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Items: 1 to 50 of 282

1.

The metabotropic glutamate receptor 5 negative allosteric modulator fenobam: pharmacokinetics, side effects, and analgesic effects in healthy human subjects.

Cavallone LF, Montana MC, Frey K, Kallogjeri D, Wages JM, Rodebaugh T, Doshi T, Kharasch ED, Gereau RW 4th.

Pain. 2019 Sep 14. doi: 10.1097/j.pain.0000000000001695. [Epub ahead of print]

PMID:
31568235
2.

Reporting Laboratory and Animal Research in ANESTHESIOLOGY: The Importance of Sex as a Biologic Variable.

Vutskits L, Clark JD, Kharasch ED.

Anesthesiology. 2019 Aug 21. doi: 10.1097/ALN.0000000000002945. [Epub ahead of print] No abstract available.

PMID:
31453813
3.

Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry.

Wang PF, Neiner A, Kharasch ED.

Drug Metab Dispos. 2019 Oct;47(10):1195-1205. doi: 10.1124/dmd.119.086348. Epub 2019 Jul 19. Review. Erratum in: Drug Metab Dispos. 2019 Oct;47(10):1231.

PMID:
31324697
4.

Observations and Observational Research.

Kharasch ED.

Anesthesiology. 2019 Jul;131(1):1-4. doi: 10.1097/ALN.0000000000002818. No abstract available.

PMID:
31180920
5.

Methadone Disposition: Implementing Lessons Learned.

Kharasch ED, Greenblatt DJ.

J Clin Pharmacol. 2019 Aug;59(8):1044-1048. doi: 10.1002/jcph.1427. Epub 2019 May 1. No abstract available.

PMID:
31044453
6.

Strain-specific altered nicotine metabolism in 3,3'-diindolylmethane (DIM) exposed mice.

Bloom AJ, Upadhyaya P, Kharasch ED.

Biopharm Drug Dispos. 2019 May;40(5-6):188-194. doi: 10.1002/bdd.2182. Epub 2019 May 20.

PMID:
31016737
7.

Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes.

Bloom AJ, Wang PF, Kharasch ED.

Pharmacol Res Perspect. 2019 Mar 11;7(2):e00468. doi: 10.1002/prp2.468. eCollection 2019 Apr.

8.

Opioid Sensitivity in Children with and without Obstructive Sleep Apnea.

Montana MC, Juriga L, Sharma A, Kharasch ED.

Anesthesiology. 2019 Jun;130(6):936-945. doi: 10.1097/ALN.0000000000002664.

PMID:
30870164
9.

Add-on plasmonic patch as a universal fluorescence enhancer.

Luan J, Morrissey JJ, Wang Z, Derami HG, Liu KK, Cao S, Jiang Q, Wang C, Kharasch ED, Naik RR, Singamaneni S.

Light Sci Appl. 2018 Jul 4;7:29. doi: 10.1038/s41377-018-0027-8. eCollection 2018.

10.

Low-dose augmentation with buprenorphine increases emotional reactivity but not reward activity in treatment resistant mid- and late-life depression.

Lin C, Karim HT, Pecina M, Aizenstein HJ, Lenze EJ, Blumberger DM, Mulsant BH, Kharasch ED, Reynolds Iii CF, Karp JF.

Neuroimage Clin. 2019;21:101679. doi: 10.1016/j.nicl.2019.101679. Epub 2019 Jan 22.

11.

Understanding Research Methods and the Readers' Toolbox: A New Article Type.

Kharasch ED.

Anesthesiology. 2019 Feb;130(2):181-182. doi: 10.1097/ALN.0000000000002588. No abstract available.

PMID:
30632984
12.

Halogen Substitution Influences Ketamine Metabolism by Cytochrome P450 2B6: In Vitro and Computational Approaches.

Wang PF, Neiner A, Lane TR, Zorn KM, Ekins S, Kharasch ED.

Mol Pharm. 2019 Feb 4;16(2):898-906. doi: 10.1021/acs.molpharmaceut.8b01214. Epub 2019 Jan 10.

PMID:
30589555
13.

Trusted Evidence: Discovery to Practice.

Kharasch ED.

Anesthesiology. 2019 Jan;130(1):1-2. doi: 10.1097/ALN.0000000000002535. No abstract available.

PMID:
30543531
14.

Urinary aquaporin 1 and perilipin 2: Can these novel markers accurately characterize small renal masses and help guide patient management?

Song JB, Morrissey JJ, Mobley JM, Figenshau KG, Vetter JM, Bhayani SB, Kharasch ED, Figenshau RS.

Int J Urol. 2019 Feb;26(2):260-265. doi: 10.1111/iju.13854. Epub 2018 Nov 22.

PMID:
30467901
15.

Bioequivalence and Therapeutic Equivalence of Generic and Brand Bupropion in Adults With Major Depression: A Randomized Clinical Trial.

Kharasch ED, Neiner A, Kraus K, Blood J, Stevens A, Schweiger J, Miller JP, Lenze EJ.

Clin Pharmacol Ther. 2019 May;105(5):1164-1174. doi: 10.1002/cpt.1309. Epub 2019 Jan 18.

PMID:
30460996
16.

Metal-Organic Framework Encapsulation Preserves the Bioactivity of Protein Therapeutics.

Wang C, Sudlow G, Wang Z, Cao S, Jiang Q, Neiner A, Morrissey JJ, Kharasch ED, Achilefu S, Singamaneni S.

Adv Healthc Mater. 2018 Nov;7(22):e1800950. doi: 10.1002/adhm.201800950. Epub 2018 Oct 19.

PMID:
30369102
17.

Postoperative Brain Function: Toward a Better Understanding and the American Society of Anesthesiologists Perioperative Brain Health Initiative.

Cole DJ, Kharasch ED.

Anesthesiology. 2018 Nov;129(5):861-863. doi: 10.1097/ALN.0000000000002085. No abstract available.

PMID:
30325803
18.

In Reply.

Kharasch ED, Houle TT.

Anesthesiology. 2018 Sep;129(3):614. doi: 10.1097/ALN.0000000000002355. No abstract available.

PMID:
30106786
19.

Stereoselective Ketamine Metabolism by Genetic Variants of Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase.

Wang PF, Neiner A, Kharasch ED.

Anesthesiology. 2018 Oct;129(4):756-768. doi: 10.1097/ALN.0000000000002371.

PMID:
30085944
20.

Editor's Note: ANESTHESIOLOGY 2018: Inspiring Investigation and Education.

Kharasch ED.

Anesthesiology. 2018 Jul;129(1):1-4. doi: 10.1097/ALN.0000000000002264. No abstract available.

PMID:
29847428
21.

Intraoperative Methadone in Same-Day Ambulatory Surgery: A Randomized, Double-Blinded, Dose-Finding Pilot Study.

Komen H, Brunt LM, Deych E, Blood J, Kharasch ED.

Anesth Analg. 2019 Apr;128(4):802-810. doi: 10.1213/ANE.0000000000003464.

PMID:
29847382
22.

Environmental Stability of Plasmonic Biosensors Based on Natural versus Artificial Antibody.

Luan J, Xu T, Cashin J, Morrissey JJ, Kharasch ED, Singamaneni S.

Anal Chem. 2018 Jul 3;90(13):7880-7887. doi: 10.1021/acs.analchem.7b05470. Epub 2018 Jun 13.

23.

Common Polymorphisms of CYP2B6 Influence Stereoselective Bupropion Disposition.

Kharasch ED, Crafford A.

Clin Pharmacol Ther. 2019 Jan;105(1):142-152. doi: 10.1002/cpt.1116. Epub 2018 Aug 9.

PMID:
29756345
24.

How central is central poststroke pain? The role of afferent input in poststroke neuropathic pain: a prospective, open-label pilot study.

Haroutounian S, Ford AL, Frey K, Nikolajsen L, Finnerup NB, Neiner A, Kharasch ED, Karlsson P, Bottros MM.

Pain. 2018 Jul;159(7):1317-1324. doi: 10.1097/j.pain.0000000000001213.

PMID:
29570507
25.

Frontiers in Opioid Pharmacology.

Rathmell JP, Kharasch ED.

Anesthesiology. 2018 May;128(5):865-866. doi: 10.1097/ALN.0000000000002193. No abstract available.

PMID:
29570112
26.

The Challenges of Translation.

Kharasch ED.

Anesthesiology. 2018 Apr;128(4):693-696. doi: 10.1097/ALN.0000000000002122. No abstract available.

PMID:
29533965
27.

Ultrarobust Biochips with Metal-Organic Framework Coating for Point-of-Care Diagnosis.

Wang C, Wang L, Tadepalli S, Morrissey JJ, Kharasch ED, Naik RR, Singamaneni S.

ACS Sens. 2018 Feb 23;3(2):342-351. doi: 10.1021/acssensors.7b00762. Epub 2018 Jan 30.

28.

Seeking and reporting apparent research misconduct: errors and integrity.

Kharasch ED, Houle TT.

Anaesthesia. 2018 Jan;73(1):125-126. doi: 10.1111/anae.14147. No abstract available.

29.

Errors and Integrity in Seeking and Reporting Apparent Research Misconduct.

Kharasch ED, Houle TT.

Anesthesiology. 2017 Nov;127(5):733-737. doi: 10.1097/ALN.0000000000001875. No abstract available.

PMID:
28825936
30.

Editor's Note: ANESTHESIOLOGY 2017: Expanding the Richness and Reach.

Kharasch ED.

Anesthesiology. 2017 Jul;127(1):1-2. doi: 10.1097/ALN.0000000000001701. No abstract available.

PMID:
28520576
31.

Single Molecule Force Spectroscopy to Compare Natural versus Artificial Antibody-Antigen Interaction.

Wang C, Hu R, Morrissey JJ, Kharasch ED, Singamaneni S.

Small. 2017 May;13(19). doi: 10.1002/smll.201604255. Epub 2017 Mar 21.

32.

Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain.

Teitelbaum AM, Murphy SE, Akk G, Baker TB, Germann A, von Weymarn LB, Bierut LJ, Goate A, Kharasch ED, Bloom AJ.

Pharmacogenomics J. 2018 Jan;18(1):136-143. doi: 10.1038/tpj.2016.92. Epub 2017 Mar 14.

33.

Current Concepts in Methadone Metabolism and Transport.

Kharasch ED.

Clin Pharmacol Drug Dev. 2017 Mar;6(2):125-134. doi: 10.1002/cpdd.326.

34.

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.

Hicks JK, Sangkuhl K, Swen JJ, Ellingrod VL, Müller DJ, Shimoda K, Bishop JR, Kharasch ED, Skaar TC, Gaedigk A, Dunnenberger HM, Klein TE, Caudle KE, Stingl JC.

Clin Pharmacol Ther. 2017 Jul;102(1):37-44. doi: 10.1002/cpt.597. Epub 2017 Feb 13. No abstract available.

35.

Aromatic Functionality of Target Proteins Influences Monomer Selection for Creating Artificial Antibodies on Plasmonic Biosensors.

Hu R, Luan J, Kharasch ED, Singamaneni S, Morrissey JJ.

ACS Appl Mater Interfaces. 2017 Jan 11;9(1):145-151. doi: 10.1021/acsami.6b12505. Epub 2016 Dec 19.

36.

Metal-Organic Framework as a Protective Coating for Biodiagnostic Chips.

Wang C, Tadepalli S, Luan J, Liu KK, Morrissey JJ, Kharasch ED, Naik RR, Singamaneni S.

Adv Mater. 2017 Feb;29(7). doi: 10.1002/adma.201604433. Epub 2016 Dec 7.

37.

Reply to comment on: Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.

Horst J, Kharasch ED.

Pediatr Blood Cancer. 2017 May;64(5). doi: 10.1002/pbc.26343. Epub 2016 Nov 10. No abstract available.

PMID:
27860157
38.

Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance.

Rao LK, Flaker AM, Friedel CC, Kharasch ED.

Anesthesiology. 2016 Dec;125(6):1103-1112.

PMID:
27763887
39.

Misidentification of Bupropion Glucuronide Metabolites and Re-evaluation of Metabolite Pharmacokinetics.

Teitelbaum AM, Kharasch ED.

Drug Metab Dispos. 2016 Nov;44(11):1851. No abstract available.

40.

Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.

Horst J, Frei-Jones M, Deych E, Shannon W, Kharasch ED.

Pediatr Blood Cancer. 2016 Dec;63(12):2123-2130. doi: 10.1002/pbc.26207. Epub 2016 Aug 30.

41.

PEGylated Artificial Antibodies: Plasmonic Biosensors with Improved Selectivity.

Luan J, Liu KK, Tadepalli S, Jiang Q, Morrissey JJ, Kharasch ED, Singamaneni S.

ACS Appl Mater Interfaces. 2016 Sep 14;8(36):23509-16. doi: 10.1021/acsami.6b07252. Epub 2016 Aug 29.

42.

Silk-Encapsulated Plasmonic Biochips with Enhanced Thermal Stability.

Wang C, Luan J, Tadepalli S, Liu KK, Morrissey JJ, Kharasch ED, Naik RR, Singamaneni S.

ACS Appl Mater Interfaces. 2016 Oct 12;8(40):26493-26500. Epub 2016 Aug 2.

43.

Development, validation and application of a comprehensive stereoselective LC/MS-MS assay for bupropion and oxidative, reductive, and glucuronide metabolites in human urine.

Teitelbaum AM, Flaker AM, Kharasch ED.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Aug 1;1027:239-53. doi: 10.1016/j.jchromb.2016.05.036. Epub 2016 May 24.

44.

Changes: Handing Off and the Future of ANESTHESIOLOGY.

Kharasch ED.

Anesthesiology. 2016 Jul;125(1):4-6. doi: 10.1097/ALN.0000000000001150. No abstract available.

PMID:
27152576
45.

Changes: Thank You, Dr. Eisenach.

Kharasch ED, Tedeschi V, Kendall G.

Anesthesiology. 2016 Jul;125(1):1-3. doi: 10.1097/ALN.0000000000001149. No abstract available.

PMID:
27152575
46.

Development and validation of a high-throughput stereoselective LC-MS/MS assay for bupropion, hydroxybupropion, erythrohydrobupropion, and threohydrobupropion in human plasma.

Teitelbaum AM, Flaker AM, Kharasch ED.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Apr 1;1017-1018:101-113. doi: 10.1016/j.jchromb.2016.02.032. Epub 2016 Feb 27.

47.

Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: A pilot randomised controlled trial.

Lenze EJ, Farber NB, Kharasch E, Schweiger J, Yingling M, Olney J, Newcomer JW.

World J Biol Psychiatry. 2016 Apr;17(3):230-8. doi: 10.3109/15622975.2016.1142607. Epub 2016 Feb 26.

48.

Perioperative Opioids and Public Health.

Kharasch ED, Brunt LM.

Anesthesiology. 2016 Apr;124(4):960-5. doi: 10.1097/ALN.0000000000001012. Review. No abstract available.

PMID:
26808634
49.

Fentanyl and Midazolam Are Ineffective in Reducing Episodic Intracranial Hypertension in Severe Pediatric Traumatic Brain Injury.

Welch TP, Wallendorf MJ, Kharasch ED, Leonard JR, Doctor A, Pineda JA.

Crit Care Med. 2016 Apr;44(4):809-18. doi: 10.1097/CCM.0000000000001558.

50.

Peptide Functionalized Gold Nanorods for the Sensitive Detection of a Cardiac Biomarker Using Plasmonic Paper Devices.

Tadepalli S, Kuang Z, Jiang Q, Liu KK, Fisher MA, Morrissey JJ, Kharasch ED, Slocik JM, Naik RR, Singamaneni S.

Sci Rep. 2015 Nov 10;5:16206. doi: 10.1038/srep16206.

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