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Items: 1 to 50 of 329

1.

Effect of Alteplase vs Aspirin on Functional Outcome for Patients With Acute Ischemic Stroke and Minor Nondisabling Neurologic Deficits: The PRISMS Randomized Clinical Trial.

Khatri P, Kleindorfer DO, Devlin T, Sawyer RN Jr, Starr M, Mejilla J, Broderick J, Chatterjee A, Jauch EC, Levine SR, Romano JG, Saver JL, Vagal A, Purdon B, Devenport J, Pavlov A, Yeatts SD; PRISMS Investigators.

JAMA. 2018 Jul 10;320(2):156-166. doi: 10.1001/jama.2018.8496.

PMID:
29998337
2.

To Treat or Not to Treat? Exploring Factors Influencing Intravenous Thrombolysis Treatment Decisions for Minor Stroke.

Levine SR, Weingast SZ, Weedon J, Stefanov DG, Katz P, Hurley D, Kasner SE, Khatri P, Broderick JP, Grotta JC, Feldmann E, Panagos PD, Romano JG, Bianchi R, Meyer BC, Scott PA, Kim D, Balucani C.

Stroke. 2018 Jul 5. pii: STROKEAHA.118.020971. doi: 10.1161/STROKEAHA.118.020971. [Epub ahead of print]

PMID:
29976582
3.
4.

Single-cell epigenetics - Chromatin modification atlas unveiled by mass cytometry.

Cheung P, Vallania F, Dvorak M, Chang SE, Schaffert S, Donato M, Rao A, Mao R, Utz PJ, Khatri P, Kuo AJ.

Clin Immunol. 2018 Jun 27. pii: S1521-6616(18)30363-2. doi: 10.1016/j.clim.2018.06.009. [Epub ahead of print]

PMID:
29960011
5.

Prevalence of celiac disease among pediatric patients with cryptogenic cirrhosis and effect of gluten-free-diet.

Joshi A, Falodia S, Kumar N, Gupta P, Khatri PC.

Indian J Gastroenterol. 2018 Jun 13. doi: 10.1007/s12664-018-0857-6. [Epub ahead of print]

PMID:
29948993
6.

KLRD1-expressing natural killer cells predict influenza susceptibility.

Bongen E, Vallania F, Utz PJ, Khatri P.

Genome Med. 2018 Jun 14;10(1):45. doi: 10.1186/s13073-018-0554-1.

7.

Prehospital Triage of Acute Ischemic Stroke Patients to an Intravenous tPA-Ready versus Endovascular-Ready Hospital: A Decision Analysis.

Benoit JL, Khatri P, Adeoye OM, Broderick JP, McMullan JT, Scheitz JF, Vagal AS, Eckman MH.

Prehosp Emerg Care. 2018 May 30:1-12. doi: 10.1080/10903127.2018.1465500. [Epub ahead of print]

PMID:
29847193
8.

Blood Pressure Management after Mechanical Thrombectomy for Acute Ischemic Stroke: A Survey of the StrokeNet Sites.

Mistry EA, Mayer SA, Khatri P.

J Stroke Cerebrovasc Dis. 2018 May 22. pii: S1052-3057(18)30221-0. doi: 10.1016/j.jstrokecerebrovasdis.2018.05.003. [Epub ahead of print]

PMID:
29801812
9.

Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging.

Cheung P, Vallania F, Warsinske HC, Donato M, Schaffert S, Chang SE, Dvorak M, Dekker CL, Davis MM, Utz PJ, Khatri P, Kuo AJ.

Cell. 2018 May 31;173(6):1385-1397.e14. doi: 10.1016/j.cell.2018.03.079. Epub 2018 Apr 26.

PMID:
29706550
10.

Pediatric Stroke Rates Over 17 Years: Report From a Population-Based Study.

Lehman LL, Khoury JC, Taylor JM, Yeramaneni S, Sucharew H, Alwell K, Moomaw CJ, Peariso K, Flaherty M, Khatri P, Broderick JP, Kissela BM, Kleindorfer DO.

J Child Neurol. 2018 Jun;33(7):463-467. doi: 10.1177/0883073818767039. Epub 2018 Apr 19.

PMID:
29673287
11.

Mechanism and Structural Factors of Lipid and Surfactant in the Formation of Self-Emulsified Nanoemulsion.

Khatri P, Shao J.

J Pharm Sci. 2018 Apr 4. pii: S0022-3549(18)30193-X. doi: 10.1016/j.xphs.2018.03.024. [Epub ahead of print]

PMID:
29626536
12.

Cell-centred meta-analysis reveals baseline predictors of anti-TNFα non-response in biopsy and blood of patients with IBD.

Gaujoux R, Starosvetsky E, Maimon N, Vallania F, Bar-Yoseph H, Pressman S, Weisshof R, Goren I, Rabinowitz K, Waterman M, Yanai H, Dotan I, Sabo E, Chowers Y, Khatri P, Shen-Orr SS; Israeli IBD research Network (IIRN).

Gut. 2018 Apr 4. pii: gutjnl-2017-315494. doi: 10.1136/gutjnl-2017-315494. [Epub ahead of print]

13.

Interpretation of biological experiments changes with evolution of the Gene Ontology and its annotations.

Tomczak A, Mortensen JM, Winnenburg R, Liu C, Alessi DT, Swamy V, Vallania F, Lofgren S, Haynes W, Shah NH, Musen MA, Khatri P.

Sci Rep. 2018 Mar 23;8(1):5115. doi: 10.1038/s41598-018-23395-2.

14.

Alteplase for the treatment of acute ischemic stroke in patients with low National Institutes of Health Stroke Scale and not clearly disabling deficits (Potential of rtPA for Ischemic Strokes with Mild Symptoms PRISMS): Rationale and design.

Yeatts SD, Broderick JP, Chatterjee A, Jauch EC, Levine SR, Romano JG, Saver JL, Vagal A, Purdon B, Devenport J, Khatri P.

Int J Stroke. 2018 Jan 1:1747493018765269. doi: 10.1177/1747493018765269. [Epub ahead of print]

PMID:
29570044
15.

Future Research Directions in Pneumonia. NHLBI Working Group Report.

Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):256-263. doi: 10.1164/rccm.201801-0139WS.

PMID:
29546996
16.

Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters.

Sweeney TE, Azad TD, Donato M, Haynes WA, Perumal TM, Henao R, Bermejo-Martin JF, Almansa R, Tamayo E, Howrylak JA, Choi A, Parnell GP, Tang B, Nichols M, Woods CW, Ginsburg GS, Kingsmore SF, Omberg L, Mangravite LM, Wong HR, Tsalik EL, Langley RJ, Khatri P.

Crit Care Med. 2018 Jun;46(6):915-925. doi: 10.1097/CCM.0000000000003084.

PMID:
29537985
17.

Mycobacterium fortuitum-induced ER-Mitochondrial calcium dynamics promotes calpain/caspase-12/caspase-9 mediated apoptosis in fish macrophages.

Datta D, Khatri P, Singh A, Saha DR, Verma G, Raman R, Mazumder S.

Cell Death Discov. 2018 Feb 20;4:30. doi: 10.1038/s41420-018-0034-9. eCollection 2018 Dec.

18.

Perfusion imaging and recurrent cerebrovascular events in intracranial atherosclerotic disease or carotid occlusion.

Sacchetti DC, Cutting SM, McTaggart RA, Chang AD, Hemendinger M, Mac Grory B, Siket MS, Burton T, Thompson B, Rostanski SK, Prabhakaran S, Willey JZ, Marshall RS, Elkind MS, Khatri P, Furie KL, Jayaraman MV, Yaghi S.

Int J Stroke. 2018 Jan 1:1747493018764075. doi: 10.1177/1747493018764075. [Epub ahead of print]

PMID:
29502498
19.

Predictors of symptomatic intracranial haemorrhage in patients with an ischaemic stroke with neurological deterioration after intravenous thrombolysis.

James B, Chang AD, McTaggart RA, Hemendinger M, Mac Grory B, Cutting SM, Burton TM, Reznik ME, Thompson B, Wendell L, Mahta A, Siket M, Madsen TE, Sheth KN, Nouh A, Furie KL, Jayaraman MV, Khatri P, Yaghi S.

J Neurol Neurosurg Psychiatry. 2018 Aug;89(8):866-869. doi: 10.1136/jnnp-2017-317341. Epub 2018 Feb 27.

PMID:
29487169
20.

A community approach to mortality prediction in sepsis via gene expression analysis.

Sweeney TE, Perumal TM, Henao R, Nichols M, Howrylak JA, Choi AM, Bermejo-Martin JF, Almansa R, Tamayo E, Davenport EE, Burnham KL, Hinds CJ, Knight JC, Woods CW, Kingsmore SF, Ginsburg GS, Wong HR, Parnell GP, Tang B, Moldawer LL, Moore FE, Omberg L, Khatri P, Tsalik EL, Mangravite LM, Langley RJ.

Nat Commun. 2018 Feb 15;9(1):694. doi: 10.1038/s41467-018-03078-2.

21.

Towards phenotyping stroke: Leveraging data from a large-scale epidemiological study to detect stroke diagnosis.

Ni Y, Alwell K, Moomaw CJ, Woo D, Adeoye O, Flaherty ML, Ferioli S, Mackey J, De Los Rios La Rosa F, Martini S, Khatri P, Kleindorfer D, Kissela BM.

PLoS One. 2018 Feb 14;13(2):e0192586. doi: 10.1371/journal.pone.0192586. eCollection 2018.

22.

A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation.

Yang Z, Zhang J, Jiang D, Khatri P, Solow-Cordero DE, Toesca DAS, Koumenis C, Denko NC, Giaccia AJ, Le QT, Koong AC.

Mol Cancer Res. 2018 May;16(5):745-753. doi: 10.1158/1541-7786.MCR-17-0307. Epub 2018 Feb 9.

PMID:
29440447
23.

Inflammatory macrophage-associated 3-gene signature predicts subclinical allograft injury and graft survival.

Azad TD, Donato M, Heylen L, Liu AB, Shen-Orr SS, Sweeney TE, Maltzman JS, Naesens M, Khatri P.

JCI Insight. 2018 Jan 25;3(2). pii: 95659. doi: 10.1172/jci.insight.95659. [Epub ahead of print]

24.

Gene annotation bias impedes biomedical research.

Haynes WA, Tomczak A, Khatri P.

Sci Rep. 2018 Jan 22;8(1):1362. doi: 10.1038/s41598-018-19333-x.

25.

Multicohort Analysis of Whole-Blood Gene Expression Data Does Not Form a Robust Diagnostic for Acute Respiratory Distress Syndrome.

Sweeney TE, Thomas NJ, Howrylak JA, Wong HR, Rogers AJ, Khatri P.

Crit Care Med. 2018 Feb;46(2):244-251. doi: 10.1097/CCM.0000000000002839.

26.

Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes.

Gee MH, Han A, Lofgren SM, Beausang JF, Mendoza JL, Birnbaum ME, Bethune MT, Fischer S, Yang X, Gomez-Eerland R, Bingham DB, Sibener LV, Fernandes RA, Velasco A, Baltimore D, Schumacher TN, Khatri P, Quake SR, Davis MM, Garcia KC.

Cell. 2018 Jan 25;172(3):549-563.e16. doi: 10.1016/j.cell.2017.11.043. Epub 2017 Dec 21.

PMID:
29275860
27.

Toward a Unified Integration Approach: Uniting Diverse Primary Care Strategies Under the Primary Care Behavioral Health (PCBH) Model.

Sandoval BE, Bell J, Khatri P, Robinson PJ.

J Clin Psychol Med Settings. 2018 Jun;25(2):187-196. doi: 10.1007/s10880-017-9516-9.

PMID:
29234927
28.

Impact of digestion on the transport of dextran-loaded self-emulsified nanoemulsion through MDCK epithelial cell monolayer and rat intestines.

Khatri P, Shao J.

Int J Pharm. 2018 Jan 30;536(1):353-359. doi: 10.1016/j.ijpharm.2017.12.009. Epub 2017 Dec 5.

PMID:
29217473
29.

Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association.

Yaghi S, Willey JZ, Cucchiara B, Goldstein JN, Gonzales NR, Khatri P, Kim LJ, Mayer SA, Sheth KN, Schwamm LH; American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Council on Quality of Care and Outcomes Research.

Stroke. 2017 Dec;48(12):e343-e361. doi: 10.1161/STR.0000000000000152. Epub 2017 Nov 2. Review.

PMID:
29097489
30.

Pediatric Sepsis Endotypes Among Adults With Sepsis.

Wong HR, Sweeney TE, Hart KW, Khatri P, Lindsell CJ.

Crit Care Med. 2017 Dec;45(12):e1289-e1291. doi: 10.1097/CCM.0000000000002733.

PMID:
28991828
31.

Unique transcriptomic response to sepsis is observed among patients of different age groups.

Raymond SL, López MC, Baker HV, Larson SD, Efron PA, Sweeney TE, Khatri P, Moldawer LL, Wynn JL.

PLoS One. 2017 Sep 8;12(9):e0184159. doi: 10.1371/journal.pone.0184159. eCollection 2017.

32.

Bone Morphogenetic Protein Promotes Lewis X Stage-Specific Embryonic Antigen 1 Expression Thereby Interfering with Neural Precursor and Stem Cell Proliferation.

Luque-Molina I, Khatri P, Schmidt-Edelkraut U, Simeonova IK, Hölzl-Wenig G, Mandl C, Ciccolini F.

Stem Cells. 2017 Dec;35(12):2417-2429. doi: 10.1002/stem.2701. Epub 2017 Sep 18.

PMID:
28869691
33.

Age, Sex, and Racial Differences in Neuroimaging Use in Acute Stroke: A Population-Based Study.

Vagal A, Sanelli P, Sucharew H, Alwell KA, Khoury JC, Khatri P, Woo D, Flaherty M, Kissela BM, Adeoye O, Ferioli S, De Los Rios La Rosa F, Martini S, Mackey J, Kleindorfer D.

AJNR Am J Neuroradiol. 2017 Oct;38(10):1905-1910. doi: 10.3174/ajnr.A5340. Epub 2017 Aug 24.

PMID:
28838913
34.

Sex-specific stroke incidence over time in the Greater Cincinnati/Northern Kentucky Stroke Study.

Madsen TE, Khoury J, Alwell K, Moomaw CJ, Rademacher E, Flaherty ML, Woo D, Mackey J, De Los Rios La Rosa F, Martini S, Ferioli S, Adeoye O, Khatri P, Broderick JP, Kissela BM, Kleindorfer D.

Neurology. 2017 Sep 5;89(10):990-996. doi: 10.1212/WNL.0000000000004325. Epub 2017 Aug 9.

PMID:
28794254
35.

Estimated Impact of Emergency Medical Service Triage of Stroke Patients on Comprehensive Stroke Centers: An Urban Population-Based Study.

Katz BS, Adeoye O, Sucharew H, Broderick JP, McMullan J, Khatri P, Widener M, Alwell KS, Moomaw CJ, Kissela BM, Flaherty ML, Woo D, Ferioli S, Mackey J, Martini S, De Los Rios la Rosa F, Kleindorfer DO.

Stroke. 2017 Aug;48(8):2164-2170. doi: 10.1161/STROKEAHA.116.015971. Epub 2017 Jul 12.

PMID:
28701576
36.

Practice Patterns for Acute Ischemic Stroke Workup: A Longitudinal Population-Based Study.

Loftspring MC, Kissela BM, Flaherty ML, Khoury JC, Alwell K, Moomaw CJ, Kleindorfer DO, Woo D, Adeoye O, Ferioli S, Broderick JP, Khatri P.

J Am Heart Assoc. 2017 Jun 23;6(6). pii: e005097. doi: 10.1161/JAHA.116.005097.

37.

Endovascular Therapy Demonstrates Benefit over Intravenous Recombinant Tissue Plasminogen Activator Based on Repeatedly Measured National Institutes of Health Stroke Scale.

Fan L, Yeatts SD, Foster LD, Khatri P, Tomsick T, Broderick JP, Palesch YY.

Interv Neurol. 2017 Mar;6(1-2):25-30. doi: 10.1159/000452137. Epub 2016 Oct 19.

38.

Impact of Thrombus Length on Outcomes After Intra-Arterial Aspiration Thrombectomy in the THERAPY Trial.

Yoo AJ, Khatri P, Mocco J, Zaidat OO, Gupta R, Frei D, Lopes D, Shownkeen H, Berkhemer OA, Meyer D, Hak SS, Kuo SS, Buell H, Bose A, Sit SP, von Kummer R; THERAPY Trial Investigators.

Stroke. 2017 Jul;48(7):1895-1900. doi: 10.1161/STROKEAHA.116.016253. Epub 2017 Jun 8.

39.

Analyses of thrombi in acute ischemic stroke: A consensus statement on current knowledge and future directions.

De Meyer SF, Andersson T, Baxter B, Bendszus M, Brouwer P, Brinjikji W, Campbell BC, Costalat V, Dávalos A, Demchuk A, Dippel D, Fiehler J, Fischer U, Gilvarry M, Gounis MJ, Gralla J, Jansen O, Jovin T, Kallmes D, Khatri P, Lees KR, López-Cancio E, Majoie C, Marquering H, Narata AP, Nogueira R, Ringleb P, Siddiqui A, Szikora I, Vale D, von Kummer R, Yoo AJ, Hacke W, Liebeskind DS; Clot Summit Group.

Int J Stroke. 2017 Aug;12(6):606-614. doi: 10.1177/1747493017709671. Epub 2017 May 23. Review.

PMID:
28534706
40.

Sex differences in cardiovascular risk profiles of ischemic stroke patients with diabetes in the Greater Cincinnati/Northern Kentucky Stroke Study.

Madsen TE, Khoury JC, Alwell KA, Moomaw CJ, Demel SL, Flaherty ML, Woo D, Mackey J, De Los Rios La Rosa F, Martini S, Ferioli S, Adeoye O, Khatri P, Kissela BM, Kleindorfer D.

J Diabetes. 2018 Jun;10(6):496-501. doi: 10.1111/1753-0407.12567. Epub 2017 Aug 9.

PMID:
28523847
41.

Generalizable Biomarkers in Critical Care: Toward Precision Medicine.

Sweeney TE, Khatri P.

Crit Care Med. 2017 Jun;45(6):934-939. doi: 10.1097/CCM.0000000000002402. No abstract available.

42.

A B-Cell Gene Signature Correlates With the Extent of Gluten-Induced Intestinal Injury in Celiac Disease.

Garber ME, Saldanha A, Parker JS, Jones WD, Kaukinen K, Laurila K, Lähdeaho ML, Khatri P, Khosla C, Adelman DC, Mäki M.

Cell Mol Gastroenterol Hepatol. 2017 Jan 28;4(1):1-17. doi: 10.1016/j.jcmgh.2017.01.011. eCollection 2017 Jul.

43.

Observed Cost and Variations in Short Term Cost-Effectiveness of Therapy for Ischemic Stroke in Interventional Management of Stroke (IMS) III.

Simpson KN, Simpson AN, Mauldin PD, Palesch YY, Yeatts SD, Kleindorfer D, Tomsick TA, Foster LD, Demchuk AM, Khatri P, Hill MD, Jauch EC, Jovin TG, Yan B, von Kummer R, Molina CA, Goyal M, Schonewille WJ, Mazighi M, Engelter ST, Anderson C, Spilker J, Carrozzella J, Ryckborst KJ, Janis LS, Broderick JP; Interventional Management of Stroke (IMS) III Investigators.

J Am Heart Assoc. 2017 May 8;6(5). pii: e004513. doi: 10.1161/JAHA.116.004513.

44.

Selection of patients for intra-arterial treatment for acute ischaemic stroke: development and validation of a clinical decision tool in two randomised trials.

Venema E, Mulder MJHL, Roozenbeek B, Broderick JP, Yeatts SD, Khatri P, Berkhemer OA, Emmer BJ, Roos YBWEM, Majoie CBLM, van Oostenbrugge RJ, van Zwam WH, van der Lugt A, Steyerberg EW, Dippel DWJ, Lingsma HF.

BMJ. 2017 May 3;357:j1710. doi: 10.1136/bmj.j1710.

45.

Validation of the Sepsis MetaScore for Diagnosis of Neonatal Sepsis.

Sweeney TE, Wynn JL, Cernada M, Serna E, Wong HR, Baker HV, Vento M, Khatri P.

J Pediatric Infect Dis Soc. 2018 May 15;7(2):129-135. doi: 10.1093/jpids/pix021.

PMID:
28419265
46.

Towards personalised intra-arterial treatment of patients with acute ischaemic stroke: a study protocol for development and validation of a clinical decision aid.

Mulder MJ, Venema E, Roozenbeek B, Broderick JP, Yeatts SD, Khatri P, Berkhemer OA, Roos YB, Majoie CB, van Oostenbrugge RJ, van Zwam WH, van der Lugt A, Steyerberg EW, Dippel DW, Lingsma HF.

BMJ Open. 2017 Mar 22;7(3):e013699. doi: 10.1136/bmjopen-2016-013699.

47.

Gene Expression Analysis to Assess the Relevance of Rodent Models to Human Lung Injury.

Sweeney TE, Lofgren S, Khatri P, Rogers AJ.

Am J Respir Cell Mol Biol. 2017 Aug;57(2):184-192. doi: 10.1165/rcmb.2016-0395OC.

PMID:
28324666
48.

The authors reply.

Sweeney TE, Khatri P.

Crit Care Med. 2017 Apr;45(4):e457-e458. doi: 10.1097/CCM.0000000000002269. No abstract available.

49.

Transport of lipid nano-droplets through MDCK epithelial cell monolayer.

Khatri P, Shao J.

Colloids Surf B Biointerfaces. 2017 May 1;153:237-243. doi: 10.1016/j.colsurfb.2017.02.024. Epub 2017 Feb 21.

PMID:
28267668
50.

Chemical Space Mimicry for Drug Discovery.

Yuan W, Jiang D, Nambiar DK, Liew LP, Hay MP, Bloomstein J, Lu P, Turner B, Le QT, Tibshirani R, Khatri P, Moloney MG, Koong AC.

J Chem Inf Model. 2017 Apr 24;57(4):875-882. doi: 10.1021/acs.jcim.6b00754. Epub 2017 Apr 3.

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