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Items: 1 to 50 of 168


Sulodexide promotes arterial relaxation via endothelium-dependent nitric oxide-mediated pathway.

Raffetto JD, Calanni F, Mattana P, Khalil RA.

Biochem Pharmacol. 2019 Aug;166:347-356. doi: 10.1016/j.bcp.2019.04.021. Epub 2019 Apr 20.


A Disintegrin and Metalloproteinase (ADAM) and ADAM with thrombospondin motifs (ADAMTS) family in vascular biology and disease.

Zhong S, Khalil RA.

Biochem Pharmacol. 2019 Jun;164:188-204. doi: 10.1016/j.bcp.2019.03.033. Epub 2019 Mar 21. Review.


Molecular determinants of microvascular dysfunction in hypertensive pregnancy and preeclampsia.

Yu W, Gao W, Rong D, Wu Z, Khalil RA.

Microcirculation. 2018 Oct 19:e12508. doi: 10.1111/micc.12508. [Epub ahead of print]


Adaptive reduction of human myometrium contractile activity in response to prolonged uterine stretch during term and twin pregnancy. Role of TREK-1 channel.

Yin Z, He W, Li Y, Li D, Li H, Yang Y, Wei Z, Shen B, Wang X, Cao Y, Khalil RA.

Biochem Pharmacol. 2018 Jun;152:252-263. doi: 10.1016/j.bcp.2018.03.021. Epub 2018 Mar 22.


Placental growth factor reverses decreased vascular and uteroplacental MMP-2 and MMP-9 and increased MMP-1 and MMP-7 and collagen types I and IV in hypertensive pregnancy.

Ren Z, Cui N, Zhu M, Khalil RA.

Am J Physiol Heart Circ Physiol. 2018 Jul 1;315(1):H33-H47. doi: 10.1152/ajpheart.00045.2018. Epub 2018 Mar 23.


Evolving mechanisms of vascular smooth muscle contraction highlight key targets in vascular disease.

Liu Z, Khalil RA.

Biochem Pharmacol. 2018 Jul;153:91-122. doi: 10.1016/j.bcp.2018.02.012. Epub 2018 Feb 13. Review.


Progesterone inhibits contraction and increases TREK-1 potassium channel expression in late pregnant rat uterus.

Yin Z, Li Y, He W, Li D, Li H, Yang Y, Shen B, Wang X, Cao Y, Khalil RA.

Oncotarget. 2017 Dec 7;9(1):651-661. doi: 10.18632/oncotarget.23084. eCollection 2018 Jan 2.



Khalil RA.

Adv Pharmacol. 2018;81:xi-xii. doi: 10.1016/S1054-3589(17)30098-4. No abstract available.


Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease.

Wang X, Khalil RA.

Adv Pharmacol. 2018;81:241-330. doi: 10.1016/bs.apha.2017.08.002. Epub 2017 Sep 19.


Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide-Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model.

Christou H, Hudalla H, Michael Z, Filatava EJ, Li J, Zhu M, Possomato-Vieira JS, Dias-Junior C, Kourembanas S, Khalil RA.

J Pharmacol Exp Ther. 2018 Feb;364(2):258-274. doi: 10.1124/jpet.117.244798. Epub 2017 Dec 6.


Small infrarenal aortic diameter associated with lower-extremity peripheral artery disease in Chinese hypertensive adults.

Liu J, Jia X, Jia S, Qin X, Zhang T, Liu L, Li H, Rong D, Zhou Z, Song Y, Zuo S, Duan C, Wu Z, Wei R, Ge Y, Wang X, Kong W, Xu X, Khalil RA, Huo Y, Guo W.

Sci Rep. 2017 Nov 6;7(1):14547. doi: 10.1038/s41598-017-12587-x.


Angiogenic imbalance and diminished matrix metalloproteinase-2 and -9 underlie regional decreases in uteroplacental vascularization and feto-placental growth in hypertensive pregnancy.

Dias-Junior CA, Chen J, Cui N, Chiang CL, Zhu M, Ren Z, Possomato-Vieira JS, Khalil RA.

Biochem Pharmacol. 2017 Dec 15;146:101-116. doi: 10.1016/j.bcp.2017.09.005. Epub 2017 Sep 11.



Khalil RA.

Prog Mol Biol Transl Sci. 2017;148:xi-xii. doi: 10.1016/S1877-1173(17)30081-9. No abstract available.


Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia.

Chen J, Khalil RA.

Prog Mol Biol Transl Sci. 2017;148:87-165. doi: 10.1016/bs.pmbts.2017.04.001. Epub 2017 May 22. Review.


Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders.

Liu J, Khalil RA.

Prog Mol Biol Transl Sci. 2017;148:355-420. doi: 10.1016/bs.pmbts.2017.04.003. Epub 2017 May 10. Review.


Hyperhomocysteinaemia is an independent risk factor for peripheral arterial disease in a Chinese Han population.

Rong D, Liu J, Jia X, Al-Nafisee D, Jia S, Sun G, Li Y, Lu W, Li H, Zhang H, Ma X, Xiong J, Liu X, Khalil RA, Guo W.

Atherosclerosis. 2017 Aug;263:205-210. doi: 10.1016/j.atherosclerosis.2017.05.006. Epub 2017 May 5.


Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-α.

Li W, Cui N, Mazzuca MQ, Mata KM, Khalil RA.

Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H491-H507. doi: 10.1152/ajpheart.00207.2017. Epub 2017 Jun 16.


Zymography as a Research Tool in the Study of Matrix Metalloproteinase Inhibitors.

Ren Z, Chen J, Khalil RA.

Methods Mol Biol. 2017;1626:79-102. doi: 10.1007/978-1-4939-7111-4_8.


Decreased homodimerization and increased TIMP-1 complexation of uteroplacental and uterine arterial matrix metalloproteinase-9 during hypertension-in-pregnancy.

Chen J, Ren Z, Zhu M, Khalil RA.

Biochem Pharmacol. 2017 Aug 15;138:81-95. doi: 10.1016/j.bcp.2017.05.005. Epub 2017 May 12.



Khalil RA.

Prog Mol Biol Transl Sci. 2017;147:xi-xii. doi: 10.1016/S1877-1173(17)30058-3. No abstract available.


Matrix Metalloproteinases in Remodeling of Lower Extremity Veins and Chronic Venous Disease.

Chen Y, Peng W, Raffetto JD, Khalil RA.

Prog Mol Biol Transl Sci. 2017;147:267-299. doi: 10.1016/bs.pmbts.2017.02.003. Epub 2017 Mar 21. Review.


Biochemical and Biological Attributes of Matrix Metalloproteinases.

Cui N, Hu M, Khalil RA.

Prog Mol Biol Transl Sci. 2017;147:1-73. doi: 10.1016/bs.pmbts.2017.02.005. Epub 2017 Mar 22. Review.



Khalil RA.

Adv Pharmacol. 2017;78:xi-xii. doi: 10.1016/S1054-3589(17)30019-4. No abstract available.


Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders.

Ringvold HC, Khalil RA.

Adv Pharmacol. 2017;78:203-301. doi: 10.1016/bs.apha.2016.06.002. Epub 2016 Jul 18. Review.


Prolonged Mechanical Circumferential Stretch Induces Metabolic Changes in Rat Inferior Vena Cava.

Anwar MA, Vorkas PA, Li J, Adesina-Georgiadis KN, Reslan OM, Raffetto JD, Want EJ, Khalil RA, Holmes E, Davies AH.

Eur J Vasc Endovasc Surg. 2016 Oct;52(4):544-552. doi: 10.1016/j.ejvs.2016.07.002. Epub 2016 Aug 11.



Khalil RA.

Adv Pharmacol. 2016;77:xiii-xiv. doi: 10.1016/S1054-3589(16)30056-4. No abstract available.


Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia.

Possomato-Vieira JS, Khalil RA.

Adv Pharmacol. 2016;77:361-431. doi: 10.1016/bs.apha.2016.04.008. Epub 2016 Jun 14.


Restoring placental growth factor-soluble fms-like tyrosine kinase-1 balance reverses vascular hyper-reactivity and hypertension in pregnancy.

Zhu M, Ren Z, Possomato-Vieira JS, Khalil RA.

Am J Physiol Regul Integr Comp Physiol. 2016 Sep 1;311(3):R505-21. doi: 10.1152/ajpregu.00137.2016. Epub 2016 Jun 8.


Pregnancy-associated adaptations in [Ca2+]i-dependent and Ca2+ sensitization mechanisms of venous contraction: implications in pregnancy-related venous disorders.

Xia Y, Khalil RA.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1851-65. doi: 10.1152/ajpheart.00876.2015. Epub 2016 May 3.


Adaptive increases in expression and vasodilator activity of estrogen receptor subtypes in a blood vessel-specific pattern during pregnancy.

Mata KM, Li W, Reslan OM, Siddiqui WT, Opsasnick LA, Khalil RA.

Am J Physiol Heart Circ Physiol. 2015 Nov 15;309(10):H1679-96. doi: 10.1152/ajpheart.00532.2015. Epub 2015 Sep 25.


Matrix Metalloproteinases as Regulators of Vein Structure and Function: Implications in Chronic Venous Disease.

MacColl E, Khalil RA.

J Pharmacol Exp Ther. 2015 Dec;355(3):410-28. doi: 10.1124/jpet.115.227330. Epub 2015 Aug 28. Review.


Genetic, immune and vasoactive factors in the vascular dysfunction associated with hypertension in pregnancy.

Ali SM, Khalil RA.

Expert Opin Ther Targets. 2015;19(11):1495-515. doi: 10.1517/14728222.2015.1067684. Epub 2015 Aug 17. Review.


Cooperative Role of Mineralocorticoid Receptor and Caveolin-1 in Regulating the Vascular Response to Low Nitric Oxide-High Angiotensin II-Induced Cardiovascular Injury.

Pojoga LH, Yao TM, Opsasnick LA, Siddiqui WT, Reslan OM, Adler GK, Williams GH, Khalil RA.

J Pharmacol Exp Ther. 2015 Oct;355(1):32-47. doi: 10.1124/jpet.115.226043. Epub 2015 Jul 16.


Critical Role of Striatin in Blood Pressure and Vascular Responses to Dietary Sodium Intake.

Garza AE, Pojoga LH, Moize B, Hafiz WM, Opsasnick LA, Siddiqui WT, Horenstein M, Adler GK, Williams GH, Khalil RA.

Hypertension. 2015 Sep;66(3):674-80. doi: 10.1161/HYPERTENSIONAHA.115.05600. Epub 2015 Jul 13.


Non-aneurysmal aberrant right subclavian artery causing dysphagia in a young girl: challenges encountered using supraclavicular approach.

Darwazah AK, Eida M, Khalil RA, Ismail H, Hanbali N.

J Cardiothorac Surg. 2015 Jul 5;10:92. doi: 10.1186/s13019-015-0303-0.


Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia.

Shah DA, Khalil RA.

Biochem Pharmacol. 2015 Jun 15;95(4):211-26. doi: 10.1016/j.bcp.2015.04.012. Epub 2015 Apr 24. Review.


Understanding basic muscle electrophysiology while keeping an eye on diseases of the heart, lung and blood.

Khalil RA.

Recent Pat Cardiovasc Drug Discov. 2014;9(1):1. No abstract available.


Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat.

Mazzuca MQ, Mata KM, Li W, Rangan SS, Khalil RA.

J Pharmacol Exp Ther. 2015 Feb;352(2):291-304. doi: 10.1124/jpet.114.219865. Epub 2014 Dec 3.


Downregulation of microvascular endothelial type B endothelin receptor is a central vascular mechanism in hypertensive pregnancy.

Mazzuca MQ, Li W, Reslan OM, Yu P, Mata KM, Khalil RA.

Hypertension. 2014 Sep;64(3):632-43. doi: 10.1161/HYPERTENSIONAHA.114.03315. Epub 2014 Jun 9.


Dissociation of hyperglycemia from altered vascular contraction and relaxation mechanisms in caveolin-1 null mice.

Pojoga LH, Yao TM, Opsasnick LA, Garza AE, Reslan OM, Adler GK, Williams GH, Khalil RA.

J Pharmacol Exp Ther. 2014 Feb;348(2):260-70. doi: 10.1124/jpet.113.209189. Epub 2013 Nov 26.


Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats.

Ou M, Dang Y, Mazzuca MQ, Basile R, Khalil RA.

J Cell Physiol. 2014 Apr;229(4):489-501. doi: 10.1002/jcp.24469.


Estrogen, vascular estrogen receptor and hormone therapy in postmenopausal vascular disease.

Khalil RA.

Biochem Pharmacol. 2013 Dec 15;86(12):1627-42. doi: 10.1016/j.bcp.2013.09.024. Epub 2013 Oct 4.


EMMPRIN-mediated induction of uterine and vascular matrix metalloproteinases during pregnancy and in response to estrogen and progesterone.

Dang Y, Li W, Tran V, Khalil RA.

Biochem Pharmacol. 2013 Sep 15;86(6):734-47. doi: 10.1016/j.bcp.2013.06.030. Epub 2013 Jul 13.


Novel therapies and botanical and mechanical approaches for management of cardiovascular disease.

Khalil RA.

Recent Pat Cardiovasc Drug Discov. 2013 Apr;8(1):1. No abstract available.


Enhanced endothelin receptor type B-mediated vasodilation and underlying [Ca²⁺]i in mesenteric microvessels of pregnant rats.

Mazzuca MQ, Dang Y, Khalil RA.

Br J Pharmacol. 2013 Jul;169(6):1335-51. doi: 10.1111/bph.12225.


Protein Kinase C Inhibitors as Modulators of Vascular Function and their Application in Vascular Disease.

Khalil RA.

Pharmaceuticals (Basel). 2013;6(3):407-39. doi: 10.3390/ph6030407.


Subtype-specific estrogen receptor-mediated vasodilator activity in the cephalic, thoracic, and abdominal vasculature of female rat.

Reslan OM, Yin Z, do Nascimento GR, Khalil RA.

J Cardiovasc Pharmacol. 2013 Jul;62(1):26-40. doi: 10.1097/FJC.0b013e31828bc88a.


Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins.

Kucukguven A, Khalil RA.

Curr Drug Targets. 2013 Mar;14(3):287-324. Review.


Prolonged Mechanical Stretch Alters the Metabolic Profile in Rat Inferior Vena Cava.

Anwar MA, Vorkas P, Li J, Resslan O, Want E, Raffetto JD, Khalil RA, Holmes E, Davies AH.

J Vasc Surg Venous Lymphat Disord. 2013 Jan;1(1):105-6. doi: 10.1016/j.jvsv.2012.10.022. Epub 2012 Dec 8. No abstract available.


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