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Items: 1 to 50 of 87

1.

Immune correlates of tuberculosis disease and risk translate across species.

Ahmed M, Thirunavukkarasu S, Rosa BA, Thomas KA, Das S, Rangel-Moreno J, Lu L, Mehra S, Mbandi SK, Thackray LB, Diamond MS, Murphy KM, Means T, Martin J, Kaushal D, Scriba TJ, Mitreva M, Khader SA.

Sci Transl Med. 2020 Jan 29;12(528). pii: eaay0233. doi: 10.1126/scitranslmed.aay0233.

PMID:
31996462
2.

Mycobacterium tuberculosis HN878 infection induces human-like B cell follicles in mice.

Alberto Choreño-Parra J, Bobba S, Rangel-Moreno J, Ahmed M, Mehra S, Rosa B, Martin J, Mitreva M, Kaushal D, Zúñiga J, Khader SA.

J Infect Dis. 2019 Dec 13. pii: jiz663. doi: 10.1093/infdis/jiz663. [Epub ahead of print]

PMID:
31832640
3.

Mechanisms of reactivation of latent tuberculosis infection due to SIV coinfection.

Bucşan AN, Chatterjee A, Singh DK, Foreman TW, Lee TH, Threeton B, Kirkpatrick MG, Ahmed M, Golden N, Alvarez X, Hoxie JA, Mehra S, Rengarajan J, Khader SA, Kaushal D.

J Clin Invest. 2019 Dec 2;129(12):5254-5260. doi: 10.1172/JCI125810.

4.

Targeting innate immunity for tuberculosis vaccination.

Khader SA, Divangahi M, Hanekom W, Hill PC, Maeurer M, Makar KW, Mayer-Barber KD, Mhlanga MM, Nemes E, Schlesinger LS, van Crevel R, Vankalayapati R, Xavier RJ, Netea MG; Bill and Melinda Gates Foundation Collaboration for TB Vaccine Discovery Innate Immunity Working Group18.

J Clin Invest. 2019 Sep 3;129(9):3482-3491. doi: 10.1172/JCI128877. Review.

5.
6.

Publisher Correction: Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis.

Ardain A, Domingo-Gonzalez R, Das S, Kazer SW, Howard NC, Singh A, Ahmed M, Nhamoyebonde S, Rangel-Moreno J, Ogongo P, Lu L, Ramsuran D, de la Luz Garcia-Hernandez M, Ulland TK, Darby M, Park E, Karim F, Melocchi L, Madansein R, Dullabh KJ, Dunlap M, Marin-Agudelo N, Ebihara T, Ndung'u T, Kaushal D, Pym AS, Kolls JK, Steyn A, Zúñiga J, Horsnell W, Yokoyama WM, Shalek AK, Kløverpris HN, Colonna M, Leslie A, Khader SA.

Nature. 2019 Aug;572(7768):E10. doi: 10.1038/s41586-019-1458-y.

PMID:
31337923
7.

Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis.

Ardain A, Domingo-Gonzalez R, Das S, Kazer SW, Howard NC, Singh A, Ahmed M, Nhamoyebonde S, Rangel-Moreno J, Ogongo P, Lu L, Ramsuran D, de la Luz Garcia-Hernandez M, K Ulland T, Darby M, Park E, Karim F, Melocchi L, Madansein R, Dullabh KJ, Dunlap M, Marin-Agudelo N, Ebihara T, Ndung'u T, Kaushal D, Pym AS, Kolls JK, Steyn A, Zúñiga J, Horsnell W, Yokoyama WM, Shalek AK, Kløverpris HN, Colonna M, Leslie A, Khader SA.

Nature. 2019 Jun;570(7762):528-532. doi: 10.1038/s41586-019-1276-2. Epub 2019 Jun 5. Erratum in: Nature. 2019 Jul 24;:.

8.

Mucosal-activated invariant T cells do not exhibit significant lung recruitment and proliferation profiles in macaques in response to infection with Mycobacterium tuberculosis CDC1551.

Bucsan AN, Rout N, Foreman TW, Khader SA, Rengarajan J, Kaushal D.

Tuberculosis (Edinb). 2019 May;116S:S11-S18. doi: 10.1016/j.tube.2019.04.006. Epub 2019 Apr 26.

PMID:
31072689
9.

Advances in Cardiovascular Disease Lipid Research Can Provide Novel Insights Into Mycobacterial Pathogenesis.

Thirunavukkarasu S, Khader SA.

Front Cell Infect Microbiol. 2019 Apr 18;9:116. doi: 10.3389/fcimb.2019.00116. eCollection 2019. Review.

10.

Friend or Foe: The Protective and Pathological Roles of Inducible Bronchus-Associated Lymphoid Tissue in Pulmonary Diseases.

Marin ND, Dunlap MD, Kaushal D, Khader SA.

J Immunol. 2019 May 1;202(9):2519-2526. doi: 10.4049/jimmunol.1801135. Review.

PMID:
31010841
11.

HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis.

Corleis B, Bucsan AN, Deruaz M, Vrbanac VD, Lisanti-Park AC, Gates SJ, Linder AH, Paer JM, Olson GS, Bowman BA, Schiff AE, Medoff BD, Tager AM, Luster AD, Khader SA, Kaushal D, Kwon DS.

Cell Rep. 2019 Feb 5;26(6):1409-1418.e5. doi: 10.1016/j.celrep.2019.01.021.

12.

The Tale of IL-12 and IL-23: A Paradigm Shift.

Khader SA, Thirunavukkarasu S.

J Immunol. 2019 Feb 1;202(3):629-630. doi: 10.4049/jimmunol.1801603. No abstract available.

13.

Publisher Correction: Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes.

Howard NC, Marin ND, Ahmed M, Rosa BA, Martin J, Bambouskova M, Sergushichev A, Loginicheva E, Kurepina N, Rangel-Moreno J, Chen L, Kreiswirth BN, Klein RS, Balada-Llasat JM, Torrelles JB, Amarasinghe GK, Mitreva M, Artyomov MN, Hsu FF, Mathema B, Khader SA.

Nat Microbiol. 2018 Nov;3(11):1327. doi: 10.1038/s41564-018-0281-9.

PMID:
30327492
14.

Corkscrewing of retinal arterioles leading to diagnosis of coarctation of aorta.

Shaik A, Praveen Kumar KV, Chiranjeevi P, Khader SA.

J Postgrad Med. 2018 Oct-Dec;64(4):253-254. doi: 10.4103/jpgm.JPGM_137_18.

15.

Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes.

Howard NC, Marin ND, Ahmed M, Rosa BA, Martin J, Bambouskova M, Sergushichev A, Loginicheva E, Kurepina N, Rangel-Moreno J, Chen L, Kreiswirth BN, Klein RS, Balada-Llasat JM, Torrelles JB, Amarasinghe GK, Mitreva M, Artyomov MN, Hsu FF, Mathema B, Khader SA.

Nat Microbiol. 2018 Oct;3(10):1099-1108. doi: 10.1038/s41564-018-0245-0. Epub 2018 Sep 17. Erratum in: Nat Microbiol. 2018 Nov;3(11):1327.

16.

A novel role for C-C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis.

Dunlap MD, Howard N, Das S, Scott N, Ahmed M, Prince O, Rangel-Moreno J, Rosa BA, Martin J, Kaushal D, Kaplan G, Mitreva M, Kim KW, Randolph GJ, Khader SA.

Mucosal Immunol. 2018 Nov;11(6):1727-1742. doi: 10.1038/s41385-018-0071-y. Epub 2018 Aug 16.

17.

Aspergillus fumigatus Preexposure Worsens Pathology and Improves Control of Mycobacterium abscessus Pulmonary Infection in Mice.

Monin L, Mehta S, Elsegeiny W, Gopal R, McAleer JP, Oury TD, Kolls J, Khader SA.

Infect Immun. 2018 Feb 20;86(3). pii: e00859-17. doi: 10.1128/IAI.00859-17. Print 2018 Mar.

18.

In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis.

Gautam US, Foreman TW, Bucsan AN, Veatch AV, Alvarez X, Adekambi T, Golden NA, Gentry KM, Doyle-Meyers LA, Russell-Lodrigue KE, Didier PJ, Blanchard JL, Kousoulas KG, Lackner AA, Kalman D, Rengarajan J, Khader SA, Kaushal D, Mehra S.

Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):E62-E71. doi: 10.1073/pnas.1711373114. Epub 2017 Dec 18.

19.

Interleukin-17 limits hypoxia-inducible factor 1α and development of hypoxic granulomas during tuberculosis.

Domingo-Gonzalez R, Das S, Griffiths KL, Ahmed M, Bambouskova M, Gopal R, Gondi S, Muñoz-Torrico M, Salazar-Lezama MA, Cruz-Lagunas A, Jiménez-Álvarez L, Ramirez-Martinez G, Espinosa-Soto R, Sultana T, Lyons-Weiler J, Reinhart TA, Arcos J, de la Luz Garcia-Hernandez M, Mastrangelo MA, Al-Hammadi N, Townsend R, Balada-Llasat JM, Torrelles JB, Kaplan G, Horne W, Kolls JK, Artyomov MN, Rangel-Moreno J, Zúñiga J, Khader SA.

JCI Insight. 2017 Oct 5;2(19). pii: 92973. doi: 10.1172/jci.insight.92973.

20.

RNA Interference Screening Reveals Host CaMK4 as a Regulator of Cryptococcal Uptake and Pathogenesis.

Srikanta D, Hole CR, Williams M, Khader SA, Doering TL.

Infect Immun. 2017 Nov 17;85(12). pii: e00195-17. doi: 10.1128/IAI.00195-17. Print 2017 Dec.

21.

Nonpathologic Infection of Macaques by an Attenuated Mycobacterial Vaccine Is Not Reactivated in the Setting of HIV Co-Infection.

Foreman TW, Veatch AV, LoBato DN, Didier PJ, Doyle-Meyers LA, Russell-Lodrigue KE, Lackner AA, Kousoulas KG, Khader SA, Kaushal D, Mehra S.

Am J Pathol. 2017 Dec;187(12):2811-2820. doi: 10.1016/j.ajpath.2017.08.014. Epub 2017 Sep 19.

22.

Dancing with the Stars: Phenolic Glycolipids Partners with Macrophages.

Dunlap MD, Khader SA.

Cell Host Microbe. 2017 Sep 13;22(3):249-251. doi: 10.1016/j.chom.2017.08.016.

23.

A novel nanoemulsion vaccine induces mucosal Interleukin-17 responses and confers protection upon Mycobacterium tuberculosis challenge in mice.

Ahmed M, Smith DM, Hamouda T, Rangel-Moreno J, Fattom A, Khader SA.

Vaccine. 2017 Sep 5;35(37):4983-4989. doi: 10.1016/j.vaccine.2017.07.073. Epub 2017 Jul 31.

24.

A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression.

García-Hernández ML, Uribe-Uribe NO, Espinosa-González R, Kast WM, Khader SA, Rangel-Moreno J.

Front Immunol. 2017 May 17;8:563. doi: 10.3389/fimmu.2017.00563. eCollection 2017.

25.

Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity.

Eddens T, Elsegeiny W, Garcia-Hernadez ML, Castillo P, Trevejo-Nunez G, Serody K, Campfield BT, Khader SA, Chen K, Rangel-Moreno J, Kolls JK.

Cell Rep. 2017 Mar 28;18(13):3078-3090. doi: 10.1016/j.celrep.2017.03.016.

26.

Rationalized design of a mucosal vaccine protects against Mycobacterium tuberculosis challenge in mice.

Ahmed M, Jiao H, Domingo-Gonzalez R, Das S, Griffiths KL, Rangel-Moreno J, Nagarajan UM, Khader SA.

J Leukoc Biol. 2017 Jun;101(6):1373-1381. doi: 10.1189/jlb.4A0616-270R. Epub 2017 Mar 3.

27.

Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection.

Treerat P, Prince O, Cruz-Lagunas A, Muñoz-Torrico M, Salazar-Lezama MA, Selman M, Fallert-Junecko B, Reinhardt TA, Alcorn JF, Kaushal D, Zuñiga J, Rangel-Moreno J, Kolls JK, Khader SA.

Mucosal Immunol. 2017 Jul;10(4):1069-1081. doi: 10.1038/mi.2017.15. Epub 2017 Mar 1.

28.

HLA Alleles are Genetic Markers for Susceptibility and Resistance towards Leprosy in a Mexican Mestizo Population.

Aguilar-Medina M, Escamilla-Tilch M, Frías-Castro LO, Romero-Quintana G, Estrada-García I, Estrada-Parra S, Granados J, Arambula Meraz E, Sánchez-Schmitz G, Khader SA, Rangel-Moreno J, Ramos-Payán R.

Ann Hum Genet. 2017 Jan;81(1):35-40. doi: 10.1111/ahg.12183. Epub 2016 Dec 27.

29.

Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy.

Griffiths KL, Ahmed M, Das S, Gopal R, Horne W, Connell TD, Moynihan KD, Kolls JK, Irvine DJ, Artyomov MN, Rangel-Moreno J, Khader SA.

Nat Commun. 2016 Dec 22;7:13894. doi: 10.1038/ncomms13894.

30.

Cytokines and Chemokines in Mycobacterium tuberculosis Infection.

Domingo-Gonzalez R, Prince O, Cooper A, Khader SA.

Microbiol Spectr. 2016 Oct;4(5). doi: 10.1128/microbiolspec.TBTB2-0018-2016. Review.

31.

CD4+ T-cell-independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection.

Foreman TW, Mehra S, LoBato DN, Malek A, Alvarez X, Golden NA, Bucşan AN, Didier PJ, Doyle-Meyers LA, Russell-Lodrigue KE, Roy CJ, Blanchard J, Kuroda MJ, Lackner AA, Chan J, Khader SA, Jacobs WR Jr, Kaushal D.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5636-44. doi: 10.1073/pnas.1611987113. Epub 2016 Sep 6.

32.

A novel multivalent tuberculosis vaccine confers protection in a mouse model of tuberculosis.

Griffiths KL, Villarreal DO, Weiner DB, Khader SA.

Hum Vaccin Immunother. 2016 Oct 2;12(10):2649-2653. doi: 10.1080/21645515.2016.1197454. Epub 2016 Jun 20.

33.

Computational Analysis Reveals a Key Regulator of Cryptococcal Virulence and Determinant of Host Response.

Gish SR, Maier EJ, Haynes BC, Santiago-Tirado FH, Srikanta DL, Ma CZ, Li LX, Williams M, Crouch EC, Khader SA, Brent MR, Doering TL.

mBio. 2016 Apr 19;7(2):e00313-16. doi: 10.1128/mBio.00313-16.

34.

Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis.

Monin L, Griffiths KL, Lam WY, Gopal R, Kang DD, Ahmed M, Rajamanickam A, Cruz-Lagunas A, Zúñiga J, Babu S, Kolls JK, Mitreva M, Rosa BA, Ramos-Payan R, Morrison TE, Murray PJ, Rangel-Moreno J, Pearce EJ, Khader SA.

J Clin Invest. 2015 Dec;125(12):4699-713. doi: 10.1172/JCI77378. Epub 2015 Nov 16.

35.

Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis.

Kaushal D, Foreman TW, Gautam US, Alvarez X, Adekambi T, Rangel-Moreno J, Golden NA, Johnson AM, Phillips BL, Ahsan MH, Russell-Lodrigue KE, Doyle LA, Roy CJ, Didier PJ, Blanchard JL, Rengarajan J, Lackner AA, Khader SA, Mehra S.

Nat Commun. 2015 Oct 13;6:8533. doi: 10.1038/ncomms9533.

36.

The DosR Regulon Modulates Adaptive Immunity and Is Essential for Mycobacterium tuberculosis Persistence.

Mehra S, Foreman TW, Didier PJ, Ahsan MH, Hudock TA, Kissee R, Golden NA, Gautam US, Johnson AM, Alvarez X, Russell-Lodrigue KE, Doyle LA, Roy CJ, Niu T, Blanchard JL, Khader SA, Lackner AA, Sherman DR, Kaushal D.

Am J Respir Crit Care Med. 2015 May 15;191(10):1185-96. doi: 10.1164/rccm.201408-1502OC.

37.

Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge.

Monin L, Griffiths KL, Slight S, Lin Y, Rangel-Moreno J, Khader SA.

Mucosal Immunol. 2015 Sep;8(5):1099-109. doi: 10.1038/mi.2014.136. Epub 2015 Jan 28.

38.

LAG3 expression in active Mycobacterium tuberculosis infections.

Phillips BL, Mehra S, Ahsan MH, Selman M, Khader SA, Kaushal D.

Am J Pathol. 2015 Mar;185(3):820-33. doi: 10.1016/j.ajpath.2014.11.003. Epub 2014 Dec 27.

39.

Chemokines in tuberculosis: the good, the bad and the ugly.

Monin L, Khader SA.

Semin Immunol. 2014 Dec;26(6):552-8. doi: 10.1016/j.smim.2014.09.004. Epub 2014 Oct 22. Review.

40.

Bringing in the cavalry: IL-26 mediates neutrophil recruitment to the lungs.

Griffiths KL, Khader SA.

Am J Respir Crit Care Med. 2014 Nov 15;190(10):1079-80. doi: 10.1164/rccm.201410-1870ED. No abstract available.

PMID:
25398102
41.

Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection.

Gopal R, Monin L, Slight S, Uche U, Blanchard E, Fallert Junecko BA, Ramos-Payan R, Stallings CL, Reinhart TA, Kolls JK, Kaushal D, Nagarajan U, Rangel-Moreno J, Khader SA.

PLoS Pathog. 2014 May 15;10(5):e1004099. doi: 10.1371/journal.ppat.1004099. eCollection 2014 May.

42.

Editorial overview: Vaccines: Vaccines for infectious diseases: are we there yet?

Khader SA, Kolls JK.

Curr Opin Immunol. 2014 Jun;28:ix-x. doi: 10.1016/j.coi.2014.03.005. Epub 2014 Apr 12. No abstract available.

PMID:
24735901
43.

Mycobacterium tuberculosis impairs dendritic cell functions through the serine hydrolase Hip1.

Madan-Lala R, Sia JK, King R, Adekambi T, Monin L, Khader SA, Pulendran B, Rengarajan J.

J Immunol. 2014 May 1;192(9):4263-72. doi: 10.4049/jimmunol.1303185. Epub 2014 Mar 21.

44.

Novel vaccine approaches for protection against intracellular pathogens.

Griffiths KL, Khader SA.

Curr Opin Immunol. 2014 Jun;28:58-63. doi: 10.1016/j.coi.2014.02.003. Epub 2014 Mar 6. Review.

45.

Mucosal pre-exposure to Th17-inducing adjuvants exacerbates pathology after influenza infection.

Gopal R, Rangel-Moreno J, Fallert Junecko BA, Mallon DJ, Chen K, Pociask DA, Connell TD, Reinhart TA, Alcorn JF, Ross TM, Kolls JK, Khader SA.

Am J Pathol. 2014 Jan;184(1):55-63. doi: 10.1016/j.ajpath.2013.09.012. Epub 2013 Nov 1.

46.

Variants in toll-like receptor 9 gene influence susceptibility to tuberculosis in a Mexican population.

Torres-García D, Cruz-Lagunas A, García-Sancho Figueroa MC, Fernández-Plata R, Baez-Saldaña R, Mendoza-Milla C, Barquera R, Carrera-Eusebio A, Ramírez-Bravo S, Campos L, Angeles J, Vargas-Alarcón G, Granados J, Gopal R, Khader SA, Yunis EJ, Zuñiga J.

J Transl Med. 2013 Sep 21;11:220. doi: 10.1186/1479-5876-11-220.

47.

S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis.

Gopal R, Monin L, Torres D, Slight S, Mehra S, McKenna KC, Fallert Junecko BA, Reinhart TA, Kolls J, Báez-Saldaña R, Cruz-Lagunas A, Rodríguez-Reyna TS, Kumar NP, Tessier P, Roth J, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Cumming B, Kasprowicz VO, Steyn AJ, Babu S, Kaushal D, Zúñiga J, Vogl T, Rangel-Moreno J, Khader SA.

Am J Respir Crit Care Med. 2013 Nov 1;188(9):1137-46. doi: 10.1164/rccm.201304-0803OC.

48.

The emergence of OXA-48- and NDM-1-positive Klebsiella pneumoniae in Riyadh, Saudi Arabia.

Shibl A, Al-Agamy M, Memish Z, Senok A, Khader SA, Assiri A.

Int J Infect Dis. 2013 Dec;17(12):e1130-3. doi: 10.1016/j.ijid.2013.06.016. Epub 2013 Aug 30.

49.

IL-10 restrains IL-17 to limit lung pathology characteristics following pulmonary infection with Francisella tularensis live vaccine strain.

Slight SR, Monin L, Gopal R, Avery L, Davis M, Cleveland H, Oury TD, Rangel-Moreno J, Khader SA.

Am J Pathol. 2013 Nov;183(5):1397-1404. doi: 10.1016/j.ajpath.2013.07.008. Epub 2013 Sep 3.

50.

Vaccines against tuberculosis: moving forward with new concepts.

Gopal R, Khader SA.

Expert Rev Vaccines. 2013 Aug;12(8):829-31. doi: 10.1586/14760584.2013.814836. Epub 2013 Aug 14. No abstract available.

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