AR, Grigorenko NA, Hyvönen MT, Cerrada-Gimenez M, Alhonen L, Jänne J.

Mini Rev Med Chem. 2007 Aug;7(8):813-20. Review.

PMID:
17692042
37.

A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane.

Dufe VT, Ingner D, Heby O, Khomutov AR, Persson L, Al-Karadaghi S.

Biochem J. 2007 Jul 15;405(2):261-8.

38.

Inhibition of agmatine transport in liver mitochondria by new charge-deficient agmatine analogues.

Grillo MA, Battaglia V, Colombatto S, Rossi CA, Simonian AR, Salvi M, Khomutov AR, Toninello A.

Biochem Soc Trans. 2007 Apr;35(Pt 2):401-4.

PMID:
17371286
39.

Novel approach to design an isosteric charge-deficient analogue of spermine and its biochemically important derivatives.

Khomutov AR, Grigorenko NA, Skuridin SG.

Biochem Soc Trans. 2007 Apr;35(Pt 2):369-73.

PMID:
17371280
40.

[Aminooxy analogues of spermine and their monoacetyl derivatives].

Simonian AR, Vespalainen J, Khomutov AR.

Bioorg Khim. 2006 Nov-Dec;32(6):643-50. Russian.

PMID:
17180915
41.

Antileishmanial effect of 3-aminooxy-1-aminopropane is due to polyamine depletion.

Singh S, Mukherjee A, Khomutov AR, Persson L, Heby O, Chatterjee M, Madhubala R.

Antimicrob Agents Chemother. 2007 Feb;51(2):528-34. Epub 2006 Nov 13.

42.

activated polyamine catabolism in acute pancreatitis: alpha-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality.

Hyvönen MT, Herzig KH, Sinervirta R, Albrecht E, Nordback I, Sand J, Keinänen TA, Vepsäläinen J, Grigorenko N, Khomutov AR, Krüger B, Jänne J, Alhonen L.

Am J Pathol. 2006 Jan;168(1):115-22.

43.

Alpha-methyl polyamines: efficient synthesis and tolerance studies in vivo and in vitro. First evidence for dormant stereospecificity of polyamine oxidase.

Järvinen AJ, Cerrada-Gimenez M, Grigorenko NA, Khomutov AR, Vepsäläinen JJ, Sinervirta RM, Keinänen TA, Alhonen LI, Jänne JE.

J Med Chem. 2006 Jan 12;49(1):399-406.

PMID:
16392825
44.

[New charge-deficient agmatine analogs].

Simonian AR, Grigorenko NA, Vepsalainen J, Khomutov AR.

Bioorg Khim. 2005 Nov-Dec;31(6):645-50. Russian.

PMID:
16363138
45.

Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase.

Järvinen A, Keinänen TA, Grigorenko NA, Khomutov AR, Uimari A, Vepsäläinen J, Närvänen A, Alhonen L, Jänne J.

J Biol Chem. 2006 Feb 24;281(8):4589-95. Epub 2005 Dec 14.

46.

Hypophosphoric acid is a unique substrate of pyrophosphorolysis catalyzed by HIV-1 reverse transcriptase.

Kukhanova MK, Zakirova NF, Ivanov AV, Alexandrova LA, Jasco MV, Khomutov AR.

Biochem Biophys Res Commun. 2005 Dec 23;338(3):1335-41. Epub 2005 Oct 25.

PMID:
16271706
47.

[A charge-deficient analogue of spermine with chelating properties].

Khomutov AR, Grigorenko NA, Demin AV, Vepsalainen J, Casero RA, Woster PM.

Bioorg Khim. 2005 May-Jun;31(3):303-11. Russian.

PMID:
16004389
48.

3-Aminooxy-1-aminopropane and derivatives have an antiproliferative effect on cultured Plasmodium falciparum by decreasing intracellular polyamine concentrations.

Das Gupta R, Krause-Ihle T, Bergmann B, Müller IB, Khomutov AR, Müller S, Walter RD, Lüersen K.

Antimicrob Agents Chemother. 2005 Jul;49(7):2857-64.

49.

[New oxaanalogues of spermine].

Khomutov AR, Simonian AR, Vespalainen J, Keinanen TA, Alhonen L, Janne J.

Bioorg Khim. 2005 Mar-Apr;31(2):206-12. Russian.

PMID:
15889796
50.

[New syntheses of alpha-methyl- and alpha,alpha'-dimethylspermine].

Grigorenko NA, Vepsalainen J, Jarvinen A, Keinanen TA, Alhonen L, Janne J, Khomutov AR.

Bioorg Khim. 2005 Mar-Apr;31(2):200-5. Russian.

PMID:
15889795

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