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Items: 1 to 50 of 59


Context-dependent expression of a conditionally-inducible form of active Akt.

Park S, Burke RE, Kareva T, Kholodilov N, Aimé P, Franke TF, Levy O, Greene LA.

PLoS One. 2018 Jun 19;13(6):e0197899. doi: 10.1371/journal.pone.0197899. eCollection 2018.


Upregulation of neuronal astrocyte elevated gene-1 protects nigral dopaminergic neurons in vivo.

Leem E, Kim HJ, Choi M, Kim S, Oh YS, Lee KJ, Choe YS, Um JY, Shin WH, Jeong JY, Jin BK, Kim DW, McLean C, Fisher PB, Kholodilov N, Ahn KS, Lee JM, Jung UJ, Lee SG, Kim SR.

Cell Death Dis. 2018 May 1;9(5):449. doi: 10.1038/s41419-018-0491-3.


Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo.

Kim S, Moon GJ, Oh YS, Park J, Shin WH, Jeong JY, Choi KS, Jin BK, Kholodilov N, Burke RE, Kim HJ, Ha CM, Lee SG, Kim SR.

Exp Mol Med. 2018 Feb 9;50(2):e440. doi: 10.1038/emm.2017.261.


Combining Constitutively Active Rheb Expression and Chondroitinase Promotes Functional Axonal Regeneration after Cervical Spinal Cord Injury.

Wu D, Klaw MC, Connors T, Kholodilov N, Burke RE, Côté MP, Tom VJ.

Mol Ther. 2017 Dec 6;25(12):2715-2726. doi: 10.1016/j.ymthe.2017.08.011. Epub 2017 Aug 19.


A quantitative evaluation of a 2.5-kb rat tyrosine hydroxylase promoter to target expression in ventral mesencephalic dopamine neurons in vivo.

Rolland AS, Kareva T, Kholodilov N, Burke RE.

Neuroscience. 2017 Mar 27;346:126-134. doi: 10.1016/j.neuroscience.2017.01.014. Epub 2017 Jan 18.


Expression mediated by three partial sequences of the human tyrosine hydroxylase promoter in vivo.

Rolland AS, Kareva T, Yarygina O, Kholodilov N, Burke RE.

Mol Ther Methods Clin Dev. 2016 Sep 21;3:16062. doi: 10.1038/mtm.2016.62. eCollection 2016.


Expressing Constitutively Active Rheb in Adult Dorsal Root Ganglion Neurons Enhances the Integration of Sensory Axons that Regenerate Across a Chondroitinase-Treated Dorsal Root Entry Zone Following Dorsal Root Crush.

Wu D, Klaw MC, Kholodilov N, Burke RE, Detloff MR, Côté MP, Tom VJ.

Front Mol Neurosci. 2016 Jul 5;9:49. doi: 10.3389/fnmol.2016.00049. eCollection 2016.


Expressing Constitutively Active Rheb in Adult Neurons after a Complete Spinal Cord Injury Enhances Axonal Regeneration beyond a Chondroitinase-Treated Glial Scar.

Wu D, Klaw MC, Connors T, Kholodilov N, Burke RE, Tom VJ.

J Neurosci. 2015 Aug 5;35(31):11068-80. doi: 10.1523/JNEUROSCI.0719-15.2015.


An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease.

Tagliaferro P, Kareva T, Oo TF, Yarygina O, Kholodilov N, Burke RE.

Neurobiol Dis. 2015 Oct;82:359-371. doi: 10.1016/j.nbd.2015.07.009. Epub 2015 Jul 17.


In vivo AAV1 transduction with hRheb(S16H) protects hippocampal neurons by BDNF production.

Jeon MT, Nam JH, Shin WH, Leem E, Jeong KH, Jung UJ, Bae YS, Jin YH, Kholodilov N, Burke RE, Lee SG, Jin BK, Kim SR.

Mol Ther. 2015 Mar;23(3):445-55. doi: 10.1038/mt.2014.241. Epub 2014 Dec 15.


Induction of GDNF and BDNF by hRheb(S16H) transduction of SNpc neurons: neuroprotective mechanisms of hRheb(S16H) in a model of Parkinson's disease.

Nam JH, Leem E, Jeon MT, Jeong KH, Park JW, Jung UJ, Kholodilov N, Burke RE, Jin BK, Kim SR.

Mol Neurobiol. 2015 Apr;51(2):487-99. doi: 10.1007/s12035-014-8729-2. Epub 2014 May 25.


Rheb GTPase regulates β-secretase levels and amyloid β generation.

Shahani N, Pryor W, Swarnkar S, Kholodilov N, Thinakaran G, Burke RE, Subramaniam S.

J Biol Chem. 2014 Feb 28;289(9):5799-808. doi: 10.1074/jbc.M113.532713. Epub 2013 Dec 24.


Quantitative morphological comparison of axon-targeting strategies for gene therapies directed to the nigro-striatal projection.

Padmanabhan S, Kareva T, Kholodilov N, Burke RE.

Gene Ther. 2014 Feb;21(2):115-22. doi: 10.1038/gt.2013.74. Epub 2013 Dec 5.


Neurotrophic effects of serum- and glucocorticoid-inducible kinase on adult murine mesencephalic dopamine neurons.

Chen X, Tagliaferro P, Kareva T, Yarygina O, Kholodilov N, Burke RE.

J Neurosci. 2012 Aug 15;32(33):11299-308. doi: 10.1523/JNEUROSCI.5910-11.2012.


Regulation of presynaptic neurotransmission by macroautophagy.

Hernandez D, Torres CA, Setlik W, Cebrián C, Mosharov EV, Tang G, Cheng HC, Kholodilov N, Yarygina O, Burke RE, Gershon M, Sulzer D.

Neuron. 2012 Apr 26;74(2):277-84. doi: 10.1016/j.neuron.2012.02.020.


AAV transduction of dopamine neurons with constitutively active Rheb protects from neurodegeneration and mediates axon regrowth.

Kim SR, Kareva T, Yarygina O, Kholodilov N, Burke RE.

Mol Ther. 2012 Feb;20(2):275-86. doi: 10.1038/mt.2011.213. Epub 2011 Oct 18.


Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling.

Kim SR, Ries V, Cheng HC, Kareva T, Oo TF, Yu WH, Duff K, Kholodilov N, Burke RE.

Neurobiol Dis. 2011 Nov;44(2):215-22. doi: 10.1016/j.nbd.2011.07.003. Epub 2011 Jul 18.


Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration.

Kim SR, Chen X, Oo TF, Kareva T, Yarygina O, Wang C, During M, Kholodilov N, Burke RE.

Ann Neurol. 2011 Jul;70(1):110-20. doi: 10.1002/ana.22383. Epub 2011 Mar 17.


Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy.

Cheng HC, Kim SR, Oo TF, Kareva T, Yarygina O, Rzhetskaya M, Wang C, During M, Talloczy Z, Tanaka K, Komatsu M, Kobayashi K, Okano H, Kholodilov N, Burke RE.

J Neurosci. 2011 Feb 9;31(6):2125-35. doi: 10.1523/JNEUROSCI.5519-10.2011.


WITHDRAWN: Analysis of synphilin-1 and synuclein interactions by yeast two-hybrid β-galactosidase liquid assay.

Neystat M, Rzhetskaya M, Kholodilov N, Burke RE.

Neurosci Lett. 2011 Jan 12. [Epub ahead of print]


Glial cell line-derived neurotrophic factor receptor-α1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra.

Kholodilov N, Kim SR, Yarygina O, Kareva T, Cho JW, Baohan A, Burke RE.

J Neurochem. 2011 Feb;116(4):486-98. doi: 10.1111/j.1471-4159.2010.07128.x. Epub 2011 Jan 19.


Regulation of the postnatal development of dopamine neurons of the substantia nigra in vivo by Akt/protein kinase B.

Ries V, Cheng HC, Baohan A, Kareva T, Oo TF, Rzhetskaya M, Bland RJ, During MJ, Kholodilov N, Burke RE.

J Neurochem. 2009 Jul;110(1):23-33. doi: 10.1111/j.1471-4159.2009.06101.x. Epub 2009 Apr 16.


Brain-derived neurotrophic factor regulates early postnatal developmental cell death of dopamine neurons of the substantia nigra in vivo.

Oo TF, Marchionini DM, Yarygina O, O'Leary PD, Hughes RA, Kholodilov N, Burke RE.

Mol Cell Neurosci. 2009 Aug;41(4):440-7. doi: 10.1016/j.mcn.2009.04.009. Epub 2009 May 3.


JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration.

Ries V, Silva RM, Oo TF, Cheng HC, Rzhetskaya M, Kholodilov N, Flavell RA, Kuan CY, Rakic P, Burke RE.

J Neurochem. 2008 Dec;107(6):1578-88. doi: 10.1111/j.1471-4159.2008.05713.x. Epub 2008 Nov 5.


Antiapoptotic and trophic effects of dominant-negative forms of dual leucine zipper kinase in dopamine neurons of the substantia nigra in vivo.

Chen X, Rzhetskaya M, Kareva T, Bland R, During MJ, Tank AW, Kholodilov N, Burke RE.

J Neurosci. 2008 Jan 16;28(3):672-80. doi: 10.1523/JNEUROSCI.2132-07.2008.


Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease.

Ries V, Henchcliffe C, Kareva T, Rzhetskaya M, Bland R, During MJ, Kholodilov N, Burke RE.

Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18757-62. Epub 2006 Nov 20.


CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism.

Silva RM, Ries V, Oo TF, Yarygina O, Jackson-Lewis V, Ryu EJ, Lu PD, Marciniak SJ, Ron D, Przedborski S, Kholodilov N, Greene LA, Burke RE.

J Neurochem. 2005 Nov;95(4):974-86. Epub 2005 Aug 31.


The role of GDNF in patterning the excretory system.

Shakya R, Jho EH, Kotka P, Wu Z, Kholodilov N, Burke R, D'Agati V, Costantini F.

Dev Biol. 2005 Jul 1;283(1):70-84.


Glial cell line-derived neurotrophic factor receptor GFRalpha1 is expressed in the rat striatum during postnatal development.

Cho J, Yarygina O, Oo TF, Kholodilov NG, Burke RE.

Brain Res Mol Brain Res. 2004 Aug 23;127(1-2):96-104.


CEP11004, a novel inhibitor of the mixed lineage kinases, suppresses apoptotic death in dopamine neurons of the substantia nigra induced by 6-hydroxydopamine.

Ganguly A, Oo TF, Rzhetskaya M, Pratt R, Yarygina O, Momoi T, Kholodilov N, Burke RE.

J Neurochem. 2004 Jan;88(2):469-80.


Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

Dauer W, Kholodilov N, Vila M, Trillat AC, Goodchild R, Larsen KE, Staal R, Tieu K, Schmitz Y, Yuan CA, Rocha M, Jackson-Lewis V, Hersch S, Sulzer D, Przedborski S, Burke R, Hen R.

Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14524-9. Epub 2002 Oct 10.


Analysis of synphilin-1 and synuclein interactions by yeast two-hybrid beta-galactosidase liquid assay.

Neystat M, Rzhetskaya M, Kholodilov N, Burke RE.

Neurosci Lett. 2002 Jun 7;325(2):119-23.


The expression of mRNAs for the proteasome complex is developmentally regulated in the rat mesencephalon.

El-Khodor BF, Kholodilov NG, Yarygina O, Burke RE.

Brain Res Dev Brain Res. 2001 Jul 23;129(1):47-56.


Expression of cyclin-dependent kinase 5 and its activator p35 in models of induced apoptotic death in neurons of the substantia nigra in vivo.

Neystat M, Rzhetskaya M, Oo TF, Kholodilov N, Yarygina O, Wilson A, El-Khodor BF, Burke RE.

J Neurochem. 2001 Jun;77(6):1611-25.


Synuclein-1 is selectively up-regulated in response to nerve growth factor treatment in PC12 cells.

Stefanis L, Kholodilov N, Rideout HJ, Burke RE, Greene LA.

J Neurochem. 2001 Feb;76(4):1165-76.


Upregulation of cytosolic branched chain aminotransferase in substantia nigra following developmental striatal target injury.

Kholodilov NG, Neystat M, Oo TF, Hutson SM, Burke RE.

Brain Res Mol Brain Res. 2000 Feb 22;75(2):281-6.


Activation of caspase-3 in developmental models of programmed cell death in neurons of the substantia nigra.

Jeon BS, Kholodilov NG, Oo TF, Kim SY, Tomaselli KJ, Srinivasan A, Stefanis L, Burke RE.

J Neurochem. 1999 Jul;73(1):322-33.


Alpha-synuclein expression in substantia nigra and cortex in Parkinson's disease.

Neystat M, Lynch T, Przedborski S, Kholodilov N, Rzhetskaya M, Burke RE.

Mov Disord. 1999 May;14(3):417-22.


A novel simple satellite DNA is colocalized with the Stalker retrotransposon in Drosophila melanogaster heterochromatin.

Makunin IV, Pokholkova GV, Kholodilov NG, Zakharkin SO, Bonaccorsi S, Dimitri P, Zhimulev IF.

Mol Gen Genet. 1999 Mar;261(2):381-7.


Programmed cell death: does it play a role in Parkinson's disease?

Burke RE, Kholodilov NG.

Ann Neurol. 1998 Sep;44(3 Suppl 1):S126-33. Review.


[An analysis of the DNA sequence in the region of the breakpoint of the T(1;2)dor(var7) translocation inducing the mosaic-type position effect in Drosophila melanogaster].

Makunin IV, Zakharkin SO, Kokoza EV, Pokholkova GV, Kholodilov NG, Zhimulev IF.

Tsitol Genet. 1996 Jan-Feb;30(1):8-14. Russian.


Genomic alterations in cervical carcinoma: losses of chromosome heterozygosity and human papilloma virus tumor status.

Mullokandov MR, Kholodilov NG, Atkin NB, Burk RD, Johnson AB, Klinger HP.

Cancer Res. 1996 Jan 1;56(1):197-205.


[Isolation and characteristics of repeat DNA sequences from precentromere heterochromatin from the second chromosome of Drosophila melanogaster].

Makunin IV, Pokholkova GV, Zakharkin SO, Kholodilov NG, Zhimulev IF.

Dokl Akad Nauk. 1995 Sep;344(2):266-9. Russian. No abstract available.


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