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Items: 1 to 50 of 125

1.

Mechanical Thrombectomy in Acute Ischemic Stroke Patients Greater than 90 Years of Age: Experience in 26 Patients in a Large Tertiary Care Center and Outcome Comparison with Younger Patients.

Sweid A, Weinberg JH, Xu V, Shivashankar K, Alexander TD, Khalife J, Elmer N, Gooch MR, Herial N, Chalouhi N, Jabbour P, Rosenwasser RH, Tjoumakaris S.

World Neurosurg. 2019 Oct 12. pii: S1878-8750(19)32639-7. doi: 10.1016/j.wneu.2019.10.024. [Epub ahead of print]

PMID:
31614218
2.

MiR-16 regulates crosstalk in NF-κB tolerogenic inflammatory signaling between myeloma cells and bone marrow macrophages.

Khalife J, Ghose J, Martella M, Viola D, Rocci A, Troadec E, Terrazas C, Satoskar AR, Gunes EG, Dona A, Sanchez JF, Bergsagel PL, Chesi M, Pozhitkov A, Rosen S, Marcucci G, Keats JJ, Hofmeister CC, Krishnan A, Caserta E, Pichiorri F.

JCI Insight. 2019 Nov 1;4(21). pii: 129348. doi: 10.1172/jci.insight.129348.

3.

Essential role of GEXP15, a specific Protein Phosphatase type 1 partner, in Plasmodium berghei in asexual erythrocytic proliferation and transmission.

Hollin T, De Witte C, Fréville A, Guerrera IC, Chhuon C, Saliou JM, Herbert F, Pierrot C, Khalife J.

PLoS Pathog. 2019 Jul 26;15(7):e1007973. doi: 10.1371/journal.ppat.1007973. eCollection 2019 Jul.

4.

Plasmodium pseudo-Tyrosine Kinase-like binds PP1 and SERA5 and is exported to host erythrocytes.

Gnangnon B, Fréville A, Cailliau K, Leroy C, De Witte C, Tulasne D, Martoriarti A, Jung V, Guerrera IC, Marion S, Khalife J, Pierrot C.

Sci Rep. 2019 May 31;9(1):8120. doi: 10.1038/s41598-019-44542-3.

5.

The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum.

Tonk M, Pierrot C, Cabezas-Cruz A, Rahnamaeian M, Khalife J, Vilcinskas A.

Parasitol Res. 2019 Jun;118(6):1993-1998. doi: 10.1007/s00436-019-06305-x. Epub 2019 Apr 18.

PMID:
31001677
6.

Leflunomide regulates c-Myc expression in myeloma cells through PIM targeting.

Buettner R, Morales C, Caserta E, Troadec E, Gunes EG, Viola D, Khalife J, Li H, Keats JJ, Christofferson A, Wu X, Synold TW, Palmer J, Sanchez JF, Pozhitkov A, Vaidehi N, Marcucci G, Krishnan A, Rosenzweig MA, Pichiorri F, Rosen ST.

Blood Adv. 2019 Apr 9;3(7):1027-1032. doi: 10.1182/bloodadvances.2018027227. No abstract available.

7.

DHE-Induced Peripheral Arterial Vasospasm in Primary Raynaud Phenomenon: Case Report.

Khalife J, Lauritsen CG, Liang J, Shah SO.

Neurohospitalist. 2019 Apr;9(2):113-115. doi: 10.1177/1941874418797764. Epub 2018 Sep 11.

PMID:
30915191
8.

Characterization of a Protein Phosphatase Type-1 and a Kinase Anchoring Protein in Plasmodium falciparum.

Lenne A, De Witte C, Tellier G, Hollin T, Aliouat EM, Martoriati A, Cailliau K, Saliou JM, Khalife J, Pierrot C.

Front Microbiol. 2018 Oct 31;9:2617. doi: 10.3389/fmicb.2018.02617. eCollection 2018.

9.

Identification of novel quinazoline derivatives as potent antiplasmodial agents.

Bouchut A, Rotili D, Pierrot C, Valente S, Lafitte S, Schultz J, Hoglund U, Mazzone R, Lucidi A, Fabrizi G, Pechalrieu D, Arimondo PB, Skinner-Adams TS, Chua MJ, Andrews KT, Mai A, Khalife J.

Eur J Med Chem. 2019 Jan 1;161:277-291. doi: 10.1016/j.ejmech.2018.10.041. Epub 2018 Oct 17.

PMID:
30366254
10.

Daratumumab induces CD38 internalization and impairs myeloma cell adhesion.

Ghose J, Viola D, Terrazas C, Caserta E, Troadec E, Khalife J, Gunes EG, Sanchez J, McDonald T, Marcucci G, Kaur B, Rosenzweig M, Keats J, Rosen S, Krishnan A, Satoskar AR, Hofmeister CC, Pichiorri F.

Oncoimmunology. 2018 Jul 23;7(10):e1486948. doi: 10.1080/2162402X.2018.1486948. eCollection 2018.

11.

Peptides derived from Plasmodium falciparum leucine-rich repeat 1 bind to serine/threonine phosphatase type 1 and inhibit parasite growth in vitro.

Pierrot C, Zhang X, Zanghi G, Fréville A, Rebollo A, Khalife J.

Drug Des Devel Ther. 2018 Jan 9;12:85-88. doi: 10.2147/DDDT.S153095. eCollection 2018. No abstract available. Erratum in: Drug Des Devel Ther. 2018 Mar 29;12 :655. Zhangi, Gigliola [corrected to Zanghi, Gigliola].

12.

Copper 64-labeled daratumumab as a PET/CT imaging tracer for multiple myeloma.

Caserta E, Chea J, Minnix M, Poku EK, Viola D, Vonderfecht S, Yazaki P, Crow D, Khalife J, Sanchez JF, Palmer JM, Hui S, Carlesso N, Keats J, Kim Y, Buettner R, Marcucci G, Rosen S, Shively J, Colcher D, Krishnan A, Pichiorri F.

Blood. 2018 Feb 15;131(7):741-745. doi: 10.1182/blood-2017-09-807263. Epub 2018 Jan 4. Erratum in: Blood. 2018 Jun 21;131(25):2869.

13.

Effects of Ascorbic Acid on Tax, NF-κB and MMP-9 in Human T-cell Lymphotropic Virus Type 1 Positive Malignant T-Lymphocytes.

Harakeh S, Khalife J, Baydoun E, Azar R, Al-Hejin A, Barbour E, Azhar E, Niedzwiecki A, Al Jaouni S, Diab-Assaf M, Kamal MA, Rath M.

Anticancer Agents Med Chem. 2018;18(2):237-244. doi: 10.2174/1871520617666170725160628.

PMID:
28745235
14.

First-Trimester Combined Multimarker Prospective Study for the Detection of Pregnancies at a High Risk of Developing Preeclampsia Using the Fetal Medicine Foundation-Algorithm.

Guizani M, Valsamis J, Dutemeyer V, Kang X, Ceccotti V, Khalife J, Duiella SF, Blavier F, Faraca A, Cos T, Jani JC.

Fetal Diagn Ther. 2018;43(4):266-273. doi: 10.1159/000477934. Epub 2017 Jul 18.

PMID:
28715818
15.

A Longitudinal Study on Fetal Weight Estimation at Third Trimester of Pregnancy: Comparison of Magnetic Resonance Imaging and 2-D Ultrasound Predictions.

Kadji C, Cannie MM, Van Wettere M, Bevilacqua E, Dütemeyer V, Strizek B, Khalifé J, Kang X, Jani JC.

Fetal Diagn Ther. 2017;42(3):181-188. doi: 10.1159/000453356. Epub 2017 Apr 14.

PMID:
28407631
16.

Effect of blood type on anti-α-Gal immunity and the incidence of infectious diseases.

Cabezas-Cruz A, Mateos-Hernández L, Alberdi P, Villar M, Riveau G, Hermann E, Schacht AM, Khalife J, Correia-Neves M, Gortazar C, de la Fuente J.

Exp Mol Med. 2017 Mar 10;49(3):e301. doi: 10.1038/emm.2016.164.

17.

Hospital Contracting Reforms: The Lebanese Ministry of Public Health Experience.

Khalife J, Rafeh N, Makouk J, El-Jardali F, Ekman B, Kronfol N, Hamadeh G, Ammar W.

Health Syst Reform. 2017 Jan 2;3(1):34-41. doi: 10.1080/23288604.2016.1272979.

PMID:
31514709
18.

Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.

Sauer B, Skinner-Adams TS, Bouchut A, Chua MJ, Pierrot C, Erdmann F, Robaa D, Schmidt M, Khalife J, Andrews KT, Sippl W.

Eur J Med Chem. 2017 Feb 15;127:22-40. doi: 10.1016/j.ejmech.2016.12.041. Epub 2016 Dec 23.

PMID:
28038325
19.

Antiplasmodial Activity Is an Ancient and Conserved Feature of Tick Defensins.

Cabezas-Cruz A, Tonk M, Bouchut A, Pierrot C, Pierce RJ, Kotsyfakis M, Rahnamaeian M, Vilcinskas A, Khalife J, Valdés JJ.

Front Microbiol. 2016 Oct 24;7:1682. eCollection 2016.

20.

Targeting the RAS/MAPK pathway with miR-181a in acute myeloid leukemia.

Huang X, Schwind S, Santhanam R, Eisfeld AK, Chiang CL, Lankenau M, Yu B, Hoellerbauer P, Jin Y, Tarighat SS, Khalife J, Walker A, Perrotti D, Bloomfield CD, Wang H, Lee RJ, Lee LJ, Marcucci G.

Oncotarget. 2016 Sep 13;7(37):59273-59286. doi: 10.18632/oncotarget.11150.

21.

Identification of Plasmodium falciparum Translation Initiation eIF2β Subunit: Direct Interaction with Protein Phosphatase Type 1.

Tellier G, Lenne A, Cailliau-Maggio K, Cabezas-Cruz A, Valdés JJ, Martoriati A, Aliouat el M, Gosset P, Delaire B, Fréville A, Pierrot C, Khalife J.

Front Microbiol. 2016 May 26;7:777. doi: 10.3389/fmicb.2016.00777. eCollection 2016.

22.

Phosphatases are emerging as novel druggable targets in Plasmodium.

Khalife J, Pierrot C.

Future Microbiol. 2016 May;11:603-6. doi: 10.2217/fmb-2016-0029. Epub 2016 May 9. No abstract available.

23.

Analysis of the interactome of the Ser/Thr Protein Phosphatase type 1 in Plasmodium falciparum.

Hollin T, De Witte C, Lenne A, Pierrot C, Khalife J.

BMC Genomics. 2016 Mar 17;17:246. doi: 10.1186/s12864-016-2571-z.

24.

Relationship Between Pneumocystis carinii Burden and the Degree of Host Immunosuppression in an Airborne Transmission Experimental Model.

Khalife S, Chabé M, Gantois N, Audebert C, Pottier M, Hlais S, Pinçon C, Chassat T, Pierrot C, Khalife J, Aliouat-Denis CM, Aliouat el M.

J Eukaryot Microbiol. 2016 May;63(3):309-17. doi: 10.1111/jeu.12280. Epub 2015 Nov 24.

PMID:
26509699
25.

Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment.

Chalmers IW, Fitzsimmons CM, Brown M, Pierrot C, Jones FM, Wawrzyniak JM, Fernandez-Fuentes N, Tukahebwa EM, Dunne DW, Khalife J, Hoffmann KF.

PLoS Negl Trop Dis. 2015 Jul 6;9(7):e0003920. doi: 10.1371/journal.pntd.0003920. eCollection 2015.

26.

Targeting leukemia stem cells in vivo with antagomiR-126 nanoparticles in acute myeloid leukemia.

Dorrance AM, Neviani P, Ferenchak GJ, Huang X, Nicolet D, Maharry KS, Ozer HG, Hoellarbauer P, Khalife J, Hill EB, Yadav M, Bolon BN, Lee RJ, Lee LJ, Croce CM, Garzon R, Caligiuri MA, Bloomfield CD, Marcucci G.

Leukemia. 2015 Nov;29(11):2143-53. doi: 10.1038/leu.2015.139. Epub 2015 Jun 9.

27.

Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia.

Khalife J, Radomska HS, Santhanam R, Huang X, Neviani P, Saultz J, Wang H, Wu YZ, Alachkar H, Anghelina M, Dorrance A, Curfman J, Bloomfield CD, Medeiros BC, Perrotti D, Lee LJ, Lee RJ, Caligiuri MA, Pichiorri F, Croce CM, Garzon R, Guzman ML, Mendler JH, Marcucci G.

Leukemia. 2015 Oct;29(10):1981-92. doi: 10.1038/leu.2015.106. Epub 2015 May 14.

28.

Drug-induced exposure of Schistosoma mansoni antigens SmCD59a and SmKK7.

Reimers N, Homann A, Höschler B, Langhans K, Wilson RA, Pierrot C, Khalife J, Grevelding CG, Chalmers IW, Yazdanbakhsh M, Hoffmann KF, Hokke CH, Haas H, Schramm G.

PLoS Negl Trop Dis. 2015 Mar 16;9(3):e0003593. doi: 10.1371/journal.pntd.0003593. eCollection 2015 Mar.

29.

Genome wide in silico analysis of Plasmodium falciparum phosphatome.

Pandey R, Mohmmed A, Pierrot C, Khalife J, Malhotra P, Gupta D.

BMC Genomics. 2014 Nov 25;15:1024. doi: 10.1186/1471-2164-15-1024.

30.

Identification of a Plasmodium falciparum inhibitor-2 motif involved in the binding and regulation activity of protein phosphatase type 1.

Fréville A, Tellier G, Vandomme A, Pierrot C, Vicogne J, Cantrelle FX, Martoriati A, Cailliau-Maggio K, Khalife J, Landrieu I.

FEBS J. 2014 Oct;281(19):4519-34. doi: 10.1111/febs.12960. Epub 2014 Sep 8.

31.

Impact of operator experience on the variability of fetal lung volume estimation by 3D-ultrasound (VOCAL) and magnetic resonance imaging in fetuses with congenital diaphragmatic hernia.

Strizek B, Cos Sanchez T, Khalifé J, Jani J, Cannie M.

J Matern Fetal Neonatal Med. 2015 May;28(7):858-64. doi: 10.3109/14767058.2014.935760. Epub 2014 Jul 11.

PMID:
24946026
32.

Observations on the Ministry of Public Health program of support to the hospitalization of patients in Lebanon.

Kronfol N, Khalife J, Romanos J, Makouk J, Noun P, Ammar W.

J Med Liban. 2014 Jan-Mar;62(1):33-9.

PMID:
24684124
33.

SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome.

Alachkar H, Santhanam R, Maharry K, Metzeler KH, Huang X, Kohlschmidt J, Mendler JH, Benito JM, Hickey C, Neviani P, Dorrance AM, Anghelina M, Khalife J, Tarighat SS, Volinia S, Whitman SP, Paschka P, Hoellerbauer P, Wu YZ, Han L, Bolon BN, Blum W, Mrózek K, Carroll AJ, Perrotti D, Andreeff M, Caligiuri MA, Konopleva M, Garzon R, Bloomfield CD, Marcucci G.

J Clin Invest. 2014 Apr;124(4):1512-24. doi: 10.1172/JCI70921. Epub 2014 Mar 3.

34.

PhosphoTyrosyl phosphatase activator of Plasmodium falciparum: identification of its residues involved in binding to and activation of PP2A.

Vandomme A, Fréville A, Cailliau K, Kalamou H, Bodart JF, Khalife J, Pierrot C.

Int J Mol Sci. 2014 Feb 11;15(2):2431-53. doi: 10.3390/ijms15022431.

35.

Hospital accreditation, reimbursement and case mix: links and insights for contractual systems.

Ammar W, Khalife J, El-Jardali F, Romanos J, Harb H, Hamadeh G, Dimassi H.

BMC Health Serv Res. 2013 Dec 5;13:505. doi: 10.1186/1472-6963-13-505.

36.

Plasmodium falciparum encodes a conserved active inhibitor-2 for Protein Phosphatase type 1: perspectives for novel anti-plasmodial therapy.

Fréville A, Cailliau-Maggio K, Pierrot C, Tellier G, Kalamou H, Lafitte S, Martoriati A, Pierce RJ, Bodart JF, Khalife J.

BMC Biol. 2013 Jul 9;11:80. doi: 10.1186/1741-7007-11-80.

37.

Smoking behavior and sociodemographic differences among young people: further evidence from southern Sweden based on public health survey data.

Ekman B, Khalife J, Moussa K, Emmelin M.

Scand J Public Health. 2013 Nov;41(7):662-71. doi: 10.1177/1403494813493221. Epub 2013 Jun 26.

PMID:
23804965
38.

The ferroquine antimalarial conundrum: redox activation and reinvasion inhibition.

Dubar F, Slomianny C, Khalife J, Dive D, Kalamou H, Guérardel Y, Grellier P, Biot C.

Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7690-3. doi: 10.1002/anie.201303690. Epub 2013 Jun 13.

PMID:
23765846
39.

In rare acute myeloid leukemia patients harboring both RUNX1 and NPM1 mutations, RUNX1 mutations are unusual in structure and present in the germline.

Mendler JH, Maharry K, Becker H, Eisfeld AK, Senter L, Mrózek K, Kohlschmidt J, Metzeler KH, Schwind S, Whitman SP, Khalife J, Caligiuri MA, Klisovic RB, Moore JO, Carter TH, Marcucci G, Bloomfield CD.

Haematologica. 2013 Aug;98(8):e92-4. doi: 10.3324/haematol.2013.089904. Epub 2013 Jun 10. No abstract available.

40.

Progressive cross-reactivity in IgE responses: an explanation for the slow development of human immunity to schistosomiasis?

Fitzsimmons CM, Jones FM, Pinot de Moira A, Protasio AV, Khalife J, Dickinson HA, Tukahebwa EM, Dunne DW.

Infect Immun. 2012 Dec;80(12):4264-70. doi: 10.1128/IAI.00641-12. Epub 2012 Sep 24.

41.

RUNX1 mutations are associated with poor outcome in younger and older patients with cytogenetically normal acute myeloid leukemia and with distinct gene and MicroRNA expression signatures.

Mendler JH, Maharry K, Radmacher MD, Mrózek K, Becker H, Metzeler KH, Schwind S, Whitman SP, Khalife J, Kohlschmidt J, Nicolet D, Powell BL, Carter TH, Wetzler M, Moore JO, Kolitz JE, Baer MR, Carroll AJ, Larson RA, Caligiuri MA, Marcucci G, Bloomfield CD.

J Clin Oncol. 2012 Sep 1;30(25):3109-18. doi: 10.1200/JCO.2011.40.6652. Epub 2012 Jul 2.

42.

Current strategies for drug development against major human parasites: malaria and schistosomiasis.

Khalife J.

Curr Pharm Des. 2012;18(24):3453. No abstract available.

PMID:
22721585
43.

Opening up the advantages of the ruthenocenic bioprobes of ferroquine: distribution and localization in Plasmodium falciparum-infected erythrocytes.

Biot C, Dubar F, Khalife J, Slomianny C.

Metallomics. 2012 Aug;4(8):780-3. doi: 10.1039/c2mt20063e. Epub 2012 Jun 15.

PMID:
22700030
44.

Deciphering the Resistance-Counteracting Functions of Ferroquine in Plasmodium falciparum-Infected Erythrocytes.

Dubar F, Bohic S, Dive D, Guérardel Y, Cloetens P, Khalife J, Biot C.

ACS Med Chem Lett. 2012 Apr 13;3(6):480-3. doi: 10.1021/ml300062q. eCollection 2012 Jun 14.

45.

Inhibition of protein-protein interactions in Plasmodium falciparum: future drug targets.

Pierrot C, Fréville A, Olivier C, Souplet V, Khalife J.

Curr Pharm Des. 2012;18(24):3522-30. Review.

PMID:
22607144
46.

In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes.

Dubar F, Bohic S, Slomianny C, Morin JC, Thomas P, Kalamou H, Guérardel Y, Cloetens P, Khalife J, Biot C.

Chem Commun (Camb). 2012 Jan 21;48(6):910-2. doi: 10.1039/c1cc16211j. Epub 2011 Dec 5.

PMID:
22143053
47.

Plasmodium falciparum inhibitor-3 homolog increases protein phosphatase type 1 activity and is essential for parasitic survival.

Fréville A, Landrieu I, García-Gimeno MA, Vicogne J, Montbarbon M, Bertin B, Verger A, Kalamou H, Sanz P, Werkmeister E, Pierrot C, Khalife J.

J Biol Chem. 2012 Jan 6;287(2):1306-21. doi: 10.1074/jbc.M111.276865. Epub 2011 Nov 28.

48.

The antimalarial ferroquine: from bench to clinic.

Biot C, Nosten F, Fraisse L, Ter-Minassian D, Khalife J, Dive D.

Parasite. 2011 Aug;18(3):207-14. Review.

49.

Gene profiling analysis reveals the contribution of CD24 and P2Y6R to the susceptibility of young rats to Plasmodium berghei infection.

Pierrot C, dit Vampouille AA, Vandomme A, Lafitte S, Pierce RJ, Hot D, Khalife J.

Cell Microbiol. 2011 May;13(5):752-63. doi: 10.1111/j.1462-5822.2011.01574.x. Epub 2011 Feb 16.

PMID:
21323829
50.

The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance.

Dubar F, Egan TJ, Pradines B, Kuter D, Ncokazi KK, Forge D, Paul JF, Pierrot C, Kalamou H, Khalife J, Buisine E, Rogier C, Vezin H, Forfar I, Slomianny C, Trivelli X, Kapishnikov S, Leiserowitz L, Dive D, Biot C.

ACS Chem Biol. 2011 Mar 18;6(3):275-87. doi: 10.1021/cb100322v. Epub 2011 Jan 7.

PMID:
21162558

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