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Items: 42

1.

Advances in Engineered Human Liver Platforms for Drug Metabolism Studies.

Underhill GH, Khetani SR.

Drug Metab Dispos. 2018 Nov;46(11):1626-1637. doi: 10.1124/dmd.118.083295. Epub 2018 Aug 22.

2.

Microfabrication of liver and heart tissues for drug development.

Brown GE, Khetani SR.

Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750). pii: 20170225. doi: 10.1098/rstb.2017.0225. Review.

PMID:
29786560
3.

Bioengineered Liver Models for Drug Testing and Cell Differentiation Studies.

Underhill GH, Khetani SR.

Cell Mol Gastroenterol Hepatol. 2017 Dec 6;5(3):426-439.e1. doi: 10.1016/j.jcmgh.2017.11.012. eCollection 2018 Mar. Review.

4.

Correction to: Pluripotent Stem Cell-Derived Human Tissue: Platforms to Evaluate Drug Metabolism and Safety.

Meseguer-Ripolles J, Khetani SR, Blanco JG, Iredale M, Hay DC.

AAPS J. 2018 Feb 12;20(2):30. doi: 10.1208/s12248-018-0191-z.

PMID:
29435689
5.

A Cell Culture Platform to Maintain Long-term Phenotype of Primary Human Hepatocytes and Endothelial Cells.

Ware BR, Durham MJ, Monckton CP, Khetani SR.

Cell Mol Gastroenterol Hepatol. 2017 Nov 24;5(3):187-207. doi: 10.1016/j.jcmgh.2017.11.007. eCollection 2018 Mar.

6.

Pluripotent Stem Cell-Derived Human Tissue: Platforms to Evaluate Drug Metabolism and Safety.

Meseguer-Ripolles J, Khetani SR, Blanco JG, Iredale M, Hay DC.

AAPS J. 2017 Dec 21;20(1):20. doi: 10.1208/s12248-017-0171-8. Review. Erratum in: AAPS J. 2018 Feb 12;20(2):30.

7.

A polyelectrolyte multilayer platform for investigating growth factor delivery modes in human liver cultures.

Lin C, Romero R, Sorokina LV, Ballinger KR, Place LW, Kipper MJ, Khetani SR.

J Biomed Mater Res A. 2018 Apr;106(4):971-984. doi: 10.1002/jbm.a.36293. Epub 2017 Dec 4.

PMID:
29139224
8.

miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model.

Mosedale M, Eaddy JS, Trask OJ Jr, Holman NS, Wolf KK, LeCluyse E, Ware BR, Khetani SR, Lu J, Brock WJ, Roth SE, Watkins PB.

Toxicol Sci. 2018 Jan 1;161(1):149-158. doi: 10.1093/toxsci/kfx206.

PMID:
29029277
9.

Microengineered cultures containing human hepatic stellate cells and hepatocytes for drug development.

Davidson MD, Kukla DA, Khetani SR.

Integr Biol (Camb). 2017 Aug 14;9(8):662-677. doi: 10.1039/c7ib00027h.

PMID:
28702667
10.

Micropatterned Co-Cultures of Human Hepatocytes and Stromal Cells for the Assessment of Drug Clearance and Drug-Drug Interactions.

Lin C, Khetani SR.

Curr Protoc Toxicol. 2017 May 2;72:14.17.1-14.17.23. doi: 10.1002/cptx.23.

11.

Exploring Chronic Drug Effects on Microengineered Human Liver Cultures Using Global Gene Expression Profiling.

Ware BR, McVay M, Sunada WY, Khetani SR.

Toxicol Sci. 2017 Jun 1;157(2):387-398. doi: 10.1093/toxsci/kfx059.

PMID:
28369597
12.

Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury.

Lin C, Khetani SR.

Biomed Res Int. 2016;2016:1829148. Epub 2016 Sep 20. Review.

13.

Engineered Liver Platforms for Different Phases of Drug Development.

Ware BR, Khetani SR.

Trends Biotechnol. 2017 Feb;35(2):172-183. doi: 10.1016/j.tibtech.2016.08.001. Epub 2016 Sep 2. Review.

14.

Water-Stable Metal-Organic Framework/Polymer Composites Compatible with Human Hepatocytes.

Neufeld MJ, Ware BR, Lutzke A, Khetani SR, Reynolds MM.

ACS Appl Mater Interfaces. 2016 Aug 3;8(30):19343-52. doi: 10.1021/acsami.6b05948. Epub 2016 Jul 22.

PMID:
27447022
15.

Superhydrophobic Coatings with Edible Materials.

Wang W, Lockwood K, Boyd LM, Davidson MD, Movafaghi S, Vahabi H, Khetani SR, Kota AK.

ACS Appl Mater Interfaces. 2016 Jul 27;8(29):18664-8. doi: 10.1021/acsami.6b06958. Epub 2016 Jul 14.

PMID:
27403590
16.
17.

Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens.

March S, Ramanan V, Trehan K, Ng S, Galstian A, Gural N, Scull MA, Shlomai A, Mota MM, Fleming HE, Khetani SR, Rice CM, Bhatia SN.

Nat Protoc. 2015 Dec;10(12):2027-53. doi: 10.1038/nprot.2015.128. Epub 2015 Nov 19.

18.

Prediction of Drug Clearance and Drug-Drug Interactions in Microscale Cultures of Human Hepatocytes.

Lin C, Shi J, Moore A, Khetani SR.

Drug Metab Dispos. 2016 Jan;44(1):127-36. doi: 10.1124/dmd.115.066027. Epub 2015 Oct 9.

19.

Stem cell-derived liver cells for drug testing and disease modeling.

Davidson MD, Ware BR, Khetani SR.

Discov Med. 2015 May;19(106):349-58. Review.

20.

The application of engineered liver tissues for novel drug discovery.

Lin C, Ballinger KR, Khetani SR.

Expert Opin Drug Discov. 2015 May;10(5):519-40. doi: 10.1517/17460441.2015.1032241. Epub 2015 Apr 3. Review.

PMID:
25840592
21.

Establishment of a hepatocyte-kupffer cell coculture model for assessment of proinflammatory cytokine effects on metabolizing enzymes and drug transporters.

Nguyen TV, Ukairo O, Khetani SR, McVay M, Kanchagar C, Seghezzi W, Ayanoglu G, Irrechukwu O, Evers R.

Drug Metab Dispos. 2015 May;43(5):774-85. doi: 10.1124/dmd.114.061317. Epub 2015 Mar 4.

22.

Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes.

Ware BR, Berger DR, Khetani SR.

Toxicol Sci. 2015 Jun;145(2):252-62. doi: 10.1093/toxsci/kfv048. Epub 2015 Feb 24.

PMID:
25716675
23.

Microengineered liver tissues for drug testing.

Khetani SR, Berger DR, Ballinger KR, Davidson MD, Lin C, Ware BR.

J Lab Autom. 2015 Jun;20(3):216-50. doi: 10.1177/2211068214566939. Epub 2015 Jan 23. Review.

PMID:
25617027
24.

Hormone and Drug-Mediated Modulation of Glucose Metabolism in a Microscale Model of the Human Liver.

Davidson MD, Lehrer M, Khetani SR.

Tissue Eng Part C Methods. 2015 Jul;21(7):716-25. doi: 10.1089/ten.TEC.2014.0512. Epub 2015 Jan 30.

25.

Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication.

Giugliano S, Kriss M, Golden-Mason L, Dobrinskikh E, Stone AE, Soto-Gutierrez A, Mitchell A, Khetani SR, Yamane D, Stoddard M, Li H, Shaw GM, Edwards MG, Lemon SM, Gale M Jr, Shah VH, Rosen HR.

Gastroenterology. 2015 Feb;148(2):392-402.e13. doi: 10.1053/j.gastro.2014.10.040. Epub 2014 Nov 4.

26.

Enhancing the functional maturity of induced pluripotent stem cell-derived human hepatocytes by controlled presentation of cell-cell interactions in vitro.

Berger DR, Ware BR, Davidson MD, Allsup SR, Khetani SR.

Hepatology. 2015 Apr;61(4):1370-81. doi: 10.1002/hep.27621.

PMID:
25421237
27.

Pluripotent stem cell-derived hepatocyte-like cells.

Schwartz RE, Fleming HE, Khetani SR, Bhatia SN.

Biotechnol Adv. 2014 Mar-Apr;32(2):504-13. doi: 10.1016/j.biotechadv.2014.01.003. Epub 2014 Jan 16. Review.

28.

Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac.

Chan TS, Yu H, Moore A, Khetani SR, Tweedie D.

Drug Metab Dispos. 2013 Dec;41(12):2024-32. doi: 10.1124/dmd.113.053397. Epub 2013 Aug 19. Erratum in: Drug Metab Dispos. 2014 Jan;42(1):200. Kehtani, Salman R [corrected to Khetani, Salman R].

29.

Bioactivation and toxicity of acetaminophen in a rat hepatocyte micropatterned coculture system.

Ukairo O, McVay M, Krzyzewski S, Aoyama S, Rose K, Andersen ME, Khetani SR, Lecluyse EL.

J Biochem Mol Toxicol. 2013 Oct;27(10):471-8. doi: 10.1002/jbt.21512. Epub 2013 Aug 5.

PMID:
23918466
30.

Long-term stability of primary rat hepatocytes in micropatterned cocultures.

Ukairo O, Kanchagar C, Moore A, Shi J, Gaffney J, Aoyama S, Rose K, Krzyzewski S, McGeehan J, Andersen ME, Khetani SR, Lecluyse EL.

J Biochem Mol Toxicol. 2013 Mar;27(3):204-12. doi: 10.1002/jbt.21469. Epub 2013 Jan 11.

PMID:
23315828
31.

Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans.

Khetani SR, Kanchagar C, Ukairo O, Krzyzewski S, Moore A, Shi J, Aoyama S, Aleo M, Will Y.

Toxicol Sci. 2013 Mar;132(1):107-17. doi: 10.1093/toxsci/kfs326. Epub 2012 Nov 14.

PMID:
23152190
32.

Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites.

Wang WW, Khetani SR, Krzyzewski S, Duignan DB, Obach RS.

Drug Metab Dispos. 2010 Oct;38(10):1900-5. doi: 10.1124/dmd.110.034876. Epub 2010 Jul 1.

33.

Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures.

Ploss A, Khetani SR, Jones CT, Syder AJ, Trehan K, Gaysinskaya VA, Mu K, Ritola K, Rice CM, Bhatia SN.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3141-5. doi: 10.1073/pnas.0915130107. Epub 2010 Feb 1.

34.

Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system.

Jones CT, Catanese MT, Law LM, Khetani SR, Syder AJ, Ploss A, Oh TS, Schoggins JW, MacDonald MR, Bhatia SN, Rice CM.

Nat Biotechnol. 2010 Feb;28(2):167-71. doi: 10.1038/nbt.1604. Epub 2010 Jan 31.

35.

Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers.

Chen AA, Khetani SR, Lee S, Bhatia SN, Van Vliet KJ.

Biomaterials. 2009 Feb;30(6):1113-20. doi: 10.1016/j.biomaterials.2008.10.055. Epub 2008 Nov 28.

36.

T-cadherin modulates hepatocyte functions in vitro.

Khetani SR, Chen AA, Ranscht B, Bhatia SN.

FASEB J. 2008 Nov;22(11):3768-75. doi: 10.1096/fj.07-105155. Epub 2008 Jul 17.

37.

Microscale culture of human liver cells for drug development.

Khetani SR, Bhatia SN.

Nat Biotechnol. 2008 Jan;26(1):120-6. Epub 2007 Nov 18.

PMID:
18026090
38.

In vitro liver tissue model established from transgenic mice: role of HIF-1alpha on hypoxic gene expression.

Allen JW, Khetani SR, Johnson RS, Bhatia SN.

Tissue Eng. 2006 Nov;12(11):3135-47.

PMID:
17518628
39.

Engineering tissues for in vitro applications.

Khetani SR, Bhatia SN.

Curr Opin Biotechnol. 2006 Oct;17(5):524-31. Epub 2006 Sep 15. Review.

PMID:
16978857
40.

Quantum dots to monitor RNAi delivery and improve gene silencing.

Chen AA, Derfus AM, Khetani SR, Bhatia SN.

Nucleic Acids Res. 2005 Dec 13;33(22):e190.

41.

In vitro zonation and toxicity in a hepatocyte bioreactor.

Allen JW, Khetani SR, Bhatia SN.

Toxicol Sci. 2005 Mar;84(1):110-9. Epub 2004 Dec 8.

PMID:
15590888
42.

Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling.

Khetani SR, Szulgit G, Del Rio JA, Barlow C, Bhatia SN.

Hepatology. 2004 Sep;40(3):545-54.

PMID:
15349892

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