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The association between hepatocellular carcinoma and direct-acting anti-viral treatment in patients with decompensated cirrhosis.

Mecci AJ, Kemos P, Leen C, Lawson A, Richardson P, Khakoo SI, Agarwal K, Mutimer D, Rosenberg WM, Foster GR, Irving WL; HCV Research UK.

Aliment Pharmacol Ther. 2019 May 31. doi: 10.1111/apt.15296. [Epub ahead of print]


Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes.

Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI.

Front Immunol. 2019 Apr 5;10:605. doi: 10.3389/fimmu.2019.00605. eCollection 2019.


Generation of functional hepatocyte 3D discoids in an acoustofluidic bioreactor.

Khedr MMS, Messaoudi W, Jonnalagadda US, Abdelmotelb AM, Glynne-Jones P, Hill M, Khakoo SI, Abu Hilal M.

Biomicrofluidics. 2019 Feb 12;13(1):014112. doi: 10.1063/1.5082603. eCollection 2019 Jan.


Immunological biomarkers as indicators for outcome after discontinuation of nucleos(t)ide analogue therapy in patients with HBeAg-negative chronic hepatitis B.

Kranidioti H, Manolakopoulos S, Kontos G, Breen MS, Kourikou A, Deutsch M, Quesada-Del-Bosque ME, Martinez-Nunez RT, Naiyer MM, Woelk CH, Sanchez-Elsner T, Hadziyannis E, Papatheodoridis G, Khakoo SI.

J Viral Hepat. 2019 Jun;26(6):697-709. doi: 10.1111/jvh.13068. Epub 2019 Feb 27.


Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus.

Vergara C, Thio CL, Johnson E, Kral AH, O'Brien TR, Goedert JJ, Mangia A, Piazzolla V, Mehta SH, Kirk GD, Kim AY, Lauer GM, Chung RT, Cox AL, Peters MG, Khakoo SI, Alric L, Cramp ME, Donfield SM, Edlin BR, Busch MP, Alexander G, Rosen HR, Murphy EL, Latanich R, Wojcik GL, Taub MA, Valencia A, Thomas DL, Duggal P.

Gastroenterology. 2019 Apr;156(5):1496-1507.e7. doi: 10.1053/j.gastro.2018.12.014. Epub 2018 Dec 26.


Conserved and variable natural killer cell receptors: diverse approaches to viral infections.

Bastidas-Legarda LY, Khakoo SI.

Immunology. 2019 Apr;156(4):319-328. doi: 10.1111/imm.13039. Epub 2019 Jan 17. Review.


Activity of IL-12/15/18 primed natural killer cells against hepatocellular carcinoma.

Zhuang L, Fulton RJ, Rettman P, Sayan AE, Coad J, Al-Shamkhani A, Khakoo SI.

Hepatol Int. 2019 Jan;13(1):75-83. doi: 10.1007/s12072-018-9909-3. Epub 2018 Nov 22.


Inhibitory killer cell immunoglobulin-like receptors strengthen CD8+ T cell-mediated control of HIV-1, HCV, and HTLV-1.

Boelen L, Debebe B, Silveira M, Salam A, Makinde J, Roberts CH, Wang ECY, Frater J, Gilmour J, Twigger K, Ladell K, Miners KL, Jayaraman J, Traherne JA, Price DA, Qi Y, Martin MP, Macallan DC, Thio CL, Astemborski J, Kirk G, Donfield SM, Buchbinder S, Khakoo SI, Goedert JJ, Trowsdale J, Carrington M, Kollnberger S, Asquith B.

Sci Immunol. 2018 Nov 9;3(29). pii: eaao2892. doi: 10.1126/sciimmunol.aao2892.


A novel antibody combination to identify KIR2DS2high natural killer cells in KIR2DL3/L2/S2 heterozygous donors.

Blunt MD, Rettman P, Bastidas-Legarda LY, Fulton R, Capizzuto V, Naiyer MM, Traherne JA, Khakoo SI.

HLA. 2019 Jan;93(1):32-35. doi: 10.1111/tan.13413.


Human CD49a+ Lung Natural Killer Cell Cytotoxicity in Response to Influenza A Virus.

Cooper GE, Ostridge K, Khakoo SI, Wilkinson TMA, Staples KJ.

Front Immunol. 2018 Jul 20;9:1671. doi: 10.3389/fimmu.2018.01671. eCollection 2018.


Vasoactive intestinal peptide induces proliferation of human hepatocytes.

Khedr MEMS, Abdelmotelb AM, Bedwell TA, Shtaya A, Alzoubi MN, Abu Hilal M, Khakoo SI.

Cell Prolif. 2018 Oct;51(5):e12482. doi: 10.1111/cpr.12482. Epub 2018 Jul 20.


Hepatocellular carcinoma: Prospects for natural killer cell immunotherapy.

Kumar N, Khakoo SI.

HLA. 2018 Apr 17. doi: 10.1111/tan.13275. [Epub ahead of print] Review.


Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection.

Huang H, Duggal P, Thio CL, Latanich R, Goedert JJ, Mangia A, Cox AL, Kirk GD, Mehta S, Aneja J, Alric L, Donfield SM, Cramp ME, Khakoo SI, Tobler LH, Busch M, Alexander GJ, Rosen HR, Edlin BR, Segal FP, Lauer GM, Thomas DL, Daly MJ, Chung RT, Kim AY.

Sci Rep. 2017 Nov 20;7(1):15843. doi: 10.1038/s41598-017-16011-2.


IL-12 and IL-15 induce the expression of CXCR6 and CD49a on peripheral natural killer cells.

Hydes T, Noll A, Salinas-Riester G, Abuhilal M, Armstrong T, Hamady Z, Primrose J, Takhar A, Walter L, Khakoo SI.

Immun Inflamm Dis. 2018 Mar;6(1):34-46. doi: 10.1002/iid3.190. Epub 2017 Sep 27.


KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C.

Naiyer MM, Cassidy SA, Magri A, Cowton V, Chen K, Mansour S, Kranidioti H, Mbiribindi B, Rettman P, Harris S, Fanning LJ, Mulder A, Claas FHJ, Davidson AD, Patel AH, Purbhoo MA, Khakoo SI.

Sci Immunol. 2017 Sep 15;2(15). pii: eaal5296. doi: 10.1126/sciimmunol.aal5296.


Hepatitis C bio-behavioural surveys in people who inject drugs-a systematic review of sensitivity to the theoretical assumptions of respondent driven sampling.

Buchanan R, Khakoo SI, Coad J, Grellier L, Parkes J.

Harm Reduct J. 2017 Jul 11;14(1):44. doi: 10.1186/s12954-017-0172-z. Review.


HLA-Bw4 80(T) and multiple HLA-Bw4 copies combined with KIR3DL1 associate with spontaneous clearance of HCV infection in people who inject drugs.

Thöns C, Senff T, Hydes TJ, Manser AR, Heinemann FM, Heinold A, Heilmann M, Kim AY, Uhrberg M, Scherbaum N, Lauer GM, Khakoo SI, Timm J.

J Hepatol. 2017 Sep;67(3):462-470. doi: 10.1016/j.jhep.2017.03.040. Epub 2017 Apr 13.


Treatment outcomes in treatment experienced and treatment naïve patients on Tenofovir disoproxil fumarate for chronic hepatitis B.

Naftel J, Khakoo SI, Buchanan R.

J Infect. 2017 Jan;74(1):100-102. doi: 10.1016/j.jinf.2016.10.004. Epub 2016 Oct 25. No abstract available.


Bone marrow transplantation for MHC class I deficiency corrects T-cell immunity but dissociates natural killer cell repertoire formation from function.

Gao Y, Arkwright PD, Carter R, Cazaly A, Harrison RJ, Mant A, Cant AJ, Gadola S, Elliott TJ, Khakoo SI, Williams AP.

J Allergy Clin Immunol. 2016 Dec;138(6):1733-1736.e2. doi: 10.1016/j.jaci.2016.06.029. Epub 2016 Jul 27. No abstract available.


Hepatitis B viral replication influences the expression of natural killer cell ligands.

Koumbi L, Pollicino T, Raimondo G, Kumar N, Karayiannis P, Khakoo SI.

Ann Gastroenterol. 2016 Jul-Sep;29(3):348-57. doi: 10.20524/aog.2016.0036. Epub 2016 Apr 25.


A vision of KIR variation at super resolution.

Hammond JA, Carrington M, Khakoo SI.

Immunology. 2016 Jul;148(3):249-52. doi: 10.1111/imm.12606. Epub 2016 Apr 5.


STAT4-associated natural killer cell tolerance following liver transplantation.

Jamil KM, Hydes TJ, Cheent KS, Cassidy SA, Traherne JA, Jayaraman J, Trowsdale J, Alexander GJ, Little AM, McFarlane H, Heneghan MA, Purbhoo MA, Khakoo SI.

Gut. 2017 Feb;66(2):352-361. doi: 10.1136/gutjnl-2015-309395. Epub 2016 Feb 17.


The interaction of genetic determinants in the outcome of HCV infection: evidence for discrete immunological pathways.

Hydes TJ, Moesker B, Traherne JA, Ashraf S, Alexander GJ, Dimitrov BD, Woelk CH, Trowsdale J, Khakoo SI.

Tissue Antigens. 2015 Oct;86(4):267-75. doi: 10.1111/tan.12650.


NK cells: tuned by peptide?

Das J, Khakoo SI.

Immunol Rev. 2015 Sep;267(1):214-27. doi: 10.1111/imr.12315. Review.


Outcome after discontinuation of nucleot(s)ide analogues in chronic hepatitis B: relapse rate and associated factors.

Kranidioti H, Manolakopoulos S, Khakoo SI.

Ann Gastroenterol. 2015 Apr-Jun;28(2):173-181. Review.


Influence of IFNL3.rs12979860 and IFNL4.ss469415590 polymorphism on clearance of hepatitis C virus infection among Egyptians.

Knapp S, Zakaria Z, Hashem M, Zaghla H, Khakoo SI, Waked I, Thursz M, Abdelwahab SF.

Hepatol Int. 2015 Apr;9(2):251-7. doi: 10.1007/s12072-015-9619-z. Epub 2015 Mar 12.


Innate and adaptive genetic pathways in HCV infection.

Buchanan R, Hydes T, Khakoo SI.

Tissue Antigens. 2015 Apr;85(4):231-40. doi: 10.1111/tan.12540. Epub 2015 Feb 24. Review.


Peptide selectivity discriminates NK cells from KIR2DL2- and KIR2DL3-positive individuals.

Cassidy S, Mukherjee S, Myint TM, Mbiribindi B, North H, Traherne J, Mulder A, Claas FH, Purbhoo MA, Das J, Khakoo SI.

Eur J Immunol. 2015 Feb;45(2):492-500. doi: 10.1002/eji.201444613. Epub 2014 Nov 29.


Genome-wide association study of hepatitis C virus- and cryoglobulin-related vasculitis.

Zignego AL, Wojcik GL, Cacoub P, Visentini M, Casato M, Mangia A, Latanich R, Charles ED, Gragnani L, Terrier B, Piazzola V, Dustin LB, Khakoo SI, Busch MP, Lauer GM, Kim AY, Alric L, Thomas DL, Duggal P.

Genes Immun. 2014 Oct;15(7):500-5. doi: 10.1038/gene.2014.41. Epub 2014 Jul 17.


The Association of Physicians launches new summer research studentships for medical undergraduates.

Khakoo SI.

QJM. 2014 Oct;107(10):787. doi: 10.1093/qjmed/hcu104. Epub 2014 Jun 16. No abstract available.


Effects of Peptide on NK cell-mediated MHC I recognition.

Cassidy SA, Cheent KS, Khakoo SI.

Front Immunol. 2014 Mar 31;5:133. doi: 10.3389/fimmu.2014.00133. eCollection 2014. Review.


T cells but not NK cells are associated with a favourable outcome for resected colorectal liver metastases.

Pugh SA, Harrison RJ, Primrose JN, Khakoo SI.

BMC Cancer. 2014 Mar 13;14:180. doi: 10.1186/1471-2407-14-180.


The allele 4 of neck region liver-lymph node-specific ICAM-3-grabbing integrin variant is associated with spontaneous clearance of hepatitis C virus and decrease of viral loads.

Ezzikouri S, Rebbani K, Fakhir FZ, Alaoui R, Nadir S, Diepolder H, Thursz M, Khakoo SI, Benjelloun S.

Clin Microbiol Infect. 2014 May;20(5):O325-32. doi: 10.1111/1469-0691.12403. Epub 2013 Nov 6.


Synergistic inhibition of natural killer cells by the nonsignaling molecule CD94.

Cheent KS, Jamil KM, Cassidy S, Liu M, Mbiribindi B, Mulder A, Claas FH, Purbhoo MA, Khakoo SI.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16981-6. doi: 10.1073/pnas.1304366110. Epub 2013 Sep 30.


Synergism of tapasin and human leukocyte antigens in resolving hepatitis C virus infection.

Ashraf S, Nitschke K, Warshow UM, Brooks CR, Kim AY, Lauer GM, Hydes TJ, Cramp ME, Alexander G, Little AM, Thimme R, Neumann-Haefelin C, Khakoo SI.

Hepatology. 2013 Sep;58(3):881-9. doi: 10.1002/hep.26415. Epub 2013 Jul 29.


Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts.

Duggal P, Thio CL, Wojcik GL, Goedert JJ, Mangia A, Latanich R, Kim AY, Lauer GM, Chung RT, Peters MG, Kirk GD, Mehta SH, Cox AL, Khakoo SI, Alric L, Cramp ME, Donfield SM, Edlin BR, Tobler LH, Busch MP, Alexander G, Rosen HR, Gao X, Abdel-Hamid M, Apps R, Carrington M, Thomas DL.

Ann Intern Med. 2013 Feb 19;158(4):235-45. doi: 10.7326/0003-4819-158-4-201302190-00003.


A peptide antagonist disrupts NK cell inhibitory synapse formation.

Borhis G, Ahmed PS, Mbiribindi B, Naiyer MM, Davis DM, Purbhoo MA, Khakoo SI.

J Immunol. 2013 Mar 15;190(6):2924-30. doi: 10.4049/jimmunol.1201032. Epub 2013 Feb 4.


Genetic variation in the interleukin-28B gene is associated with spontaneous clearance and progression of hepatitis C virus in Moroccan patients.

Ezzikouri S, Alaoui R, Rebbani K, Brahim I, Fakhir FZ, Nadir S, Diepolder H, Khakoo SI, Thursz M, Benjelloun S.

PLoS One. 2013;8(1):e54793. doi: 10.1371/journal.pone.0054793. Epub 2013 Jan 24.


Innate immunity: a new chapter for hepatitis C.

Hydes T, Khakoo SI.

Ann Gastroenterol. 2012;25(3):232-240. Review.


Natural killer cell responses during viral infections: flexibility and conditioning of innate immunity by experience.

Vidal SM, Khakoo SI, Biron CA.

Curr Opin Virol. 2011 Dec;1(6):497-512. doi: 10.1016/j.coviro.2011.10.017. Review.


KIR2DL2 enhances protective and detrimental HLA class I-mediated immunity in chronic viral infection.

Seich Al Basatena NK, Macnamara A, Vine AM, Thio CL, Astemborski J, Usuku K, Osame M, Kirk GD, Donfield SM, Goedert JJ, Bangham CR, Carrington M, Khakoo SI, Asquith B.

PLoS Pathog. 2011 Oct;7(10):e1002270. doi: 10.1371/journal.ppat.1002270. Epub 2011 Oct 13.


HIV-1 adaptation to NK-cell-mediated immune pressure.

Alter G, Heckerman D, Schneidewind A, Fadda L, Kadie CM, Carlson JM, Oniangue-Ndza C, Martin M, Li B, Khakoo SI, Carrington M, Allen TM, Altfeld M.

Nature. 2011 Aug 3;476(7358):96-100. doi: 10.1038/nature10237.


KIR/HLA interactions and pathogen immunity.

Jamil KM, Khakoo SI.

J Biomed Biotechnol. 2011;2011:298348. doi: 10.1155/2011/298348. Epub 2011 May 19. Review.


A polymorphism in IL28B distinguishes exposed, uninfected individuals from spontaneous resolvers of HCV infection.

Knapp S, Warshow U, Ho KM, Hegazy D, Little AM, Fowell A, Alexander G, Thursz M, Cramp M, Khakoo SI.

Gastroenterology. 2011 Jul;141(1):320-5, 325.e1-2. doi: 10.1053/j.gastro.2011.04.005. Epub 2011 Apr 14.


NK receptors: it's all in the name.

Khakoo SI, Jamil K, Cheent KS.

Gut. 2012 Feb;61(2):325-6. doi: 10.1136/gut.2011.240747. Epub 2011 Mar 12. No abstract available.


Natural killer cells and hepatitis C: action and reaction.

Cheent K, Khakoo SI.

Gut. 2011 Feb;60(2):268-78. doi: 10.1136/gut.2010.212555. Epub 2010 Sep 28. Review.


Increased degranulation of natural killer cells during acute HCV correlates with the magnitude of virus-specific T cell responses.

Pelletier S, Drouin C, Bédard N, Khakoo SI, Bruneau J, Shoukry NH.

J Hepatol. 2010 Nov;53(5):805-16. doi: 10.1016/j.jhep.2010.05.013. Epub 2010 Jul 17.


Association of NKG2A with treatment for chronic hepatitis C virus infection.

Harrison RJ, Ettorre A, Little AM, Khakoo SI.

Clin Exp Immunol. 2010 Aug;161(2):306-14. doi: 10.1111/j.1365-2249.2010.04169.x. Epub 2010 Jun 9.


Peptide antagonism as a mechanism for NK cell activation.

Fadda L, Borhis G, Ahmed P, Cheent K, Pageon SV, Cazaly A, Stathopoulos S, Middleton D, Mulder A, Claas FH, Elliott T, Davis DM, Purbhoo MA, Khakoo SI.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10160-5. doi: 10.1073/pnas.0913745107. Epub 2010 May 3.


Activation of natural killer cells during acute infection with hepatitis C virus.

Amadei B, Urbani S, Cazaly A, Fisicaro P, Zerbini A, Ahmed P, Missale G, Ferrari C, Khakoo SI.

Gastroenterology. 2010 Apr;138(4):1536-45. doi: 10.1053/j.gastro.2010.01.006. Epub 2010 Jan 18.

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