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Items: 1 to 50 of 72

1.

TLR2 Plays a Pivotal Role in Mediating Mucosal Serotonin Production in the Gut.

Wang H, Kwon YH, Dewan V, Vahedi F, Syed S, Fontes ME, Ashkar AA, Surette MG, Khan WI.

J Immunol. 2019 May 15;202(10):3041-3052. doi: 10.4049/jimmunol.1801034. Epub 2019 Apr 5.

PMID:
30952815
2.

Emerging Roles for Serotonin in Regulating Metabolism: New Implications for an Ancient Molecule.

Yabut JM, Crane JD, Green AE, Keating DJ, Khan WI, Steinberg GR.

Endocr Rev. 2019 Mar 22. pii: er.2018-00283. doi: 10.1210/er.2018-00283. [Epub ahead of print]

PMID:
30901029
3.

Autophagy: roles in intestinal mucosal homeostasis and inflammation.

Haq S, Grondin J, Banskota S, Khan WI.

J Biomed Sci. 2019 Feb 14;26(1):19. doi: 10.1186/s12929-019-0512-2. Review.

4.

Modulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to Colitis.

Kwon YH, Wang H, Denou E, Ghia JE, Rossi L, Fontes ME, Bernier SP, Shajib MS, Banskota S, Collins SM, Surette MG, Khan WI.

Cell Mol Gastroenterol Hepatol. 2019;7(4):709-728. doi: 10.1016/j.jcmgh.2019.01.004. Epub 2019 Feb 1.

5.

Abnormal absorptive colonic motor activity in germ-free mice is rectified by butyrate, an effect possibly mediated by mucosal serotonin.

Vincent AD, Wang XY, Parsons SP, Khan WI, Huizinga JD.

Am J Physiol Gastrointest Liver Physiol. 2018 Nov 1;315(5):G896-G907. doi: 10.1152/ajpgi.00237.2017. Epub 2018 Aug 10.

PMID:
30095295
6.

Serotonin in the gut: Blessing or a curse.

Banskota S, Ghia JE, Khan WI.

Biochimie. 2019 Jun;161:56-64. doi: 10.1016/j.biochi.2018.06.008. Epub 2018 Jun 14. Review.

PMID:
29909048
7.

Inflammation-related differences in mucosa-associated microbiota and intestinal barrier function in colonic Crohn's disease.

Libertucci J, Dutta U, Kaur S, Jury J, Rossi L, Fontes ME, Shajib MS, Khan WI, Surette MG, Verdu EF, Armstrong D.

Am J Physiol Gastrointest Liver Physiol. 2018 Sep 1;315(3):G420-G431. doi: 10.1152/ajpgi.00411.2017. Epub 2018 May 31.

PMID:
29848021
8.

Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration.

Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1550-E1559. doi: 10.1073/pnas.1720553115. Epub 2018 Jan 31.

9.

Loss-of-function mutations in ADCY3 cause monogenic severe obesity.

Saeed S, Bonnefond A, Tamanini F, Mirza MU, Manzoor J, Janjua QM, Din SM, Gaitan J, Milochau A, Durand E, Vaillant E, Haseeb A, De Graeve F, Rabearivelo I, Sand O, Queniat G, Boutry R, Schott DA, Ayesha H, Ali M, Khan WI, Butt TA, Rinne T, Stumpel C, Abderrahmani A, Lang J, Arslan M, Froguel P.

Nat Genet. 2018 Feb;50(2):175-179. doi: 10.1038/s41588-017-0023-6. Epub 2018 Jan 8.

10.

Comparison of Fecal Calprotectin Methods for Predicting Relapse of Pediatric Inflammatory Bowel Disease.

Kittanakom S, Shajib MS, Garvie K, Turner J, Brooks D, Odeh S, Issenman R, Chetty VT, Macri J, Khan WI.

Can J Gastroenterol Hepatol. 2017;2017:1450970. doi: 10.1155/2017/1450970. Epub 2017 Apr 16.

11.

Diverse Effects of Gut-Derived Serotonin in Intestinal Inflammation.

Shajib MS, Baranov A, Khan WI.

ACS Chem Neurosci. 2017 May 17;8(5):920-931. doi: 10.1021/acschemneuro.6b00414. Epub 2017 Mar 27. Review.

PMID:
28288510
12.

Different Th17 immunity in gut, liver, and adipose tissues during obesity: the role of diet, genetics, and microbes.

Cavallari JF, Denou E, Foley KP, Khan WI, Schertzer JD.

Gut Microbes. 2016;7(1):82-9. doi: 10.1080/19490976.2015.1127481.

13.

Fecal calprotectin: its scope and utility in the management of inflammatory bowel disease.

Ikhtaire S, Shajib MS, Reinisch W, Khan WI.

J Gastroenterol. 2016 May;51(5):434-46. doi: 10.1007/s00535-016-1182-4. Epub 2016 Feb 20. Review.

PMID:
26897740
14.

New Role of Nod Proteins in Regulation of Intestinal Goblet Cell Response in the Context of Innate Host Defense in an Enteric Parasite Infection.

Wang H, Kim JJ, Denou E, Gallagher A, Thornton DJ, Shajib MS, Xia L, Schertzer JD, Grencis RK, Philpott DJ, Khan WI.

Infect Immun. 2015 Nov 2;84(1):275-85. doi: 10.1128/IAI.01187-15. Print 2016 Jan.

15.

Overlap Chronic Placental Inflammation Is Associated with a Unique Gene Expression Pattern.

Raman K, Wang H, Troncone MJ, Khan WI, Pare G, Terry J.

PLoS One. 2015 Jul 24;10(7):e0133738. doi: 10.1371/journal.pone.0133738. eCollection 2015.

16.

Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation.

Kim JJ, Wang H, Terc JD, Zambrowicz B, Yang QM, Khan WI.

Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15;309(6):G455-65. doi: 10.1152/ajpgi.00299.2014. Epub 2015 Jul 23.

17.

Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance.

Denou E, Lolmède K, Garidou L, Pomie C, Chabo C, Lau TC, Fullerton MD, Nigro G, Zakaroff-Girard A, Luche E, Garret C, Serino M, Amar J, Courtney M, Cavallari JF, Henriksbo BD, Barra NG, Foley KP, McPhee JB, Duggan BM, O'Neill HM, Lee AJ, Sansonetti P, Ashkar AA, Khan WI, Surette MG, Bouloumié A, Steinberg GR, Burcelin R, Schertzer JD.

EMBO Mol Med. 2015 Mar;7(3):259-74. doi: 10.15252/emmm.201404169.

18.

5-HT7 receptor signaling: improved therapeutic strategy in gut disorders.

Kim JJ, Khan WI.

Front Behav Neurosci. 2014 Dec 11;8:396. doi: 10.3389/fnbeh.2014.00396. eCollection 2014. Review.

19.

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis.

Crane JD, Palanivel R, Mottillo EP, Bujak AL, Wang H, Ford RJ, Collins A, Blümer RM, Fullerton MD, Yabut JM, Kim JJ, Ghia JE, Hamza SM, Morrison KM, Schertzer JD, Dyck JR, Khan WI, Steinberg GR.

Nat Med. 2015 Feb;21(2):166-72. doi: 10.1038/nm.3766. Epub 2014 Dec 8.

20.

The role of serotonin and its receptors in activation of immune responses and inflammation.

Shajib MS, Khan WI.

Acta Physiol (Oxf). 2015 Mar;213(3):561-74. doi: 10.1111/apha.12430. Epub 2014 Dec 11. Review.

PMID:
25439045
21.

Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis.

Flannigan KL, Agbor TA, Blackler RW, Kim JJ, Khan WI, Verdu EF, Ferraz JG, Wallace JL.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13559-64. doi: 10.1073/pnas.1413390111. Epub 2014 Sep 3.

22.

T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes.

Chu DK, Mohammed-Ali Z, Jiménez-Saiz R, Walker TD, Goncharova S, Llop-Guevara A, Kong J, Gordon ME, Barra NG, Gillgrass AE, Van Seggelen H, Khan WI, Ashkar AA, Bramson JL, Humbles AA, Kolbeck R, Waserman S, Jordana M.

Mucosal Immunol. 2014 Nov;7(6):1395-404. doi: 10.1038/mi.2014.29. Epub 2014 Apr 30.

PMID:
24781052
23.

The Role of 5-HT Dysregulation in Inflammatory Bowel Disease.

Khan WI.

Gastroenterol Hepatol (N Y). 2013 Apr;9(4):259-61. No abstract available.

24.
25.

Small molecule immunomodulins from cultures of the human microbiome member Lactobacillus plantarum.

Zvanych R, Lukenda N, Kim JJ, Li X, Petrof EO, Khan WI, Magarvey NA.

J Antibiot (Tokyo). 2014 Jan;67(1):85-8. doi: 10.1038/ja.2013.126. Epub 2013 Nov 27.

PMID:
24281660
26.

Interleukin 13 and serotonin: linking the immune and endocrine systems in murine models of intestinal inflammation.

Shajib MS, Wang H, Kim JJ, Sunjic I, Ghia JE, Denou E, Collins M, Denburg JA, Khan WI.

PLoS One. 2013 Aug 28;8(8):e72774. doi: 10.1371/journal.pone.0072774. eCollection 2013.

27.

Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation.

Kim JJ, Bridle BW, Ghia JE, Wang H, Syed SN, Manocha MM, Rengasamy P, Shajib MS, Wan Y, Hedlund PB, Khan WI.

J Immunol. 2013 May 1;190(9):4795-804. doi: 10.4049/jimmunol.1201887. Epub 2013 Apr 3.

28.

Lactobacillus rhamnosus ingestion promotes innate host defense in an enteric parasitic infection.

McClemens J, Kim JJ, Wang H, Mao YK, Collins M, Kunze W, Bienenstock J, Forsythe P, Khan WI.

Clin Vaccine Immunol. 2013 Jun;20(6):818-26. doi: 10.1128/CVI.00047-13. Epub 2013 Mar 27.

29.

Goblet cells and mucins: role in innate defense in enteric infections.

Kim JJ, Khan WI.

Pathogens. 2013 Feb 4;2(1):55-70. doi: 10.3390/pathogens2010055. Review.

30.

Serotonin and GI Disorders: An Update on Clinical and Experimental Studies.

Manocha M, Khan WI.

Clin Transl Gastroenterol. 2012 Apr 26;3:e13. doi: 10.1038/ctg.2012.8.

31.

Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling.

Hanson D, Murray PG, Coulson T, Sud A, Omokanye A, Stratta E, Sakhinia F, Bonshek C, Wilson LC, Wakeling E, Temtamy SA, Aglan M, Rosser EM, Mansour S, Carcavilla A, Nampoothiri S, Khan WI, Banerjee I, Chandler KE, Black GC, Clayton PE.

J Mol Endocrinol. 2012 Oct 30;49(3):267-75. doi: 10.1530/JME-12-0034. Print 2012 Dec.

PMID:
23018678
32.

IL-13-mediated immunological control of enterochromaffin cell hyperplasia and serotonin production in the gut.

Manocha M, Shajib MS, Rahman MM, Wang H, Rengasamy P, Bogunovic M, Jordana M, Mayer L, Khan WI.

Mucosal Immunol. 2013 Jan;6(1):146-55. doi: 10.1038/mi.2012.58. Epub 2012 Jul 4.

PMID:
22763407
33.

Impact of 5-HT₃ receptor antagonists on peripheral and central diseases.

Fakhfouri G, Rahimian R, Ghia JE, Khan WI, Dehpour AR.

Drug Discov Today. 2012 Jul;17(13-14):741-7. doi: 10.1016/j.drudis.2012.02.009. Epub 2012 Feb 25. Review.

PMID:
22390946
34.

Investigating intestinal inflammation in DSS-induced model of IBD.

Kim JJ, Shajib MS, Manocha MM, Khan WI.

J Vis Exp. 2012 Feb 1;(60). pii: 3678. doi: 10.3791/3678.

35.

Serotonin activates dendritic cell function in the context of gut inflammation.

Li N, Ghia JE, Wang H, McClemens J, Cote F, Suehiro Y, Mallet J, Khan WI.

Am J Pathol. 2011 Feb;178(2):662-71. doi: 10.1016/j.ajpath.2010.10.028.

36.

Adoptive transfer of macrophage from mice with depression-like behavior enhances susceptibility to colitis.

Ghia JE, Park AJ, Blennerhassett P, Khan WI, Collins SM.

Inflamm Bowel Dis. 2011 Jul;17(7):1474-89. doi: 10.1002/ibd.21531. Epub 2011 Jan 18.

PMID:
21246669
37.

A mouse model of airway disease: oncostatin M-induced pulmonary eosinophilia, goblet cell hyperplasia, and airway hyperresponsiveness are STAT6 dependent, and interstitial pulmonary fibrosis is STAT6 independent.

Fritz DK, Kerr C, Fattouh R, Llop-Guevara A, Khan WI, Jordana M, Richards CD.

J Immunol. 2011 Jan 15;186(2):1107-18. doi: 10.4049/jimmunol.0903476. Epub 2010 Dec 15.

38.

Mechanisms underlying gut dysfunction in a murine model of chronic parasitic infection.

Motomura Y, Khan WI, El-Sharkawy RT, Verma-Gandhu M, Grencis RK, Collins SM.

Am J Physiol Gastrointest Liver Physiol. 2010 Dec;299(6):G1354-60. doi: 10.1152/ajpgi.00324.2010. Epub 2010 Sep 23.

39.

Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice.

Bercik P, Verdu EF, Foster JA, Macri J, Potter M, Huang X, Malinowski P, Jackson W, Blennerhassett P, Neufeld KA, Lu J, Khan WI, Corthesy-Theulaz I, Cherbut C, Bergonzelli GE, Collins SM.

Gastroenterology. 2010 Dec;139(6):2102-2112.e1. doi: 10.1053/j.gastro.2010.06.063. Epub 2010 Jun 27.

PMID:
20600016
40.

Gut hormones: emerging role in immune activation and inflammation.

Khan WI, Ghia JE.

Clin Exp Immunol. 2010 Jul 1;161(1):19-27. doi: 10.1111/j.1365-2249.2010.04150.x. Epub 2010 Apr 9. Review.

41.

Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection.

Hasnain SZ, Wang H, Ghia JE, Haq N, Deng Y, Velcich A, Grencis RK, Thornton DJ, Khan WI.

Gastroenterology. 2010 May;138(5):1763-71. doi: 10.1053/j.gastro.2010.01.045. Epub 2010 Feb 4.

42.

Persistent gut motor dysfunction in a murine model of T-cell-induced enteropathy.

Mizutani T, Akiho H, Khan WI, Murao H, Ogino H, Kanayama K, Nakamura K, Takayanagi R.

Neurogastroenterol Motil. 2010 Feb;22(2):196-203, e65. doi: 10.1111/j.1365-2982.2009.01396.x. Epub 2009 Sep 7.

PMID:
19735478
43.

Serotonin has a key role in pathogenesis of experimental colitis.

Ghia JE, Li N, Wang H, Collins M, Deng Y, El-Sharkawy RT, Côté F, Mallet J, Khan WI.

Gastroenterology. 2009 Nov;137(5):1649-60. doi: 10.1053/j.gastro.2009.08.041. Epub 2009 Aug 23.

PMID:
19706294
44.

CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis.

Zhang S, Bernard D, Khan WI, Kaplan MH, Bramson JL, Wan Y.

Eur J Immunol. 2009 May;39(5):1252-9. doi: 10.1002/eji.200839152.

45.

Reactivation of inflammatory bowel disease in a mouse model of depression.

Ghia JE, Blennerhassett P, Deng Y, Verdu EF, Khan WI, Collins SM.

Gastroenterology. 2009 Jun;136(7):2280-2288.e1-4. doi: 10.1053/j.gastro.2009.02.069. Epub 2009 Mar 9.

PMID:
19272381
46.

Helminth antigen-based strategy to ameliorate inflammation in an experimental model of colitis.

Motomura Y, Wang H, Deng Y, El-Sharkawy RT, Verdu EF, Khan WI.

Clin Exp Immunol. 2009 Jan;155(1):88-95. doi: 10.1111/j.1365-2249.2008.03805.x. Epub 2008 Nov 6.

47.

Physiological changes in the gastrointestinal tract and host protective immunity: learning from the mouse-Trichinella spiralis model.

Khan WI.

Parasitology. 2008 May;135(6):671-82. doi: 10.1017/S0031182008004381. Review.

PMID:
18501042
48.

Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments.

Motomura Y, Ghia JE, Wang H, Akiho H, El-Sharkawy RT, Collins M, Wan Y, McLaughlin JT, Khan WI.

Gut. 2008 Apr;57(4):475-81. doi: 10.1136/gut.2007.129296. Epub 2008 Jan 15. Erratum in: Gut. 2008 Sep;57(9):1340.

PMID:
18198200
49.

Cytokine modulation of muscarinic receptors in the murine intestine.

Akiho H, Khan WI, Al-Kaabi A, Blennerhassett P, Deng Y, Collins SM.

Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G250-5. Epub 2007 Apr 12.

50.

CD4+ T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection.

Wang H, Steeds J, Motomura Y, Deng Y, Verma-Gandhu M, El-Sharkawy RT, McLaughlin JT, Grencis RK, Khan WI.

Gut. 2007 Jul;56(7):949-57. Epub 2007 Feb 15.

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