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Items: 1 to 50 of 149

1.

Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma.

Shao YW, Wood GA, Lu J, Tang QL, Liu J, Molyneux S, Chen Y, Fang H, Adissu H, McKee T, Waterhouse P, Khokha R.

Oncogene. 2018 Aug 9. doi: 10.1038/s41388-018-0444-4. [Epub ahead of print]

PMID:
30093633
2.

Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities.

Casey AE, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, Cruickshank J, Shehata M, Drysdale E, Fang H, Kim H, Isserlin R, Bailey S, Medina T, Deblois G, Shiah YJ, Barsyte-Lovejoy D, Hofer S, Bader G, Lupien M, Arrowsmith C, Knapp S, De Carvalho D, Berman H, Boutros PC, Kislinger T, Khokha R.

J Cell Biol. 2018 Aug 6;217(8):2951-2974. doi: 10.1083/jcb.201804042. Epub 2018 Jun 19.

3.

CDH4 is a novel determinant of osteosarcoma tumorigenesis and metastasis.

Tang Q, Lu J, Zou C, Shao Y, Chen Y, Narala S, Fang H, Xu H, Wang J, Shen J, Khokha R.

Oncogene. 2018 Jul;37(27):3617-3630. doi: 10.1038/s41388-018-0231-2. Epub 2018 Apr 3.

PMID:
29610525
4.

Metalloproteinases in extracellular vesicles.

Shimoda M, Khokha R.

Biochim Biophys Acta. 2017 Nov;1864(11 Pt A):1989-2000. doi: 10.1016/j.bbamcr.2017.05.027. Epub 2017 Jun 1. Review.

PMID:
28578911
5.

Planarians as models of cadmium-induced neoplasia provide measurable benchmarks for mechanistic studies.

Voura EB, Montalvo MJ, Dela Roca KT, Fisher JM, Defamie V, Narala SR, Khokha R, Mulligan ME, Evans CA.

Ecotoxicol Environ Saf. 2017 Aug;142:544-554. doi: 10.1016/j.ecoenv.2017.04.044. Epub 2017 May 5.

PMID:
28482323
6.

TIMPs: versatile extracellular regulators in cancer.

Jackson HW, Defamie V, Waterhouse P, Khokha R.

Nat Rev Cancer. 2017 Jan;17(1):38-53. doi: 10.1038/nrc.2016.115. Epub 2016 Dec 9. Review.

PMID:
27932800
7.

Tumor suppression by stromal TIMPs.

Shimoda M, Jackson HW, Khokha R.

Mol Cell Oncol. 2016 Mar 30;3(3):e975082. doi: 10.4161/23723556.2014.975082. eCollection 2016 May.

8.

MiR-26a inhibits stem cell-like phenotype and tumor growth of osteosarcoma by targeting Jagged1.

Lu J, Song G, Tang Q, Yin J, Zou C, Zhao Z, Xie X, Xu H, Huang G, Wang J, Lee DF, Khokha R, Yang H, Shen J.

Oncogene. 2017 Jan 12;36(2):231-241. doi: 10.1038/onc.2016.194. Epub 2016 Jun 6.

PMID:
27270422
9.

RANKL/RANK control Brca1 mutation-driven mammary tumors.

Sigl V, Owusu-Boaitey K, Joshi PA, Kavirayani A, Wirnsberger G, Novatchkova M, Kozieradzki I, Schramek D, Edokobi N, Hersl J, Sampson A, Odai-Afotey A, Lazaro C, Gonzalez-Suarez E, Pujana MA, Cimba F, Heyn H, Vidal E, Cruickshank J, Berman H, Sarao R, Ticevic M, Uribesalgo I, Tortola L, Rao S, Tan Y, Pfeiler G, Lee EY, Bago-Horvath Z, Kenner L, Popper H, Singer C, Khokha R, Jones LP, Penninger JM.

Cell Res. 2016 Jul;26(7):761-74. doi: 10.1038/cr.2016.69. Epub 2016 May 31.

10.

RANKL blockade prevents and treats aggressive osteosarcomas.

Chen Y, Di Grappa MA, Molyneux SD, McKee TD, Waterhouse P, Penninger JM, Khokha R.

Sci Transl Med. 2015 Dec 9;7(317):317ra197. doi: 10.1126/scitranslmed.aad0295. Erratum in: Sci Transl Med. 2016 Feb 3;8(324):324er2.

PMID:
26659571
11.

Progesterone and Synthetic Progestin Controversies--Reply.

Joshi PA, Goodwin PJ, Khokha R.

JAMA Oncol. 2015 Oct;1(7):987-8. doi: 10.1001/jamaoncol.2015.2294. No abstract available.

PMID:
26448288
12.

Timp3 loss accelerates tumour invasion and increases prostate inflammation in a mouse model of prostate cancer.

Adissu HA, McKerlie C, Di Grappa M, Waterhouse P, Xu Q, Fang H, Khokha R, Wood GA.

Prostate. 2015 Dec;75(16):1831-43. doi: 10.1002/pros.23056. Epub 2015 Sep 1.

PMID:
26332574
13.

Progesterone Exposure and Breast Cancer Risk: Understanding the Biological Roots.

Joshi PA, Goodwin PJ, Khokha R.

JAMA Oncol. 2015 Jun;1(3):283-5. doi: 10.1001/jamaoncol.2015.0512. No abstract available.

PMID:
26181171
14.

RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1.

Joshi PA, Waterhouse PD, Kannan N, Narala S, Fang H, Di Grappa MA, Jackson HW, Penninger JM, Eaves C, Khokha R.

Stem Cell Reports. 2015 Jul 14;5(1):31-44. doi: 10.1016/j.stemcr.2015.05.012. Epub 2015 Jun 18.

15.

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.

Moriarity BS, Otto GM, Rahrmann EP, Rathe SK, Wolf NK, Weg MT, Manlove LA, LaRue RS, Temiz NA, Molyneux SD, Choi K, Holly KJ, Sarver AL, Scott MC, Forster CL, Modiano JF, Khanna C, Hewitt SM, Khokha R, Yang Y, Gorlick R, Dyer MA, Largaespada DA.

Nat Genet. 2015 Jun;47(6):615-24. doi: 10.1038/ng.3293. Epub 2015 May 11.

16.

Timp3 deficient mice show resistance to developing breast cancer.

Jackson HW, Hojilla CV, Weiss A, Sanchez OH, Wood GA, Khokha R.

PLoS One. 2015 Mar 25;10(3):e0120107. doi: 10.1371/journal.pone.0120107. eCollection 2015.

17.

A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland.

Shiah YJ, Tharmapalan P, Casey AE, Joshi PA, McKee TD, Jackson HW, Beristain AG, Chan-Seng-Yue MA, Bader GD, Lydon JP, Waterhouse PD, Boutros PC, Khokha R.

Stem Cell Reports. 2015 Mar 10;4(3):313-322. doi: 10.1016/j.stemcr.2015.01.011. Epub 2015 Feb 19.

18.

Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 null mice.

Jackson HW, Waterhouse P, Sinha A, Kislinger T, Berman HK, Khokha R.

Nat Cell Biol. 2015 Mar;17(3):217-27. doi: 10.1038/ncb3118. Epub 2015 Feb 23.

PMID:
25706237
19.

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.

Harris IS, Treloar AE, Inoue S, Sasaki M, Gorrini C, Lee KC, Yung KY, Brenner D, Knobbe-Thomsen CB, Cox MA, Elia A, Berger T, Cescon DW, Adeoye A, Brüstle A, Molyneux SD, Mason JM, Li WY, Yamamoto K, Wakeham A, Berman HK, Khokha R, Done SJ, Kavanagh TJ, Lam CW, Mak TW.

Cancer Cell. 2015 Feb 9;27(2):211-22. doi: 10.1016/j.ccell.2014.11.019. Epub 2015 Jan 22. Erratum in: Cancer Cell. 2015 Feb 9;27(2):314.

20.

TIMP3 controls cell fate to confer hepatocellular carcinoma resistance.

Defamie V, Sanchez O, Murthy A, Khokha R.

Oncogene. 2015 Jul 30;34(31):4098-108. doi: 10.1038/onc.2014.339. Epub 2014 Oct 27.

PMID:
25347747
21.

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state.

Shimoda M, Principe S, Jackson HW, Luga V, Fang H, Molyneux SD, Shao YW, Aiken A, Waterhouse PD, Karamboulas C, Hess FM, Ohtsuka T, Okada Y, Ailles L, Ludwig A, Wrana JL, Kislinger T, Khokha R.

Nat Cell Biol. 2014 Sep;16(9):889-901. doi: 10.1038/ncb3021. Epub 2014 Aug 24.

PMID:
25150980
22.

Human somatic cell mutagenesis creates genetically tractable sarcomas.

Molyneux SD, Waterhouse PD, Shelton D, Shao YW, Watling CM, Tang QL, Harris IS, Dickson BC, Tharmapalan P, Sandve GK, Zhang X, Bailey SD, Berman H, Wunder JS, Izsvák Z, Lupien M, Mak TW, Khokha R.

Nat Genet. 2014 Sep;46(9):964-72. doi: 10.1038/ng.3065. Epub 2014 Aug 17. Erratum in: Nat Genet. 2014 Dec;46(12):1372. Iszvak, Zsuzsanna [corrected to Izsvák, Zsuzsanna.

PMID:
25129143
23.

High CD49f expression is associated with osteosarcoma tumor progression: a study using patient-derived primary cell cultures.

Penfornis P, Cai DZ, Harris MR, Walker R, Licini D, Fernandes JD, Orr G, Koganti T, Hicks C, Induru S, Meyer MS, Khokha R, Barr J, Pochampally RR.

Cancer Med. 2014 Aug;3(4):796-811. doi: 10.1002/cam4.249. Epub 2014 May 7.

24.

PKA signaling drives mammary tumorigenesis through Src.

Beristain AG, Molyneux SD, Joshi PA, Pomroy NC, Di Grappa MA, Chang MC, Kirschner LS, Privé GG, Pujana MA, Khokha R.

Oncogene. 2015 Feb 26;34(9):1160-73. doi: 10.1038/onc.2014.41. Epub 2014 Mar 24.

PMID:
24662820
25.

Fully interlocking: a story of teamwork among breast epithelial cells.

Alexander CM, Joshi PA, Khokha R.

Dev Cell. 2014 Jan 27;28(2):114-5. doi: 10.1016/j.devcel.2014.01.011.

26.

Localized interleukin-12 delivery for immunotherapy of solid tumours.

Wei LZ, Xu Y, Nelles EM, Furlonger C, Wang JC, Di Grappa MA, Khokha R, Medin JA, Paige CJ.

J Cell Mol Med. 2013 Nov;17(11):1465-74. doi: 10.1111/jcmm.12121. Epub 2013 Nov 19.

27.

Proteolysis during tumor cell extravasation in vitro: metalloproteinase involvement across tumor cell types.

Voura EB, English JL, Yu HY, Ho AT, Subarsky P, Hill RP, Hojilla CV, Khokha R.

PLoS One. 2013 Oct 23;8(10):e78413. doi: 10.1371/journal.pone.0078413. eCollection 2013.

28.

Metalloproteinases and their natural inhibitors in inflammation and immunity.

Khokha R, Murthy A, Weiss A.

Nat Rev Immunol. 2013 Sep;13(9):649-65. doi: 10.1038/nri3499. Review.

PMID:
23969736
29.

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.

Gorrini C, Baniasadi PS, Harris IS, Silvester J, Inoue S, Snow B, Joshi PA, Wakeham A, Molyneux SD, Martin B, Bouwman P, Cescon DW, Elia AJ, Winterton-Perks Z, Cruickshank J, Brenner D, Tseng A, Musgrave M, Berman HK, Khokha R, Jonkers J, Mak TW, Gauthier ML.

J Exp Med. 2013 Jul 29;210(8):1529-44. doi: 10.1084/jem.20121337. Epub 2013 Jul 15.

30.

Proteolytic factors in exosomes.

Shimoda M, Khokha R.

Proteomics. 2013 May;13(10-11):1624-36. doi: 10.1002/pmic.201200458. Review.

PMID:
23526769
31.

Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells.

Lee HJ, Gallego-Ortega D, Ledger A, Schramek D, Joshi P, Szwarc MM, Cho C, Lydon JP, Khokha R, Penninger JM, Ormandy CJ.

Development. 2013 Apr;140(7):1397-401. doi: 10.1242/dev.088948. Epub 2013 Mar 5.

32.

Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay.

Fiorentino L, Cavalera M, Menini S, Marchetti V, Mavilio M, Fabrizi M, Conserva F, Casagrande V, Menghini R, Pontrelli P, Arisi I, D'Onofrio M, Lauro D, Khokha R, Accili D, Pugliese G, Gesualdo L, Lauro R, Federici M.

EMBO Mol Med. 2013 Mar;5(3):441-55. doi: 10.1002/emmm.201201475. Epub 2013 Feb 12.

33.

Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.

Hewing NJ, Weskamp G, Vermaat J, Farage E, Glomski K, Swendeman S, Chan RV, Chiang MF, Khokha R, Anand-Apte B, Blobel CP.

Invest Ophthalmol Vis Sci. 2013 Jan 30;54(1):864-70. doi: 10.1167/iovs.12-10954.

34.

QUANTIFYING NANOPARTICLE TRANSPORT IN VIVO USING HYPERSPECTRAL IMAGING WITH A DORSAL SKINFOLD WINDOW CHAMBER.

McKee TD, Chen J, Corbin I, Zheng G, Khokha R.

J Innov Opt Health Sci. 2012 Oct;5(4). pii: 1250023. doi: 10.1142/S179354581250023X. Epub 2012 Nov 26.

35.

Active allies: hormones, stem cells and the niche in adult mammopoiesis.

Joshi PA, Di Grappa MA, Khokha R.

Trends Endocrinol Metab. 2012 Jun;23(6):299-309. doi: 10.1016/j.tem.2012.04.002. Epub 2012 May 19. Review.

PMID:
22613704
36.

The mammary stem cell conundrum: is it unipotent or multipotent?

Joshi PA, Khokha R.

Breast Cancer Res. 2012 Mar 16;14(2):305.

37.

Homotypic RANK signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells.

Beristain AG, Narala SR, Di Grappa MA, Khokha R.

J Cell Sci. 2012 Feb 15;125(Pt 4):943-55. doi: 10.1242/jcs.094029. Epub 2012 Mar 15.

38.

Stromal TIMP3 regulates liver lymphocyte populations and provides protection against Th1 T cell-driven autoimmune hepatitis.

Murthy A, Shao YW, Defamie V, Wedeles C, Smookler D, Khokha R.

J Immunol. 2012 Mar 15;188(6):2876-83. doi: 10.4049/jimmunol.1102199. Epub 2012 Feb 8.

39.

Notch activation by the metalloproteinase ADAM17 regulates myeloproliferation and atopic barrier immunity by suppressing epithelial cytokine synthesis.

Murthy A, Shao YW, Narala SR, Molyneux SD, Zúñiga-Pflücker JC, Khokha R.

Immunity. 2012 Jan 27;36(1):105-19. doi: 10.1016/j.immuni.2012.01.005.

40.

iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.

McIlwain DR, Lang PA, Maretzky T, Hamada K, Ohishi K, Maney SK, Berger T, Murthy A, Duncan G, Xu HC, Lang KS, Häussinger D, Wakeham A, Itie-Youten A, Khokha R, Ohashi PS, Blobel CP, Mak TW.

Science. 2012 Jan 13;335(6065):229-32. doi: 10.1126/science.1214448.

41.

TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence.

Hojilla CV, Jackson HW, Khokha R.

PLoS One. 2011;6(10):e26718. doi: 10.1371/journal.pone.0026718. Epub 2011 Oct 28.

42.

Increased neovascularization in mice lacking tissue inhibitor of metalloproteinases-3.

Ebrahem Q, Qi JH, Sugimoto M, Ali M, Sears JE, Cutler A, Khokha R, Vasanji A, Anand-Apte B.

Invest Ophthalmol Vis Sci. 2011 Aug 3;52(9):6117-23. doi: 10.1167/iovs.10-5899.

43.

Mammary gland reprogramming: metalloproteinases couple form with function.

Khokha R, Werb Z.

Cold Spring Harb Perspect Biol. 2011 Apr 1;3(4). pii: a004333. doi: 10.1101/cshperspect.a004333. Review.

44.

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site.

Le Gall SM, Maretzky T, Issuree PD, Niu XD, Reiss K, Saftig P, Khokha R, Lundell D, Blobel CP.

J Cell Sci. 2010 Nov 15;123(Pt 22):3913-22. doi: 10.1242/jcs.069997. Epub 2010 Oct 27.

45.

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer.

Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, Pasparakis M, Khokha R, Ormandy CJ, Widschwendter M, Schett G, Penninger JM.

Nature. 2010 Nov 4;468(7320):98-102. doi: 10.1038/nature09387. Epub 2010 Sep 29.

46.

TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool.

Nakajima H, Ito M, Smookler DS, Shibata F, Fukuchi Y, Morikawa Y, Ikeda Y, Arai F, Suda T, Khokha R, Kitamura T.

Blood. 2010 Nov 25;116(22):4474-82. doi: 10.1182/blood-2010-01-266528. Epub 2010 Aug 26.

47.

Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice.

Molyneux SD, Di Grappa MA, Beristain AG, McKee TD, Wai DH, Paderova J, Kashyap M, Hu P, Maiuri T, Narala SR, Stambolic V, Squire J, Penninger J, Sanchez O, Triche TJ, Wood GA, Kirschner LS, Khokha R.

J Clin Invest. 2010 Sep;120(9):3310-25. doi: 10.1172/JCI42391. Epub 2010 Aug 9.

48.

Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice.

Murthy A, Defamie V, Smookler DS, Di Grappa MA, Horiuchi K, Federici M, Sibilia M, Blobel CP, Khokha R.

J Clin Invest. 2010 Aug;120(8):2731-44. doi: 10.1172/JCI42686. Epub 2010 Jul 12.

49.

Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload.

Koskivirta I, Kassiri Z, Rahkonen O, Kiviranta R, Oudit GY, McKee TD, Kytö V, Saraste A, Jokinen E, Liu PP, Vuorio E, Khokha R.

J Biol Chem. 2010 Aug 6;285(32):24487-93. doi: 10.1074/jbc.M110.136820. Epub 2010 Jun 1.

50.

Progesterone induces adult mammary stem cell expansion.

Joshi PA, Jackson HW, Beristain AG, Di Grappa MA, Mote PA, Clarke CL, Stingl J, Waterhouse PD, Khokha R.

Nature. 2010 Jun 10;465(7299):803-7. doi: 10.1038/nature09091.

PMID:
20445538

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