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Items: 48


AAA ATPase Afg1 preserves organellar fidelity and cellular healthspan by maintaining mitochondrial matrix proteostasis.

Germany EM, Zahayko N, Huebsch ML, Fox JL, Prahlad V, Khalimonchuk O.

J Cell Sci. 2018 Oct 11. pii: jcs.219956. doi: 10.1242/jcs.219956. [Epub ahead of print]


Intraperitoneal nanotherapy for metastatic ovarian cancer based on siRNA-mediated suppression of DJ-1 protein combined with a low dose of cisplatin.

Schumann C, Chan S, Millar JA, Bortnyak Y, Carey K, Fedchyk A, Wong L, Korzun T, Moses AS, Lorenz A, Shea D, Taratula O, Khalimonchuk O, Taratula O.

Nanomedicine. 2018 Apr 7;14(4):1395-1405. doi: 10.1016/j.nano.2018.03.005. [Epub ahead of print]


Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission.

Tsushima K, Bugger H, Wende AR, Soto J, Jenson GA, Tor AR, McGlauflin R, Kenny HC, Zhang Y, Souvenir R, Hu XX, Sloan CL, Pereira RO, Lira VA, Spitzer KW, Sharp TL, Shoghi KI, Sparagna GC, Rog-Zielinska EA, Kohl P, Khalimonchuk O, Schaffer JE, Abel ED.

Circ Res. 2018 Jan 5;122(1):58-73. doi: 10.1161/CIRCRESAHA.117.311307. Epub 2017 Nov 1.


Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2.

Xie JL, Bohovych I, Wong EOY, Lambert JP, Gingras AC, Khalimonchuk O, Cowen LE, Leach MD.

Microb Cell. 2017 Oct 2;4(10):342-361. doi: 10.15698/mic2017.10.594.


Metalloproteases of the Inner Mitochondrial Membrane.

Levytskyy RM, Bohovych I, Khalimonchuk O.

Biochemistry. 2017 Sep 12;56(36):4737-4746. doi: 10.1021/acs.biochem.7b00663. Epub 2017 Aug 30. Review.


Correction for Khalimonchuk et al., "Formation of the Redox Cofactor Centers during Cox1 Maturation in Yeast Cytochrome Oxidase".

Khalimonchuk O, Bestwick M, Meunier B, Watts TC, Winge DR.

Mol Cell Biol. 2017 May 16;37(11). pii: e00127-17. doi: 10.1128/MCB.00127-17. Print 2017 Jun 1. No abstract available.


The Assembly Factor Pet117 Couples Heme a Synthase Activity to Cytochrome Oxidase Assembly.

Taylor NG, Swenson S, Harris NJ, Germany EM, Fox JL, Khalimonchuk O.

J Biol Chem. 2017 Feb 3;292(5):1815-1825. doi: 10.1074/jbc.M116.766980. Epub 2016 Dec 20.


Evidence for Pipecolate Oxidase in Mediating Protection Against Hydrogen Peroxide Stress.

Natarajan SK, Muthukrishnan E, Khalimonchuk O, Mott JL, Becker DF.

J Cell Biochem. 2017 Jul;118(7):1678-1688. doi: 10.1002/jcb.25825. Epub 2016 Dec 13.


Sending Out an SOS: Mitochondria as a Signaling Hub.

Bohovych I, Khalimonchuk O.

Front Cell Dev Biol. 2016 Oct 13;4:109. eCollection 2016. Review.


Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling To Modulate Physiological Plasticity and Cellular Stress Responses.

Bohovych I, Kastora S, Christianson S, Topil D, Kim H, Fangman T, Zhou YJ, Barrientos A, Lee J, Brown AJ, Khalimonchuk O.

Mol Cell Biol. 2016 Aug 12;36(17):2300-12. doi: 10.1128/MCB.00156-16. Print 2016 Sep 1.


Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions.

Anandhan A, Lei S, Levytskyy R, Pappa A, Panayiotidis MI, Cerny RL, Khalimonchuk O, Powers R, Franco R.

Mol Neurobiol. 2017 Jul;54(5):3825-3842. doi: 10.1007/s12035-016-9906-2. Epub 2016 Jun 20.


Mechanistic Nanotherapeutic Approach Based on siRNA-Mediated DJ-1 Protein Suppression for Platinum-Resistant Ovarian Cancer.

Schumann C, Chan S, Khalimonchuk O, Khal S, Moskal V, Shah V, Alani AW, Taratula O, Taratula O.

Mol Pharm. 2016 Jun 6;13(6):2070-83. doi: 10.1021/acs.molpharmaceut.6b00205. Epub 2016 May 26.


Mitochondrial Quality Control Proteases in Neuronal Welfare.

Levytskyy RM, Germany EM, Khalimonchuk O.

J Neuroimmune Pharmacol. 2016 Dec;11(4):629-644. Epub 2016 May 2. Review.


Analysis of Oligomerization Properties of Heme a Synthase Provides Insights into Its Function in Eukaryotes.

Swenson S, Cannon A, Harris NJ, Taylor NG, Fox JL, Khalimonchuk O.

J Biol Chem. 2016 May 6;291(19):10411-25. doi: 10.1074/jbc.M115.707539. Epub 2016 Mar 3.


Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.

Navarro-Yepes J, Anandhan A, Bradley E, Bohovych I, Yarabe B, de Jong A, Ovaa H, Zhou Y, Khalimonchuk O, Quintanilla-Vega B, Franco R.

Mol Neurobiol. 2016 Oct;53(8):5229-51. doi: 10.1007/s12035-015-9414-9. Epub 2015 Sep 26.


Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic Function and Respiratory Supercomplex Stability.

Bohovych I, Fernandez MR, Rahn JJ, Stackley KD, Bestman JE, Anandhan A, Franco R, Claypool SM, Lewis RE, Chan SS, Khalimonchuk O.

Sci Rep. 2015 Sep 14;5:13989. doi: 10.1038/srep13989.


Mitochondrial dysfunction and loss of glutamate uptake in primary astrocytes exposed to titanium dioxide nanoparticles.

Wilson CL, Natarajan V, Hayward SL, Khalimonchuk O, Kidambi S.

Nanoscale. 2015 Nov 28;7(44):18477-88. doi: 10.1039/c5nr03646a. Epub 2015 Aug 14.


ROS-induced nanotherapeutic approach for ovarian cancer treatment based on the combinatorial effect of photodynamic therapy and DJ-1 gene suppression.

Schumann C, Taratula O, Khalimonchuk O, Palmer AL, Cronk LM, Jones CV, Escalante CA, Taratula O.

Nanomedicine. 2015 Nov;11(8):1961-70. doi: 10.1016/j.nano.2015.07.005. Epub 2015 Jul 31.


Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking.

McAtee CO, Berkebile AR, Elowsky CG, Fangman T, Barycki JJ, Wahl JK 3rd, Khalimonchuk O, Naslavsky N, Caplan S, Simpson MA.

J Biol Chem. 2015 May 22;290(21):13144-56. doi: 10.1074/jbc.M115.647446. Epub 2015 Apr 8.


Mitochondrial protein quality control: the mechanisms guarding mitochondrial health.

Bohovych I, Chan SS, Khalimonchuk O.

Antioxid Redox Signal. 2015 Apr 20;22(12):977-94. doi: 10.1089/ars.2014.6199. Epub 2015 Feb 11. Review.


Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.

Anandhan A, Rodriguez-Rocha H, Bohovych I, Griggs AM, Zavala-Flores L, Reyes-Reyes EM, Seravalli J, Stanciu LA, Lee J, Rochet JC, Khalimonchuk O, Franco R.

Neurobiol Dis. 2015 Sep;81:76-92. doi: 10.1016/j.nbd.2014.11.018. Epub 2014 Dec 8.


Stress-triggered activation of the metalloprotease Oma1 involves its C-terminal region and is important for mitochondrial stress protection in yeast.

Bohovych I, Donaldson G, Christianson S, Zahayko N, Khalimonchuk O.

J Biol Chem. 2014 May 9;289(19):13259-72. doi: 10.1074/jbc.M113.542910. Epub 2014 Mar 19.


Oxidative stress, redox signaling, and autophagy: cell death versus survival.

Navarro-Yepes J, Burns M, Anandhan A, Khalimonchuk O, del Razo LM, Quintanilla-Vega B, Pappa A, Panayiotidis MI, Franco R.

Antioxid Redox Signal. 2014 Jul 1;21(1):66-85. doi: 10.1089/ars.2014.5837. Epub 2014 Mar 24. Review.


YCF1-mediated cadmium resistance in yeast is dependent on copper metabolism and antioxidant enzymes.

Wei W, Smith N, Wu X, Kim H, Seravalli J, Khalimonchuk O, Lee J.

Antioxid Redox Signal. 2014 Oct 1;21(10):1475-89. doi: 10.1089/ars.2013.5436. Epub 2014 Feb 25.


Late-stage maturation of the Rieske Fe/S protein: Mzm1 stabilizes Rip1 but does not facilitate its translocation by the AAA ATPase Bcs1.

Cui TZ, Smith PM, Fox JL, Khalimonchuk O, Winge DR.

Mol Cell Biol. 2012 Nov;32(21):4400-9. doi: 10.1128/MCB.00441-12. Epub 2012 Aug 27.


Oligomerization of heme o synthase in cytochrome oxidase biogenesis is mediated by cytochrome oxidase assembly factor Coa2.

Khalimonchuk O, Kim H, Watts T, Perez-Martinez X, Winge DR.

J Biol Chem. 2012 Aug 3;287(32):26715-26. doi: 10.1074/jbc.M112.377200. Epub 2012 Jun 5.


Structure, function, and assembly of heme centers in mitochondrial respiratory complexes.

Kim HJ, Khalimonchuk O, Smith PM, Winge DR.

Biochim Biophys Acta. 2012 Sep;1823(9):1604-16. doi: 10.1016/j.bbamcr.2012.04.008. Epub 2012 Apr 24. Review.


Selective Oma1 protease-mediated proteolysis of Cox1 subunit of cytochrome oxidase in assembly mutants.

Khalimonchuk O, Jeong MY, Watts T, Ferris E, Winge DR.

J Biol Chem. 2012 Mar 2;287(10):7289-300. doi: 10.1074/jbc.M111.313148. Epub 2012 Jan 4.


The LYR protein Mzm1 functions in the insertion of the Rieske Fe/S protein in yeast mitochondria.

Atkinson A, Smith P, Fox JL, Cui TZ, Khalimonchuk O, Winge DR.

Mol Cell Biol. 2011 Oct;31(19):3988-96. doi: 10.1128/MCB.05673-11. Epub 2011 Aug 1.


Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria.

Troadec MB, Warner D, Wallace J, Thomas K, Spangrude GJ, Phillips J, Khalimonchuk O, Paw BH, Ward DM, Kaplan J.

Blood. 2011 May 19;117(20):5494-502. doi: 10.1182/blood-2010-11-319483. Epub 2011 Feb 10.


Mne1 is a novel component of the mitochondrial splicing apparatus responsible for processing of a COX1 group I intron in yeast.

Watts T, Khalimonchuk O, Wolf RZ, Turk EM, Mohr G, Winge DR.

J Biol Chem. 2011 Mar 25;286(12):10137-46. doi: 10.1074/jbc.M110.205625. Epub 2011 Jan 21.


Analysis of Leigh syndrome mutations in the yeast SURF1 homolog reveals a new member of the cytochrome oxidase assembly factor family.

Bestwick M, Jeong MY, Khalimonchuk O, Kim H, Winge DR.

Mol Cell Biol. 2010 Sep;30(18):4480-91. doi: 10.1128/MCB.00228-10. Epub 2010 Jul 12.


Mzm1 influences a labile pool of mitochondrial zinc important for respiratory function.

Atkinson A, Khalimonchuk O, Smith P, Sabic H, Eide D, Winge DR.

J Biol Chem. 2010 Jun 18;285(25):19450-9. doi: 10.1074/jbc.M110.109793. Epub 2010 Apr 19.


Formation of the redox cofactor centers during Cox1 maturation in yeast cytochrome oxidase.

Khalimonchuk O, Bestwick M, Meunier B, Watts TC, Winge DR.

Mol Cell Biol. 2010 Feb;30(4):1004-17. doi: 10.1128/MCB.00640-09. Epub 2009 Dec 7. Erratum in: Mol Cell Biol. 2017 May 16;37(11):.


Proteomic remodelling of mitochondrial oxidative pathways in pressure overload-induced heart failure.

Bugger H, Schwarzer M, Chen D, Schrepper A, Amorim PA, Schoepe M, Nguyen TD, Mohr FW, Khalimonchuk O, Weimer BC, Doenst T.

Cardiovasc Res. 2010 Jan 15;85(2):376-84. doi: 10.1093/cvr/cvp344. Epub 2009 Oct 19.


The role of Coa2 in hemylation of yeast Cox1 revealed by its genetic interaction with Cox10.

Bestwick M, Khalimonchuk O, Pierrel F, Winge DR.

Mol Cell Biol. 2010 Jan;30(1):172-85. doi: 10.1128/MCB.00869-09.


SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.

Hao HX, Khalimonchuk O, Schraders M, Dephoure N, Bayley JP, Kunst H, Devilee P, Cremers CW, Schiffman JD, Bentz BG, Gygi SP, Winge DR, Kremer H, Rutter J.

Science. 2009 Aug 28;325(5944):1139-42. doi: 10.1126/science.1175689. Epub 2009 Jul 23.


Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.

Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED.

Circulation. 2009 Mar 10;119(9):1272-83. doi: 10.1161/CIRCULATIONAHA.108.792101. Epub 2009 Feb 23.


Coa2 is an assembly factor for yeast cytochrome c oxidase biogenesis that facilitates the maturation of Cox1.

Pierrel F, Khalimonchuk O, Cobine PA, Bestwick M, Winge DR.

Mol Cell Biol. 2008 Aug;28(16):4927-39. doi: 10.1128/MCB.00057-08. Epub 2008 Jun 9.


Pet191 is a cytochrome c oxidase assembly factor in Saccharomyces cerevisiae.

Khalimonchuk O, Rigby K, Bestwick M, Pierrel F, Cobine PA, Winge DR.

Eukaryot Cell. 2008 Aug;7(8):1427-31. doi: 10.1128/EC.00132-08. Epub 2008 May 23.


Mapping the functional interaction of Sco1 and Cox2 in cytochrome oxidase biogenesis.

Rigby K, Cobine PA, Khalimonchuk O, Winge DR.

J Biol Chem. 2008 May 30;283(22):15015-22. doi: 10.1074/jbc.M710072200. Epub 2008 Apr 7.


Function and redox state of mitochondrial localized cysteine-rich proteins important in the assembly of cytochrome c oxidase.

Khalimonchuk O, Winge DR.

Biochim Biophys Acta. 2008 Apr;1783(4):618-28. Epub 2007 Nov 9. Review.


Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly.

Pierrel F, Bestwick ML, Cobine PA, Khalimonchuk O, Cricco JA, Winge DR.

EMBO J. 2007 Oct 17;26(20):4335-46. Epub 2007 Sep 20.


Evidence for a pro-oxidant intermediate in the assembly of cytochrome oxidase.

Khalimonchuk O, Bird A, Winge DR.

J Biol Chem. 2007 Jun 15;282(24):17442-9. Epub 2007 Apr 12.


Sequential processing of a mitochondrial tandem protein: insights into protein import in Schizosaccharomyces pombe.

Khalimonchuk O, Ott M, Funes S, Ostermann K, Rödel G, Herrmann JM.

Eukaryot Cell. 2006 Jul;5(7):997-1006.


Biogenesis of cytochrome c oxidase.

Khalimonchuk O, Rödel G.

Mitochondrion. 2005 Dec;5(6):363-88. Epub 2005 Sep 29. Review.


[The reversion of Pichia guilliermondii transformants to the wild-type phenotype].

Piniaga IuV, Prokopiv TM, Petrishin AV, Khalimonchuk OV, Protchenko OV, Fedorovich DV, Boretskiĭ IuR.

Mikrobiologiia. 2002 May-Jun;71(3):368-72. Russian.


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