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[Regulators of the male epigenome: Markers and potential targets for anticancer therapy].

Rousseaux S, Bourova-Flin E, Chuffart F, Khochbin S.

Bull Cancer. 2019 Oct;106(10):836-838. doi: 10.1016/j.bulcan.2019.08.003. Epub 2019 Aug 23. French. No abstract available.


Transcription factor dimerization activates the p300 acetyltransferase.

Ortega E, Rengachari S, Ibrahim Z, Hoghoughi N, Gaucher J, Holehouse AS, Khochbin S, Panne D.

Nature. 2018 Oct;562(7728):538-544. doi: 10.1038/s41586-018-0621-1. Epub 2018 Oct 15.


Histone variants: critical determinants in tumour heterogeneity.

Wang T, Chuffart F, Bourova-Flin E, Wang J, Mi J, Rousseaux S, Khochbin S.

Front Med. 2019 Jun;13(3):289-297. doi: 10.1007/s11684-018-0667-3. Epub 2019 Jun 11. Review.


Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male Germ Cells.

Shiota H, Barral S, Buchou T, Tan M, Couté Y, Charbonnier G, Reynoird N, Boussouar F, Gérard M, Zhu M, Bargier L, Puthier D, Chuffart F, Bourova-Flin E, Picaud S, Filippakopoulos P, Goudarzi A, Ibrahim Z, Panne D, Rousseaux S, Zhao Y, Khochbin S.

Cell Rep. 2018 Sep 25;24(13):3477-3487.e6. doi: 10.1016/j.celrep.2018.08.069.


Characterization of Post-Meiotic Male Germ Cell Genome Organizational States.

Govin J, Barral S, Morozumi Y, Hoghoughi N, Buchou T, Rousseaux S, Khochbin S.

Methods Mol Biol. 2018;1832:293-307. doi: 10.1007/978-1-4939-8663-7_16.


Inhibition of BET Proteins Reduces Right Ventricle Hypertrophy and Pulmonary Hypertension Resulting from Combined Hypoxia and Pulmonary Inflammation.

Chabert C, Khochbin S, Rousseaux S, Veyrenc S, Furze R, Smithers N, Prinjha RK, Schlattner U, Pison C, Dubouchaud H.

Int J Mol Sci. 2018 Jul 30;19(8). pii: E2224. doi: 10.3390/ijms19082224.


Pregnancy exposure to atmospheric pollution and meteorological conditions and placental DNA methylation.

Abraham E, Rousseaux S, Agier L, Giorgis-Allemand L, Tost J, Galineau J, Hulin A, Siroux V, Vaiman D, Charles MA, Heude B, Forhan A, Schwartz J, Chuffart F, Bourova-Flin E, Khochbin S, Slama R, Lepeule J; EDEN mother-child cohort study group.

Environ Int. 2018 Sep;118:334-347. doi: 10.1016/j.envint.2018.05.007. Epub 2018 Jun 21.


Induction of autophagy and autophagy-dependent apoptosis in diffuse large B-cell lymphoma by a new antimalarial artemisinin derivative, SM1044.

Cheng C, Wang T, Song Z, Peng L, Gao M, Hermine O, Rousseaux S, Khochbin S, Mi JQ, Wang J.

Cancer Med. 2018 Feb;7(2):380-396. doi: 10.1002/cam4.1276. Epub 2017 Dec 26.


Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia.

Wang T, Cheng C, Peng L, Gao M, Xi M, Rousseaux S, Khochbin S, Wang J, Mi J.

J Cell Mol Med. 2018 Mar;22(3):1614-1626. doi: 10.1111/jcmm.13436. Epub 2017 Dec 20.


Identity crisis in pulmonary arterial hypertension.

Ruffenach G, Bonnet S, Rousseaux S, Khochbin S, Provencher S, Perros F.

Pulm Circ. 2018 Jan-Mar;8(1):2045893217746054. doi: 10.1177/2045893217746054.


Histone variants: essential actors in male genome programming.

Hoghoughi N, Barral S, Vargas A, Rousseaux S, Khochbin S.

J Biochem. 2018 Feb 1;163(2):97-103. doi: 10.1093/jb/mvx079. Review.


[The mystery of histone disappearance during spermatogenesis].

Barral S, Morozumi Y, Hoghoughi N, Rousseaux S, Khochbin S.

Med Sci (Paris). 2017 Jun-Jul;33(6-7):588-590. doi: 10.1051/medsci/20173306010. Epub 2017 Jul 19. French. No abstract available.


Muscle hypertrophy in hypoxia with inflammation is controlled by bromodomain and extra-terminal domain proteins.

Chabert C, Khochbin S, Rousseaux S, Furze R, Smithers N, Prinjha R, Schlattner U, Pison C, Dubouchaud H.

Sci Rep. 2017 Sep 21;7(1):12133. doi: 10.1038/s41598-017-12112-0.


Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock.

Col E, Hoghoughi N, Dufour S, Penin J, Koskas S, Faure V, Ouzounova M, Hernandez-Vargash H, Reynoird N, Daujat S, Folco E, Vigneron M, Schneider R, Verdel A, Khochbin S, Herceg Z, Caron C, Vourc'h C.

Sci Rep. 2017 Jul 14;7(1):5418. doi: 10.1038/s41598-017-05343-8.


The Role of Bromodomain Testis-Specific Factor, BRDT, in Cancer: A Biomarker and A Possible Therapeutic Target.

Bourova-Flin E, Chuffart F, Rousseaux S, Khochbin S.

Cell J. 2017 Spring;19(Suppl 1):1-8. doi: 10.22074/cellj.2017.5060. Epub 2017 May 17. Review.


Histone Variant H2A.L.2 Guides Transition Protein-Dependent Protamine Assembly in Male Germ Cells.

Barral S, Morozumi Y, Tanaka H, Montellier E, Govin J, de Dieuleveult M, Charbonnier G, Couté Y, Puthier D, Buchou T, Boussouar F, Urahama T, Fenaille F, Curtet S, Héry P, Fernandez-Nunez N, Shiota H, Gérard M, Rousseaux S, Kurumizaka H, Khochbin S.

Mol Cell. 2017 Apr 6;66(1):89-101.e8. doi: 10.1016/j.molcel.2017.02.025. Epub 2017 Mar 30.


MS_HistoneDB, a manually curated resource for proteomic analysis of human and mouse histones.

El Kennani S, Adrait A, Shaytan AK, Khochbin S, Bruley C, Panchenko AR, Landsman D, Pflieger D, Govin J.

Epigenetics Chromatin. 2017 Jan 10;10:2. doi: 10.1186/s13072-016-0109-x. eCollection 2017.


A bromodomain-DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT.

Miller TC, Simon B, Rybin V, Grötsch H, Curtet S, Khochbin S, Carlomagno T, Müller CW.

Nat Commun. 2016 Dec 19;7:13855. doi: 10.1038/ncomms13855.


Structure of p300 in complex with acyl-CoA variants.

Kaczmarska Z, Ortega E, Goudarzi A, Huang H, Kim S, Márquez JA, Zhao Y, Khochbin S, Panne D.

Nat Chem Biol. 2017 Jan;13(1):21-29. doi: 10.1038/nchembio.2217. Epub 2016 Oct 31.


Purification and Analysis of Male Germ Cells from Adult Mouse Testis.

Buchou T, Tan M, Barral S, Vitte AL, Rousseaux S, Arechaga J, Khochbin S.

Methods Mol Biol. 2017;1510:159-168.


Remodeling somatic nuclei via exogenous expression of protamine 1 to create spermatid-like structures for somatic nuclear transfer.

Czernik M, Iuso D, Toschi P, Khochbin S, Loi P.

Nat Protoc. 2016 Nov;11(11):2170-2188. doi: 10.1038/nprot.2016.130. Epub 2016 Oct 6.


The growing landscape of tubulin acetylation: lysine 40 and many more.

Sadoul K, Khochbin S.

Biochem J. 2016 Jul 1;473(13):1859-68. doi: 10.1042/BCJ20160172. Review.


Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters.

Goudarzi A, Zhang D, Huang H, Barral S, Kwon OK, Qi S, Tang Z, Buchou T, Vitte AL, He T, Cheng Z, Montellier E, Gaucher J, Curtet S, Debernardi A, Charbonnier G, Puthier D, Petosa C, Panne D, Rousseaux S, Roeder RG, Zhao Y, Khochbin S.

Mol Cell. 2016 Apr 21;62(2):169-180. doi: 10.1016/j.molcel.2016.03.014.


Exogenous Expression of Human Protamine 1 (hPrm1) Remodels Fibroblast Nuclei into Spermatid-like Structures.

Iuso D, Czernik M, Toschi P, Fidanza A, Zacchini F, Feil R, Curtet S, Buchou T, Shiota H, Khochbin S, Ptak GE, Loi P.

Cell Rep. 2015 Dec 1;13(9):1765-71. doi: 10.1016/j.celrep.2015.10.066. Epub 2015 Nov 25.


Atad2 is a generalist facilitator of chromatin dynamics in embryonic stem cells.

Morozumi Y, Boussouar F, Tan M, Chaikuad A, Jamshidikia M, Colak G, He H, Nie L, Petosa C, de Dieuleveult M, Curtet S, Vitte AL, Rabatel C, Debernardi A, Cosset FL, Verhoeyen E, Emadali A, Schweifer N, Gianni D, Gut M, Guardiola P, Rousseaux S, Gérard M, Knapp S, Zhao Y, Khochbin S.

J Mol Cell Biol. 2016 Aug;8(4):349-62. doi: 10.1093/jmcb/mjv060. Epub 2015 Oct 12.


Arsenic trioxide rewires mantle cell lymphoma response to bortezomib.

Zhao LL, Liu YF, Peng LJ, Fei AM, Cui W, Miao SC, Hermine O, Gressin R, Khochbin S, Chen SJ, Wang J, Mi JQ.

Cancer Med. 2015 Nov;4(11):1754-66. doi: 10.1002/cam4.511. Epub 2015 Aug 26.


A six gene expression signature defines aggressive subtypes and predicts outcome in childhood and adult acute lymphoblastic leukemia.

Wang J, Mi JQ, Debernardi A, Vitte AL, Emadali A, Meyer JA, Charmpi K, Ycart B, Callanan MB, Carroll WL, Khochbin S, Rousseaux S.

Oncotarget. 2015 Jun 30;6(18):16527-42.


Histone Acylation beyond Acetylation: Terra Incognita in Chromatin Biology.

Rousseaux S, Khochbin S.

Cell J. 2015 Spring;17(1):1-6. Epub 2015 Apr 8. Review.


Histone deacetylase 6 is a FoxO transcription factor-dependent effector in skeletal muscle atrophy.

Ratti F, Ramond F, Moncollin V, Simonet T, Milan G, Méjat A, Thomas JL, Streichenberger N, Gilquin B, Matthias P, Khochbin S, Sandri M, Schaeffer L.

J Biol Chem. 2015 Feb 13;290(7):4215-24. doi: 10.1074/jbc.M114.600916. Epub 2014 Dec 15.


Lessons from yeast on emerging roles of the ATAD2 protein family in gene regulation and genome organization.

Cattaneo M, Morozumi Y, Perazza D, Boussouar F, Jamshidikia M, Rousseaux S, Verdel A, Khochbin S.

Mol Cells. 2014 Dec 31;37(12):851-6. doi: 10.14348/molcells.2014.0258. Epub 2014 Nov 5. Review.


HDAC6-ubiquitin interaction controls the duration of HSF1 activation after heat shock.

Pernet L, Faure V, Gilquin B, Dufour-Guérin S, Khochbin S, Vourc'h C.

Mol Biol Cell. 2014 Dec 15;25(25):4187-94. doi: 10.1091/mbc.E14-06-1032. Epub 2014 Oct 8.


Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity.

Brambilla C, Laffaire J, Lantuejoul S, Moro-Sibilot D, Mignotte H, Arbib F, Toffart AC, Petel F, Hainaut P, Rousseaux S, Khochbin S, de Reyniès A, Brambilla E.

Clin Cancer Res. 2014 Nov 15;20(22):5777-86. doi: 10.1158/1078-0432.CCR-14-0459. Epub 2014 Sep 4.


The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway.

Le Borgne M, Chartier N, Buchet-Poyau K, Destaing O, Faurobert E, Thibert C, Rouault JP, Courchet J, Nègre D, Bouvard D, Albiges-Rizo C, Rousseaux S, Khochbin S, Segretain D, Crépieux P, Guillou F, Durand P, Perrard MH, Billaud M.

Development. 2014 May;141(10):2096-107. doi: 10.1242/dev.108514.


Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark.

Dai L, Peng C, Montellier E, Lu Z, Chen Y, Ishii H, Debernardi A, Buchou T, Rousseaux S, Jin F, Sabari BR, Deng Z, Allis CD, Ren B, Khochbin S, Zhao Y.

Nat Chem Biol. 2014 May;10(5):365-70. doi: 10.1038/nchembio.1497. Epub 2014 Mar 30.


Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription.

Di Cerbo V, Mohn F, Ryan DP, Montellier E, Kacem S, Tropberger P, Kallis E, Holzner M, Hoerner L, Feldmann A, Richter FM, Bannister AJ, Mittler G, Michaelis J, Khochbin S, Feil R, Schuebeler D, Owen-Hughes T, Daujat S, Schneider R.

Elife. 2014 Mar 25;3:e01632. doi: 10.7554/eLife.01632.


Genome-scale acetylation-dependent histone eviction during spermatogenesis.

Goudarzi A, Shiota H, Rousseaux S, Khochbin S.

J Mol Biol. 2014 Oct 9;426(20):3342-9. doi: 10.1016/j.jmb.2014.02.023. Epub 2014 Mar 5. Review.


A specific CBP/p300-dependent gene expression programme drives the metabolic remodelling in late stages of spermatogenesis.

Boussouar F, Goudarzi A, Buchou T, Shiota H, Barral S, Debernardi A, Guardiola P, Brindle P, Martinez G, Arnoult C, Khochbin S, Rousseaux S.

Andrology. 2014 May;2(3):351-9. doi: 10.1111/j.2047-2927.2014.00184.x. Epub 2014 Feb 13.


Receptor-Independent Ectopic Activity of Prolactin Predicts Aggressive Lung Tumors and Indicates HDACi-Based Therapeutic Strategies.

Le Bescont A, Vitte AL, Debernardi A, Curtet S, Buchou T, Vayr J, de Reyniès A, Ito A, Guardiola P, Brambilla C, Yoshida M, Brambilla E, Rousseaux S, Khochbin S.

Antioxid Redox Signal. 2015 Jul 1;23(1):1-14. doi: 10.1089/ars.2013.5581. Epub 2014 Mar 6.


Motor-driven marginal band coiling promotes cell shape change during platelet activation.

Diagouraga B, Grichine A, Fertin A, Wang J, Khochbin S, Sadoul K.

J Cell Biol. 2014 Jan 20;204(2):177-85. doi: 10.1083/jcb.201306085. Epub 2014 Jan 13.


Sustaining cancer through addictive ectopic gene activation.

Wang J, Rousseaux S, Khochbin S.

Curr Opin Oncol. 2014 Jan;26(1):73-7. doi: 10.1097/CCO.0000000000000032. Review.


Histone variants and sensing of chromatin functional states.

Govin J, Khochbin S.

Nucleus. 2013 Nov-Dec;4(6):438-42. doi: 10.4161/nucl.27088. Epub 2013 Nov 8.


Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B.

Montellier E, Boussouar F, Rousseaux S, Zhang K, Buchou T, Fenaille F, Shiota H, Debernardi A, Héry P, Curtet S, Jamshidikia M, Barral S, Holota H, Bergon A, Lopez F, Guardiola P, Pernet K, Imbert J, Petosa C, Tan M, Zhao Y, Gérard M, Khochbin S.

Genes Dev. 2013 Aug 1;27(15):1680-92. doi: 10.1101/gad.220095.113. Epub 2013 Jul 24.


Cancer hallmarks sustained by ectopic activations of placenta/male germline genes.

Rousseaux S, Wang J, Khochbin S.

Cell Cycle. 2013 Aug 1;12(15):2331-2. doi: 10.4161/cc.25545. Epub 2013 Jul 11. No abstract available.


Malignant genome reprogramming by ATAD2.

Boussouar F, Jamshidikia M, Morozumi Y, Rousseaux S, Khochbin S.

Biochim Biophys Acta. 2013 Oct;1829(10):1010-4. doi: 10.1016/j.bbagrm.2013.06.003. Epub 2013 Jul 3. Review.


Identification of a novel BET bromodomain inhibitor-sensitive, gene regulatory circuit that controls Rituximab response and tumour growth in aggressive lymphoid cancers.

Emadali A, Rousseaux S, Bruder-Costa J, Rome C, Duley S, Hamaidia S, Betton P, Debernardi A, Leroux D, Bernay B, Kieffer-Jaquinod S, Combes F, Ferri E, McKenna CE, Petosa C, Bruley C, Garin J, Ferro M, Gressin R, Callanan MB, Khochbin S.

EMBO Mol Med. 2013 Aug;5(8):1180-95. doi: 10.1002/emmm.201202034. Epub 2013 Jul 4.


Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers.

Rousseaux S, Debernardi A, Jacquiau B, Vitte AL, Vesin A, Nagy-Mignotte H, Moro-Sibilot D, Brichon PY, Lantuejoul S, Hainaut P, Laffaire J, de Reyniès A, Beer DG, Timsit JF, Brambilla C, Brambilla E, Khochbin S.

Sci Transl Med. 2013 May 22;5(186):186ra66. doi: 10.1126/scitranslmed.3005723.


Shielding Cenp-A removal in post-meiotic male cells.

Shiota H, Goudarzi A, Rousseaux S, Khochbin S.

Epigenomics. 2013 Apr;5(2):122. No abstract available.


Transgenerational inheritance of chromatin states.

Shiota H, Goudarzi A, Rousseaux S, Khochbin S.

Epigenomics. 2013 Apr;5(2):121-2. doi: 10.2217/epi.13.12. No abstract available.


When are the BET factors the most sensitive to bromodomain inhibitors?

Khochbin S.

Transcription. 2013 Mar-Apr;4(2):54-7. doi: 10.4161/trns.23191. Epub 2013 Feb 14.


Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells.

Wang L, Xiang S, Williams KA, Dong H, Bai W, Nicosia SV, Khochbin S, Bepler G, Zhang X.

PLoS One. 2012;7(9):e44265. doi: 10.1371/journal.pone.0044265. Epub 2012 Sep 5.

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