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Is Foetal Programming by Mismatched Pre- and Postnatal Nutrition Contributing to the Prevalence of Obesity in Nepal?

Khanal P, Nielsen MO.

Prev Nutr Food Sci. 2019 Sep;24(3):235-244. doi: 10.3746/pnf.2019.24.3.235. Epub 2019 Sep 30. Review.


A one-step tRNA-CRISPR system for genome-wide genetic interaction mapping in mammalian cells.

Zhao Y, Tyrishkin K, Sjaarda C, Khanal P, Stafford J, Rauh M, Liu X, Babak T, Yang X.

Sci Rep. 2019 Oct 10;9(1):14499. doi: 10.1038/s41598-019-51090-3.


Differentially methylated gene patterns between age-matched sarcopenic and non-sarcopenic women.

He L, Khanal P, Morse CI, Williams A, Thomis M.

J Cachexia Sarcopenia Muscle. 2019 Sep 11. doi: 10.1002/jcsm.12478. [Epub ahead of print]


A gain-of-functional screen identifies the Hippo pathway as a central mediator of receptor tyrosine kinases during tumorigenesis.

Azad T, Nouri K, Janse van Rensburg HJ, Maritan SM, Wu L, Hao Y, Montminy T, Yu J, Khanal P, Mulligan LM, Yang X.

Oncogene. 2019 Sep 2. doi: 10.1038/s41388-019-0988-y. [Epub ahead of print]


A kinome-wide screen using a NanoLuc LATS luminescent biosensor identifies ALK as a novel regulator of the Hippo pathway in tumorigenesis and immune evasion.

Nouri K, Azad T, Lightbody E, Khanal P, Nicol CJ, Yang X.

FASEB J. 2019 Nov;33(11):12487-12499. doi: 10.1096/fj.201901343R. Epub 2019 Aug 20.


Workshop on proposal writing on research for health care professionals: a brief report.

Shrestha S, Danekhu K, Sharma N, Khanal P, Ansari SR, Shrestha S, Piryani RM, Mohamed Ibrahim MI.

J Multidiscip Healthc. 2019 Jul 22;12:565-572. doi: 10.2147/JMDH.S211257. eCollection 2019.


Genetic parameters of meat quality, carcass composition, and growth traits in commercial swine.

Khanal P, Maltecca C, Schwab C, Gray K, Tiezzi F.

J Anim Sci. 2019 Sep 3;97(9):3669-3683. doi: 10.1093/jas/skz247.


Zika virus infection of pregnant rats and associated neurological consequences in the offspring.

Sherer ML, Khanal P, Talham G, Brannick EM, Parcells MS, Schwarz JM.

PLoS One. 2019 Jun 20;14(6):e0218539. doi: 10.1371/journal.pone.0218539. eCollection 2019.


Prevalence and correlates of postabortion long-acting reversible contraceptive (LARC) use among young women (24 and below) in Nepal: Strategy in the search for improvements.

Mehata S, Bhattarai N, Menzel J, Shah M, Khanal P, Tofigh S, Khanal MN, Regmi SC, Andersen K.

Reprod Health. 2019 May 14;16(1):55. doi: 10.1186/s12978-019-0708-7.


Pleomorphic Adenoma of the Submandibular Gland: A Case Report.

Khanal P.

JNMA J Nepal Med Assoc. 2019 Jan-Feb;57(215):53-55.


Identification of Prolyl isomerase Pin1 as a novel positive regulator of YAP/TAZ in breast cancer cells.

Khanal P, Yeung B, Zhao Y, Yang X.

Sci Rep. 2019 Apr 23;9(1):6394. doi: 10.1038/s41598-019-42767-w.


Influence of crossbreeding on meat goat doe fitness when comparing Boer F1 with base breeds in the Southeastern United States.

Khanal P, Leite-Browning ML, Browning R Jr.

J Anim Sci. 2019 Jan 1;97(1):78-89. doi: 10.1093/jas/sky421.


ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons.

Hlushchenko I, Khanal P, Abouelezz A, Paavilainen VO, Hotulainen P.

Front Cell Neurosci. 2018 Aug 3;12:217. doi: 10.3389/fncel.2018.00217. eCollection 2018.


A Retrospective Study Analyzing the Appropriateness of Initial Treatment of Clostridium difficile in Patients with Active Malignancy.

Fisher A, Khanal P, Gniado E, Khaddour L, Orosey M, Hader I, Yadav S, Halalau A.

Gastroenterol Res Pract. 2018 May 27;2018:7192728. doi: 10.1155/2018/7192728. eCollection 2018.


Metabolic syndrome and biochemical changes among non-alcoholic fatty liver disease patients attending a tertiary care hospital of Nepal.

Pardhe BD, Shakya S, Bhetwal A, Mathias J, Khanal PR, Pandit R, Shakya J, Joshi HO, Marahatta SB.

BMC Gastroenterol. 2018 Jul 6;18(1):109. doi: 10.1186/s12876-018-0843-6.


Fetal over- and undernutrition differentially program thyroid axis adaptability in adult sheep.

Johnsen L, Lyckegaard NB, Khanal P, Quistorff B, Raun K, Nielsen MO.

Endocr Connect. 2018 May;7(5):777-790. doi: 10.1530/EC-18-0014.


Ugly bugs in healthy guts! Carriage of multidrug-resistant and ESBL-producing commensal Enterobacteriaceae in the intestine of healthy Nepalese adults.

Maharjan A, Bhetwal A, Shakya S, Satyal D, Shah S, Joshi G, Khanal PR, Parajuli NP.

Infect Drug Resist. 2018 Apr 26;11:547-554. doi: 10.2147/IDR.S156593. eCollection 2018.


Historical Development of Health Research Ethics in Nepal.

Khanal P, Maharjan S, Ghimire N, Karki KB.

J Nepal Health Res Counc. 2018 Mar 13;16(1):105-107.


Impacts of pre- and postnatal nutrition on glucagon regulation and hepatic signalling in sheep.

Adhikari B, Khanal P, Nielsen MO.

J Endocrinol. 2018 Jul;238(1):1-12. doi: 10.1530/JOE-17-0705. Epub 2018 Apr 19.


Identification of Cdk1-LATS-Pin1 as a Novel Signaling Axis in Anti-tubulin Drug Response of Cancer Cells.

Yeung B, Khanal P, Mehta V, Trinkle-Mulcahy L, Yang X.

Mol Cancer Res. 2018 Jun;16(6):1035-1045. doi: 10.1158/1541-7786.MCR-17-0684. Epub 2018 Mar 9.


Cysteine residues are essential for dimerization of Hippo pathway components YAP2L and TAZ.

Khanal P, Jia Z, Yang X.

Sci Rep. 2018 Feb 22;8(1):3485. doi: 10.1038/s41598-018-21828-6.


Isolation of Potential Phages against Multidrug-Resistant Bacterial Isolates: Promising Agents in the Rivers of Kathmandu, Nepal.

Bhetwal A, Maharjan A, Shakya S, Satyal D, Ghimire S, Khanal PR, Parajuli NP.

Biomed Res Int. 2017;2017:3723254. doi: 10.1155/2017/3723254. Epub 2017 Nov 22.


The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1.

Janse van Rensburg HJ, Azad T, Ling M, Hao Y, Snetsinger B, Khanal P, Minassian LM, Graham CH, Rauh MJ, Yang X.

Cancer Res. 2018 Mar 15;78(6):1457-1470. doi: 10.1158/0008-5472.CAN-17-3139. Epub 2018 Jan 16.


Enteric Fever Caused by Salmonella enterica Serovars with Reduced Susceptibility of Fluoroquinolones at a Community Based Teaching Hospital of Nepal.

Bhetwal A, Maharjan A, Khanal PR, Parajuli NP.

Int J Microbiol. 2017;2017:2869458. doi: 10.1155/2017/2869458. Epub 2017 Nov 6.


Body image dissatisfaction in patients undergoing breast reconstruction: Examining the roles of breast symmetry and appearance investment.

Teo I, Reece GP, Huang SC, Mahajan K, Andon J, Khanal P, Sun C, Nicklaus K, Merchant F, Markey MK, Fingeret MC.

Psychooncology. 2018 Mar;27(3):857-863. doi: 10.1002/pon.4586. Epub 2017 Dec 19.


Effect of age and estrogen on biochemical markers of bone turnover in postmenopausal women: a population-based study from Nepal.

Pardhe BD, Pathak S, Bhetwal A, Ghimire S, Shakya S, Khanal PR, Marahatta SB.

Int J Womens Health. 2017 Oct 25;9:781-788. doi: 10.2147/IJWH.S145191. eCollection 2017.


Renaissance of Conventional First-Line Antibiotics in Salmonella enterica Clinical Isolates: Assessment of MICs for Therapeutic Antimicrobials in Enteric Fever Cases from Nepal.

Khanal PR, Satyal D, Bhetwal A, Maharjan A, Shakya S, Tandukar S, Parajuli NP.

Biomed Res Int. 2017;2017:2868143. doi: 10.1155/2017/2868143. Epub 2017 Sep 5.


Impacts of prenatal nutrition on animal production and performance: a focus on growth and metabolic and endocrine function in sheep.

Khanal P, Nielsen MO.

J Anim Sci Biotechnol. 2017 Sep 1;8:75. doi: 10.1186/s40104-017-0205-1. eCollection 2017. Review.


Bringing all together for research capacity building in LMICs.

Khanal P.

Lancet Glob Health. 2017 Sep;5(9):e868. doi: 10.1016/S2214-109X(17)30259-0. No abstract available.


Elevated Cardiovascular Risks among Postmenopausal Women: A Community Based Case Control Study from Nepal.

Pardhe BD, Ghimire S, Shakya J, Pathak S, Shakya S, Bhetwal A, Khanal PR, Parajuli NP.

Biochem Res Int. 2017;2017:3824903. doi: 10.1155/2017/3824903. Epub 2017 May 2.


Evaluating the Trends of Bloodstream Infections among Pediatric and Adult Patients at a Teaching Hospital of Kathmandu, Nepal: Role of Drug Resistant Pathogens.

Parajuli NP, Parajuli H, Pandit R, Shakya J, Khanal PR.

Can J Infect Dis Med Microbiol. 2017;2017:8763135. doi: 10.1155/2017/8763135. Epub 2017 Apr 6.


Shigellosis Caused by CTX-M Type ESBL Producing Shigella flexneri in Two Siblings of Rural Nepal: First Case Report from the Country.

Parajuli NP, Joshi G, Pardhe BD, Shakya J, Bhetwal A, Shakya S, Pandit R, Shrestha SS, Khanal PR.

Case Rep Infect Dis. 2017;2017:1862320. doi: 10.1155/2017/1862320. Epub 2017 Feb 21.


Emerging Perils of Extended Spectrum ╬▓-Lactamase Producing Enterobacteriaceae Clinical Isolates in a Teaching Hospital of Nepal.

Parajuli NP, Maharjan P, Joshi G, Khanal PR.

Biomed Res Int. 2016;2016:1782835. doi: 10.1155/2016/1782835. Epub 2016 Dec 29.


High rates of multidrug resistance among uropathogenic Escherichia coli in children and analyses of ESBL producers from Nepal.

Parajuli NP, Maharjan P, Parajuli H, Joshi G, Paudel D, Sayami S, Khanal PR.

Antimicrob Resist Infect Control. 2017 Jan 11;6:9. doi: 10.1186/s13756-016-0168-6. eCollection 2017.


Bacteremia caused by a rare pathogen - Chromobacterium violaceum: a case report from Nepal.

Parajuli NP, Bhetwal A, Ghimire S, Maharjan A, Shakya S, Satyal D, Pandit R, Khanal PR.

Int J Gen Med. 2016 Dec 5;9:441-446. eCollection 2016.


Cerebral Venous Sinus Thrombosis during Everest Expedition: A Case Report and Review of the Literature.

Khanal P, Thapa L, Shrestha AM, Bhattarai S, Sapkota D, Sharma N, Devkota UP.

Case Rep Neurol Med. 2016;2016:8314040. Epub 2016 Oct 31.


Pride in autistic diversity: against treatment or for inclusion?

Bhandari P, Khanal P.

Lancet. 2016 Nov 19;388(10059):2477. doi: 10.1016/S0140-6736(16)32176-6. No abstract available.


Health beyond health to bridge the global health gap.

Khanal P, Bhattarai N.

Lancet Glob Health. 2016 Nov;4(11):e792. doi: 10.1016/S2214-109X(16)30256-X. No abstract available.


Strengthening of information systems and research to tackle HIV and non-communicable diseases.

Khanal P, Khanal A.

Lancet Diabetes Endocrinol. 2016 Oct;4(10):815. doi: 10.1016/S2213-8587(16)30219-4. No abstract available.


Early, Isolated Duodenal Mucosa-Associated Lymphoid Tissue Lymphoma Presenting without Symptoms or Grossly Apparent Endoscopic Lesions and Diagnosed by Random Duodenal Biopsies.

Gjeorgjievski M, Makki I, Khanal P, Amin MB, Blenc AM, Desai T, Cappell MS.

Case Rep Gastroenterol. 2016 Jun 27;10(2):323-31. doi: 10.1159/000447293. eCollection 2016 May-Aug.


Long-Term Impacts of Foetal Malnutrition Followed by Early Postnatal Obesity on Fat Distribution Pattern and Metabolic Adaptability in Adult Sheep.

Khanal P, Johnsen L, Axel AM, Hansen PW, Kongsted AH, Lyckegaard NB, Nielsen MO.

PLoS One. 2016 Jun 3;11(6):e0156700. doi: 10.1371/journal.pone.0156700. eCollection 2016.


Sorption Kinetics on Open Carbon Nanohorn Aggregates: The Effect of Molecular Diameter.

Russell BA, Khanal P, Calbi MM, Yudasaka M, Iijima S, Migone AD.

Molecules. 2016 Apr 21;21(4):521. doi: 10.3390/molecules21040521.


National health insurance policy in Nepal: challenges for implementation.

Mishra SR, Khanal P, Karki DK, Kallestrup P, Enemark U.

Glob Health Action. 2015 Aug 21;8:28763. doi: 10.3402/gha.v8.28763. eCollection 2015.


Sustaining progress in maternal and child health in Nepal.

Khanal V, Khanal P, Lee AH.

Lancet. 2015 Jun 27;385(9987):2573. doi: 10.1016/S0140-6736(15)60963-1. Epub 2015 Jun 16. No abstract available.


Late gestation under- and overnutrition have differential impacts when combined with a post-natal obesogenic diet on glucose-lactate-insulin adaptations during metabolic challenges in adolescent sheep.

Khanal P, Axel AM, Kongsted AH, Husted SV, Johnsen L, Pandey D, Pedersen KL, Birtwistle M, Markussen B, Kadarmideen HN, Nielsen MO.

Acta Physiol (Oxf). 2015 Feb;213(2):519-36. doi: 10.1111/apha.12391. Epub 2014 Oct 13.


YAP-induced resistance of cancer cells to antitubulin drugs is modulated by a Hippo-independent pathway.

Zhao Y, Khanal P, Savage P, She YM, Cyr TD, Yang X.

Cancer Res. 2014 Aug 15;74(16):4493-503. doi: 10.1158/0008-5472.CAN-13-2712. Epub 2014 May 8.


Collaborative virtual reality based advanced cardiac life support training simulator using virtual reality principles.

Khanal P, Vankipuram A, Ashby A, Vankipuram M, Gupta A, Drumm-Gurnee D, Josey K, Tinker L, Smith M.

J Biomed Inform. 2014 Oct;51:49-59. doi: 10.1016/j.jbi.2014.04.005. Epub 2014 Apr 13.


Biotechnological production of inducible defense-related proteins in edible radish (raphanus sativus) found in Nepal.

Khanal P, Karmacharya A, Sharma S, Nepal AK, Shrestha K.

J Clin Diagn Res. 2014 Jan;8(1):112-5. doi: 10.7860/JCDR/2014/6788.3956. Epub 2014 Jan 12.


COT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast cancer.

Kim G, Khanal P, Kim JY, Yun HJ, Lim SC, Shim JH, Choi HS.

Mol Carcinog. 2015 Jun;54(6):440-8. doi: 10.1002/mc.22112. Epub 2013 Nov 22.


Design and development of a virtual reality simulator for advanced cardiac life support training.

Vankipuram A, Khanal P, Ashby A, Vankipuram M, Gupta A, DrummGurnee D, Josey K, Smith M.

IEEE J Biomed Health Inform. 2014 Jul;18(4):1478-84. doi: 10.1109/JBHI.2013.2285102. Epub 2013 Oct 9.


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