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Items: 30


The cytochrome P450 CYP72A552 is key to production of hederagenin-based saponins that mediate plant defense against herbivores.

Liu Q, Khakimov B, Cárdenas PD, Cozzi F, Olsen CE, Jensen KR, Hauser TP, Bak S.

New Phytol. 2019 May;222(3):1599-1609. doi: 10.1111/nph.15689. Epub 2019 Feb 25.


Effect of fecal microbiota transplantation route of administration on gut colonization and host response in preterm pigs.

Brunse A, Martin L, Rasmussen TS, Christensen L, Skovsted Cilieborg M, Wiese M, Khakimov B, Pieper R, Nielsen DS, Sangild PT, Thymann T.

ISME J. 2019 Mar;13(3):720-733. doi: 10.1038/s41396-018-0301-z. Epub 2018 Oct 26.


Biomarkers of Individual Foods, and Separation of Diets Using Untargeted LC-MS-based Plasma Metabolomics in a Randomized Controlled Trial.

Acar E, Gürdeniz G, Khakimov B, Savorani F, Korndal SK, Larsen TM, Engelsen SB, Astrup A, Dragsted LO.

Mol Nutr Food Res. 2019 Jan;63(1):e1800215. doi: 10.1002/mnfr.201800215. Epub 2018 Aug 26.


Co-expression of squalene epoxidases with triterpene cyclases boosts production of triterpenoids in plants and yeast.

Dong L, Pollier J, Bassard JE, Ntallas G, Almeida A, Lazaridi E, Khakimov B, Arendt P, de Oliveira LS, Lota F, Goossens A, Michoux F, Bak S.

Metab Eng. 2018 Sep;49:1-12. doi: 10.1016/j.ymben.2018.07.002. Epub 2018 Jul 23.


Investigation of Variations in the Human Urine Metabolome amongst European Populations: An Exploratory Search for Biomarkers of People at Risk-of-Poverty.

Trimigno A, Khakimov B, Savorani F, Tenori L, Hendrixson V, Čivilis A, Glibetic M, Gurinovic M, Pentikäinen S, Sallinen J, Garduno Diaz S, Pasqui F, Khokhar S, Luchinat C, Bordoni A, Capozzi F, Balling Engelsen S.

Mol Nutr Food Res. 2019 Jan;63(1):e1800216. doi: 10.1002/mnfr.201800216. Epub 2018 Jun 25.


CoMiniGut-a small volume in vitro colon model for the screening of gut microbial fermentation processes.

Wiese M, Khakimov B, Nielsen S, Sørensen H, van den Berg F, Nielsen DS.

PeerJ. 2018 Jan 19;6:e4268. doi: 10.7717/peerj.4268. eCollection 2018.


Cool-Climate Red Wines-Chemical Composition and Comparison of Two Protocols for ¹H-NMR Analysis.

Aru V, Sørensen KM, Khakimov B, Toldam-Andersen TB, Balling Engelsen S.

Molecules. 2018 Jan 13;23(1). pii: E160. doi: 10.3390/molecules23010160.


A Single Oxidosqualene Cyclase Produces the Seco-Triterpenoid α-Onocerin.

Almeida A, Dong L, Khakimov B, Bassard JE, Moses T, Lota F, Goossens A, Appendino G, Bak S.

Plant Physiol. 2018 Feb;176(2):1469-1484. doi: 10.1104/pp.17.01369. Epub 2017 Dec 4.


Chemical characterization by gas chromatography-mass spectrometry and inductively coupled plasma-optical emission spectroscopy of membrane permeates from an industrial dairy ingredient production used as process water.

Skou PB, Khakimov B, Hansen TH, Aunsbjerg SD, Knøchel S, Thaysen D, van den Berg F.

J Dairy Sci. 2018 Jan;101(1):135-146. doi: 10.3168/jds.2017-12950. Epub 2017 Oct 18.


Untargeted GC-MS Metabolomics Reveals Changes in the Metabolite Dynamics of Industrial Scale Batch Fermentations of Streptoccoccus thermophilus Broth.

Khakimov B, Christiansen LD, Heins AL, Sørensen KM, Schöller C, Clausen A, Skov T, Gernaey KV, Engelsen SB.

Biotechnol J. 2017 Oct;12(10). doi: 10.1002/biot.201700400. Epub 2017 Oct 16.


Isolation and Structural Characterization of Echinocystic Acid Triterpenoid Saponins from the Australian Medicinal and Food Plant Acacia ligulata.

Jæger D, Ndi CP, Crocoll C, Simpson BS, Khakimov B, Guzman-Genuino RM, Hayball JD, Xing X, Bulone V, Weinstein P, Møller BL, Semple SJ.

J Nat Prod. 2017 Oct 27;80(10):2692-2698. doi: 10.1021/acs.jnatprod.7b00437. Epub 2017 Oct 4.


Antibiotic Treatment Preventing Necrotising Enterocolitis Alters Urinary and Plasma Metabolomes in Preterm Pigs.

Jiang P, Trimigno A, Stanstrup J, Khakimov B, Viereck N, Engelsen SB, Sangild PT, Dragsted LO.

J Proteome Res. 2017 Oct 6;16(10):3547-3557. doi: 10.1021/acs.jproteome.7b00263. Epub 2017 Sep 14.


Resveratrol in the foodomics era: 1:25,000.

Khakimov B, Engelsen SB.

Ann N Y Acad Sci. 2017 Sep;1403(1):48-58. doi: 10.1111/nyas.13425. Epub 2017 Sep 3. Review.


Identification of weak and gender specific effects in a short 3 weeks intervention study using barley and oat mixed linkage β-glucan dietary supplements: a human fecal metabolome study by GC-MS.

Trimigno A, Khakimov B, Mejia JLC, Mikkelsen MS, Kristensen M, Jespersen BM, Engelsen SB.

Metabolomics. 2017;13(10):108. doi: 10.1007/s11306-017-1247-2. Epub 2017 Aug 18.


From metabolome to phenotype: GC-MS metabolomics of developing mutant barley seeds reveals effects of growth, temperature and genotype.

Khakimov B, Rasmussen MA, Kannangara RM, Jespersen BM, Munck L, Engelsen SB.

Sci Rep. 2017 Aug 15;7(1):8195. doi: 10.1038/s41598-017-08129-0.


Toward Reliable Lipoprotein Particle Predictions from NMR Spectra of Human Blood: An Interlaboratory Ring Test.

Monsonis Centelles S, Hoefsloot HCJ, Khakimov B, Ebrahimi P, Lind MV, Kristensen M, de Roo N, Jacobs DM, van Duynhoven J, Cannet C, Fang F, Humpfer E, Schäfer H, Spraul M, Engelsen SB, Smilde AK.

Anal Chem. 2017 Aug 1;89(15):8004-8012. doi: 10.1021/acs.analchem.7b01329. Epub 2017 Jul 20.


Gas chromatography - mass spectrometry data processing made easy.

Johnsen LG, Skou PB, Khakimov B, Bro R.

J Chromatogr A. 2017 Jun 23;1503:57-64. doi: 10.1016/j.chroma.2017.04.052. Epub 2017 Apr 27.


Screening for Triterpenoid Saponins in Plants Using Hyphenated Analytical Platforms.

Khakimov B, Tseng LH, Godejohann M, Bak S, Engelsen SB.

Molecules. 2016 Nov 24;21(12). pii: E1614.


Counteracting Age-related Loss of Skeletal Muscle Mass: a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial.

Bechshøft RL, Reitelseder S, Højfeldt G, Castro-Mejía JL, Khakimov B, Ahmad HF, Kjær M, Engelsen SB, Johansen SM, Rasmussen MA, Lassen AJ, Jensen T, Beyer N, Serena A, Perez-Cueto FJ, Nielsen DS, Jespersen AP, Holm L.

Trials. 2016 Aug 9;17(1):397. doi: 10.1186/s13063-016-1512-0.


A comprehensive and comparative GC-MS metabolomics study of non-volatiles in Tanzanian grown mango, pineapple, jackfruit, baobab and tamarind fruits.

Khakimov B, Mongi RJ, Sørensen KM, Ndabikunze BK, Chove BE, Engelsen SB.

Food Chem. 2016 Dec 15;213:691-699. doi: 10.1016/j.foodchem.2016.07.005. Epub 2016 Jul 5.


New Nordic Diet versus Average Danish Diet: A Randomized Controlled Trial Revealed Healthy Long-Term Effects of the New Nordic Diet by GC-MS Blood Plasma Metabolomics.

Khakimov B, Poulsen SK, Savorani F, Acar E, Gürdeniz G, Larsen TM, Astrup A, Dragsted LO, Engelsen SB.

J Proteome Res. 2016 Jun 3;15(6):1939-54. doi: 10.1021/acs.jproteome.6b00109. Epub 2016 May 20.


Lepidopteran defence droplets - a composite physical and chemical weapon against potential predators.

Pentzold S, Zagrobelny M, Khakimov B, Engelsen SB, Clausen H, Petersen BL, Borch J, Møller BL, Bak S.

Sci Rep. 2016 Mar 4;6:22407. doi: 10.1038/srep22407.


GC-MS Metabolite Profiling of Extreme Southern Pinot noir Wines: Effects of Vintage, Barrel Maturation, and Fermentation Dominate over Vineyard Site and Clone Selection.

Schueuermann C, Khakimov B, Engelsen SB, Bremer P, Silcock P.

J Agric Food Chem. 2016 Mar 23;64(11):2342-51. doi: 10.1021/acs.jafc.5b05861. Epub 2016 Mar 8.


Identification and genome organization of saponin pathway genes from a wild crucifer, and their use for transient production of saponins in Nicotiana benthamiana.

Khakimov B, Kuzina V, Erthmann PØ, Fukushima EO, Augustin JM, Olsen CE, Scholtalbers J, Volpin H, Andersen SB, Hauser TP, Muranaka T, Bak S.

Plant J. 2015 Nov;84(3):478-90. doi: 10.1111/tpj.13012.


The use of trimethylsilyl cyanide derivatization for robust and broad-spectrum high-throughput gas chromatography-mass spectrometry based metabolomics.

Khakimov B, Motawia MS, Bak S, Engelsen SB.

Anal Bioanal Chem. 2013 Nov;405(28):9193-205. doi: 10.1007/s00216-013-7341-z. Epub 2013 Oct 4.


Plant metabolomics: resolution and quantification of elusive peaks in liquid chromatography-mass spectrometry profiles of complex plant extracts using multi-way decomposition methods.

Khakimov B, Amigo JM, Bak S, Engelsen SB.

J Chromatogr A. 2012 Nov 30;1266:84-94. doi: 10.1016/j.chroma.2012.10.023. Epub 2012 Oct 16.


UDP-glycosyltransferases from the UGT73C subfamily in Barbarea vulgaris catalyze sapogenin 3-O-glucosylation in saponin-mediated insect resistance.

Augustin JM, Drok S, Shinoda T, Sanmiya K, Nielsen JK, Khakimov B, Olsen CE, Hansen EH, Kuzina V, Ekstrøm CT, Hauser T, Bak S.

Plant Physiol. 2012 Dec;160(4):1881-95. doi: 10.1104/pp.112.202747. Epub 2012 Oct 1.


[Minimally invasive interventions for acute cholecystitis complicated by mechanical jaundice in elderly and senile patients].

Khozhibaev AM, Atadzhanov ShK, Khakimov BB, Khoshimov MA.

Vestn Khir Im I I Grek. 2007;166(3):66-9. Russian.


[Predicting the maximum allowable concentrations of new chemical substances in atmospheric air in accordance with a complex of indicators using splines].

Murzakaev FG, Maksimov GG, Khakimov BV.

Gig Sanit. 1980 Jun;(6):56-9. Russian. No abstract available.


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