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Items: 1 to 50 of 104

1.

TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+CD8+ thymocytes.

Emmanuel AO, Arnovitz S, Haghi L, Mathur PS, Mondal S, Quandt J, Okoreeh MK, Maienschein-Cline M, Khazaie K, Dose M, Gounari F.

Nat Immunol. 2018 Dec;19(12):1366-1378. doi: 10.1038/s41590-018-0254-4. Epub 2018 Nov 12.

PMID:
30420627
2.

Dietary Fiber Treatment Corrects the Composition of Gut Microbiota, Promotes SCFA Production, and Suppresses Colon Carcinogenesis.

Bishehsari F, Engen PA, Preite NZ, Tuncil YE, Naqib A, Shaikh M, Rossi M, Wilber S, Green SJ, Hamaker BR, Khazaie K, Voigt RM, Forsyth CB, Keshavarzian A.

Genes (Basel). 2018 Feb 16;9(2). pii: E102. doi: 10.3390/genes9020102.

3.

Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner.

Saadalla AM, Osman A, Gurish MF, Dennis KL, Blatner NR, Pezeshki A, McNagny KM, Cheroutre H, Gounari F, Khazaie K.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1588-1592. doi: 10.1073/pnas.1716804115. Epub 2018 Feb 2.

4.

Epigenetic Therapy: Novel Translational Implications for Arrest of Environmental Dioxin-Induced Disease in Females.

Khan Z, Zheng Y, Jones TL, Delaney AA, Correa LF, Shenoy CC, Khazaie K, Daftary GS.

Endocrinology. 2018 Jan 1;159(1):477-489. doi: 10.1210/en.2017-00860.

PMID:
29165700
5.

PD-1 Blockade Promotes Epitope Spreading in Anticancer CD8+ T Cell Responses by Preventing Fratricidal Death of Subdominant Clones To Relieve Immunodomination.

Memarnejadian A, Meilleur CE, Shaler CR, Khazaie K, Bennink JR, Schell TD, Haeryfar SMM.

J Immunol. 2017 Nov 1;199(9):3348-3359. doi: 10.4049/jimmunol.1700643. Epub 2017 Sep 22.

6.

Progressive Fibrosis: A Progesterone- and KLF11-Mediated Sexually Dimorphic Female Response.

Shenoy CC, Khan Z, Zheng Y, Jones TL, Khazaie K, Daftary GS.

Endocrinology. 2017 Oct 1;158(10):3605-3619. doi: 10.1210/en.2017-00171.

PMID:
28938437
7.

The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer.

Khan MW, Saadalla A, Ewida AH, Al-Katranji K, Al-Saoudi G, Giaccone ZT, Gounari F, Zhang M, Frank DA, Khazaie K.

Cancer Immunol Immunother. 2018 Jan;67(1):13-23. doi: 10.1007/s00262-017-2057-0. Epub 2017 Sep 5.

8.

Mucosa-associated invariant T cells infiltrate hepatic metastases in patients with colorectal carcinoma but are rendered dysfunctional within and adjacent to tumor microenvironment.

Shaler CR, Tun-Abraham ME, Skaro AI, Khazaie K, Corbett AJ, Mele T, Hernandez-Alejandro R, Haeryfar SMM.

Cancer Immunol Immunother. 2017 Dec;66(12):1563-1575. doi: 10.1007/s00262-017-2050-7. Epub 2017 Aug 10.

PMID:
28798979
9.

Light/Dark Shifting Promotes Alcohol-Induced Colon Carcinogenesis: Possible Role of Intestinal Inflammatory Milieu and Microbiota.

Bishehsari F, Saadalla A, Khazaie K, Engen PA, Voigt RM, Shetuni BB, Forsyth C, Shaikh M, Vitaterna MH, Turek F, Keshavarzian A.

Int J Mol Sci. 2016 Dec 2;17(12). pii: E2017.

10.

KLF10 Mediated Epigenetic Dysregulation of Epithelial CD40/CD154 Promotes Endometriosis.

Delaney AA, Khan Z, Zheng Y, Correa LF, Zanfagnin V, Shenoy CC, Schoolmeester JK, Saadalla AM, El-Nashar S, Famuyide AO, Subramaniam M, Hawse JR, Khazaie K, Daftary GS.

Biol Reprod. 2016 Sep;95(3):62. doi: 10.1095/biolreprod.116.140764. Epub 2016 Aug 3.

11.

Loss of TGFβ signaling promotes colon cancer progression and tumor-associated inflammation.

Principe DR, DeCant B, Staudacher J, Vitello D, Mangan RJ, Wayne EA, Mascariñas E, Diaz AM, Bauer J, McKinney RD, Khazaie K, Pasche B, Dawson DW, Munshi HG, Grippo PJ, Jung B.

Oncotarget. 2017 Jan 17;8(3):3826-3839. doi: 10.18632/oncotarget.9830.

12.

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.

Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM.

Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3.

13.

The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism.

Zaanan A, Okamoto K, Kawakami H, Khazaie K, Huang S, Sinicrope FA.

J Biol Chem. 2015 Sep 25;290(39):23838-49. doi: 10.1074/jbc.M115.657833. Epub 2015 Aug 5.

14.

Preferential expansion of pro-inflammatory Tregs in human non-small cell lung cancer.

Phillips JD, Knab LM, Blatner NR, Haghi L, DeCamp MM, Meyerson SL, Heiferman MJ, Heiferman JR, Gounari F, Bentrem DJ, Khazaie K.

Cancer Immunol Immunother. 2015 Sep;64(9):1185-91. doi: 10.1007/s00262-015-1725-1. Epub 2015 Jun 6.

15.

T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine.

Dennis KL, Saadalla A, Blatner NR, Wang S, Venkateswaran V, Gounari F, Cheroutre H, Weaver CT, Roers A, Egilmez NK, Khazaie K.

Cancer Immunol Res. 2015 Jul;3(7):806-14. doi: 10.1158/2326-6066.CIR-14-0169. Epub 2015 Apr 8.

16.

Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation.

Gounaris E, Heiferman MJ, Heiferman JR, Shrivastav M, Vitello D, Blatner NR, Knab LM, Phillips JD, Cheon EC, Grippo PJ, Khazaie K, Munshi HG, Bentrem DJ.

PLoS One. 2015 Mar 6;10(3):e0121402. doi: 10.1371/journal.pone.0121402. eCollection 2015.

17.

Corrigendum. Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis.

Reissfelder C, Stamova S, Gossmann C, Braun M, Bonertz A, Walliczek U, Grimm M, Rahbari NN, Koch M, Saadati M, Benner A, Büchler MW, Jäger D, Halama N, Khazaie K, Weitz J, Beckhove P.

J Clin Invest. 2015 Mar 2;125(3):1364. doi: 10.1172/JCI81442. Epub 2015 Mar 2. No abstract available.

18.

Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis.

Reissfelder C, Stamova S, Gossmann C, Braun M, Bonertz A, Walliczek U, Grimm M, Rahbari NN, Koch M, Saadati M, Benner A, Büchler MW, Jäger D, Halama N, Khazaie K, Weitz J, Beckhove P.

J Clin Invest. 2015 Feb;125(2):739-51. doi: 10.1172/JCI74894. Epub 2014 Dec 22. Erratum in: J Clin Invest. 2015 Mar 2;125(3):1364.

19.

MRI-monitored intra-tumoral injection of iron-oxide labeled Clostridium novyi-NT anaerobes in pancreatic carcinoma mouse model.

Zheng L, Zhang Z, Khazaie K, Saha S, Lewandowski RJ, Zhang G, Larson AC.

PLoS One. 2014 Dec 30;9(12):e116204. doi: 10.1371/journal.pone.0116204. eCollection 2014.

20.

Methods for the study of mast cells in cancer.

Blatner NR, Tsai F, Khazaie K.

Methods Mol Biol. 2015;1220:443-60. doi: 10.1007/978-1-4939-1568-2_27.

PMID:
25388267
21.

Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells.

Chung AY, Li Q, Blair SJ, De Jesus M, Dennis KL, LeVea C, Yao J, Sun Y, Conway TF, Virtuoso LP, Battaglia NG, Furtado S, Mathiowitz E, Mantis NJ, Khazaie K, Egilmez NK.

Cancer Res. 2014 Oct 1;74(19):5377-85. doi: 10.1158/0008-5472.CAN-14-0918. Epub 2014 Sep 16.

22.

Antigen-loaded dendritic cell migration: MR imaging in a pancreatic carcinoma model.

Zhang Z, Li W, Procissi D, Li K, Sheu AY, Gordon AC, Guo Y, Khazaie K, Huan Y, Han G, Larson AC.

Radiology. 2015 Jan;274(1):192-200. doi: 10.1148/radiol.14132172. Epub 2014 Sep 15.

23.

β-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells.

Keerthivasan S, Aghajani K, Dose M, Molinero L, Khan MW, Venkateswaran V, Weber C, Emmanuel AO, Sun T, Bentrem DJ, Mulcahy M, Keshavarzian A, Ramos EM, Blatner N, Khazaie K, Gounari F.

Sci Transl Med. 2014 Feb 26;6(225):225ra28. doi: 10.1126/scitranslmed.3007607.

24.

Current status of interleukin-10 and regulatory T-cells in cancer.

Dennis KL, Blatner NR, Gounari F, Khazaie K.

Curr Opin Oncol. 2013 Nov;25(6):637-45. doi: 10.1097/CCO.0000000000000006. Review.

25.

Adenomatous polyps are driven by microbe-instigated focal inflammation and are controlled by IL-10-producing T cells.

Dennis KL, Wang Y, Blatner NR, Wang S, Saadalla A, Trudeau E, Roers A, Weaver CT, Lee JJ, Gilbert JA, Chang EB, Khazaie K.

Cancer Res. 2013 Oct 1;73(19):5905-13. doi: 10.1158/0008-5472.CAN-13-1511. Epub 2013 Aug 16.

26.

The two faces of regulatory T cells in cancer.

Blatner NR, Gounari F, Khazaie K.

Oncoimmunology. 2013 May 1;2(5):e23852. Epub 2013 Apr 15.

27.

Targeted chemo-immunotherapy of leukemia.

Khazaie K.

Leuk Lymphoma. 2013 Jul;54(7):1353-4. doi: 10.3109/10428194.2013.779693. No abstract available.

PMID:
23607287
28.

Fluorescence endoscopy of cathepsin activity discriminates dysplasia from colitis.

Gounaris E, Martin J, Ishihara Y, Khan MW, Lee G, Sinh P, Chen EZ, Angarone M, Weissleder R, Khazaie K, Barrett TA.

Inflamm Bowel Dis. 2013 Jun;19(7):1339-45. doi: 10.1097/MIB.0b013e318281f3f8.

29.

PI3K/AKT signaling is essential for communication between tissue-infiltrating mast cells, macrophages, and epithelial cells in colitis-induced cancer.

Khan MW, Keshavarzian A, Gounaris E, Melson JE, Cheon EC, Blatner NR, Chen ZE, Tsai FN, Lee G, Ryu H, Barrett TA, Bentrem DJ, Beckhove P, Khazaie K.

Clin Cancer Res. 2013 May 1;19(9):2342-54. doi: 10.1158/1078-0432.CCR-12-2623. Epub 2013 Mar 13.

30.

Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells.

Hix LM, Karavitis J, Khan MW, Shi YH, Khazaie K, Zhang M.

J Biol Chem. 2013 Apr 26;288(17):11676-88. doi: 10.1074/jbc.M112.441402. Epub 2013 Mar 13.

31.

Quantitative magnetic resonance imaging in the transgenic APC(Δ468) mouse model of hereditary colon cancer.

Zhang Z, Li W, Blatner NR, Dennis KL, Procissi D, Khazaie K, Larson AC.

Mol Imaging. 2013 Jan-Feb;12(1):59-66.

PMID:
23348792
32.

Ethanol-induced mast cell-mediated inflammation leads to increased susceptibility of intestinal tumorigenesis in the APC Δ468 min mouse model of colon cancer.

Wimberly AL, Forsyth CB, Khan MW, Pemberton A, Khazaie K, Keshavarzian A.

Alcohol Clin Exp Res. 2013 Jan;37 Suppl 1:E199-208. doi: 10.1111/j.1530-0277.2012.01894.x.

33.

Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer.

Blatner NR, Mulcahy MF, Dennis KL, Scholtens D, Bentrem DJ, Phillips JD, Ham S, Sandall BP, Khan MW, Mahvi DM, Halverson AL, Stryker SJ, Boller AM, Singal A, Sneed RK, Sarraj B, Ansari MJ, Oft M, Iwakura Y, Zhou L, Bonertz A, Beckhove P, Gounari F, Khazaie K.

Sci Transl Med. 2012 Dec 12;4(164):164ra159. doi: 10.1126/scitranslmed.3004566.

34.

Regulation of COX2 expression in mouse mammary tumor cells controls bone metastasis and PGE2-induction of regulatory T cell migration.

Karavitis J, Hix LM, Shi YH, Schultz RF, Khazaie K, Zhang M.

PLoS One. 2012;7(9):e46342. doi: 10.1371/journal.pone.0046342. Epub 2012 Sep 28.

35.

Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid.

Khazaie K, Zadeh M, Khan MW, Bere P, Gounari F, Dennis K, Blatner NR, Owen JL, Klaenhammer TR, Mohamadzadeh M.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10462-7. doi: 10.1073/pnas.1207230109. Epub 2012 Jun 11.

36.

Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation.

Serebrennikova OB, Tsatsanis C, Mao C, Gounaris E, Ren W, Siracusa LD, Eliopoulos AG, Khazaie K, Tsichlis PN.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):E1082-91. doi: 10.1073/pnas.1115098109. Epub 2012 Mar 26.

37.

The significant role of mast cells in cancer.

Khazaie K, Blatner NR, Khan MW, Gounari F, Gounaris E, Dennis K, Bonertz A, Tsai FN, Strouch MJ, Cheon E, Phillips JD, Beckhove P, Bentrem DJ.

Cancer Metastasis Rev. 2011 Mar;30(1):45-60. doi: 10.1007/s10555-011-9286-z. Review.

PMID:
21287360
38.

Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice.

Cheon EC, Khazaie K, Khan MW, Strouch MJ, Krantz SB, Phillips J, Blatner NR, Hix LM, Zhang M, Dennis KL, Salabat MR, Heiferman M, Grippo PJ, Munshi HG, Gounaris E, Bentrem DJ.

Cancer Res. 2011 Mar 1;71(5):1627-36. doi: 10.1158/0008-5472.CAN-10-1923. Epub 2011 Jan 7.

39.

HTLV-1 Tax: Linking transformation, DNA damage and apoptotic T-cell death.

Chlichlia K, Khazaie K.

Chem Biol Interact. 2010 Nov 5;188(2):359-65. doi: 10.1016/j.cbi.2010.06.005. Epub 2010 Jun 15. Review.

PMID:
20558150
40.

Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression.

Strouch MJ, Cheon EC, Salabat MR, Krantz SB, Gounaris E, Melstrom LG, Dangi-Garimella S, Wang E, Munshi HG, Khazaie K, Bentrem DJ.

Clin Cancer Res. 2010 Apr 15;16(8):2257-65. doi: 10.1158/1078-0432.CCR-09-1230. Epub 2010 Apr 6.

41.

In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction.

Blatner NR, Bonertz A, Beckhove P, Cheon EC, Krantz SB, Strouch M, Weitz J, Koch M, Halverson AL, Bentrem DJ, Khazaie K.

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6430-5. doi: 10.1073/pnas.0913683107. Epub 2010 Mar 22. Erratum in: Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12405.

42.

Cathepsin B is not the processing enzyme for mouse prorenin.

Mercure C, Lacombe MJ, Khazaie K, Reudelhuber TL.

Am J Physiol Regul Integr Comp Physiol. 2010 May;298(5):R1212-6. doi: 10.1152/ajpregu.00830.2009. Epub 2010 Feb 17.

43.

Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis.

Brown JB, Lee G, Managlia E, Grimm GR, Dirisina R, Goretsky T, Cheresh P, Blatner NR, Khazaie K, Yang GY, Li L, Barrett TA.

Gastroenterology. 2010 Feb;138(2):595-605, 605.e1-3. doi: 10.1053/j.gastro.2009.10.038. Epub 2009 Oct 29.

44.

Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma.

Bonertz A, Weitz J, Pietsch DH, Rahbari NN, Schlude C, Ge Y, Juenger S, Vlodavsky I, Khazaie K, Jaeger D, Reissfelder C, Antolovic D, Aigner M, Koch M, Beckhove P.

J Clin Invest. 2009 Nov;119(11):3311-21. doi: 10.1172/JCI39608. Epub 2009 Oct 5.

45.

Current developments with peptide-based human tumor vaccines.

Khazaie K, Bonertz A, Beckhove P.

Curr Opin Oncol. 2009 Nov;21(6):524-30. doi: 10.1097/CCO.0b013e328331a78e. Review.

PMID:
19770763
46.

T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis.

Gounaris E, Blatner NR, Dennis K, Magnusson F, Gurish MF, Strom TB, Beckhove P, Gounari F, Khazaie K.

Cancer Res. 2009 Jul 1;69(13):5490-7. doi: 10.1158/0008-5472.CAN-09-0304.

47.

Mast cells in tumor growth: angiogenesis, tissue remodelling and immune-modulation.

Maltby S, Khazaie K, McNagny KM.

Biochim Biophys Acta. 2009 Aug;1796(1):19-26. doi: 10.1016/j.bbcan.2009.02.001. Epub 2009 Feb 21. Review.

48.

Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1.

Li X, Gounari F, Protopopov A, Khazaie K, von Boehmer H.

J Exp Med. 2008 Nov 24;205(12):2851-61. doi: 10.1084/jem.20081561. Epub 2008 Nov 3.

49.

Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth.

Gounaris E, Tung CH, Restaino C, Maehr R, Kohler R, Joyce JA, Ploegh HL, Barrett TA, Weissleder R, Khazaie K.

PLoS One. 2008 Aug 13;3(8):e2916. doi: 10.1371/journal.pone.0002916. Erratum in: PLoS ONE.2008;3(10).doi.org/10.1371/annotation/499b225f-e661-4124-aa2f-60bef89bd14a.. Plough, Hidde L [corrected to Ploegh, Hidde L].

50.

Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages.

Ha SD, Martins A, Khazaie K, Han J, Chan BM, Kim SO.

J Immunol. 2008 Jul 1;181(1):690-7.

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