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DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs.

Oshima G, Poli EC, Bolt MJ, Chlenski A, Forde M, Jutzy JMS, Biyani N, Posner MC, Pitroda SP, Weichselbaum RR, Khodarev NN.

Cancer Res. 2019 Feb 1;79(3):650-662. doi: 10.1158/0008-5472.CAN-18-0692. Epub 2018 Dec 11.


STING promotes homeostasis via regulation of cell proliferation and chromosomal stability.

Ranoa DRE, Widau RC, Mallon S, Parekh AD, Nicolae CM, Huang X, Bolt MJ, Arina A, Parry R, Kron SJ, Moldovan GL, Khodarev NN, Weichselbaum RR.

Cancer Res. 2018 Nov 27. pii: canres.1972.2018. doi: 10.1158/0008-5472.CAN-18-1972. [Epub ahead of print]


Author Correction: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis.

Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR.

Nat Commun. 2018 Nov 13;9(1):4827. doi: 10.1038/s41467-018-07303-w.


Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis.

Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR.

Nat Commun. 2018 May 4;9(1):1793. doi: 10.1038/s41467-018-04278-6. Erratum in: Nat Commun. 2018 Nov 13;9(1):4827.


JAK2 Inhibitor SAR302503 Abrogates PD-L1 Expression and Targets Therapy-Resistant Non-small Cell Lung Cancers.

Pitroda SP, Stack ME, Liu GF, Song SS, Chen L, Liang H, Parekh AD, Huang X, Roach P, Posner MC, Weichselbaum RR, Khodarev NN.

Mol Cancer Ther. 2018 Apr;17(4):732-739. doi: 10.1158/1535-7163.MCT-17-0667. Epub 2018 Feb 21.


Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors.

Luke JJ, Lemons JM, Karrison TG, Pitroda SP, Melotek JM, Zha Y, Al-Hallaq HA, Arina A, Khodarev NN, Janisch L, Chang P, Patel JD, Fleming GF, Moroney J, Sharma MR, White JR, Ratain MJ, Gajewski TF, Weichselbaum RR, Chmura SJ.

J Clin Oncol. 2018 Jun 1;36(16):1611-1618. doi: 10.1200/JCO.2017.76.2229. Epub 2018 Feb 13.


In Vivo Delivery and Therapeutic Effects of a MicroRNA on Colorectal Liver Metastases.

Oshima G, Guo N, He C, Stack ME, Poon C, Uppal A, Wightman SC, Parekh A, Skowron KB, Posner MC, Lin W, Khodarev NN, Weichselbaum RR.

Mol Ther. 2017 Jul 5;25(7):1588-1595. doi: 10.1016/j.ymthe.2017.04.005. Epub 2017 Apr 28.


CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response.

Qadir AS, Ceppi P, Brockway S, Law C, Mu L, Khodarev NN, Kim J, Zhao JC, Putzbach W, Murmann AE, Chen Z, Chen W, Liu X, Salomon AR, Liu H, Weichselbaum RR, Yu J, Peter ME.

Cell Rep. 2017 Mar 7;18(10):2373-2386. doi: 10.1016/j.celrep.2017.02.037.


Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones.

Oshima G, Stack ME, Wightman SC, Bryan D, Poli E, Xue L, Skowron KB, Uppal A, Pitroda SP, Huang X, Posner MC, Hellman S, Weichselbaum RR, Khodarev NN.

J Vis Exp. 2016 Nov 30;(117). doi: 10.3791/54657.


Basal Tumor Cell Isolation and Patient-Derived Xenograft Engraftment Identify High-Risk Clinical Bladder Cancers.

Skowron KB, Pitroda SP, Namm JP, Balogun O, Beckett MA, Zenner ML, Fayanju O, Huang X, Fernandez C, Zheng W, Qiao G, Chin R, Kron SJ, Khodarev NN, Posner MC, Steinberg GD, Weichselbaum RR.

Sci Rep. 2016 Oct 24;6:35854. doi: 10.1038/srep35854.


Clinical and molecular markers of long-term survival after oligometastasis-directed stereotactic body radiotherapy (SBRT).

Wong AC, Watson SP, Pitroda SP, Son CH, Das LC, Stack ME, Uppal A, Oshima G, Khodarev NN, Salama JK, Weichselbaum RR, Chmura SJ.

Cancer. 2016 Jul 15;122(14):2242-50. doi: 10.1002/cncr.30058. Epub 2016 May 20.


Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs.

Ranoa DR, Parekh AD, Pitroda SP, Huang X, Darga T, Wong AC, Huang L, Andrade J, Staley JP, Satoh T, Akira S, Weichselbaum RR, Khodarev NN.

Oncotarget. 2016 May 3;7(18):26496-515. doi: 10.18632/oncotarget.8420.


Imaging of tumor clones with differential liver colonization.

Oshima G, Wightman SC, Uppal A, Stack ME, Pitroda SP, Oskvarek JJ, Huang X, Posner MC, Hellman S, Weichselbaum RR, Khodarev NN.

Sci Rep. 2015 Jun 22;5:10946. doi: 10.1038/srep10946.


Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcome.

Wightman SC, Uppal A, Pitroda SP, Ganai S, Burnette B, Stack M, Oshima G, Khan S, Huang X, Posner MC, Weichselbaum RR, Khodarev NN.

Br J Cancer. 2015 Jul 14;113(2):327-35. doi: 10.1038/bjc.2015.193. Epub 2015 Jun 4.


microRNAs and oligometastasis.

Khodarev NN, Pitroda SP, Weichselbaum RR.

Aging (Albany NY). 2015 Mar;7(3):146-7. No abstract available.


Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact.

Kim M, Christley S, Khodarev NN, Fleming I, Huang Y, Chang E, Zaborina O, Alverdy JC.

J Trauma Acute Care Surg. 2015 Apr;78(4):823-9. doi: 10.1097/TA.0000000000000574.


14q32-encoded microRNAs mediate an oligometastatic phenotype.

Uppal A, Wightman SC, Mallon S, Oshima G, Pitroda SP, Zhang Q, Huang X, Darga TE, Huang L, Andrade J, Liu H, Ferguson MK, Greene GL, Posner MC, Hellman S, Khodarev NN, Weichselbaum RR.

Oncotarget. 2015 Feb 28;6(6):3540-52.


Towards a molecular basis of oligometastatic disease: potential role of micro-RNAs.

Uppal A, Ferguson MK, Posner MC, Hellman S, Khodarev NN, Weichselbaum RR.

Clin Exp Metastasis. 2014 Aug;31(6):735-48. doi: 10.1007/s10585-014-9664-3. Epub 2014 Jun 27. Review.


RIG-I-like receptor LGP2 protects tumor cells from ionizing radiation.

Widau RC, Parekh AD, Ranck MC, Golden DW, Kumar KA, Sood RF, Pitroda SP, Liao Z, Huang X, Darga TE, Xu D, Huang L, Andrade J, Roizman B, Weichselbaum RR, Khodarev NN.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E484-91. doi: 10.1073/pnas.1323253111. Epub 2014 Jan 13.


Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs.

Lussier YA, Khodarev NN, Regan K, Corbin K, Li H, Ganai S, Khan SA, Gnerlich JL, Darga TE, Fan H, Karpenko O, Paty PB, Posner MC, Chmura SJ, Hellman S, Ferguson MK, Weichselbaum RR.

PLoS One. 2012;7(12):e50141. doi: 10.1371/journal.pone.0050141. Epub 2012 Dec 10. Erratum in: PLoS One. 2013;8(6). doi: 10.1371/annotation/2489ae5e-3650-4897-8df6-3e974ca585c4. Gnerlich, Jennifer [corrected to Gnerlich, Jennifer L].


Tumor endothelial inflammation predicts clinical outcome in diverse human cancers.

Pitroda SP, Zhou T, Sweis RF, Filippo M, Labay E, Beckett MA, Mauceri HJ, Liang H, Darga TE, Perakis S, Khan SA, Sutton HG, Zhang W, Khodarev NN, Garcia JG, Weichselbaum RR.

PLoS One. 2012;7(10):e46104. doi: 10.1371/journal.pone.0046104. Epub 2012 Oct 4.


Molecular pathways: interferon/stat1 pathway: role in the tumor resistance to genotoxic stress and aggressive growth.

Khodarev NN, Roizman B, Weichselbaum RR.

Clin Cancer Res. 2012 Jun 1;18(11):3015-21. doi: 10.1158/1078-0432.CCR-11-3225. Epub 2012 May 21.


Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in glioblastoma multiforme in a subtype-specific manner.

Duarte CW, Willey CD, Zhi D, Cui X, Harris JJ, Vaughan LK, Mehta T, McCubrey RO, Khodarev NN, Weichselbaum RR, Gillespie GY.

PLoS One. 2012;7(1):e29653. doi: 10.1371/journal.pone.0029653. Epub 2012 Jan 5.


MicroRNA expression characterizes oligometastasis(es).

Lussier YA, Xing HR, Salama JK, Khodarev NN, Huang Y, Zhang Q, Khan SA, Yang X, Hasselle MD, Darga TE, Malik R, Fan H, Perakis S, Filippo M, Corbin K, Lee Y, Posner MC, Chmura SJ, Hellman S, Weichselbaum RR.

PLoS One. 2011;6(12):e28650. doi: 10.1371/journal.pone.0028650. Epub 2011 Dec 13.


Progression of cancer from indolent to aggressive despite antigen retention and increased expression of interferon-gamma inducible genes.

Wu TH, Schreiber K, Arina A, Khodarev NN, Efimova EV, Rowley DA, Weichselbaum RR, Schreiber H.

Cancer Immun. 2011 Jun 30;11:2.


The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunity.

Burnette BC, Liang H, Lee Y, Chlewicki L, Khodarev NN, Weichselbaum RR, Fu YX, Auh SL.

Cancer Res. 2011 Apr 1;71(7):2488-96. doi: 10.1158/0008-5472.CAN-10-2820. Epub 2011 Feb 7.


MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients.

MacDermed DM, Khodarev NN, Pitroda SP, Edwards DC, Pelizzari CA, Huang L, Kufe DW, Weichselbaum RR.

BMC Med Genomics. 2010 May 6;3:16. doi: 10.1186/1755-8794-3-16.


Ad.Egr-TNF and local ionizing radiation suppress metastases by interferon-beta-dependent activation of antigen-specific CD8+ T cells.

Meng Y, Mauceri HJ, Khodarev NN, Darga TE, Pitroda SP, Beckett MA, Kufe DW, Weichselbaum RR.

Mol Ther. 2010 May;18(5):912-20. doi: 10.1038/mt.2010.18. Epub 2010 Mar 2.


STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect.

Pitroda SP, Wakim BT, Sood RF, Beveridge MG, Beckett MA, MacDermed DM, Weichselbaum RR, Khodarev NN.

BMC Med. 2009 Nov 5;7:68. doi: 10.1186/1741-7015-7-68.


STAT1 pathway mediates amplification of metastatic potential and resistance to therapy.

Khodarev NN, Roach P, Pitroda SP, Golden DW, Bhayani M, Shao MY, Darga TE, Beveridge MG, Sood RF, Sutton HG, Beckett MA, Mauceri HJ, Posner MC, Weichselbaum RR.

PLoS One. 2009 Jun 8;4(6):e5821. doi: 10.1371/journal.pone.0005821.


Radioresistance of Stat1 over-expressing tumour cells is associated with suppressed apoptotic response to cytotoxic agents and increased IL6-IL8 signalling.

Efimova EV, Liang H, Pitroda SP, Labay E, Darga TE, Levina V, Lokshin A, Roizman B, Weichselbaum RR, Khodarev NN.

Int J Radiat Biol. 2009 May;85(5):421-31. doi: 10.1080/09553000902838566. Erratum in: Int J Radiat Biol. 2009 Jul;85(7):642.


MUC1-induced transcriptional programs associated with tumorigenesis predict outcome in breast and lung cancer.

Khodarev NN, Pitroda SP, Beckett MA, MacDermed DM, Huang L, Kufe DW, Weichselbaum RR.

Cancer Res. 2009 Apr 1;69(7):2833-7. doi: 10.1158/0008-5472.CAN-08-4513. Epub 2009 Mar 24.


MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment.

Pitroda SP, Khodarev NN, Beckett MA, Kufe DW, Weichselbaum RR.

Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5837-41. doi: 10.1073/pnas.0812029106. Epub 2009 Mar 16.


Translational strategies exploiting TNF-alpha that sensitize tumors to radiation therapy.

Mauceri HJ, Beckett MA, Liang H, Sutton HG, Pitroda S, Galka E, Efimova E, Darga T, Khodarev NN, King CR, Posner MC, Hellman S, Kufe DW, Weichselbaum RR.

Cancer Gene Ther. 2009 Apr;16(4):373-81. doi: 10.1038/cgt.2008.86. Epub 2008 Oct 31.


Diverse TNFalpha-induced death pathways are enhanced by inhibition of NF-kappaB.

Katdare M, Efimova EV, Labay E, Khodarev NN, Darga TE, Garofalo M, Nakamura S, Kufe DW, Posner MC, Weichselbaum RR.

Int J Oncol. 2007 Dec;31(6):1519-28.


Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells.

Khodarev NN, Minn AJ, Efimova EV, Darga TE, Labay E, Beckett M, Mauceri HJ, Roizman B, Weichselbaum RR.

Cancer Res. 2007 Oct 1;67(19):9214-20.


Progression of Barrett's metaplasia to adenocarcinoma is associated with the suppression of the transcriptional programs of epidermal differentiation.

Kimchi ET, Posner MC, Park JO, Darga TE, Kocherginsky M, Karrison T, Hart J, Smith KD, Mezhir JJ, Weichselbaum RR, Khodarev NN.

Cancer Res. 2005 Apr 15;65(8):3146-54.


Interaction of amifostine and ionizing radiation on transcriptional patterns of apoptotic genes expressed in human microvascular endothelial cells (HMEC).

Khodarev NN, Kataoka Y, Murley JS, Weichselbaum RR, Grdina DJ.

Int J Radiat Oncol Biol Phys. 2004 Oct 1;60(2):553-63.


Glioblastoma cells block radiation-induced programmed cell death of endothelial cells.

Brown CK, Khodarev NN, Yu J, Moo-Young T, Labay E, Darga TE, Posner MC, Weichselbaum RR, Mauceri HJ.

FEBS Lett. 2004 May 7;565(1-3):167-70.


STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells.

Khodarev NN, Beckett M, Labay E, Darga T, Roizman B, Weichselbaum RR.

Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1714-9. Epub 2004 Jan 30.


Endothelial cells co-cultured with wild-type and dominant/negative p53-transfected glioblastoma cells exhibit differential sensitivity to radiation-induced apoptosis.

Khodarev NN, Labay E, Darga T, Yu J, Mauceri H, Gupta N, Kataoka Y, Weichselbaum RR.

Int J Cancer. 2004 Mar 20;109(2):214-9.


Receiver operating characteristic analysis: a general tool for DNA array data filtration and performance estimation.

Khodarev NN, Park J, Kataoka Y, Nodzenski E, Hellman S, Roizman B, Weichselbaum RR, Pelizzari CA.

Genomics. 2003 Feb;81(2):202-9.


Tumour-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells.

Khodarev NN, Yu J, Labay E, Darga T, Brown CK, Mauceri HJ, Yassari R, Gupta N, Weichselbaum RR.

J Cell Sci. 2003 Mar 15;116(Pt 6):1013-22.


Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine.

Kataoka Y, Murley JS, Khodarev NN, Weichselbaum RR, Grdina DJ.

Int J Radiat Oncol Biol Phys. 2002 May 1;53(1):180-9.


Method of RNA purification from endothelial cells for DNA array experiments.

Khodarev NN, Yu J, Nodzenski E, Murley JS, Kataoka Y, Brown CK, Grdina DJ, Weichselbaum RR.

Biotechniques. 2002 Feb;32(2):316, 318, 320. No abstract available.


Dose-dependent and independent temporal patterns of gene responses to ionizing radiation in normal and tumor cells and tumor xenografts.

Khodarev NN, Park JO, Yu J, Gupta N, Nodzenski E, Roizman B, Weichselbaum RR.

Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12665-70.


Angiostatin effects on endothelial cells mediated by ceramide and RhoA.

Gupta N, Nodzenski E, Khodarev NN, Yu J, Khorasani L, Beckett MA, Kufe DW, Weichselbaum RR.

EMBO Rep. 2001 Jun;2(6):536-40.


Quantitative analysis of DNA array autoradiographs.

Pelizzari CA, Khodarev NN, Gupta N, Calvin DP, Weichselbaum RR.

Nucleic Acids Res. 2000 Nov 15;28(22):4577-81.


LINE L1 retrotransposable element is targeted during the initial stages of apoptotic DNA fragmentation.

Khodarev NN, Bennett T, Shearing N, Sokolova I, Koudelik J, Walter S, Villalobos M, Vaughan AT.

J Cell Biochem. 2000 Sep 7;79(3):486-95.


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