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Items: 18

1.

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor.

Plantevin Krenitsky V, Nadolny L, Delgado M, Ayala L, Clareen SS, Hilgraf R, Albers R, Hegde S, D'Sidocky N, Sapienza J, Wright J, McCarrick M, Bahmanyar S, Chamberlain P, Delker SL, Muir J, Giegel D, Xu L, Celeridad M, Lachowitzer J, Bennett B, Moghaddam M, Khatsenko O, Katz J, Fan R, Bai A, Tang Y, Shirley MA, Benish B, Bodine T, Blease K, Raymon H, Cathers BE, Satoh Y.

Bioorg Med Chem Lett. 2012 Feb 1;22(3):1433-8. doi: 10.1016/j.bmcl.2011.12.027. Epub 2011 Dec 10.

PMID:
22244937
2.

Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury.

Krenitsky VP, Delgado M, Nadolny L, Sahasrabudhe K, Ayala L, Clareen SS, Hilgraf R, Albers R, Kois A, Hughes K, Wright J, Nowakowski J, Sudbeck E, Ghosh S, Bahmanyar S, Chamberlain P, Muir J, Cathers BE, Giegel D, Xu L, Celeridad M, Moghaddam M, Khatsenko O, Omholt P, Katz J, Pai S, Fan R, Tang Y, Shirley MA, Benish B, Blease K, Raymon H, Bhagwat S, Henderson I, Cole AG, Bennett B, Satoh Y.

Bioorg Med Chem Lett. 2012 Feb 1;22(3):1427-32. doi: 10.1016/j.bmcl.2011.12.028. Epub 2011 Dec 11.

PMID:
22226655
3.

Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides.

Rayner KJ, Esau CC, Hussain FN, McDaniel AL, Marshall SM, van Gils JM, Ray TD, Sheedy FJ, Goedeke L, Liu X, Khatsenko OG, Kaimal V, Lees CJ, Fernandez-Hernando C, Fisher EA, Temel RE, Moore KJ.

Nature. 2011 Oct 19;478(7369):404-7. doi: 10.1038/nature10486.

4.

Metabolite interference in pharmacokinetic studies.

Moghaddam MF, Fan JH, Tang Y, Khatsenko O, Katz JC, Shirley MA.

Drug Metab Lett. 2007 Dec;1(4):272-5.

PMID:
19356054
5.

Absolute bioavailability of 2'-O-(2-methoxyethyl)-modified antisense oligonucleotides following intraduodenal instillation in rats.

Geary RS, Khatsenko O, Bunker K, Crooke R, Moore M, Burckin T, Truong L, Sasmor H, Levin AA.

J Pharmacol Exp Ther. 2001 Mar;296(3):898-904.

PMID:
11181922
6.

Absorption of antisense oligonucleotides in rat intestine: effect of chemistry and length.

Khatsenko O, Morgan R, Truong L, York-Defalco C, Sasmor H, Conklin B, Geary RS.

Antisense Nucleic Acid Drug Dev. 2000 Feb;10(1):35-44.

PMID:
10726659
7.

Interactions between nitric oxide and cytochrome P-450 in the liver.

Khatsenko O.

Biochemistry (Mosc). 1998 Jul;63(7):833-9. Review.

PMID:
9721336
8.

Role of nitric oxide in the inhibition of cytochrome P450 in the liver of mice infected with Chlamydia trachomatis.

Khatsenko OG, Barteneva NS, de la Maza LM, Kikkawa Y.

Biochem Pharmacol. 1998 Jun 1;55(11):1835-42.

PMID:
9714302
9.

Nitric oxide differentially affects constitutive cytochrome P450 isoforms in rat liver.

Khatsenko O, Kikkawa Y.

J Pharmacol Exp Ther. 1997 Mar;280(3):1463-70.

PMID:
9067336
10.

Evidence for nitric oxide participation in down-regulation of CYP2B1/2 gene expression at the pretranslational level.

Khatsenko OG, Boobis AR, Gross SS.

Toxicol Lett. 1997 Feb 7;90(2-3):207-16.

PMID:
9067489
11.

Undernutrition during hyperoxic exposure induces CYP2E1 in rat liver.

Khatsenko OG, Sindhu RK, Kikkawa Y.

Arch Toxicol. 1997;71(11):684-9.

PMID:
9363841
12.

Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants.

Khatsenko OG, Gross SS, Rifkind AB, Vane JR.

Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11147-51.

13.

[Benzonal--a phenobarbital-type of inducer of the mono-oxygenase system].

Novozheeva TP, Saratikov AS, Grishanova AIu, Gutkina NI, Akhmedzhanov RR, Khatsenko OG, Kozlovskaia NE.

Biull Eksp Biol Med. 1991 Feb;111(2):163-5. Russian.

PMID:
1854958
14.

Dynamics of androstenedione metabolite formation in rat liver microsomes during temporal phenobarbital induction.

Khatsenko OG, Gulyaeva LF, Mishin VM, Lyakhovich VV.

Comp Biochem Physiol C. 1991;99(3):257-61.

PMID:
1685396
15.

[Evaluation of catalytic activity of multiple forms of cytochrome P-450 in liver microsomes of Wistar rats by androstenedione metabolism].

Khatsenko OG, Guliaeva LF, Mishin VM, Liakhovich VV.

Biokhimiia. 1990 Feb;55(2):308-14. Russian.

PMID:
2340316
16.

[An immunochemical analysis of the induction of cytochrome P-450 isoforms in the liver of fresh-water fishes by 3-methylcholanthrene, beta-naphthoflavone and aroclor 1254].

Kotelevtsev SV, Ponomarëva LV, Novikov KN, Viner RI, Kozlov IuP, Khatsenko OG, Mitrofanov DV.

Nauchnye Doki Vyss Shkoly Biol Nauki. 1990;(5):23-9. Russian.

PMID:
2118391
17.

[Identification of molecular forms of cytochrome P-450 isolated from liver microsomes of rats induced with phenobarbital and 3-methylcholanthrene].

Guliaeva LF, Khatsenko OG, Gerasimov KE, Mitrofanov DV, Mishin VM.

Biokhimiia. 1989 Mar;54(3):487-94. Russian.

PMID:
2752066
18.

The phenobarbital-type induction of rat liver microsomal monooxygenases by perfluorodecalin.

Mishin VM, Obraztsov VV, Grishanova AYu, Gutkina NI, Shekhtman DG, Khatsenko OG, Lyakhovich VV.

Chem Biol Interact. 1989;72(1-2):143-55.

PMID:
2510947

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