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Items: 1 to 50 of 98

1.

Assessing Neuron-Astrocyte Spatial Interactions Using the Neuron-Astrocyte Proximity Assay.

Badia-Soteras A, Octeau JC, Verheijen MHG, Khakh BS.

Curr Protoc Neurosci. 2020 Mar;91(1):e91. doi: 10.1002/cpns.91.

PMID:
32068967
2.

Improved tools to study astrocytes.

Yu X, Nagai J, Khakh BS.

Nat Rev Neurosci. 2020 Mar;21(3):121-138. doi: 10.1038/s41583-020-0264-8. Epub 2020 Feb 10. Review.

PMID:
32042146
3.

Breakdown of spatial coding and interneuron synchronization in epileptic mice.

Shuman T, Aharoni D, Cai DJ, Lee CR, Chavlis S, Page-Harley L, Vetere LM, Feng Y, Yang CY, Mollinedo-Gajate I, Chen L, Pennington ZT, Taxidis J, Flores SE, Cheng K, Javaherian M, Kaba CC, Rao N, La-Vu M, Pandi I, Shtrahman M, Bakhurin KI, Masmanidis SC, Khakh BS, Poirazi P, Silva AJ, Golshani P.

Nat Neurosci. 2020 Feb;23(2):229-238. doi: 10.1038/s41593-019-0559-0. Epub 2020 Jan 6.

PMID:
31907437
4.

Astrocyte molecular signatures in Huntington's disease.

Diaz-Castro B, Gangwani MR, Yu X, Coppola G, Khakh BS.

Sci Transl Med. 2019 Oct 16;11(514). pii: eaaw8546. doi: 10.1126/scitranslmed.aaw8546.

PMID:
31619545
5.

Visualizing Astrocyte Morphology Using Lucifer Yellow Iontophoresis.

Moye SL, Diaz-Castro B, Gangwani MR, Khakh BS.

J Vis Exp. 2019 Sep 14;(151). doi: 10.3791/60225.

PMID:
31566622
6.

Astrocyte-Neuron Interactions in the Striatum: Insights on Identity, Form, and Function.

Khakh BS.

Trends Neurosci. 2019 Sep;42(9):617-630. doi: 10.1016/j.tins.2019.06.003. Epub 2019 Jul 24. Review.

PMID:
31351745
7.

The Emerging Nature of Astrocyte Diversity.

Khakh BS, Deneen B.

Annu Rev Neurosci. 2019 Jul 8;42:187-207. doi: 10.1146/annurev-neuro-070918-050443.

PMID:
31283899
8.

Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation.

Octeau JC, Gangwani MR, Allam SL, Tran D, Huang S, Hoang-Trong TM, Golshani P, Rumbell TH, Kozloski JR, Khakh BS.

Cell Rep. 2019 May 21;27(8):2249-2261.e7. doi: 10.1016/j.celrep.2019.04.078.

9.

Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue.

Nagai J, Rajbhandari AK, Gangwani MR, Hachisuka A, Coppola G, Masmanidis SC, Fanselow MS, Khakh BS.

Cell. 2019 May 16;177(5):1280-1292.e20. doi: 10.1016/j.cell.2019.03.019. Epub 2019 Apr 25.

PMID:
31031006
10.

A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP.

Lobas MA, Tao R, Nagai J, Kronschläger MT, Borden PM, Marvin JS, Looger LL, Khakh BS.

Nat Commun. 2019 Feb 12;10(1):711. doi: 10.1038/s41467-019-08441-5.

11.

CaImAn an open source tool for scalable calcium imaging data analysis.

Giovannucci A, Friedrich J, Gunn P, Kalfon J, Brown BL, Koay SA, Taxidis J, Najafi F, Gauthier JL, Zhou P, Khakh BS, Tank DW, Chklovskii DB, Pnevmatikakis EA.

Elife. 2019 Jan 17;8. pii: e38173. doi: 10.7554/eLife.38173.

12.

All the light that we can see: a new era in miniaturized microscopy.

Aharoni D, Khakh BS, Silva AJ, Golshani P.

Nat Methods. 2019 Jan;16(1):11-13. doi: 10.1038/s41592-018-0266-x. No abstract available.

PMID:
30573833
13.

Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior.

Yu X, Taylor AMW, Nagai J, Golshani P, Evans CJ, Coppola G, Khakh BS.

Neuron. 2018 Sep 19;99(6):1170-1187.e9. doi: 10.1016/j.neuron.2018.08.015. Epub 2018 Aug 30.

14.

Active role of capillary pericytes during stimulation-induced activity and spreading depolarization.

Khennouf L, Gesslein B, Brazhe A, Octeau JC, Kutuzov N, Khakh BS, Lauritzen M.

Brain. 2018 Jul 1;141(7):2032-2046. doi: 10.1093/brain/awy143.

15.

Making, Testing, and Using Potassium Ion Selective Microelectrodes in Tissue Slices of Adult Brain.

Octeau JC, Faas G, Mody I, Khakh BS.

J Vis Exp. 2018 May 7;(135). doi: 10.3791/57511.

16.

An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales.

Octeau JC, Chai H, Jiang R, Bonanno SL, Martin KC, Khakh BS.

Neuron. 2018 Apr 4;98(1):49-66.e9. doi: 10.1016/j.neuron.2018.03.003.

17.

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection.

Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, Novitch BG.

Cell Rep. 2017 Oct 10;21(2):517-532. doi: 10.1016/j.celrep.2017.09.047.

18.

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.

Chai H, Diaz-Castro B, Shigetomi E, Monte E, Octeau JC, Yu X, Cohn W, Rajendran PS, Vondriska TM, Whitelegge JP, Coppola G, Khakh BS.

Neuron. 2017 Aug 2;95(3):531-549.e9. doi: 10.1016/j.neuron.2017.06.029. Epub 2017 Jul 14.

19.

Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.

Khakh BS, Beaumont V, Cachope R, Munoz-Sanjuan I, Goldman SA, Grantyn R.

Trends Neurosci. 2017 Jul;40(7):422-437. doi: 10.1016/j.tins.2017.05.002. Epub 2017 May 31. Review.

20.

New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo.

Srinivasan R, Lu TY, Chai H, Xu J, Huang BS, Golshani P, Coppola G, Khakh BS.

Neuron. 2016 Dec 21;92(6):1181-1195. doi: 10.1016/j.neuron.2016.11.030. Epub 2016 Dec 8.

21.

P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus.

Xu J, Bernstein AM, Wong A, Lu XH, Khoja S, Yang XW, Davies DL, Micevych P, Sofroniew MV, Khakh BS.

J Neurosci. 2016 Aug 24;36(34):8902-20. doi: 10.1523/JNEUROSCI.1496-16.2016.

22.

Astrocyte scar formation aids central nervous system axon regeneration.

Anderson MA, Burda JE, Ren Y, Ao Y, O'Shea TM, Kawaguchi R, Coppola G, Khakh BS, Deming TJ, Sofroniew MV.

Nature. 2016 Apr 14;532(7598):195-200. doi: 10.1038/nature17623. Epub 2016 Mar 30.

23.

Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice.

Jiang R, Diaz-Castro B, Looger LL, Khakh BS.

J Neurosci. 2016 Mar 23;36(12):3453-70. doi: 10.1523/JNEUROSCI.3693-15.2016.

24.

Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium.

Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV.

Front Neurosci. 2016 Feb 22;10:46. doi: 10.3389/fnins.2016.00046. eCollection 2016.

25.

Probing the Complexities of Astrocyte Calcium Signaling.

Shigetomi E, Patel S, Khakh BS.

Trends Cell Biol. 2016 Apr;26(4):300-312. doi: 10.1016/j.tcb.2016.01.003. Epub 2016 Feb 16. Review.

26.

New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling.

Olsen ML, Khakh BS, Skatchkov SN, Zhou M, Lee CJ, Rouach N.

J Neurosci. 2015 Oct 14;35(41):13827-35. doi: 10.1523/JNEUROSCI.2603-15.2015. Review.

27.

Diversity of astrocyte functions and phenotypes in neural circuits.

Khakh BS, Sofroniew MV.

Nat Neurosci. 2015 Jul;18(7):942-52. doi: 10.1038/nn.4043. Review.

28.

Ca(2+) signaling in astrocytes from Ip3r2(-/-) mice in brain slices and during startle responses in vivo.

Srinivasan R, Huang BS, Venugopal S, Johnston AD, Chai H, Zeng H, Golshani P, Khakh BS.

Nat Neurosci. 2015 May;18(5):708-17. doi: 10.1038/nn.4001. Epub 2015 Apr 20.

29.

Astrocyte calcium signaling: from observations to functions and the challenges therein.

Khakh BS, McCarthy KD.

Cold Spring Harb Perspect Biol. 2015 Jan 20;7(4):a020404. doi: 10.1101/cshperspect.a020404. Review.

30.

Imaging intracellular Ca²⁺ signals in striatal astrocytes from adult mice using genetically-encoded calcium indicators.

Jiang R, Haustein MD, Sofroniew MV, Khakh BS.

J Vis Exp. 2014 Nov 19;(93):e51972. doi: 10.3791/51972.

31.

ATP-gated P2X receptors in health and disease.

Burnstock G, Nistri A, Khakh BS, Giniatullin R.

Front Cell Neurosci. 2014 Jul 24;8:204. doi: 10.3389/fncel.2014.00204. eCollection 2014. No abstract available.

32.

Slow neuromodulation mediated by ATP P2X receptors.

Xu J, Khakh BS.

Neuron. 2014 Jul 16;83(2):257-259. doi: 10.1016/j.neuron.2014.06.028.

33.

Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin.

Xu J, Chai H, Ehinger K, Egan TM, Srinivasan R, Frick M, Khakh BS.

J Gen Physiol. 2014 Jul;144(1):81-104. doi: 10.1085/jgp.201411169. Epub 2014 Jun 16.

34.

Astrocytes and Huntington's disease.

Khakh BS, Sofroniew MV.

ACS Chem Neurosci. 2014 Jul 16;5(7):494-6. doi: 10.1021/cn500100r. Epub 2014 May 20.

35.

Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway.

Haustein MD, Kracun S, Lu XH, Shih T, Jackson-Weaver O, Tong X, Xu J, Yang XW, O'Dell TJ, Marvin JS, Ellisman MH, Bushong EA, Looger LL, Khakh BS.

Neuron. 2014 Apr 16;82(2):413-29. doi: 10.1016/j.neuron.2014.02.041.

36.

Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.

Gray EE, Guglietta R, Khakh BS, O'Dell TJ.

J Biol Chem. 2014 May 23;289(21):14600-11. doi: 10.1074/jbc.M114.553537. Epub 2014 Apr 4.

37.

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice.

Tong X, Ao Y, Faas GC, Nwaobi SE, Xu J, Haustein MD, Anderson MA, Mody I, Olsen ML, Sofroniew MV, Khakh BS.

Nat Neurosci. 2014 May;17(5):694-703. doi: 10.1038/nn.3691. Epub 2014 Mar 30.

38.

Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system.

Zhang S, Anderson MA, Ao Y, Khakh BS, Fan J, Deming TJ, Sofroniew MV.

Biomaterials. 2014 Feb;35(6):1989-2000. doi: 10.1016/j.biomaterials.2013.11.005. Epub 2013 Dec 4.

39.

TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release.

Shigetomi E, Jackson-Weaver O, Huckstepp RT, O'Dell TJ, Khakh BS.

J Neurosci. 2013 Jun 12;33(24):10143-53. doi: 10.1523/JNEUROSCI.5779-12.2013.

40.

ATP-gated ion channels mediate adaptation to elevated sound levels.

Housley GD, Morton-Jones R, Vlajkovic SM, Telang RS, Paramananthasivam V, Tadros SF, Wong AC, Froud KE, Cederholm JM, Sivakumaran Y, Snguanwongchai P, Khakh BS, Cockayne DA, Thorne PR, Ryan AF.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7494-9. doi: 10.1073/pnas.1222295110. Epub 2013 Apr 16.

41.

Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses.

Shigetomi E, Bushong EA, Haustein MD, Tong X, Jackson-Weaver O, Kracun S, Xu J, Sofroniew MV, Ellisman MH, Khakh BS.

J Gen Physiol. 2013 May;141(5):633-47. doi: 10.1085/jgp.201210949. Epub 2013 Apr 15.

42.

Genetically encoded calcium indicators and astrocyte calcium microdomains.

Tong X, Shigetomi E, Looger LL, Khakh BS.

Neuroscientist. 2013 Jun;19(3):274-91. doi: 10.1177/1073858412468794. Epub 2012 Dec 20.

PMID:
23264008
43.

Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.

Hamby ME, Coppola G, Ao Y, Geschwind DH, Khakh BS, Sofroniew MV.

J Neurosci. 2012 Oct 17;32(42):14489-510. doi: 10.1523/JNEUROSCI.1256-12.2012.

44.

Neuromodulation by extracellular ATP and P2X receptors in the CNS.

Khakh BS, North RA.

Neuron. 2012 Oct 4;76(1):51-69. doi: 10.1016/j.neuron.2012.09.024. Review.

45.

Optimization of a GCaMP calcium indicator for neural activity imaging.

Akerboom J, Chen TW, Wardill TJ, Tian L, Marvin JS, Mutlu S, Calderón NC, Esposti F, Borghuis BG, Sun XR, Gordus A, Orger MB, Portugues R, Engert F, Macklin JJ, Filosa A, Aggarwal A, Kerr RA, Takagi R, Kracun S, Shigetomi E, Khakh BS, Baier H, Lagnado L, Wang SS, Bargmann CI, Kimmel BE, Jayaraman V, Svoboda K, Kim DS, Schreiter ER, Looger LL.

J Neurosci. 2012 Oct 3;32(40):13819-40. doi: 10.1523/JNEUROSCI.2601-12.2012.

46.

Imaging P2X4 receptor lateral mobility in microglia: regulation by calcium and p38 MAPK.

Toulme E, Khakh BS.

J Biol Chem. 2012 Apr 27;287(18):14734-48. doi: 10.1074/jbc.M111.329334. Epub 2012 Mar 5.

47.

Allosteric modulation of Ca2+ flux in ligand-gated cation channel (P2X4) by actions on lateral portals.

Samways DS, Khakh BS, Egan TM.

J Biol Chem. 2012 Mar 2;287(10):7594-602. doi: 10.1074/jbc.M111.322461. Epub 2012 Jan 4.

48.

TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3.

Shigetomi E, Tong X, Kwan KY, Corey DP, Khakh BS.

Nat Neurosci. 2011 Dec 11;15(1):70-80. doi: 10.1038/nn.3000.

49.

Neuronal P2X2 receptors are mobile ATP sensors that explore the plasma membrane when activated.

Richler E, Shigetomi E, Khakh BS.

J Neurosci. 2011 Nov 16;31(46):16716-30. doi: 10.1523/JNEUROSCI.3362-11.2011.

50.

On the Role of ATP-Gated P2X Receptors in Acute, Inflammatory and Neuropathic Pain.

Toulme E, Tsuda M, Khakh BS, Inoue K.

In: Kruger L, Light AR, editors. Translational Pain Research: From Mouse to Man. Boca Raton (FL): CRC Press/Taylor & Francis; 2010. Chapter 10.

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