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Items: 31

1.

Genotypic and phenotypic characterization of Candida albicans Lebanese hospital isolates resistant and sensitive to caspofungin.

Toutounji M, Tokajian S, Khalaf RA.

Fungal Genet Biol. 2019 Jun;127:12-22. doi: 10.1016/j.fgb.2019.02.008. Epub 2019 Feb 20.

PMID:
30794951
2.

DPP-IV Inhibitory Phenanthridines: Ligand, Structure-Based Design, and Synthesis.

Khalaf RA, Masalha D, Sabbah D.

Curr Comput Aided Drug Des. 2018 Dec 10. doi: 10.2174/1573409915666181211114743. [Epub ahead of print]

PMID:
30526469
3.

Ligand-Based Drug Design: Synthesis and Biological Evaluation of Substituted Benzoin Derivatives as Potential Antitumor Agents.

Sabbah DA, Ibrahim AH, Talib WH, Alqaisi KM, Sweidan K, Bardaweel SK, Sheikha GA, Zhong HA, Al-Shalabi E, Khalaf RA, Mubarak MS.

Med Chem. 2019;15(4):417-429. doi: 10.2174/1573406414666180912111846.

PMID:
30207238
4.

Proteomic analysis of a Candida albicans pga1 Null Strain.

Awad A, El Khoury P, Wex B, Khalaf RA.

EuPA Open Proteom. 2018 Feb 22;18:1-6. doi: 10.1016/j.euprot.2018.02.001. eCollection 2018 Jun.

5.

Tandem Mass Spectrometric Cell Wall Proteome Profiling of a Candida albicans hwp2 Mutant Strain.

Awad A, El Khoury P, Wex B, Khalaf RA.

Curr Mol Pharmacol. 2018;11(3):211-225. doi: 10.2174/1874467211666180509153228.

PMID:
29741145
6.

Synthesis of Novel Benzimidazole-2-carboxamide Derivatives and in Vivo Antihyperlipidemic Activity Evaluation.

Sheikha GA, Bkhaitan MM, Kalloush H, Hamadneh L, Khalaf RA, Al-Qirim T, Al-Hiari Y.

Chem Pharm Bull (Tokyo). 2018;66(4):423-426. doi: 10.1248/cpb.c17-00908.

7.

Proteomic analysis of a Candida albicans pir32 null strain reveals proteins involved in adhesion, filamentation and virulence.

El Khoury P, Awad A, Wex B, Khalaf RA.

PLoS One. 2018 Mar 19;13(3):e0194403. doi: 10.1371/journal.pone.0194403. eCollection 2018.

8.

Synthesis, Structural Characterization and Docking Studies of Sulfamoyl- Phenyl Acid Esters as Dipeptidyl Peptidase-IV Inhibitors.

Khalaf RA, Sabbah D, Al-Shalabi E, Al-Sheikh I, Albadawi G, Abu Sheikha G.

Curr Comput Aided Drug Des. 2018;14(2):142-151. doi: 10.2174/1573409914666180308164013.

PMID:
29521244
9.

Molecular Docking and Pharmacophore Modeling Studies of Fluorinated Benzamides as Potential CETP Inhibitors.

Khalaf RA, Al-Rawashdeh S, Sabbah D, Abu Sheikha G.

Med Chem. 2017;13(3):239-253. doi: 10.2174/1573406412666161104121042.

PMID:
27823564
10.
11.

Molecular modeling based approach, synthesis, and cytotoxic activity of novel benzoin derivatives targeting phosphoinostide 3-kinase (PI3Kα).

Sabbah DA, Saada M, Khalaf RA, Bardaweel S, Sweidan K, Al-Qirim T, Al-Zughier A, Halim HA, Sheikha GA.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3120-4. doi: 10.1016/j.bmcl.2015.06.011. Epub 2015 Jun 11.

PMID:
26099539
12.

Comparative proteomic analysis of a Candida albicans DSE1 mutant under filamentous and non-filamentous conditions.

Zohbi R, Wex B, Khalaf RA.

Yeast. 2014 Nov;31(11):441-8. doi: 10.1002/yea.3039. Epub 2014 Oct 14.

13.

Identification, typing, antifungal resistance profile, and biofilm formation of Candida albicans isolates from Lebanese hospital patients.

Bitar I, Khalaf RA, Harastani H, Tokajian S.

Biomed Res Int. 2014;2014:931372. doi: 10.1155/2014/931372. Epub 2014 Jun 1.

14.

Design, Synthesis and Biological Evaluation of N4-Sulfonamido-Succinamic, Phthalamic, Acrylic and Benzoyl Acetic Acid Derivatives as Potential DPP IV Inhibitors.

Khalaf RA, Sheikha GA, Al-Sha'er M, Taha M.

Open Med Chem J. 2013 Nov 29;7:39-48. doi: 10.2174/1874104501307010039. eCollection 2013.

15.

The Candida albicans Hwp2p can complement the lack of filamentation of a Saccharomyces cerevisiae flo11 null strain.

Younes SS, Khalaf RA.

Microbiology. 2013 Jun;159(Pt 6):1160-4. doi: 10.1099/mic.0.067249-0. Epub 2013 Apr 4.

PMID:
23558263
16.

Deletion of the Candida albicans PIR32 results in increased virulence, stress response, and upregulation of cell wall chitin deposition.

Bahnan W, Koussa J, Younes S, Abi Rizk M, Khalil B, El Sitt S, Hanna S, El-Sibai M, Khalaf RA.

Mycopathologia. 2012 Aug;174(2):107-19. doi: 10.1007/s11046-012-9533-z. Epub 2012 Mar 6.

PMID:
22391823
17.

The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence.

Daher JY, Koussa J, Younes S, Khalaf RA.

Interdiscip Perspect Infect Dis. 2011;2011:504280. doi: 10.1155/2011/504280. Epub 2011 Jun 30.

18.

Discovery of new antifungal leads via pharmacophore modeling and QSAR analysis of fungal N-myristoyl transferase inhibitors followed by in silico screening.

Taha MO, Qandil AM, Al-Haraznah T, Khalaf RA, Zalloum H, Al-Bakri AG.

Chem Biol Drug Des. 2011 Sep;78(3):391-407. doi: 10.1111/j.1747-0285.2011.01160.x. Epub 2011 Jul 13.

PMID:
21679375
19.

The Candida albicans Hwp2 is necessary for proper adhesion, biofilm formation and oxidative stress tolerance.

Younes S, Bahnan W, Dimassi HI, Khalaf RA.

Microbiol Res. 2011 Jul 20;166(5):430-6. doi: 10.1016/j.micres.2010.08.004. Epub 2010 Sep 23.

20.

Discovery of new β-D-galactosidase inhibitors via pharmacophore modeling and QSAR analysis followed by in silico screening.

Abdula AM, Khalaf RA, Mubarak MS, Taha MO.

J Comput Chem. 2011 Feb;32(3):463-82. doi: 10.1002/jcc.21635. Epub 2010 Aug 20.

PMID:
20730780
21.

Characterisation of Pga1, a putative Candida albicans cell wall protein necessary for proper adhesion and biofilm formation.

Hashash R, Younes S, Bahnan W, El Koussa J, Maalouf K, Dimassi HI, Khalaf RA.

Mycoses. 2011 Nov;54(6):491-500. doi: 10.1111/j.1439-0507.2010.01883.x. Epub 2010 Apr 6.

PMID:
20406396
22.

Yeast cell adhesion molecules have functional amyloid-forming sequences.

Ramsook CB, Tan C, Garcia MC, Fung R, Soybelman G, Henry R, Litewka A, O'Meally S, Otoo HN, Khalaf RA, Dranginis AM, Gaur NK, Klotz SA, Rauceo JM, Jue CK, Lipke PN.

Eukaryot Cell. 2010 Mar;9(3):393-404. doi: 10.1128/EC.00068-09. Epub 2009 Dec 28.

23.

Characterization of Hwp2, a Candida albicans putative GPI-anchored cell wall protein necessary for invasive growth.

Hayek P, Dib L, Yazbeck P, Beyrouthy B, Khalaf RA.

Microbiol Res. 2010 Mar 31;165(3):250-8. doi: 10.1016/j.micres.2009.03.006. Epub 2009 Jul 17.

24.

Distribution of killer cell immunoglobulin-like receptor (KIR) genotypes in patients with familial Mediterranean fever.

Mahfouz RA, Sabbagh AS, Shamseddine W, Bazarbachi A, Ibrahim G, Arayssi T, El Hajj N, Rayes R, Zaatari GS, Khazen G, Khalaf RA.

Genet Test Mol Biomarkers. 2009 Feb;13(1):91-5. doi: 10.1089/gtmb.2008.0081.

PMID:
19309280
25.

Susceptibility of Candida albicans to common and novel antifungal drugs, and relationship between the mating type locus and resistance, in Lebanese hospital isolates.

Basma R, Barada G, Ojaimi N, Khalaf RA.

Mycoses. 2009 Mar;52(2):141-8. doi: 10.1111/j.1439-0507.2008.01559.x. Epub 2008 Jun 21.

PMID:
18627469
26.

The Candida albicans Ddr48 protein is essential for filamentation, stress response, and confers partial antifungal drug resistance.

Dib L, Hayek P, Sadek H, Beyrouthy B, Khalaf RA.

Med Sci Monit. 2008 Jun;14(6):BR113-121.

PMID:
18509269
27.

Microsatellite DNA identification and genotyping of Candida albicans from Lebanese clinical isolates.

Barada G, Basma R, Khalaf RA.

Mycopathologia. 2008 Mar;165(3):115-25. doi: 10.1007/s11046-008-9089-0. Epub 2008 Feb 12.

PMID:
18266073
28.

Significant discrepancy between real-time PCR identification and hospital identification of C. albicans from Lebanese patients.

Yazbek S, Barada G, Basma R, Mahfouz J, Khalaf RA.

Med Sci Monit. 2007 May;13(5):MT7-12.

PMID:
17476200
29.
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31.

Characterization of the DNA binding and bending HMG domain of the yeast hypoxic repressor Rox1.

Deckert J, Khalaf RA, Hwang SM, Zitomer RS.

Nucleic Acids Res. 1999 Sep 1;27(17):3518-26.

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